LOCUS       NM_001163559            5128 bp    mRNA    linear   ROD 08-DEC-2024
DEFINITION  Mus musculus leucine-rich repeats and IQ motif containing 1
            (Lrriq1), transcript variant 1, mRNA.
ACCESSION   NM_001163559 XM_001478028 XM_001478416
VERSION     NM_001163559.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5128)
  AUTHORS   Fukutomi,M., Uedono,C., Fujii,A. and Sato,Y.
  TITLE     Lrriq1 is an essential factor for fertility by suppressing
            apoptosis
  JOURNAL   J Assist Reprod Genet 39 (11), 2647-2657 (2022)
   PUBMED   36129630
  REMARK    GeneRIF: Lrriq1 is an essential factor for fertility by suppressing
            apoptosis.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122850.4 and AC162918.3.
            
            On Feb 27, 2018 this sequence version replaced NM_001163559.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments with rodent ESTs and the
            orthologous human protein, but the complete combination of exons
            has not been validated by a full-length cDNA.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMN00849374, SAMN00849377
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-47                AC122850.4         47328-47374
            48-192              AC122850.4         49493-49637
            193-319             AC122850.4         56348-56474
            320-411             AC122850.4         58679-58770
            412-529             AC122850.4         59840-59957
            530-753             AC122850.4         62191-62414
            754-828             AC122850.4         65498-65572
            829-2481            AC122850.4         67538-69190
            2482-2634           AC122850.4         81140-81292
            2635-2785           AC122850.4         82943-83093
            2786-2979           AC122850.4         93625-93818
            2980-3107           AC122850.4         96176-96303
            3108-3181           AC122850.4         101763-101836
            3182-3275           AC122850.4         104835-104928
            3276-3455           AC122850.4         110254-110433
            3456-3893           AC122850.4         112792-113229
            3894-4095           AC122850.4         121740-121941
            4096-4215           AC122850.4         127194-127313
            4216-4305           AC122850.4         137357-137446
            4306-4427           AC122850.4         138122-138243
            4428-4523           AC122850.4         138754-138849
            4524-4606           AC122850.4         139086-139168
            4607-4708           AC122850.4         146442-146543
            4709-4859           AC162918.3         163826-163976       c
            4860-4920           AC162918.3         161679-161739       c
            4921-5128           AC162918.3         156078-156285       c
FEATURES             Location/Qualifiers
     source          1..5128
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 53.65 cM"
     gene            1..5128
                     /gene="Lrriq1"
                     /gene_synonym="4930503E15Rik; Gm1557"
                     /note="leucine-rich repeats and IQ motif containing 1"
                     /db_xref="GeneID:74978"
                     /db_xref="MGI:MGI:1922228"
     exon            1..47
                     /gene="Lrriq1"
                     /gene_synonym="4930503E15Rik; Gm1557"
                     /inference="alignment:Splign:2.1.0"
     exon            48..192
                     /gene="Lrriq1"
