LOCUS       NM_001374664            3273 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus leucine rich repeat (in FLII) interacting protein 2
            (Lrrfip2), transcript variant 3, mRNA.
ACCESSION   NM_001374664 XM_017313592
VERSION     NM_001374664.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3273)
  AUTHORS   Hooper,J.E., Jones,K.L., Smith,F.J., Williams,T. and Li,H.
  TITLE     An Alternative Splicing Program for Mouse Craniofacial Development
  JOURNAL   Front Physiol 11, 1099 (2020)
   PUBMED   33013468
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3273)
  AUTHORS   Jin,J., Yu,Q., Han,C., Hu,X., Xu,S., Wang,Q., Wang,J., Li,N. and
            Cao,X.
  TITLE     LRRFIP2 negatively regulates NLRP3 inflammasome activation in
            macrophages by promoting Flightless-I-mediated caspase-1 inhibition
  JOURNAL   Nat Commun 4, 2075 (2013)
   PUBMED   23942110
  REMARK    GeneRIF: LRRFIP2 inhibits NLRP3 inflammasome activation by
            recruiting the caspase-1 inhibitor Flightless-I, thus outlining a
            new mechanism for negative regulation of NLRP3 inflammasome.
REFERENCE   3  (bases 1 to 3273)
  AUTHORS   Gunawardena,H.P., Huang,Y., Kenjale,R., Wang,H., Xie,L. and Chen,X.
  TITLE     Unambiguous characterization of site-specific phosphorylation of
            leucine-rich repeat Fli-I-interacting protein 2 (LRRFIP2) in
            Toll-like receptor 4 (TLR4)-mediated signaling
  JOURNAL   J Biol Chem 286 (13), 10897-10910 (2011)
   PUBMED   21220426
  REMARK    GeneRIF: Unambiguous characterization of site-specific
            phosphorylation of leucine-rich repeat Fli-I-interacting protein 2
            (LRRFIP2) in Toll-like receptor 4 (TLR4)-mediated signaling.
REFERENCE   4  (bases 1 to 3273)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   5  (bases 1 to 3273)
  AUTHORS   Dai,P., Jeong,S.Y., Yu,Y., Leng,T., Wu,W., Xie,L. and Chen,X.
  TITLE     Modulation of TLR signaling by multiple MyD88-interacting partners
            including leucine-rich repeat Fli-I-interacting proteins
  JOURNAL   J Immunol 182 (6), 3450-3460 (2009)
   PUBMED   19265123
REFERENCE   6  (bases 1 to 3273)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC132832.13.
            
            On Oct 8, 2019 this sequence version replaced XM_017313592.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7652917.870283.1,
                                           SRR7345562.2421585.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-266               AC132832.13        148174-148439       c
            267-338             AC132832.13        146852-146923       c
            339-481             AC132832.13        125231-125373       c
            482-568             AC132832.13        105174-105260       c
            569-613             AC132832.13        77757-77801         c
            614-730             AC132832.13        76279-76395         c
            731-802             AC132832.13        73445-73516         c
            803-973             AC132832.13        66728-66898         c
            974-1066            AC132832.13        60716-60808         c
            1067-1199           AC132832.13        52290-52422         c
            1200-1249           AC132832.13        50585-50634         c
            1250-1370           AC132832.13        46761-46881         c
            1371-1450           AC132832.13        44326-44405         c
            1451-1555           AC132832.13        43193-43297         c
            1556-3273           AC132832.13        40896-42613         c
FEATURES             Location/Qualifiers
     source          1..3273
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 60.92 cM"
     gene            1..3273
                     /gene="Lrrfip2"
                     /gene_synonym="5133400F20Rik"
                     /note="leucine rich repeat (in FLII) interacting protein
                     2"
                     /db_xref="GeneID:71268"
                     /db_xref="MGI:MGI:1918518"
     exon            1..266
                     /gene="Lrrfip2"
                     /gene_synonym="5133400F20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            267..338
                     /gene="Lrrfip2"
                     /gene_synonym="5133400F20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            339..481
