LOCUS       NM_001163579            5675 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus leucine rich repeat and coiled-coil domain containing
            1 (Lrrcc1), transcript variant 1, mRNA.
ACCESSION   NM_001163579
VERSION     NM_001163579.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5675)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5675)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   3  (bases 1 to 5675)
  AUTHORS   van Berlo,J.H., Elrod,J.W., van den Hoogenhof,M.M., York,A.J.,
            Aronow,B.J., Duncan,S.A. and Molkentin,J.D.
  TITLE     The transcription factor GATA-6 regulates pathological cardiac
            hypertrophy
  JOURNAL   Circ Res 107 (8), 1032-1040 (2010)
   PUBMED   20705924
REFERENCE   4  (bases 1 to 5675)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC140350.3 and BC138734.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK173256.1, SRR9219381.307167.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                AC140350.3         97683-97708         c
            27-3104             BC138734.1         1-3078
            3105-5675           AC140350.3         63193-65763         c
FEATURES             Location/Qualifiers
     source          1..5675
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 3.08 cM"
     gene            1..5675
                     /gene="Lrrcc1"
                     /gene_synonym="1200008A14Rik; 4932441F23Rik"
                     /note="leucine rich repeat and coiled-coil domain
                     containing 1"
                     /db_xref="GeneID:71710"
                     /db_xref="MGI:MGI:1918960"
     exon            1..235
                     /gene="Lrrcc1"
                     /gene_synonym="1200008A14Rik; 4932441F23Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             147..3227
                     /gene="Lrrcc1"
                     /gene_synonym="1200008A14Rik; 4932441F23Rik"
                     /note="isoform 1 is encoded by transcript variant 1;
                     leucine-rich repeat and coiled-coil domain-containing
                     protein 1"
                     /codon_start=1
                     /product="leucine-rich repeat and coiled-coil
                     domain-containing protein 1 isoform 1"
                     /protein_id="NP_001157051.1"
                     /db_xref="CCDS:CCDS50866.1"
                     /db_xref="GeneID:71710"
                     /db_xref="MGI:MGI:1918960"
                     /translation="MEAAVCSEIEREDGDSSCGDVCFMDKGLHSISELSLDSSIHAIN
                     LHCNNISKISSIDHIWNLRHLDLSSNQISQIEGLNTLTKLCTLNLSCNLITRVEGLEA
                     LVNLTKLNLSYNHINDLSGLMPLHGLKYKLRYIDLHSNYIDSIHHLLQCTVGLHFLTN
                     LILEKDGEGNPICLIPGYRAIILQTLPQLRILDCKNIFGEPVSLEEINSSHLQCLEGL
                     LDNLVSSDSPLNISEDEVNDDVSAPPMDVLPSLKEFKSTPEDNVLASLLSVCPSSEPE
                     KINQENDFQNEVKLQKLDDQILQLLNETNNSLIDNVPEKDLRPKRDTDITSESDYGNR
                     RECSRKVPRRTKIPYYSRTIQTIKHHNKNNGAFVSCNRKMRQPYLRDLYVRSSLVNCN
                     NLRDLDEQKTGVIKVDKNFSDNSTYRSLVEQLDQEREMRWKAEQTEKKLMDYIDELHK
                     QADEKKDVHSQALITTDRLKDAIFKERHCKAQLEIIVHRLQNEVKKLTIELMKARDQQ
                     EDHIRHLRTLERALEKMEKQKAQQQAAQIRLIQEVELKASAADREINLLRTSLHQEKQ
                     QVQQLHELLALKEQEHRQEIETRQFFTDAEFQDALTKRLCKEERKHEQEVKEYQEKID
                     ILNQQYLDLENEFRIALTVEARRFKDVQDGFEDVATELAKSKHALIWAQRKENESSSL
                     IKDLTCMVKEQKTKLSEVCKLKQEAAANLQNQINTLEILIEDDKQKSIQIELLKHEKT
                     QLISELAAKESLIYGLRTERKVWGQELACQSSTLSQSRGKLEAQIESLCRENESLRKS
                     HESDCDALRIKCKIIEDQNETIRKLKDSLQEKDGQIKLLQEQIALIEKCSQEQLNEKS
                     SQLDSIVEKLERHNERKEKLKQQLKAKELELEEIRKAYSTLNKKWHDKGELLSHLEMQ
