LOCUS       NM_008516               3756 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus leucine rich repeat protein 1, neuronal (Lrrn1), mRNA.
ACCESSION   NM_008516
VERSION     NM_008516.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3756)
  AUTHORS   Maunsell,H.R., Ellis,K., Kelley,M.W. and Driver,E.C.
  TITLE     Lrrn1 Regulates Medial Boundary Formation in the Developing Mouse
            Organ of Corti
  JOURNAL   J Neurosci 43 (29), 5305-5318 (2023)
   PUBMED   37369584
  REMARK    GeneRIF: Lrrn1 Regulates Medial Boundary Formation in the
            Developing Mouse Organ of Corti.
REFERENCE   2  (bases 1 to 3756)
  AUTHORS   Moreau,M.X., Saillour,Y., Cwetsch,A.W., Pierani,A. and Causeret,F.
  TITLE     Single-cell transcriptomics of the early developing mouse cerebral
            cortex disentangle the spatial and temporal components of neuronal
            fate acquisition
  JOURNAL   Development 148 (14) (2021)
   PUBMED   34170322
REFERENCE   3  (bases 1 to 3756)
  AUTHORS   Wiwatpanit,T., Lorenzen,S.M., Cantu,J.A., Foo,C.Z., Hogan,A.K.,
            Marquez,F., Clancy,J.C., Schipma,M.J., Cheatham,M.A., Duggan,A. and
            Garcia-Anoveros,J.
  TITLE     Trans-differentiation of outer hair cells into inner hair cells in
            the absence of INSM1
  JOURNAL   Nature 563 (7733), 691-695 (2018)
   PUBMED   30305733
  REMARK    Erratum:[Nature. 2019 Jan;565(7737):E2. doi:
            10.1038/s41586-018-0795-6.. PMID: 30518865]
REFERENCE   4  (bases 1 to 3756)
  AUTHORS   Satoh,S., Takatori,A., Ogura,A., Kohashi,K., Souzaki,R.,
            Kinoshita,Y., Taguchi,T., Hossain,M.S., Ohira,M., Nakamura,Y. and
            Nakagawara,A.
  TITLE     Neuronal leucine-rich repeat 1 negatively regulates anaplastic
            lymphoma kinase in neuroblastoma
  JOURNAL   Sci Rep 6, 32682 (2016)
   PUBMED   27604320
  REMARK    GeneRIF: NLRR1 appears to be an extracellular negative regulator of
            ALK signalling in neuroblastoma and neuronal development.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3756)
  AUTHORS   Gu,Z., Imai,F., Kim,I.J., Fujita,H., Katayama,Ki., Mori,K.,
            Yoshihara,Y. and Yoshida,Y.
  TITLE     Expression of the immunoglobulin superfamily cell adhesion
            molecules in the developing spinal cord and dorsal root ganglion
  JOURNAL   PLoS One 10 (3), e0121550 (2015)
   PUBMED   25826454
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3756)
  AUTHORS   Abramova,N., Charniga,C., Goderie,S.K. and Temple,S.
  TITLE     Stage-specific changes in gene expression in acutely isolated mouse
            CNS progenitor cells
  JOURNAL   Dev Biol 283 (2), 269-281 (2005)
   PUBMED   15890332
REFERENCE   7  (bases 1 to 3756)
  AUTHORS   Haines,B.P., Gupta,R., Jones,C.M., Summerbell,D. and Rigby,P.W.
  TITLE     The NLRR gene family and mouse development: Modified differential
            display PCR identifies NLRR-1 as a gene expressed in early somitic
            myoblasts
  JOURNAL   Dev Biol 281 (2), 145-159 (2005)
   PUBMED   15893969
  REMARK    GeneRIF: NLRR-1 is expressed in a subset of myotome cells.
REFERENCE   8  (bases 1 to 3756)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   9  (bases 1 to 3756)
  AUTHORS   Aubert,J., Stavridis,M.P., Tweedie,S., O'Reilly,M., Vierlinger,K.,
            Li,M., Ghazal,P., Pratt,T., Mason,J.O., Roy,D. and Smith,A.
  TITLE     Screening for mammalian neural genes via fluorescence-activated
            cell sorter purification of neural precursors from Sox1-gfp
            knock-in mice
  JOURNAL   Proc Natl Acad Sci U S A 100 Suppl 1 (Suppl 1), 11836-11841 (2003)
   PUBMED   12923295
REFERENCE   10 (bases 1 to 3756)
  AUTHORS   Taguchi,A., Wanaka,A., Mori,T., Matsumoto,K., Imai,Y., Tagaki,T.
            and Tohyama,M.
  TITLE     Molecular cloning of novel leucine-rich repeat proteins and their
            expression in the developing mouse nervous system
  JOURNAL   Brain Res Mol Brain Res 35 (1-2), 31-40 (1996)
   PUBMED   8717337
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK139965.1, AK160841.1 and AC155327.3.
