LOCUS       NM_010732               3346 bp    mRNA    linear   ROD 04-AUG-2023
DEFINITION  Mus musculus leucine rich repeat protein 2, neuronal (Lrrn2), mRNA.
ACCESSION   NM_010732 XM_136224
VERSION     NM_010732.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3346)
  AUTHORS   Gu Z, Imai F, Kim IJ, Fujita H, Katayama Ki, Mori K, Yoshihara Y
            and Yoshida Y.
  TITLE     Expression of the immunoglobulin superfamily cell adhesion
            molecules in the developing spinal cord and dorsal root ganglion
  JOURNAL   PLoS One 10 (3), e0121550 (2015)
   PUBMED   25826454
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3346)
  AUTHORS   Tang T, Li L, Tang J, Li Y, Lin WY, Martin F, Grant D, Solloway M,
            Parker L, Ye W, Forrest W, Ghilardi N, Oravecz T, Platt KA, Rice
            DS, Hansen GM, Abuin A, Eberhart DE, Godowski P, Holt KH, Peterson
            A, Zambrowicz BP and de Sauvage FJ.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   3  (bases 1 to 3346)
  AUTHORS   Homma S, Shimada T, Hikake T and Yaginuma H.
  TITLE     Expression pattern of LRR and Ig domain-containing protein (LRRIG
            protein) in the early mouse embryo
  JOURNAL   Gene Expr Patterns 9 (1), 1-26 (2009)
   PUBMED   18848646
REFERENCE   4  (bases 1 to 3346)
  AUTHORS   Yoshida Y, Han B, Mendelsohn M and Jessell TM.
  TITLE     PlexinA1 signaling directs the segregation of proprioceptive
            sensory axons in the developing spinal cord
  JOURNAL   Neuron 52 (5), 775-788 (2006)
   PUBMED   17145500
REFERENCE   5  (bases 1 to 3346)
  AUTHORS   Dehghani H and Hahnel AC.
  TITLE     Expression profile of protein kinase C isozymes in preimplantation
            mouse development
  JOURNAL   Reproduction 130 (4), 441-451 (2005)
   PUBMED   16183862
REFERENCE   6  (bases 1 to 3346)
  AUTHORS   Haines BP, Gupta R, Jones CM, Summerbell D and Rigby PW.
  TITLE     The NLRR gene family and mouse development: Modified differential
            display PCR identifies NLRR-1 as a gene expressed in early somitic
            myoblasts
  JOURNAL   Dev Biol 281 (2), 145-159 (2005)
   PUBMED   15893969
  REMARK    GeneRIF: NLRR-2 expression appears to be predominately confined to
            the adult.
REFERENCE   7  (bases 1 to 3346)
  AUTHORS   Taguchi A, Wanaka A, Mori T, Matsumoto K, Imai Y, Tagaki T and
            Tohyama M.
  TITLE     Molecular cloning of novel leucine-rich repeat proteins and their
            expression in the developing mouse nervous system
  JOURNAL   Brain Res Mol Brain Res 35 (1-2), 31-40 (1996)
   PUBMED   8717337
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK039216.1, BC056458.1 and BB342744.1.
