LOCUS       NM_001310732            2954 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Mus musculus leucine rich repeat (in FLII) interacting protein 1
            (Lrrfip1), transcript variant 4, mRNA.
ACCESSION   NM_001310732 XM_006529211
VERSION     NM_001310732.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2954)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2954)
  AUTHORS   Yang,G.N., Ahangar,P., Strudwick,X.L., Kopecki,Z. and Cowin,A.J.
  TITLE     Overexpression of Flii during Murine Embryonic Development
            Increases Symmetrical Division of Epidermal Progenitor Cells
  JOURNAL   Int J Mol Sci 22 (15), 8235 (2021)
   PUBMED   34361001
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2954)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2954)
  AUTHORS   Liu,T.Y., Chen,Y.C., Jong,Y.J., Tsai,H.J., Lee,C.C., Chang,Y.S.,
            Chang,J.G. and Chang,Y.F.
  TITLE     Muscle developmental defects in heterogeneous nuclear
            Ribonucleoprotein A1 knockout mice
  JOURNAL   Open Biol 7 (1) (2017)
   PUBMED   28077597
REFERENCE   5  (bases 1 to 2954)
  AUTHORS   Wei,N., Cheng,Y., Wang,Z., Liu,Y., Luo,C., Liu,L., Chen,L., Xie,Z.,
            Lu,Y. and Feng,Y.
  TITLE     SRSF10 Plays a Role in Myoblast Differentiation and Glucose
            Production via Regulation of Alternative Splicing
  JOURNAL   Cell Rep 13 (8), 1647-1657 (2015)
   PUBMED   26586428
REFERENCE   6  (bases 1 to 2954)
  AUTHORS   Yang,P., An,H., Liu,X., Wen,M., Zheng,Y., Rui,Y. and Cao,X.
  TITLE     The cytosolic nucleic acid sensor LRRFIP1 mediates the production
            of type I interferon via a beta-catenin-dependent pathway
  JOURNAL   Nat Immunol 11 (6), 487-494 (2010)
   PUBMED   20453844
  REMARK    GeneRIF: LRRFIP1 and its downstream partner beta-catenin constitute
            another coactivator pathway for IRF3-mediated production of type I
            interferon
REFERENCE   7  (bases 1 to 2954)
  AUTHORS   Dai,P., Jeong,S.Y., Yu,Y., Leng,T., Wu,W., Xie,L. and Chen,X.
  TITLE     Modulation of TLR signaling by multiple MyD88-interacting partners
            including leucine-rich repeat Fli-I-interacting proteins
  JOURNAL   J Immunol 182 (6), 3450-3460 (2009)
   PUBMED   19265123
REFERENCE   8  (bases 1 to 2954)
  AUTHORS   Lee,Y.H. and Stallcup,M.R.
  TITLE     Interplay of Fli-I and FLAP1 for regulation of beta-catenin
            dependent transcription
  JOURNAL   Nucleic Acids Res 34 (18), 5052-5059 (2006)
   PUBMED   16990252
REFERENCE   9  (bases 1 to 2954)
  AUTHORS   Kwiatkowski,D.J.
  TITLE     Functions of gelsolin: motility, signaling, apoptosis, cancer
  JOURNAL   Curr Opin Cell Biol 11 (1), 103-108 (1999)
   PUBMED   10047530
  REMARK    Review article
REFERENCE   10 (bases 1 to 2954)
  AUTHORS   Liu,Y.T. and Yin,H.L.
  TITLE     Identification of the binding partners for flightless I, A novel
            protein bridging the leucine-rich repeat and the gelsolin
            superfamilies
  JOURNAL   J Biol Chem 273 (14), 7920-7927 (1998)
   PUBMED   9525888
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC162883.4.
            
            On Jul 18, 2015 this sequence version replaced XM_006529211.1.