            
            On Apr 7, 2011 this sequence version replaced NM_008516.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK139965.1, BC058701.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-122               AK139965.1         2-123
            123-3749            AK160841.1         2-3628
            3750-3756           AC155327.3         27980-27986         c
FEATURES             Location/Qualifiers
     source          1..3756
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 49.71 cM"
     gene            1..3756
                     /gene="Lrrn1"
                     /gene_synonym="2810047E21Rik; NLRR-1"
                     /note="leucine rich repeat protein 1, neuronal"
                     /db_xref="GeneID:16979"
                     /db_xref="MGI:MGI:106038"
     exon            1..518
                     /gene="Lrrn1"
                     /gene_synonym="2810047E21Rik; NLRR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            519..3756
                     /gene="Lrrn1"
                     /gene_synonym="2810047E21Rik; NLRR-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             771..2921
                     /gene="Lrrn1"
                     /gene_synonym="2810047E21Rik; NLRR-1"
                     /codon_start=1
                     /product="leucine-rich repeat neuronal protein 1
                     precursor"
                     /protein_id="NP_032542.1"
                     /db_xref="CCDS:CCDS20399.1"
                     /db_xref="GeneID:16979"
                     /db_xref="MGI:MGI:106038"
                     /translation="MARLSTGKAACQVVLGLLITSLTESSILTSECPQLCVCEIRPWF
                     TPQSTYREATTVDCNDLRLTRIPGNLSSDTQVLLLQSNNIAKTVDELQQLFNLTELDF
                     SQNNFTNIKEVGLANLTQLTTLHLEENQISEMTDYCLQDLSNLQELYINHNQISTISA
                     NAFSGLKNLLRLHLNSNKLKVIDSRWFDSTPNLEILMIGENPVIGILDMNFRPLSNLR
                     SLVLAGMYLTDVPGNALVGLDSLESLSFYDNKLIKVPQLALQKVPNLKFLDLNKNPIH
                     KIQEGDFKNMLRLKELGINNMGELVSVDRYALDNLPELTKLEATNNPKLSYIHRLAFR
                     SVPALESLMLNNNALNAVYQKTVESLPNLREISIHSNPLRCDCVIHWINSNKTNIRFM
                     EPLSMFCAMPPEYRGQQVKEVLIQDSSEQCLPMISHDTFPNHLNMDIGTTLFLDCRAM
                     AEPEPEIYWVTPIGNKITVETLSDKYKLSSEGTLEIANIQIEDSGRYTCVAQNVQGAD
                     TRVATIKVNGTLLDGAQVLKIYVKQTESHSILVSWKVNSNVMTSNLKWSSATMKIDNP
                     HITYTARVPVDVHEYNLTHLQPSTDYEVCLTVSNIHQQTQKSCVNVTTKTAAFALDIS
                     DHETSTALAAVMGSMFAVISLASIAIYIAKRFKRKNYHHSLKKYMQKTSSIPLNELYP
                     PLINLWEADSDKDKDGSADTKPTQVDTSRSYYMW"
     regulatory      3713..3718
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lrrn1"
                     /gene_synonym="2810047E21Rik; NLRR-1"
                     /note="hexamer: AATAAA"
     polyA_site      3751
                     /gene="Lrrn1"
                     /gene_synonym="2810047E21Rik; NLRR-1"
                     /note="major polyA site"
ORIGIN      
        1 agctgaccgc ttttgcttac accaggtgca cgccggctgc ggggagcaca aagcggggcg
       61 cacggagggc gccggcagca agccgtgaag ccaggcgagg gccgtgcgcc ccggtttgca
      121 gcgcttgtcg ggcggggacc ggggcccgcg gcgtcctccc agacagtggc atccttgcca
      181 ccgcactccg aggcgcctcg ggcgccttcc ttgagaccga tccttcgctg ccccgccctc
      241 tgcaccccat ttcttctacc ctctttccta ttcccgcctg tctctaccac gacccccaag
      301 aacgcgattt agcccagccc cgcgcagcag ctgttgctcc cgcggctgtc tcgccttgca
      361 tcttggtgct ctgctggggg tcccccaagg agccagtgcg cgctgcgggc tgggtggagg
      421 cgctgctctg ccggtcctca tcctccggct agtggctgct gctgccacca ccacccgctc
      481 cgtgcgcacc ccaacacccc tgtcagccca gccttaggac acgtctccag actttgattt
      541 ggctgaagta actcccacaa ggacctgtgc acatgcctgg cattgagtga tacggttcaa
      601 ggacttcaga ttgcttcctg cctcttggga agttcagaaa aaccttcaga ctccggaatt
      661 cttttccagt gagacttgct tgaatgttta cactatctgc ttgctgttct ccttgccact