            
            On Apr 7, 2010 this sequence version replaced NM_010732.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK036271.1, AK039216.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3298              AK039216.1         2-3299
            3299-3330           BC056458.1         3041-3072
            3331-3346           BB342744.1         256-271
FEATURES             Location/Qualifiers
     source          1..3346
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 57.69 cM"
     gene            1..3346
                     /gene="Lrrn2"
                     /gene_synonym="5730406J09Rik; NLRR-2"
                     /note="leucine rich repeat protein 2, neuronal"
                     /db_xref="GeneID:16980"
                     /db_xref="MGI:MGI:106037"
     exon            1..321
                     /gene="Lrrn2"
                     /gene_synonym="5730406J09Rik; NLRR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            322..3346
                     /gene="Lrrn2"
                     /gene_synonym="5730406J09Rik; NLRR-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             540..2732
                     /gene="Lrrn2"
                     /gene_synonym="5730406J09Rik; NLRR-2"
                     /codon_start=1
                     /product="leucine-rich repeat neuronal protein 2
                     precursor"
                     /protein_id="NP_034862.1"
                     /db_xref="CCDS:CCDS15289.1"
                     /db_xref="GeneID:16980"
                     /db_xref="MGI:MGI:106037"
                     /translation="MRLLVAALLLSWVAGTTAAAPVVPWRVPCPPQCACQIRPWYTPR
                     SSYREATTVDCNDLFLTAVPPRLPAGTQTLLLQSNSISRIDQTELAYLANLTELDLSQ
                     NSFSDARDCDFQALPQLLSLHLEENRLNRLEDHSFAGLTSLQELYLNHNQLCRISPRA
                     FAGLGNLLRLHLNSNLLRTIDSRWFEMLPNLEILMIGGNKVDAILDMNFRPLANLRSL
                     VLAGMSLREISDYALEGLQSLESLSFYDNQLAQVPKRALEQVPGLKFLDLNKNPLQRV
                     GPGDFANMLHLKELGLNNMEELVSIDKFALVNLPELTKLDITNNPRLSFIHPRAFHHL
                     PQMETLMLNNNALSALHQQTVESLPNLQEVGLHGNPIRCDCVIRWANATGTHVRFIEP
                     QSTLCAEPPDLQRRPVREVPFREMTDHCLPLISPRSFPSSLQIASGESTVLHCRALAE
                     PEPEIYWVTPAGVRLTPARSGRRYRVFPEGTLELRRVTAEEAGLYTCVAQNLVGADTK
                     TVSVVVGHAPFQPGRDKGPGLKLHVQETHPYHILLFWAPPPNIVSTNLTWSSASSLRD
                     HEAPALARLPRGTHRYNITRLLPATEYWACLQVAFADAHTQLACVWARTKEASPCHRA
                     LGDRPGLIAILALAVLLLAAGLAAHLGRGQSKQGVVGEKPLLPVWAFWGWSAPSVRVV
                     SAPLVLPWNPGRKQPRCQMGRGCHHHCLNIAEVPPGLSSREITRTTLH"
ORIGIN      
        1 agtgaggagg acgagcgcga gcagccagga gggaggaggc gcggcggggg cgccgggcgc
       61 cgcgggcctg ctccgtgctc cgcagacgcg cggcgctccg ggagcgccgg ccctggccgc
      121 caacctccag ccgcggcgcg caggattggg gacactgtca ttctgctgac gccctcgcag
      181 gctcagcgtt gagaccactc ccaggacaag tgtaggttgg ggaaggcgcc cggcgagcct
      241 cccgggcctg ggtagcagcg cgccgtggag cagcgatccc agccgggagg cgagtgacgg
      301 acataggaca gcgcccgcgc gggtcgccca atgaggaaat gagtgggcag tcccagtccc
      361 agtcccagtc cagtgcacaa agatgaggac ctacacccag gacagcacaa agtgatgtcc
      421 acccaccctg tgtagaatga ctgccctgag agggtggttc cccggaccct ggcagggctg
      481 ctgaacctcc gcctgcaagt cgtgaagagc aggactctcc cctgccttcc acctccacca
      541 tgaggctcct cgtggctgcc ctcttgctat cttgggtggc tggtaccacc gctgcagcac
      601 cggtggtacc ctggcgtgtg ccctgccctc ctcagtgtgc ctgccagatc cggccctggt