                     VKEVKEKFEDKERKLKAERDKSLELQKDAMEKLQNMDDAFRRQVDEIVEAHQAEIMQL
                     ANEKQKYIDCANLKVQQVEDEMRGLLDETCKNKKMMEEKIKQLACAISEIQKEM"
     exon            236..441
                     /gene="Lrrcc1"
                     /gene_synonym="1200008A14Rik; 4932441F23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            442..507
                     /gene="Lrrcc1"
                     /gene_synonym="1200008A14Rik; 4932441F23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            508..675
                     /gene="Lrrcc1"
                     /gene_synonym="1200008A14Rik; 4932441F23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            676..851
                     /gene="Lrrcc1"
                     /gene_synonym="1200008A14Rik; 4932441F23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            852..1055
                     /gene="Lrrcc1"
                     /gene_synonym="1200008A14Rik; 4932441F23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1252
                     /gene="Lrrcc1"
                     /gene_synonym="1200008A14Rik; 4932441F23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1253..1400
                     /gene="Lrrcc1"
                     /gene_synonym="1200008A14Rik; 4932441F23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1401..1549
                     /gene="Lrrcc1"
                     /gene_synonym="1200008A14Rik; 4932441F23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1550..1754
                     /gene="Lrrcc1"
                     /gene_synonym="1200008A14Rik; 4932441F23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1755..1894
                     /gene="Lrrcc1"
                     /gene_synonym="1200008A14Rik; 4932441F23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1895..2096
                     /gene="Lrrcc1"
                     /gene_synonym="1200008A14Rik; 4932441F23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2097..2282
                     /gene="Lrrcc1"
                     /gene_synonym="1200008A14Rik; 4932441F23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2283..2457
                     /gene="Lrrcc1"
                     /gene_synonym="1200008A14Rik; 4932441F23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2458..2621
                     /gene="Lrrcc1"
                     /gene_synonym="1200008A14Rik; 4932441F23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2622..2830
                     /gene="Lrrcc1"
                     /gene_synonym="1200008A14Rik; 4932441F23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2831..2968
                     /gene="Lrrcc1"
                     /gene_synonym="1200008A14Rik; 4932441F23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2969..3104
                     /gene="Lrrcc1"
                     /gene_synonym="1200008A14Rik; 4932441F23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3105..5675
                     /gene="Lrrcc1"
                     /gene_synonym="1200008A14Rik; 4932441F23Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3282..3287
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lrrcc1"
                     /gene_synonym="1200008A14Rik; 4932441F23Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      3300
                     /gene="Lrrcc1"
                     /gene_synonym="1200008A14Rik; 4932441F23Rik"
                     /note="major polyA site"
     regulatory      3396..3401
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lrrcc1"
                     /gene_synonym="1200008A14Rik; 4932441F23Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3420
                     /gene="Lrrcc1"
                     /gene_synonym="1200008A14Rik; 4932441F23Rik"
                     /note="major polyA site"