      721 gaatcgtgtt cagatctcgg tcaggaactg ggtgtggttg gcaagccacc atggccagat
      781 tgagcactgg gaaagcagct tgccaggtgg tgctgggctt gctgataact tcattaactg
      841 aatcttccat actgactagt gagtgtcccc agctttgtgt ttgtgaaatt cgtccttggt
      901 ttaccccaca gtccacctac agagaagcca ccaccgtgga ttgtaatgac ctccgcctaa
      961 ccaggatccc tggcaacctc tctagtgaca cacaagtgct tctcttacag agcaataaca
     1021 tcgccaagac cgtggacgag ctgcagcagc tcttcaactt gaccgagctg gatttctccc
     1081 agaacaactt tacaaacatc aaagaggtag ggctggcaaa cttgacccag ctcacaaccc
     1141 tgcatctaga ggaaaatcag atttcagaga tgacggatta ctgtctgcaa gacctcagca
     1201 accttcaaga actctacatc aaccacaacc agatcagcac aatctctgcc aacgcctttt
     1261 ctggcttgaa aaatctcttg aggctgcacc tgaattccaa taagttgaaa gtgatcgata
     1321 gccgctggtt tgattccact cccaacctgg aaattctcat gattggggaa aaccctgtga
     1381 ttggaatcct ggacatgaac ttcagacctc tctccaacct gagaagccta gtgttagcag
     1441 gaatgtacct cactgatgtt cccggaaacg ccttggtagg cttggatagc ctcgagagcc
     1501 tgtctttcta tgacaacaaa ctgatcaaag tccctcaact tgccctgcaa aaagttccaa
     1561 atttgaaatt tttagacctc aataaaaatc ctattcacaa aatccaagaa ggagacttta
     1621 aaaatatgct tcggttaaaa gaactgggaa tcaacaacat gggagagctg gtttccgtgg
     1681 accgctatgc cctggataac ttgccagaat tgacaaagct cgaagcaacc aataacccca
     1741 aactgtcata catccaccgt ttggctttcc gtagtgtgcc ggctctagaa agcttaatgt
     1801 tgaacaacaa tgccttgaat gccgtgtacc aaaaaacagt ggaatctctt cccaatctgc
     1861 gtgagatcag catccacagc aacccgctga ggtgtgactg tgtcatccac tggatcaact
     1921 ccaacaaaac caacattcgc ttcatggagc ccctctccat gttctgtgcc atgccaccgg
     1981 aatacagggg gcagcaggtg aaggaggtcc taatccagga ctcaagtgag cagtgcctcc
     2041 cgatgatatc gcacgataca ttccctaatc atctaaacat ggacattggt acaacacttt
     2101 tcctagactg tcgggccatg gctgagccag aaccagagat ttactgggtc actcccattg
     2161 gaaataagat aaccgtggaa actctttcag acaaatacaa gctgagtagt gagggcacct
     2221 tggagatagc aaacatacag attgaagact caggaaggta cacctgcgtt gcccagaatg
     2281 tccaaggagc agacactcga gtggcaacta tcaaggttaa tggaaccctt ctagatggtg
     2341 cacaggtgct gaaaatatat gtcaaacaga cagaatctca ttcgatttta gtatcttgga
     2401 aagttaattc caatgtcatg acatcgaact tgaaatggtc atctgccact atgaagatcg
     2461 acaaccccca cataacatac acagccaggg tgccagtaga tgttcatgaa tataacctaa
     2521 cacatctgca gccttctacg gattatgaag tgtgtctcac ggtgtccaac atccatcagc
     2581 agactcagaa gtcatgtgtc aatgtcacaa ccaaaaccgc tgccttcgcc ctggacatct
     2641 ctgaccatga aaccagcacc gcccttgctg cggtgatggg gtccatgttt gccgtcatca
     2701 gtctagcatc catcgctatt tacatcgcga aaaggtttaa gaggaaaaat taccaccatt
     2761 cgctgaaaaa gtatatgcaa aaaacctcgt ccatcccact gaacgagctg taccccccac
     2821 tcattaacct ctgggaagct gacagtgaca aggacaaaga tggctcggca gacaccaagc
     2881 caacccaggt tgacacatcc agaagctatt acatgtggta actcagtggg tgttttgctt
     2941 ctggtagtaa ggagcacaaa gacatttttg ctttattctg caaaagtaac aaggtgaaga
     3001 agacttttgt acttttgact ttgctagttg tggcagagcg gagaggatgg gtggatattt
     3061 caaagttttt tagtatagcg tatcgcaagg gggtggacac agctggtggt gactctcagc
     3121 ttccagtttg tgtttggttt ttatccttat cattattatg attattatta tattattatt
     3181 atcatcatta ttttatttta gttgattgct aaactcagta atgctgtctt aactacgatg
     3241 ctcaatgatt aatgacaggt ggggggttct cctgtgcttg acccctttct tctgaagcca
     3301 tcaatacgaa gaaccgaacc gaaccggcct ctcaacagct aacatagggt ttggaagcag
     3361 cattagatcc tttgtagcaa tctggtctac agactttaac tcaagctaag actaaacttg
     3421 ctactttgtt gaatgatgtt agttgactgt actgtaatgt tgtatcaact gaactgaatg
     3481 tttgcctttc agcaacaact ttcttttcct tcctctttgt tttttaatag ttaaagaggc
     3541 ttagaacaag ctaacaggca atagaaatat gtatatcaga ttttctaatg taatgaacta
     3601 catggtaatt gttactatat tctttttatc tttagtagac acttttaaag aagaaaagat
     3661 aattttgttg tgtttaactc accaacttgg tgtataatga agacagaagt ataataaatt
     3721 agtttgttct gattttttag aacacttgca ataatg
//