                     /gene="Lrrfip2"
                     /gene_synonym="5133400F20Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             392..1666
                     /gene="Lrrfip2"
                     /gene_synonym="5133400F20Rik"
                     /note="isoform 3 is encoded by transcript variant 3;
                     leucine-rich repeat flightless-interacting protein 2; LRR
                     FLII-interacting protein 2"
                     /codon_start=1
                     /product="leucine-rich repeat flightless-interacting
                     protein 2 isoform 3"
                     /protein_id="NP_001361593.1"
                     /db_xref="CCDS:CCDS90673.1"
                     /db_xref="GeneID:71268"
                     /db_xref="MGI:MGI:1918518"
                     /translation="MGTPGSGRKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAE
                     ARDIRMRELERQQRELDEKSDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSL
                     IDPDTSLSELRDIYDLKDQIHDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNE
                     KNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMDELKEGLR
                     QRDELIEKHGLVIIPDSTPNGDVHHEPVVGAITAVSQEAAQVLESAGEGPLDVRLRKL
                     AGEKDELLSQIRKLKLQLEEERQKCSRNDGMSGDLAGLQNGSDLQFIEMQRDANRQIS
                     EYKFKLSKAEQDIATLEQSISRLEGQVLRYKTAAENAEKIEDELKAERRKLQRELRTA
                     QDKIEEMEMTNSHLAKRLEKMKANRTALLAQQ"
     exon            482..568
                     /gene="Lrrfip2"
                     /gene_synonym="5133400F20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            569..613
                     /gene="Lrrfip2"
                     /gene_synonym="5133400F20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            614..730
                     /gene="Lrrfip2"
                     /gene_synonym="5133400F20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            731..802
                     /gene="Lrrfip2"
                     /gene_synonym="5133400F20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            803..973
                     /gene="Lrrfip2"
                     /gene_synonym="5133400F20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1066
                     /gene="Lrrfip2"
                     /gene_synonym="5133400F20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1199
                     /gene="Lrrfip2"
                     /gene_synonym="5133400F20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1200..1249
                     /gene="Lrrfip2"
                     /gene_synonym="5133400F20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..1370
                     /gene="Lrrfip2"
                     /gene_synonym="5133400F20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..1450
                     /gene="Lrrfip2"
                     /gene_synonym="5133400F20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1451..1555
                     /gene="Lrrfip2"
                     /gene_synonym="5133400F20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1556..3273
                     /gene="Lrrfip2"
                     /gene_synonym="5133400F20Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1770..1775
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lrrfip2"
                     /gene_synonym="5133400F20Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      1801
                     /gene="Lrrfip2"
                     /gene_synonym="5133400F20Rik"
     regulatory      1806..1811
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lrrfip2"
                     /gene_synonym="5133400F20Rik"
                     /note="hexamer: AATGAA"
     polyA_site      1828
                     /gene="Lrrfip2"
                     /gene_synonym="5133400F20Rik"
                     /note="major polyA site"
     regulatory      2911..2916
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lrrfip2"
                     /gene_synonym="5133400F20Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2933
                     /gene="Lrrfip2"
                     /gene_synonym="5133400F20Rik"
     regulatory      3249..3254
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lrrfip2"
                     /gene_synonym="5133400F20Rik"