            
            Transcript Variant: This variant (4) has multiple differences in
            the 3' UTR and in the coding region, but maintains the reading
            frame compared to variant 1. The resulting isoform (4) has a
            shorter and distinct C-terminus and lacks several internal segments
            compared to isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC144956.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849390, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-280               AC162883.4         35692-35971
            281-367             AC162883.4         50811-50897
            368-385             AC162883.4         55572-55589
            386-433             AC162883.4         59192-59239
            434-478             AC162883.4         60639-60683
            479-529             AC162883.4         61279-61329
            530-568             AC162883.4         64389-64427
            569-628             AC162883.4         67194-67253
            629-694             AC162883.4         69307-69372
            695-772             AC162883.4         70882-70959
            773-838             AC162883.4         73850-73915
            839-916             AC162883.4         75808-75885
            917-952             AC162883.4         82825-82860
            953-1078            AC162883.4         83433-83558
            1079-1150           AC162883.4         85495-85566
            1151-1321           AC162883.4         87375-87545
            1322-1414           AC162883.4         89546-89638
            1415-1507           AC162883.4         90828-90920
            1508-1600           AC162883.4         92603-92695
            1601-1742           AC162883.4         94404-94545
            1743-1792           AC162883.4         102389-102438
            1793-1910           AC162883.4         104670-104787
            1911-1990           AC162883.4         105326-105405
            1991-2095           AC162883.4         107889-107993
            2096-2954           AC162883.4         110334-111192
FEATURES             Location/Qualifiers
     source          1..2954
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 46.03 cM"
     gene            1..2954
                     /gene="Lrrfip1"
                     /gene_synonym="Fliiap1"
                     /note="leucine rich repeat (in FLII) interacting protein
                     1"
                     /db_xref="GeneID:16978"
                     /db_xref="MGI:MGI:1342770"
     exon            1..280
                     /gene="Lrrfip1"
                     /gene_synonym="Fliiap1"
                     /inference="alignment:Splign:2.1.0"
     exon            281..367
                     /gene="Lrrfip1"
                     /gene_synonym="Fliiap1"
                     /inference="alignment:Splign:2.1.0"
     exon            368..385
                     /gene="Lrrfip1"
                     /gene_synonym="Fliiap1"
                     /inference="alignment:Splign:2.1.0"
     exon            386..433
                     /gene="Lrrfip1"
                     /gene_synonym="Fliiap1"
                     /inference="alignment:Splign:2.1.0"
     exon            434..478
                     /gene="Lrrfip1"
                     /gene_synonym="Fliiap1"
                     /inference="alignment:Splign:2.1.0"
     exon            479..529
                     /gene="Lrrfip1"
                     /gene_synonym="Fliiap1"
                     /inference="alignment:Splign:2.1.0"
     exon            530..568
                     /gene="Lrrfip1"
                     /gene_synonym="Fliiap1"
                     /inference="alignment:Splign:2.1.0"
     exon            569..628
                     /gene="Lrrfip1"
                     /gene_synonym="Fliiap1"
                     /inference="alignment:Splign:2.1.0"
     exon            629..694
                     /gene="Lrrfip1"
                     /gene_synonym="Fliiap1"
                     /inference="alignment:Splign:2.1.0"
     exon            695..772
                     /gene="Lrrfip1"
                     /gene_synonym="Fliiap1"
                     /inference="alignment:Splign:2.1.0"
     exon            773..838
                     /gene="Lrrfip1"
                     /gene_synonym="Fliiap1"
                     /inference="alignment:Splign:2.1.0"
     exon            839..916
                     /gene="Lrrfip1"
                     /gene_synonym="Fliiap1"
                     /inference="alignment:Splign:2.1.0"
     exon            917..952
                     /gene="Lrrfip1"
                     /gene_synonym="Fliiap1"
                     /inference="alignment:Splign:2.1.0"
     exon            953..1078
                     /gene="Lrrfip1"
                     /gene_synonym="Fliiap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1150
                     /gene="Lrrfip1"
                     /gene_synonym="Fliiap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1321
                     /gene="Lrrfip1"
                     /gene_synonym="Fliiap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1322..1414
                     /gene="Lrrfip1"
                     /gene_synonym="Fliiap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1415..1507
