LOCUS       NM_133897               2829 bp    mRNA    linear   ROD 05-DEC-2024
DEFINITION  Mus musculus leucine rich repeat containing 8 family, member C
            (Lrrc8c), mRNA.
ACCESSION   NM_133897
VERSION     NM_133897.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2829)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2829)
  AUTHORS   Rutz,S., Deneka,D., Dittmann,A., Sawicka,M. and Dutzler,R.
  TITLE     Structure of a volume-regulated heteromeric LRRC8A/C channel
  JOURNAL   Nat Struct Mol Biol 30 (1), 52-61 (2023)
   PUBMED   36522427
  REMARK    GeneRIF: Structure of a volume-regulated heteromeric LRRC8A/C
            channel.
REFERENCE   3  (bases 1 to 2829)
  AUTHORS   Lopez-Cayuqueo,K.I., Planells-Cases,R., Pietzke,M., Oliveras,A.,
            Kempa,S., Bachmann,S. and Jentsch,T.J.
  TITLE     Renal Deletion of LRRC8/VRAC Channels Induces Proximal Tubulopathy
  JOURNAL   J Am Soc Nephrol 33 (8), 1528-1545 (2022)
   PUBMED   35777784
REFERENCE   4  (bases 1 to 2829)
  AUTHORS   Concepcion,A.R., Wagner,L.E. 2nd, Zhu,J., Tao,A.Y., Yang,J.,
            Khodadadi-Jamayran,A., Wang,Y.H., Liu,M., Rose,R.E., Jones,D.R.,
            Coetzee,W.A., Yule,D.I. and Feske,S.
  TITLE     The volume-regulated anion channel LRRC8C suppresses T cell
            function by regulating cyclic dinucleotide transport and STING-p53
            signaling
  JOURNAL   Nat Immunol 23 (2), 287-302 (2022)
   PUBMED   35105987
REFERENCE   5  (bases 1 to 2829)
  AUTHORS   Zhou,C., Chen,X., Planells-Cases,R., Chu,J., Wang,L., Cao,L.,
            Li,Z., Lopez-Cayuqueo,K.I., Xie,Y., Ye,S., Wang,X., Ullrich,F.,
            Ma,S., Fang,Y., Zhang,X., Qian,Z., Liang,X., Cai,S.Q., Jiang,Z.,
            Zhou,D., Leng,Q., Xiao,T.S., Lan,K., Yang,J., Li,H., Peng,C.,
            Qiu,Z., Jentsch,T.J. and Xiao,H.
  TITLE     Transfer of cGAMP into Bystander Cells via LRRC8 Volume-Regulated
            Anion Channels Augments STING-Mediated Interferon Responses and
            Anti-viral Immunity
  JOURNAL   Immunity 52 (5), 767-781 (2020)
   PUBMED   32277911
REFERENCE   6  (bases 1 to 2829)
  AUTHORS   Lumayag,S., Haldin,C.E., Corbett,N.J., Wahlin,K.J., Cowan,C.,
            Turturro,S., Larsen,P.E., Kovacs,B., Witmer,P.D., Valle,D.,
            Zack,D.J., Nicholson,D.A. and Xu,S.
  TITLE     Inactivation of the microRNA-183/96/182 cluster results in
            syndromic retinal degeneration
  JOURNAL   Proc Natl Acad Sci U S A 110 (6), E507-E516 (2013)
   PUBMED   23341629
REFERENCE   7  (bases 1 to 2829)
  AUTHORS   Hayashi,T., Nozaki,Y., Nishizuka,M., Ikawa,M., Osada,S. and
            Imagawa,M.
  TITLE     Factor for adipocyte differentiation 158 gene disruption prevents
            the body weight gain and insulin resistance induced by a high-fat
            diet
  JOURNAL   Biol Pharm Bull 34 (8), 1257-1263 (2011)
   PUBMED   21804215
  REMARK    GeneRIF: These results indicate that fad158 is a key factor in the
            development of obesity and insulin resistance caused by a high-fat
            diet.
REFERENCE   8  (bases 1 to 2829)
  AUTHORS   Wergedal,J.E., Ackert-Bicknell,C.L., Beamer,W.G., Mohan,S.,
            Baylink,D.J. and Srivastava,A.K.
  TITLE     Mapping genetic loci that regulate lipid levels in a NZB/B1NJxRF/J
            intercross and a combined intercross involving NZB/B1NJ, RF/J,
            MRL/MpJ, and SJL/J mouse strains
  JOURNAL   J Lipid Res 48 (8), 1724-1734 (2007)
   PUBMED   17496333
REFERENCE   9  (bases 1 to 2829)
  AUTHORS   Collins,M.O., Yu,L., Coba,M.P., Husi,H., Campuzano,I.,
            Blackstock,W.P., Choudhary,J.S. and Grant,S.G.