                     /gene_synonym="4930503E15Rik; Gm1557"
                     /inference="alignment:Splign:2.1.0"
     CDS             52..5073
                     /gene="Lrriq1"
                     /gene_synonym="4930503E15Rik; Gm1557"
                     /note="isoform 1 is encoded by transcript variant 1; IQ
                     domain-containing protein LRRIQ1; leucine-rich repeat and
                     IQ domain-containing protein 1"
                     /codon_start=1
                     /product="leucine-rich repeat- and IQ domain-containing
                     protein 1 isoform 1"
                     /protein_id="NP_001157031.1"
                     /db_xref="CCDS:CCDS48687.1"
                     /db_xref="GeneID:74978"
                     /db_xref="MGI:MGI:1922228"
                     /translation="MEDSDDSEAKLREEIEAELDKISISSLENDEVENDSVSDTQSDS
                     SDTDLLELPESVLHYINVIKNKSKTAEELILQDVEDTDIFSDYKKGCNHGTVTDSHMH
                     LRTGSLPESKANAEQLMKILSVIEKEEFMRSLAPSARCVSVREIITPDTPMDEYILPD
                     EADLSFGYFEVEERCRKSFEAWQDKQQELEEKDKETLEAQNEREKRTFQEEDEKRQCW
                     MRQFEVEKKHLEDLQKQDQDKMNDELHKEEKIWKEKYRQHEEHIRNLHLKMEEERTRL
                     SELQEKEKARLFKLRYDAAVKIQATYRASVTYRKYSPIIKEQMEKKRRRAQELKEKEA
                     KIRQKEEEKRRRLEEEQRVEEEKKKKMLEERRRREREYEEKKSILRQEREEQRSKEVI
                     RLREHAHSPLIITCALKKGDCHGKQQAIAHVPKGKGTIAKESVDSNSKKQEDACLAQQ
                     LNKRENTHVQQLAMKKSTGIKLKPNQAILVELKMNEKNESLPKLKINENLSKNQCSEQ
                     PSDQEFNAENVDQKNELENSNLKESVNEQYPWQGLESDTQTEEHVEHVREEKVGQETE
                     KLFGFNQEVSAEDSKQAQGVMEETREGLAEEIEIKEMTQQGGPSDENNSSPISMQKSL
                     PSLTPDNPEPVERSVTLEEDQETDLKSERIEEIPEEGVLSCDAAVINADASVHTEGEA
                     DLQDSASGKLAPSEEAGSHSANNLLATEEVEDSPKSEIQEALEKGQQTKAEADGVLTC
                     SVSQLTVLSSVEERRLAWVKTFKPWAEIFEQNQHKKIVKKRRLVKCPPNTMPPLDPSA
                     ILQYGPWKSLKQVPVITFQGLPGCSLSTLAECSNLQILSLRRCGLTSLQGLSHCTRLK
                     YIDAQENHIEAISCENLENLSVVLLNNNLLTSIHGFDGCTNLQSLELSHNKITRISGL
                     ESLKYLQELTVDHNQLISTKGLCEAPTIVYLDCSHNHLTGIDGIGNCGLLQIIKLQGN
                     YLREPPSLRNHVLLRELHLDDNSISSVEGLSSCWLPLLQYLSISQNSLATIVPLFHLV
                     SLEKLDVSNNCLSDLTNVMCWFNACYSLRELCLTGNPVLQEINWRDSILKTLPALRVL
                     NGDMLNSYANDRIEEHYHQDLRCLLALCQYQLQEFNLLPEKYITQKRDILTLHAVDRL
                     SQYYKDLMKLSHECRRAHEQGDVNTTERSAAETNKNHPDFSNTDSALQNKTLHAQTNS
                     CEADSPATSPNPLDTVFRPSTSHCEELRGRNQEKLMAHKSEQSRISSRSNSRASFIEM
                     KMADSPMSNHHNAERSSPTKAAMVIQAQWRSYIAHRQINCSAEMHPTTTEPLQDPLIN
                     NQTTSNEERRKTNMDIQEQREKAALHIQAVWKGFILRKKLATARKAIKDEESGEEYEE
                     IDLEDFEFDEDALEKDWPALDSTGFPSQTLPLSNQLPWPKNSRTLRHDETSPTIPVRP
                     AQAWLCNEKENVMSSEYTQLSSRSESGILSWTPDSKTSRKNLLQSEKEEKISEEWGFK
                     DISTAQQMLKRAKKMKSKKLRKKLEPSVRLALFKKAKNKVSVTKSSKKTQLRRDNYFE
                     AHISSQDEEEEAVSKATAAKEKLERSQEYTYQWLHTQVGFPEATSSRNLKCNHFLPEL
                     DPDVLNGGRVQLVARLVSREDTDLDLFSMTSASALSVNKDKKSQTHRYSTGSSSKLWF
                     PSELI"
     exon            193..319
                     /gene="Lrriq1"
                     /gene_synonym="4930503E15Rik; Gm1557"
                     /inference="alignment:Splign:2.1.0"
     exon            320..411
                     /gene="Lrriq1"
                     /gene_synonym="4930503E15Rik; Gm1557"
                     /inference="alignment:Splign:2.1.0"