                     /gene="Lrrfip1"
                     /gene_synonym="Fliiap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1508..1600
                     /gene="Lrrfip1"
                     /gene_synonym="Fliiap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1601..1742
                     /gene="Lrrfip1"
                     /gene_synonym="Fliiap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1743..1792
                     /gene="Lrrfip1"
                     /gene_synonym="Fliiap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1793..1910
                     /gene="Lrrfip1"
                     /gene_synonym="Fliiap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1911..1990
                     /gene="Lrrfip1"
                     /gene_synonym="Fliiap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1991..2095
                     /gene="Lrrfip1"
                     /gene_synonym="Fliiap1"
                     /inference="alignment:Splign:2.1.0"
     exon            2096..2954
                     /gene="Lrrfip1"
                     /gene_synonym="Fliiap1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2937..2942
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lrrfip1"
                     /gene_synonym="Fliiap1"
                     /note="hexamer: AATGAA"
     polyA_site      2954
                     /gene="Lrrfip1"
                     /gene_synonym="Fliiap1"
                     /note="major polyA site"
ORIGIN      
        1 ccgccccgcc ggccgcaccc cagctaggga acctcggagt tgggcgtccg agcgtgtgcg
       61 cccaggggat cgttgaaagt tctacttctg cctggacggc tttcctggat cccagaatgt
      121 ggcctcactg agaaccctct gcctgtggac tagggagcgg gtcttccgcg cgaactcttg
      181 ggtgggaagt tggtctgcac ttcacttcgg caacatgacc agcccagagg gcgcgcaaaa
      241 caaggaaatc gactgtctga gtccagaggc gcaaagactg gcggaggcca ggctcgcagc
      301 gaagcgtgca gcccgagccg aggctcgaga gatccggatg aaggagctgg aacggcagca
      361 gaaagagatc tatcaagtcc agaagaaata ttatgggctg gatacaaaat ggggcgacat
      421 cgagcagtgg atggaagaca gcgagcgcta ctctcgtaga ttccggagaa acacgtcggc
      481 ttctgacgaa gacgagcgct tgtccgtggg tagtcgcggc agcctaaggg cacagcccga
      541 gctggagtat gggagtccct acgcctggac taacggttat gacggagact attgtggatc
      601 ccagtcccta agtagaagat ctggcaggaa ttccagcttc agcggcggtg atggccgagt
      661 ctctactttg tcatcctgca gagaggagaa gttgggactc tcctgctcca accttggcct
      721 tcccagcagt ggccttgctt ccaaacccct gtctacccag aatggatccc gggcgtccat
      781 gctggatgag agcagcctct atggggctcg aaggggaagc gcctgtggtt ctcgagcacc
      841 ctcagaatat ggcagccacc tcaactccag ctcccgggcc tcttctaggg ccagctctgc
      901 aagggccagt cctgtggtag aagaaagacc agacaaagac tttgctgaga agggctcccg
      961 taacatgcct agcctgtctg cagccacact ggcatctctg ggtgggactt cctcccggag
     1021 agggagtgga gatacctcca tctccatgga caccgaagca tccatcaggg aaatcaagga
     1081 acttaatgag ttaaaggacc agattcagga tgtagaaggc aaatacatgc agggactgaa
     1141 agagatgaag gactcgctgg ccgaagttga ggagaagtac aagaaagcta tggtctccaa
     1201 cgcccagcta gacaatgaga agaccaactt catgtaccag gtggacacac tgaaggacat
     1261 gctgctggag ctggaagagc agctggccga gtctcagcgg caatacgagg agaagaacaa
     1321 ggagttcgag agggagaagc atgcccacag catcctgcag ttccagtttg ccgaagtgaa
     1381 agaggccctg cggcaaaggg aagagatgct cgaggaaatc cgacagctgc agcagaaaca
     1441 ggcgggtttt atcagggaga tttctgatct tcaggaaacg atagaatgga aagacaaaaa
     1501 gataggggca ttagaaagac agaaagagtt ctttgattcc ataaggagcg aacgagatga
     1561 ccttagagaa gaaacagtca agctgaagga ggagttgaag aaacatggaa taatcctaaa
     1621 ttcagaaata gccaccaacg gagagacttc agacacagta aatgacgttg ggtatcaagc
     1681 ccctacgaag ataacaaaag aagagctgaa tgccctcaag tcggccgggg aggggaccct
     1741 agacgttagg ttgaaaaagc tcattgatga acgggaatgt ctgttggaac agattaagaa
     1801 gctcaaaggg cagctggagg gaagacagaa gaacaacaag ctggaccttc ttcgagccga
     1861 ggacggtatc ttggagaatg ggacagacgc gcatgtcatg gatctgcaaa gagatgccaa
     1921 cagacagatc agcgacctca aatttaaact tgcaaaatct gagcaagaga taactgcctt
     1981 agaacaaaat gtaataaggt tagagagcca agtaacgcgc tatcgatcag ccgccgaaaa
     2041 tgcagaaaaa atagaagatg aactaaaggc agaaaaacgg aagctccaga gagagcttcg
     2101 ctctgcactg gacaaaacag aagagctcga ggtgagcaac ggccacctcg taaagcgact
     2161 ggaaaagatg aaagccaacc gcagcgctct cttgtcccag caataaatac cagcagcaag
     2221 tgggcacctc tctggggact cagatgccca gcctggctta tgagctttta tctgtactgt
     2281 cgggagcatt gcatctttcc ctgcctccga gggaagaagt gcttccatgc aagggtcacc
     2341 cggggagccc agcagcacca gatgcctctg tctgcagacc cttgccctgg ccgggatgat
     2401 actcagagcc tgcaggtttc ttcataagca cactgggtct cacgagagct ctggacttga
     2461 tgcacagggg cctcttaatc ccaccaacag gggtgactga ggtgggggtt aaggtgggac
     2521 ttgatttttc ttttgtgtct tgctgaaggt taagggagaa tgttccagtg ttggggacga
     2581 tccgtggtgg aacctacagt cccaatgact ccagtagtgt ctcttagtct ctgcttccca
     2641 tacacaaaac actgtggaac cacaagccat taccaagcaa agctcctcct ttggagtcga
     2701 ggcgatggtc tagacgtaaa gtgaccttaa gaagactctt tccaggcaac agatgaagct
     2761 tttctaaggg acttttgcat tggttcagtt ataagagtac ttttcccagg gtcattaggc
     2821 tacggtagct tcaccgaaaa caacagcttt tcatttgcat tatttaaacc ttatatttga
     2881 aattgaagtt gttaacttct tttaaagaat gtactgctag aaaaaaacat tttaaaaatg
     2941 aaacgttaaa gagc
//