  TITLE     Proteomic analysis of in vivo phosphorylated synaptic proteins
  JOURNAL   J Biol Chem 280 (7), 5972-5982 (2005)
   PUBMED   15572359
REFERENCE   10 (bases 1 to 2829)
  AUTHORS   Tominaga,K., Kondo,C., Kagata,T., Hishida,T., Nishizuka,M. and
            Imagawa,M.
  TITLE     The novel gene fad158, having a transmembrane domain and
            leucine-rich repeat, stimulates adipocyte differentiation
  JOURNAL   J Biol Chem 279 (33), 34840-34848 (2004)
   PUBMED   15184384
  REMARK    GeneRIF: fad158 has a role in regulating adipocyte differentiation
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC138265.9 and
            AC122566.14.
            
            On Nov 17, 2006 this sequence version replaced NM_133897.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB081508.1, AK142337.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-160               AC138265.9         94941-95100
            161-231             AC138265.9         119670-119740
            232-373             AC138265.9         154938-155079
            374-2829            AC122566.14        45316-47771
FEATURES             Location/Qualifiers
     source          1..2829
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 50.68 cM"
     gene            1..2829
                     /gene="Lrrc8c"
                     /gene_synonym="AD158; E430036I04Rik; fad158"
                     /note="leucine rich repeat containing 8 family, member C"
                     /db_xref="GeneID:100604"
                     /db_xref="MGI:MGI:2140839"
     exon            1..160
                     /gene="Lrrc8c"
                     /gene_synonym="AD158; E430036I04Rik; fad158"
                     /inference="alignment:Splign:2.1.0"
     exon            161..231
                     /gene="Lrrc8c"
                     /gene_synonym="AD158; E430036I04Rik; fad158"
                     /inference="alignment:Splign:2.1.0"
     exon            232..373
                     /gene="Lrrc8c"
                     /gene_synonym="AD158; E430036I04Rik; fad158"
                     /inference="alignment:Splign:2.1.0"
     CDS             236..2647
                     /gene="Lrrc8c"
                     /gene_synonym="AD158; E430036I04Rik; fad158"
                     /note="leucine-rich repeat-containing protein 8C; factor
                     for adipocyte differentiation 158"
                     /codon_start=1
                     /product="volume-regulated anion channel subunit LRRC8C"
                     /protein_id="NP_598658.1"
                     /db_xref="CCDS:CCDS19493.1"
                     /db_xref="GeneID:100604"
                     /db_xref="MGI:MGI:2140839"
                     /translation="MIPVTEFRQFSEQQPAFRVLKPWWDVFTDYLSVAMLMIGVFGCT
                     LQVMQDKIICLPKRVQPAQNHSSVPNVSQAVISTTPLPPPKPSPTNPATVEMKGLKTD
                     LDLQQYSFINQMCYERALHWYAKYFPYLVLIHTLVFMLCSNFWFKFPGSSSKIEHFIS
                     ILGKCFDSPWTTRALSEVSGEDSEEKDNRKNNMNRSGTIQSGPEGNLVRSQSLKSIPE
                     KFVVDKSAAGALDKKEGEQAKALFEKVKKFRLHVEEGDILYAMYVRQTVLKVIKFLII
                     IAYNSALVSKVQFTVDCNVDIQDMTGYKNFSCNHTMAHLFSKLSFCYLCFVSIYGLTC
                     LYTLYWLFYRSLREYSFEYVRQETGIDDIPDVKNDFAFMLHMIDQYDPLYSKRFAVFL
                     SEVSENKLKQLNLNNEWTPDKLRQKLQTNAHNRLELPLIMLSGLPDTVFEITELQSLK
                     LEIIKNVMIPATIAQLDNLQELCLHQCSVKIHSAALSFLKENLKVLSVKFDDMRELPP
                     WMYGLRNLEELYLVGSLSHDISKNVTLESLRDLKSLKILSIKSNVSKIPQAVVDVSSH
                     LQKMCVHNDGTKLVMLNNLKKMTNLTELELVHCDLERIPHAVFSLLSLQELDLKENNL
                     KSIEEIVSFQHLRKLTVLKLWYNSIAYIPEHIKKLTSLERLFFSHNKVEVLPSHLFLC
                     NKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVESLPDELYFCKKLKTLKIGKNS
                     LSVLSPKIGNLLFLSYLDIKGNHFEVLPPELGDCRALKRAGLVVEDALFETLPSDVRE