     exon            412..529
                     /gene="Lrriq1"
                     /gene_synonym="4930503E15Rik; Gm1557"
                     /inference="alignment:Splign:2.1.0"
     exon            530..753
                     /gene="Lrriq1"
                     /gene_synonym="4930503E15Rik; Gm1557"
                     /inference="alignment:Splign:2.1.0"
     exon            754..828
                     /gene="Lrriq1"
                     /gene_synonym="4930503E15Rik; Gm1557"
                     /inference="alignment:Splign:2.1.0"
     exon            829..2481
                     /gene="Lrriq1"
                     /gene_synonym="4930503E15Rik; Gm1557"
                     /inference="alignment:Splign:2.1.0"
     exon            2482..2634
                     /gene="Lrriq1"
                     /gene_synonym="4930503E15Rik; Gm1557"
                     /inference="alignment:Splign:2.1.0"
     exon            2635..2785
                     /gene="Lrriq1"
                     /gene_synonym="4930503E15Rik; Gm1557"
                     /inference="alignment:Splign:2.1.0"
     exon            2786..2979
                     /gene="Lrriq1"
                     /gene_synonym="4930503E15Rik; Gm1557"
                     /inference="alignment:Splign:2.1.0"
     exon            2980..3107
                     /gene="Lrriq1"
                     /gene_synonym="4930503E15Rik; Gm1557"
                     /inference="alignment:Splign:2.1.0"
     exon            3108..3181
                     /gene="Lrriq1"
                     /gene_synonym="4930503E15Rik; Gm1557"
                     /inference="alignment:Splign:2.1.0"
     exon            3182..3275
                     /gene="Lrriq1"
                     /gene_synonym="4930503E15Rik; Gm1557"
                     /inference="alignment:Splign:2.1.0"
     exon            3276..3455
                     /gene="Lrriq1"
                     /gene_synonym="4930503E15Rik; Gm1557"
                     /inference="alignment:Splign:2.1.0"
     exon            3456..3893
                     /gene="Lrriq1"
                     /gene_synonym="4930503E15Rik; Gm1557"
                     /inference="alignment:Splign:2.1.0"
     exon            3894..4095
                     /gene="Lrriq1"
                     /gene_synonym="4930503E15Rik; Gm1557"
                     /inference="alignment:Splign:2.1.0"
     exon            4096..4215
                     /gene="Lrriq1"
                     /gene_synonym="4930503E15Rik; Gm1557"
                     /inference="alignment:Splign:2.1.0"
     exon            4216..4305
                     /gene="Lrriq1"
                     /gene_synonym="4930503E15Rik; Gm1557"
                     /inference="alignment:Splign:2.1.0"
     exon            4306..4427
                     /gene="Lrriq1"
                     /gene_synonym="4930503E15Rik; Gm1557"
                     /inference="alignment:Splign:2.1.0"
     exon            4428..4523
                     /gene="Lrriq1"
                     /gene_synonym="4930503E15Rik; Gm1557"
                     /inference="alignment:Splign:2.1.0"
     exon            4524..4606
                     /gene="Lrriq1"
                     /gene_synonym="4930503E15Rik; Gm1557"
                     /inference="alignment:Splign:2.1.0"
     exon            4607..4708
                     /gene="Lrriq1"
                     /gene_synonym="4930503E15Rik; Gm1557"
                     /inference="alignment:Splign:2.1.0"