                     /note="hexamer: GATAAA"
     polyA_site      3273
                     /gene="Lrrfip2"
                     /gene_synonym="5133400F20Rik"
ORIGIN      
        1 gccaccgccg cagctgcagc cgctgctcgg gctgcggctc gtcccgggtc gcgttcgctg
       61 tgtcggccgc ggggcgaagg gcgcgctcag tgtgactcca cgaccggccg cggcgcgagg
      121 agcccttctt tttgtctccc tgcggcccgc ggggtggacg gtgcgggggg gtgcagagtg
      181 tggccggcgc tctcctctcc cggctcccgg gcggccgctc cggcccttcc gggcggcgcc
      241 gcagcctcat cccgcgccac acgcagatgt gggaagacaa atgaagggat ttagaagcca
      301 agtaaatgtc attgggaagg agagctacca ccactgagtg ctgaacagta aactcatttt
      361 tcagagttaa aaaattattt aaaaaaacaa gatggggact cctggttctg gaaggaaaag
      421 aacgccggta aaagatcgat tttctgcaga agatgaagct ttgagtaaca tcgccagaga
      481 ggcagaagca aggctagcag caaagcgggc cgccagggca gaagcaagag acatccgcat
      541 gcgggaactg gaacgacagc agagagagtt ggatgaaaaa tctgacaaac agtatgctga
      601 aaactacaca agaccttcat ctcgaaattc tgcctcggct acaacgcctc taagtgggaa
      661 ctcatccaga cggggtagtg gggacaccag cagcttaata gacccagaca cctcactgag
      721 tgaactgcgg gacatctatg acctgaagga ccagattcat gatgtagaag ggcggtacat
      781 gcagggcctt aaggaactga aggagtcttt gtctgaagta gaagagaaat acaagaaagc
      841 catggtgtcc aatgcacaac tagacaatga gaagaacaat ctgatctacc aggtggacac
      901 cctcaaggat gtcattgaag agcaggagga gcagatggca gagttttata gagagaacga
      961 agagaagtca aaggagttag aaaggcagaa acacatgtgc agcgtgctgc agcataagat
     1021 ggatgaactc aaagaaggcc ttcggcagag ggacgagctc atcgagaaac atggcttagt
     1081 tataatccca gacagcactc ccaatggtga tgtccatcat gagcctgtgg ttggagccat
     1141 tactgctgtg tctcaggaag ctgctcaggt cttggagtca gcaggagaag ggccactaga
     1201 tgtgaggcta cgaaagcttg ctggagaaaa ggacgagctc ttgtcacaga ttagaaaact
     1261 gaagctccag ttagaggaag aacggcagaa gtgttccagg aatgatggca tgtccgggga
     1321 cctggcagga ctgcagaacg gctcagactt gcagttcatc gagatgcaga gagatgccaa
     1381 tagacaaatt agtgaataca aattcaagct ttcgaaagca gaacaagaca tagctacctt
     1441 ggaacaaagt atcagccggc ttgaggggca ggtgctgagg tacaaaactg ctgctgagaa
     1501 tgcagagaaa attgaagatg agctgaaagc agaaaggagg aagctacagc gagagctacg
     1561 gacggcacag gacaagatag aggagatgga gatgaccaac agccacctgg ctaagcggct
     1621 agagaagatg aaagccaaca ggacagccct tctagcccag cagtaggagg cggcccttct
     1681 acctgggtgc tgctgaggac cttgccggga gatgctgact cttttgtaca ttgacacaag
     1741 ccccttcaag tactgttttg agtcttgtca ttaaacagcc acctttgtat tttataattt
     1801 atgagaatga agcaggttta atcgttaatg gatttggatt ttgtttgtag ttcacttcta
     1861 cagtgagaac tagtctgtgc tgtctttatt ttcaacattc tagaatcacg ttttctcacc
     1921 atcttcttcc tgccgcctcg ctgacagagg cactgggtgg ccttgctgtg ggttctggag
     1981 gatggccatt ctgagcactg agacacttgc tggagacctc aaaaacccaa gtgccttctc
     2041 caaagtgtga tgcaggcttc agagaccaat ggccaaggtt cctcctcttc ttaccagagt
     2101 gtttacattt cagtgaggat gtgttcagca gtggggagtc tgtttcactc aaatttatgt
     2161 ttggaggaaa aacctttttt tttttttgag ggtaagatat ttaaattata taaaagtttt
     2221 agaaaacaat atggggagtg tatattaaac tttgctacat ggggcagagc aagtccaagc
     2281 ctgtactcca aagactaggc tcctcagtct tcacacccac tgtgctgttc cgtgcgtttt
     2341 catctgctgc ttacctgtga atgaagcctc agacaagctc aagggaggag ggagggacag
     2401 tgcaggcagg cagggaatcc gcctgaatct acctactaaa acacaccttt ctgccatcca
     2461 cgattggctg agggcagtcg atgttaaaga agcctttagg acaagtcatg gctaccatgt
     2521 acagtcttgc tcttcttttc tcaagatgag atactctggg atacagaact ttcttctagt
     2581 tttttgagag aaaggatcga tgtagcccgg ctggcctcca cctcacaatc atcctcattg
     2641 ggcctctttg agtgctggga ttccaggcag gtactttcat acctggttcc agaatataaa
     2701 gtccttaaga actttcatct ttaaagagcc cagttcaaga tacccctgcc cctgctgtaa
     2761 ccactttata gggtttgtga ttctcatttg tcagaatcaa ggtggtttca tgggaatgat
     2821 tactatagct caaagtgttt acagaaacta tattgaggaa aaaatctaat gaatcaaagc
     2881 ctcttaataa atctagcctt ggaactagat aataaaatta actcaaaagt gaatgataat
     2941 tgtccctttt ttagagtcac tagcccttca ctttaaggat atggaaacta catcctgagc
     3001 tgagaagatc ctgtgcatct tctaatagaa gcaacaattg tatgggcagg aatgcagatc
     3061 tcttatcgtt tctcagctac aatctggtca tccagctctt cacacctaga aggcacctct
     3121 tcctttccac tgacgtcact cagcctgaat tcctcctggg ctcctgaacc ttccctctga
     3181 ggagcccctg cttggcccta gcccttgttt tagtctattc aattgaaatg gctctatttc
     3241 ttcattaaga taaattgttt tcttttaacc ttc
//