     regulatory      5649..5654
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lrrcc1"
                     /gene_synonym="1200008A14Rik; 4932441F23Rik"
                     /note="hexamer: AATAAA"
     polyA_site      5675
                     /gene="Lrrcc1"
                     /gene_synonym="1200008A14Rik; 4932441F23Rik"
                     /note="major polyA site"
ORIGIN      
        1 ggccgcgcag ggcggggaaa gtgcggcagg cggttagagt cctcgccccg ccccttgctc
       61 actccccgct cccgcttttg gaggcgtgag caagctggga cccagcgctg ggcgccggtt
      121 aacacccact ccccgtcgcg ggtaccatgg aggcggcggt gtgtagcgaa atcgaacggg
      181 aggatggcga cagcagctgc ggggatgtgt gtttcatgga caaaggcctg cacagtatat
      241 cagagttatc tttagattca tccattcatg ccatcaattt gcattgtaat aacatctcca
      301 agatctcatc cattgaccac atttggaacc tacgacattt agatctgtca tctaatcaaa
      361 taagtcaaat tgaaggcctg aacacactga caaagctatg cactttaaat ttgtcctgca
      421 atttgatcac aagagtggaa ggacttgaag cactggttaa tctgactaaa ctgaacttgt
      481 cttataatca cataaatgat cttagtgggt tgatgcccct tcatggacta aagtataaac
      541 ttagatatat tgacctccat agtaattata tagatagcat ccatcactta cttcagtgta
      601 cagtaggatt gcacttccta accaatctta ttttagagaa agatggagaa ggtaatccta
      661 tctgccttat accagggtac cgagcaatca ttctccagac tttaccacaa ctgagaatct
      721 tagattgcaa gaatatattt ggagagccag taagcttgga agaaataaac tcatcccatc
      781 tacagtgctt agaaggactt ttggataact tagtttcttc tgattccccc ctgaatataa
      841 gtgaagatga ggtcaatgat gatgtgtcag caccaccaat ggatgtgttg ccttctttga
      901 aggaatttaa aagtacacca gaagacaatg ttttagcctc acttttatct gtgtgtccat
      961 cttctgaacc agaaaaaatt aatcaggaaa acgactttca gaatgaggtg aaacttcaga
     1021 aattagatga ccaaatccta cagcttctca atgaaactaa taattcctta atagataatg
     1081 ttcctgagaa agacctcaga ccaaaaagag acacagatat aacttctgaa agtgactatg
     1141 gaaacagaag agagtgcagc agaaaagttc ccaggagaac aaaaatccca tattattcca
     1201 gaactattca aaccattaag caccacaata aaaacaatgg tgcttttgta agttgtaatc
     1261 gtaaaatgag acagccttac cttagagatt tatatgtaag atcatcttta gtaaactgta
     1321 ataacttacg agacttagat gagcagaaga ctggcgtaat taaagtagac aagaacttct
     1381 cggacaacag cacctaccgg tccctcgtgg aacagttaga ccaagagaga gagatgcggt
     1441 ggaaagctga gcaaacggaa aagaaactta tggattatat cgatgagcta cataagcaag
     1501 cagatgagaa aaaagatgtt cacagccagg ctctcattac cacagataga ctaaaggatg
     1561 ctatttttaa ggagagacat tgcaaggctc aacttgaaat tatagttcac agacttcaaa
     1621 atgaagttaa aaaactaact attgaattaa tgaaagcgcg agatcaacag gaagatcaca
     1681 tcagacacct gagaaccctg gaaagggcat tggaaaaaat ggagaagcag aaagcacagc
     1741 agcaggcggc acagataaga ctgatccaag aggtggagct caaagcctca gctgctgatc
     1801 gagaaataaa cttacttcga acttctcttc accaagaaaa gcagcaagtg caacaacttc
     1861 atgaacttct ggcgttgaaa gagcaggaac acaggcaaga aattgaaact cggcagtttt
     1921 tcactgatgc tgagttccag gatgcattaa ctaaacgatt atgcaaagaa gaacgaaaac
     1981 atgagcaaga agtaaaagaa taccaagaaa aaattgatat attaaaccag cagtatttgg
     2041 acttagaaaa tgagttccgt attgctttaa ctgttgaagc tagaagattt aaagatgttc
     2101 aggatggctt tgaagatgtt gcgactgagt tagcgaagag taaacatgct cttatttggg
     2161 ctcagcgtaa agaaaatgag tcgtcttctt taattaaaga tctgacatgt atggtgaagg
     2221 aacagaagac aaagctctcc gaagtctgca aactgaagca ggaagcagca gccaatttac
     2281 agaatcaaat caacactctt gaaattttga ttgaagatga caagcagaag agcattcaaa
     2341 tagaacttct caaacatgaa aaaacccagc tgatttctga gctggcagcc aaagagtcac
     2401 tgatttatgg cttacggact gagagaaaag tatggggaca ggaactggca tgtcagagct
     2461 cgacactatc ccagagtcgt gggaaattag aagcccagat tgaaagttta tgcagagaaa
     2521 atgaatctct gagaaaaagc catgaaagtg actgtgatgc attgagaata aagtgcaaga
     2581 tcattgaaga ccaaaatgaa accatccgga aactaaaaga cagtttacaa gaaaaagatg
     2641 ggcaaatcaa attgctacaa gaacagatcg ctctcatcga aaagtgttct caagagcaac