     exon            4709..4859
                     /gene="Lrriq1"
                     /gene_synonym="4930503E15Rik; Gm1557"
                     /inference="alignment:Splign:2.1.0"
     exon            4860..4920
                     /gene="Lrriq1"
                     /gene_synonym="4930503E15Rik; Gm1557"
                     /inference="alignment:Splign:2.1.0"
     exon            4921..5128
                     /gene="Lrriq1"
                     /gene_synonym="4930503E15Rik; Gm1557"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttgagcgtc tgtgggcgct gtcttgcagg aagtccagat agcgttgagc tatggaggac
       61 agtgacgaca gcgaggcaaa gctcagagaa gaaatcgaag ctgaattgga taaaatcagc
      121 atctcttcct tggaaaatga tgaggttgaa aatgattcag tgtcagacac acagagtgac
      181 agtagtgaca ctgatttgct tgaattgcca gagtcagttc ttcattatat caacgtcata
      241 aagaacaaga gtaaaactgc tgaagaactc attcttcaag acgtagaaga tactgatatc
      301 ttcagtgatt ataagaaagg ttgtaaccat ggcacagtga ctgacagtca catgcatttg
      361 aggactgggt cattgccgga atctaaagca aatgctgagc aattaatgaa gatattatct
      421 gtaatagaaa aggaagaatt tatgagaagt ctagctcctt ctgccaggtg tgtttccgtt
      481 cgtgagatta ttactcctga cacacccatg gatgaatata ttttaccaga tgaggctgat
      541 ttgagtttcg gatactttga agtagaagaa agatgtagaa aatcttttga agcttggcag
      601 gacaaacaac aagaactaga agaaaaggat aaagaaactc tggaagctca gaatgaaaga
      661 gaaaagcgga cctttcaaga ggaagacgag aagagacagt gctggatgag acagtttgaa
      721 gttgaaaaga aacacttaga ggatcttcag aagcaagacc aagacaaaat gaatgatgaa
      781 ctccataaag aagagaaaat atggaaagaa aaatacagac agcatgagga acatatcaga
      841 aacttgcact taaaaatgga ggaggagaga acaagattaa gtgagctaca agaaaaagaa
      901 aaggcacgtt tattcaaact gcggtatgat gcagctgtaa aaattcaagc cacttataga
      961 gcatcagtaa cttaccgaaa atatagccca atcataaaag agcaaatgga aaagaagagg
     1021 aggagagcac aggagttgaa agagaaggag gcaaagatac gacagaagga ggaagaaaag
     1081 aggaggagac ttgaagagga gcagagggta gaggaggaga agaagaagaa gatgctggag
     1141 gagaggagga gacgagagag ggaatacgaa gagaaaaaga gcatcctgag acaagagaga
     1201 gaagagcaac gaagcaagga agtgataaga ctgagggaac atgcccactc gccactgatc
     1261 attacctgtg ctttaaagaa aggagattgc catggcaagc agcaagctat tgcacatgtg
     1321 ccaaagggta agggtactat agccaaagag tcagtggaca gcaactcaaa gaagcaagaa
     1381 gatgcttgcc tcgctcagca attaaacaag agagaaaaca cacacgtgca gcagcttgcg
     1441 atgaagaaat caacaggaat aaaattaaaa ccaaaccagg caattttggt agaattaaaa
     1501 atgaacgaga aaaatgaaag tttaccaaaa ttaaaaatca atgaaaactt atcaaaaaac
     1561 caatgttcag aacaaccttc tgaccaagaa tttaacgctg aaaatgtaga ccaaaaaaat
     1621 gaattggaaa actccaacct aaaggaaagt gtgaatgaac agtacccgtg gcaaggacta
     1681 gagtcagata ctcagacaga ggaacatgtg gagcatgtca gggaggagaa ggtgggacaa
     1741 gaaaccgaaa aactatttgg attcaatcaa gaagtgagtg cagaagacag taaacaagca
     1801 caaggagtca tggaggagac ccgggaggga ttggctgaag agatagaaat caaagagatg
     1861 acacagcaag gtgggccatc ggatgagaat aatagctcac ctatttccat gcagaaaagc
     1921 ctaccatcac tgacaccaga caatcctgaa cctgtagaaa gaagtgtaac actagaagaa
     1981 gaccaagaga ctgatttaaa atcagaaaga attgaggaaa tcccagaaga aggtgtgctg
     2041 tcctgtgatg ctgcagtcat taacgcagat gcctctgtgc atacagaagg cgaggcagac
     2101 ctgcaggatt ctgcctcagg caagcttgct cccagtgaag aagctggtag tcacagtgct
     2161 aataacctct tggccactga agaagtggaa gactctccta aatctgaaat tcaagaagct
     2221 ctggaaaaag gacagcagac aaaggctgaa gctgatggtg tcctgacttg ctctgtttca
     2281 cagttaacag ttttatcttc agttgaggaa aggagactag cttgggtaaa aacatttaaa