      661 acacaccccg ctcgtcctac cgtgaagcca ccactgtcga ctgcaatgac ctcttcctga
      721 cggcagtgcc cccaaggctc cctgcgggga cacagaccct gctcctgcag agtaacagca
      781 tcagccggat agaccagact gagcttgcct acttggccaa cctcacagag ctggacctgt
      841 cccagaacag cttctcagat gcccgagact gcgatttcca agccctgcct cagctgctga
      901 gcctacatct agaagagaac cggctgaacc ggctggagga tcacagcttc gctgggctga
      961 ccagcctgca ggagctctat ctcaaccata accagctctg ccgcatctcc cccagggcct
     1021 ttgcagggct gggtaacctg ctgagactgc acctcaattc caacctgctt aggaccatcg
     1081 acagccgctg gttcgagatg ctgcccaact tggaaatcct catgattggc ggcaacaagg
     1141 tggatgccat cttggacatg aacttccggc ccctggccaa cctgcgcagc ctggtgctgg
     1201 caggcatgag cttgcgggag atctcagact acgctctgga gggactgcaa agcctggaga
     1261 gtctctcttt ctacgacaat cagctggccc aggtgcccaa gcgggcattg gagcaggtgc
     1321 ctgggctcaa gttcctagac ctgaacaaaa acccactgca gcgggtcgga ccgggagact
     1381 ttgccaacat gctgcacctc aaggaactag gactaaacaa catggaggaa ctggtctcca
     1441 tcgacaagtt tgctctggta aatctccctg agctgaccaa gttggacatc accaacaacc
     1501 cacggctttc tttcatccat cctcgcgcct ttcaccacct gccccagatg gagactctca
     1561 tgctcaacaa caatgctctc agtgccttgc accagcagac agtggagtct ctgcccaacc
     1621 tacaggaggt ggggctccac ggcaacccca tccgctgtga ctgtgtcatc cgctgggcca
     1681 acgccacggg cacccacgtc cgtttcatcg aaccacagtc caccctgtgt gctgagcctc
     1741 cagaccttca gcgccgccca gtccgggagg tgcccttccg ggagatgaca gaccactgcc
     1801 tgcccctcat ctctccccga agtttcccct ccagtctgca gatagccagt ggagagagca
     1861 cggtacttca ctgtcgggca ctggctgaac cagaacctga gatctactgg gtcaccccag
     1921 ctggagttcg actgacacct gctcgctcag gcaggaggta ccgagtgttc cctgagggta
     1981 ccctagagtt gcggagggtg acggcggaag aggcaggcct atacacctgt gtggcccaga
     2041 acttggtagg ggctgacact aaaaccgtca gtgttgtggt tggccacgct cccttccagc
     2101 caggcaggga caaaggacca ggactgaagc tccatgtgca ggagacacac ccatatcaca
     2161 tcctgctgtt ttgggcaccc ccacccaata tagtctccac caacctcacc tggtctagcg
     2221 cctcctccct ccgggaccat gaagctcctg ctttggcccg actgccgcgg ggcacccacc
     2281 gctacaacat tacccgcctc cttccggcca cagagtactg ggcctgcctg caagtggcct
     2341 ttgctgatgc ccacacccag ttggcttgtg tttgggccag gactaaagag gcctctcctt
     2401 gccacagagc cctgggggac cggcccgggc tcatagccat cctggctctt gcggtcctcc
     2461 tgctggcagc tgggcttgca gcccacctcg gcagaggcca gtccaagcag ggggtggtgg
     2521 gtgagaagcc tcttcttccg gtctgggctt tctggggctg gagcgccccc tctgtccggg
     2581 tagtgtctgc accccttgtc ctgccctgga atccagggag gaagcagccc agatgtcaga
     2641 tggggagagg gtgccaccac cattgtctca acattgctga agttccgcca ggtctcagca
     2701 gtagagaaat aactaggaca actctacact aaacgggacg tgatctgggc cagatgcctg
     2761 ccaggaacgt ggcgttgatt gatccacgtg cttgaggcct ggcagcttga ccaagaaaga
     2821 tggggttcgg cagctcctgg ggatgccctc acagccccca aatggttgct gttgccttct
     2881 ggggtcctcg gctgtgattc tgaggagagt gtccaaggaa caggaaggac tctgcctaga
     2941 gcctcctacc gccccagagg cttctgggcc tcagcttggc tgtcccctgc ctgtgtccct
     3001 aggcccttgg cccacaggaa atgccccctc ctcttctctt tctttgtaca gtctcagttg
     3061 cttgctcctc cccctcctgg gcaagggctg aaagaggctt ctcctacctg tcttgggagc
     3121 ctgccccaaa agcaggagtg tccccagctg gatctgaagg atatttggag agagaggtat
     3181 ccagggatgc ctcatctcat agcctgggct ctgaagttga ctttctatag gcaattttgt
     3241 atctttgtgg agaaatgtgt cacctgtccc caacccaatt cactcttttt tcctgttttt
     3301 aaaaaaaata aaaataaacg atgccaataa cagtggggag aagatg
//