     2701 ttaatgaaaa gtcttcacaa ctagattcta tagttgagaa actagagaga cacaatgaga
     2761 gaaaggaaaa attaaagcaa cagttgaaag caaaggaatt agaacttgaa gaaatcagaa
     2821 aagcttacag cacactaaat aagaaatggc atgataaagg agaactactc tctcatcttg
     2881 aaatgcaagt aaaagaagta aaagaaaaat ttgaagacaa ggaaaggaaa ctgaaagcag
     2941 agagagacaa aagtcttgag ctacaaaagg atgcaatgga aaagcttcag aacatggatg
     3001 atgcctttag aagacaagtg gatgagattg tggaagcgca ccaagctgaa ataatgcagc
     3061 tagcaaatga gaagcagaag tatattgact gtgcaaattt aaaggttcaa caagttgaag
     3121 acgaaatgcg aggacttctg gacgaaacat gcaagaacaa aaaaatgatg gaagaaaaaa
     3181 ttaagcaact tgcttgtgct ataagtgaga tacagaaaga aatgtgatgt tggagggaac
     3241 aagtttagtt gaaccggacc aacagaccta ttgtcaaaat gattaaacac tgtaacagta
     3301 gtgactgctg tgactgtgaa atgtctcttt ctacacattt cattatgaat agatttaaga
     3361 gacttgatga aatattgtat atgtggtgtt tttataataa agcattaatt atgtttatta
     3421 gatggagcta tcataataac tagacataaa gcacttttcg tgtctctgtg ctataccttg
     3481 ttgataattg cacacttact tgcagacttg cagaatgtta caatttgacc aaaggaaaga
     3541 tacaaaaata atcattgttg agcctgtgct aatgtagaac tagttgtatt tacaggttat
     3601 ccattagttg atgtgactcc cttcttttaa agtgtcttta agatgtagag gaaaaatatt
     3661 gtaagtctat aggataatca aaaatgtgtt ctcattcaga aagctttagc tatctccaca
     3721 tgactcagtt tcatcttttc tggtgcattt gttcattaaa ggtgaaattt gtagttttat
     3781 aaatattgtc tgatctagaa gagtgcagca gtcccactgt cattcacagt gccactcatt
     3841 gcgtgaagag acttctgact ctgcaactgg aaacactcat ttcacttcct gtctagtctc
     3901 atattgctaa ttcaatgtca tcaccactta tgttggtaaa tgtatgtcct taccttgtcc
     3961 tgtatctgag aagaagaaaa tataacacat tcaaaactaa tatcattaat aagctaaatt
     4021 ttacaaagta catagaaccc aaataacatt taaatatccc tgaagagaag gtcttatggt
     4081 gttgttatag ctgagctgca tgcttcagtc aggtggtagc tggtagtcta attcctacct
     4141 gaaccggtca gtgcctgcct gacacttcca agttcatgca tccataagtt ttctgtctga
     4201 tggtaagcat ggaattgagt tagcacagat ttgtgaacat agatgttgta atacagagga
     4261 tgtttcagga aggctgtgga cttcttggtg ttctctatag aggcaaacat tccatgaatg
     4321 cttgcataat tattaccaca ttgacagtgc actgggctcc cctatctgtg agatggagga
     4381 atagaatgct gaagttcata ataggaggat agattatggt atgattatga ttggattgta
     4441 ctgtgtttgt atgtgtgtgt gtgtgtagtt ttttgttgtt ttgtggtttt gtttttagca
     4501 ggggcaggag gaatcagata atccatacat tctctgaaat accagtttta taaattattc
     4561 agttttctga atctagggga ttcttcaaga atccagcaac ttaccttcag atataaattc
     4621 ttgacttaaa agtacctcag cttaatgacc ttagaactta catactatgg catgaacttg
     4681 ggttctaata tgtacttaca tctcaatttg gaagttattc atacaactaa ccacaattcc
     4741 caaaatcagg atcccctccc caagaccact gaacttctcc tgaactgtga tattagattc
     4801 acagggctgt ggagtacttt aataactaga aaagataatc tactgttatc caatggaatc
     4861 ccaatatatt tgtgcatggg gcaggatcct gaatgttttc aaggataaca gattaactct
     4921 acacatcttt gtcaaggtgt ccgggaatac agagcactgc tcccaactct agtagtttta
     4981 tgtatcactt ctgtagctaa tgacacatat ctgtaggtta gtattattac aagccattta
     5041 aacatttctg tgacaaataa tagagaaatg tacatggagt agggtaaaag taaagttgct
     5101 aaaactggta atggttgagt tgccagactg ataactatgg ctaactcctg tggcttacca
     5161 tttatgggca tactatgcta gaagcagatg tggaagagtg ggactcatag ggtagtccta
     5221 attatctctt attcgcctgc tggaagtttt cttctgcttt ccatactgtt aggaacaaga
     5281 gataggtttc aatggcatca gcttcagtaa gggaccacaa tctggttttc cattttatcc
     5341 acaagaatag acttttgggc tgctggagtt taagtagaag tttctactat attttttatc
     5401 ttattatctt attttctgta tatgaatgtt taacctgcat atatgtctgt gtaccacgtg
     5461 tgtggctggt acccatggag accagaaaat gatattagat gccctagact cagaattgca
     5521 aatagttgtg agctgccatg tgggtggtag aaactgaacc tagggactct agaggagcag
     5581 ccagtgagtg ctcttacctc catctctcca acccctccat tatatttttg ttgaatttgt
     5641 tttcttataa taaacttaca tttcttatgt ttcaa
//