     2341 ccctgggctg aaatctttga gcaaaatcaa cataagaaaa ttgttaaaaa aaggagactt
     2401 gtgaagtgcc caccaaatac aatgcctcct ttagatccat cagccattct ccagtatggc
     2461 ccttggaaat ctttaaagca ggttccagtg attacatttc agggtttgcc tggttgtagt
     2521 ctctctacac tggcagagtg ctcaaatctt cagatcctgt ctctccgacg ctgtggatta
     2581 acttccttgc agggactgag ccactgcaca cgccttaagt acatcgatgc acaggaaaac
     2641 cacattgaag ctatcagttg tgaaaatttg gaaaatctct ctgttgttct tcttaataat
     2701 aatctgctga cttctattca tggttttgat ggatgcacta atctccaaag ccttgaactc
     2761 tcacataata aaatcactcg aatcagtggt ttagaatctt tgaaatatct tcaagaacta
     2821 actgtggacc acaatcagtt aattagcact aaaggtcttt gtgaagcacc caccatcgtg
     2881 tacctggatt gctcacataa ccatcttact ggcattgacg gcattggaaa ttgtggattg
     2941 ctccagataa taaagctgca gggaaattac ctaagagagc ctccgtcctt aagaaatcat
     3001 gttctgctca gagagctgca tttggatgac aacagcatct caagtgtgga aggactttct
     3061 tcttgttggt tgcctttact acagtatcta agcatttcac aaaacagctt agccacaatt
     3121 gtgccacttt ttcatcttgt ctctttggag aagctggatg tcagcaacaa ttgtctttct
     3181 gatctgacaa atgtcatgtg ttggttcaat gcatgctact ctctccgtga gctttgtctc
     3241 actggaaacc cagtactcca ggaaataaac tggagagatt ctatacttaa aacattacct
     3301 gctctgagag tcctcaacgg tgacatgctg aactcttacg ccaatgaccg tattgaagag
     3361 cactatcatc aagacttaag atgtttgttg gcactttgtc agtaccagct tcaagagttc
     3421 aacttattac ctgaaaagta tatcacacag aagagggaca ttctcactct gcatgctgta
     3481 gacagactct cacagtacta taaagactta atgaaactca gtcatgaatg cagacgtgca
     3541 catgaacaag gggatgtcaa taccactgag aggtctgcag cagaaaccaa caaaaaccat
     3601 ccagacttct caaacactga cagcgcactg caaaacaaga cccttcatgc ccagactaac
     3661 agttgtgagg ccgattcacc agccacttct ccaaacccgt tggacactgt cttcagacct
     3721 tctacatcac actgtgaaga actgagagga agaaatcagg aaaagcttat ggcgcacaag
     3781 agtgagcaga gtaggatcag tagtcgctcc aacagcagag cctcattcat agaaatgaag
     3841 atggcagatt ctccaatgag taatcatcac aatgctgaac gaagttcacc aaccaaggca
     3901 gctatggtaa tccaagcaca atggcgtagt tacattgcac acagacagat taattgctct
     3961 gcagaaatgc atcctaccac aacagaaccc ctgcaagatc ccctcatcaa taaccagact
     4021 acttctaatg aagaaagaag aaaaactaat atggatatcc aagaacagag ggagaaggct
     4081 gctcttcata ttcaggcagt ttggaagggc tttattttac gaaagaagct ggcgaccgcc
     4141 cgaaaggcta tcaaagatga ggaatctgga gaagagtatg aagaaattga tttagaggat
     4201 tttgaatttg atgaggatgc cttggagaaa gactggccag ctttagattc tactggcttc
     4261 ccttcacaaa cactgcctct ctccaaccag ctgccctggc caaagaactc tcggactttg
     4321 agacatgacg aaacttcacc taccatacca gttcgtccag ctcaggcatg gctgtgcaat
     4381 gagaaagaaa atgtgatgtc gtccgagtac acacagttaa gcagcagatc agaaagcgga
     4441 attttatcct ggacacctga ctcaaaaaca agtaggaaga atttactaca atctgaaaag
     4501 gaagaaaaaa tttcagaaga atggggcttt aaggatatct ctacagctca gcaaatgcta
     4561 aagagagcaa agaaaatgaa atcaaagaaa ttaaggaaga aattagaacc ttctgtgcga
     4621 ctagcattat tcaaaaaagc caaaaataaa gtttctgtta caaagtcatc aaagaagaca
     4681 cagctcagaa gagacaatta ctttgaagca cacatctctt cccaagatga ggaggaagag
     4741 gcagtctcca aggcaactgc tgcaaaggaa aagttagaac ggagtcagga gtacacctac
     4801 cagtggcttc atacacaagt tggctttcct gaagcaacca gttccaggaa cctgaaatgc
     4861 aatcactttt tgcctgagtt agatccagat gtacttaatg gtggaagagt tcaacttgtg
     4921 gcaaggcttg taagcagaga agacacggat ttagaccttt tttccatgac cagtgcaagt
     4981 gctttgtctg tgaacaaaga caaaaagagc cagacacaca gatactcgac tggatcctca
     5041 agtaagctat ggtttccttc agagctaatt tagaaatcac aaatgaatcg accgaggcta
     5101 atggcagcag caagacttct tttacaga
//