                     QMKAD"
     exon            374..2829
                     /gene="Lrrc8c"
                     /gene_synonym="AD158; E430036I04Rik; fad158"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagacgagga ccgaggcgcc gccgcggccg tggccgcagc actctgagcg cgacaagcca
       61 tgagcagcga cgccgcggtc gcttgccgcc gctgagccca acccggacac agctcgccgc
      121 gccctggcat ccttttctgc ggataccctc gcccccagag attaatgtgg ctgcttatga
      181 ctaaggattc tgggaccaca gatgttcaga gaagtaacat atacatataa gaaacatgat
      241 tccggtgacc gagttccggc agttctccga gcagcagccc gccttccggg tgctgaagcc
      301 gtggtgggat gtgttcacgg attacctctc ggtggccatg ctgatgatcg gagtgtttgg
      361 atgtacttta caggtcatgc aagacaagat catctgcctt ccgaaaagag tgcagcctgc
      421 tcagaaccac tcttccgttc ccaatgtctc ccaggcagtt atcagtacca ctccgctgcc
      481 cccacctaaa ccctcaccga ccaaccccgc gaccgtggag atgaagggac tgaagacaga
      541 cctggacctt cagcagtaca gtttcatcaa ccagatgtgc tacgagcgag ccctccactg
      601 gtatgccaag tacttcccat acctggtgct catccacacc ctggtcttca tgctctgtag
      661 caacttctgg ttcaaattcc ccggatccag ttccaaaata gaacatttca tctccatcct
      721 ggggaagtgc tttgactccc cgtggaccac acgggctctc tccgaagtgt ccggagagga
      781 ctccgaagag aaggacaaca gaaaaaacaa catgaacagg tccggcacca tccagtctgg
      841 tcccgagggc aacctggtga ggtcccagtc tctcaagtca attcctgaaa agttcgtggt
      901 tgacaaatct gctgcggggg ctctggacaa gaaggaaggt gagcaggcca aggccttgtt
      961 tgagaaggtg aagaagttca gactgcatgt ggaagaaggt gatatcctgt acgccatgta
     1021 cgtgcgacag actgtgctga aggtcatcaa attcctaatc atcattgcct acaacagtgc
     1081 cctggtttcc aaagtccagt tcacagtgga ctgtaatgtg gacatccagg acatgacggg
     1141 ctataagaac ttttcttgca atcacaccat ggctcatttg ttctctaagc tctccttttg
     1201 ctacctgtgc tttgtaagca tctatggcct gacgtgcctt tacaccttat actggctgtt
     1261 ctaccgttct ctgagggaat attccttcga gtatgtccgg caggagacgg gaatcgatga
     1321 cattccggat gtgaaaaatg actttgcttt catgctccat atgatagacc agtatgaccc
     1381 tctctattcc aagcggtttg cagtgttcct gtctgaagtc agcgagaaca agttaaaaca
     1441 actcaattta aataacgagt ggaccccgga caaactgcgg cagaagctgc agacaaatgc
     1501 ccacaaccgc ctggagctgc cgctgatcat gctgtctggc ctcccggaca ccgtgtttga
     1561 aatcacagag ttgcagtctc tgaagctgga gatcattaag aatgtcatga tccccgccac
     1621 catcgcccag ctagacaacc tgcaggagct ctgtctgcac cagtgctccg tcaagatcca
     1681 cagcgccgcg ctctccttcc tgaaggagaa tctcaaggtc ctgagtgtca agtttgatga
     1741 catgagggag ctgcccccct ggatgtacgg cctccggaac ctggaagagc tctatctggt
     1801 tggctctctg agtcacgaca tctccaaaaa tgtcaccctg gagtctctga gggacctcaa
     1861 aagccttaaa atcctttcca tcaagagcaa cgtctccaag atccctcagg ccgtggtgga
     1921 tgtgtccagc cacctccaga agatgtgcgt ccacaatgat ggcaccaaac tggtgatgct
     1981 caacaacctg aagaagatga ccaacctgac ggagctggag ctggtccact gcgacctgga
     2041 acgcatcccc cacgccgtgt tcagcctgct cagtctccag gagctggacc tgaaggagaa
     2101 caacctcaag tccatagagg agatcgtgag cttccagcac ttgagaaagc tgaccgtgct
     2161 caaactgtgg tataacagca tcgcttacat tccagagcac atcaagaaac tgaccagcct
     2221 ggagagactg tttttcagcc acaataaggt agaggtgctt ccctcccacc tcttcctgtg
     2281 caacaaaatc agatacctgg acttgtccta taacgacatc cgcttcatcc cgcccgaaat
     2341 cggagttctg caaagtttac agtatttttc catcacttgt aacaaagtgg agagcctccc
     2401 agatgaactc tacttctgca agaaacttaa aactttgaag attgggaaaa acagcctctc
     2461 cgtactttca ccaaaaattg gaaatctact atttctttcc tacttagaca tcaaaggcaa
     2521 tcactttgaa gtcctccctc ccgagctggg agactgccgg gctctgaagc gagccgggct
     2581 agttgtggaa gatgctctgt ttgagactct gccctcagat gtccgggagc agatgaaagc
     2641 agactaactt atttttcatc agagtatgac tgaaacatgc ttctaccaaa tacaatataa
     2701 agaattaggt agtcctaatg cctttcctat attatttttt tttccttttc cacacaagac
     2761 aacatgtaca caaagattga gtaaggagta tgtatttttt aataaaaatt taattgtatt
     2821 ttttcaata
//
