LOCUS       NM_029053               2231 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Mus musculus leucine rich repeat containing 74B (Lrrc74b),
            transcript variant 1, mRNA.
ACCESSION   NM_029053 XM_148428 XM_899183 XM_899189 XM_911919 XM_922200
            XM_922208 XM_990304 XM_990331 XM_990387
VERSION     NM_029053.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2231)
  AUTHORS   Vong,K.I., Lee,S., Au,K.S., Crowley,T.B., Capra,V., Martino,J.,
            Haller,M., Araujo,C., Machado,H.R., George,R., Gerding,B.,
            James,K.N., Stanley,V., Jiang,N., Alu,K., Meave,N., Nidhiry,A.S.,
            Jiwani,F., Tang,I., Nisal,A., Jhamb,I., Patel,A., Patel,A.,
            McEvoy-Venneri,J., Barrows,C., Shen,C., Ha,Y.J., Howarth,R.,
            Strain,M., Ashley-Koch,A.E., Azam,M., Mumtaz,S., Bot,G.M.,
            Finnell,R.H., Kibar,Z., Marwan,A.I., Melikishvili,G., Meltzer,H.S.,
            Mutchinick,O.M., Stevenson,D.A., Mroczkowski,H.J., Ostrander,B.,
            Schindewolf,E., Moldenhauer,J., Zackai,E.H., Emanuel,B.S.,
            Garcia-Minaur,S., Nowakowska,B.A., Stevenson,R.E., Zaki,M.S.,
            Northrup,H., McNamara,H.K., Aldinger,K.A., Phelps,I.G., Deng,M.,
            Glass,I.A., Morrow,B., McDonald-McGinn,D.M., Sanna-Cherchi,S.,
            Lamb,D.J. and Gleeson,J.G.
  CONSRTM   Spina Bifida Sequencing Consortiumdouble dagger
  TITLE     Risk of meningomyelocele mediated by the common 22q11.2 deletion
  JOURNAL   Science 384 (6695), 584-590 (2024)
   PUBMED   38696583
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB634732.1, BC115678.1, AC113006.9 and AK161226.1.
            
            On Feb 26, 2009 this sequence version replaced NM_029053.2.
            
            Transcript Variant: This variant (1) represents the longer variant
            and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC115678.1, SRR7345562.3271720.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                BB634732.1         2-24
            24-1261             BC115678.1         1-1238
            1262-2039           AC113006.9         193368-194145       c
            2040-2231           AK161226.1         1942-2133
FEATURES             Location/Qualifiers
     source          1..2231
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 10.87 cM"
     gene            1..2231
                     /gene="Lrrc74b"
                     /gene_synonym="4930451C15Rik; mCG12354; mCP17390"
                     /note="leucine rich repeat containing 74B"
                     /db_xref="GeneID:74685"
                     /db_xref="MGI:MGI:1921935"
     exon            1..169
                     /gene="Lrrc74b"
                     /gene_synonym="4930451C15Rik; mCG12354; mCP17390"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..1212
                     /gene="Lrrc74b"
                     /gene_synonym="4930451C15Rik; mCG12354; mCP17390"
                     /note="isoform 1 is encoded by transcript variant 1;
                     leucine-rich repeat-containing protein LOC400891 homolog;
                     leucine-rich repeat-containing protein 74B"
                     /codon_start=1
                     /product="leucine-rich repeat-containing protein 74B
                     isoform 1"
                     /protein_id="NP_083329.2"
                     /db_xref="CCDS:CCDS28006.2"
                     /db_xref="GeneID:74685"
                     /db_xref="MGI:MGI:1921935"
                     /translation="MKGPCEVQKNEDQEGEAAATGPQAETLEAERSWTADSHSALEAE
                     GTHGLGERVMATLYLKSCRANSVVPVSCLLRQEGASELNLRHRGLGPQGVRALASVLT
                     SNPYIKRLDLRDNGLCGAGAEALADVLRKNSIISDVDLSENQIGAAGLQAICTALALN
                     PTVEKMQLQGNRLEEQAAQHLAALLLHHRGLKSLDLSYNQLNDLAGEILGPAVAENTG
                     LTELNLSWNHLRGLGATAFARGLEANIFLKVLDISHNGFGDSGASAIGDALRVNNVLE
                     ELNMRNNRISVSGALKLGLGLQVNQTLRILIISKNPIRSDGCVGLLKSVRNNKSSALE
                     LLDVSDIQVSRECEDLASSMSEILPGLCIKRYTSRRKDWPQASTPSQPASAPSDSGL"
     exon            170..312
                     /gene="Lrrc74b"
                     /gene_synonym="4930451C15Rik; mCG12354; mCP17390"
                     /inference="alignment:Splign:2.1.0"
     exon            313..445
                     /gene="Lrrc74b"
                     /gene_synonym="4930451C15Rik; mCG12354; mCP17390"
                     /inference="alignment:Splign:2.1.0"
     exon            446..652
                     /gene="Lrrc74b"
                     /gene_synonym="4930451C15Rik; mCG12354; mCP17390"
                     /inference="alignment:Splign:2.1.0"
     exon            653..762
                     /gene="Lrrc74b"
                     /gene_synonym="4930451C15Rik; mCG12354; mCP17390"
                     /inference="alignment:Splign:2.1.0"
     exon            763..878
                     /gene="Lrrc74b"
                     /gene_synonym="4930451C15Rik; mCG12354; mCP17390"
                     /inference="alignment:Splign:2.1.0"
     exon            879..957
                     /gene="Lrrc74b"
                     /gene_synonym="4930451C15Rik; mCG12354; mCP17390"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1053
                     /gene="Lrrc74b"
                     /gene_synonym="4930451C15Rik; mCG12354; mCP17390"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..2231
                     /gene="Lrrc74b"
                     /gene_synonym="4930451C15Rik; mCG12354; mCP17390"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1247..1252
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lrrc74b"
                     /gene_synonym="4930451C15Rik; mCG12354; mCP17390"
                     /note="hexamer: AATACA"
     polyA_site      1268
                     /gene="Lrrc74b"
                     /gene_synonym="4930451C15Rik; mCG12354; mCP17390"
                     /note="major polyA site"
     regulatory      1499..1504
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lrrc74b"
                     /gene_synonym="4930451C15Rik; mCG12354; mCP17390"
                     /note="hexamer: ATTACA"
     polyA_site      1522
                     /gene="Lrrc74b"
                     /gene_synonym="4930451C15Rik; mCG12354; mCP17390"
                     /note="major polyA site"
ORIGIN      
        1 agagtctgcg tcccggactg ggtagtgaga gtaaacatga agggtccctg cgaagttcag
       61 aagaatgaag atcaagaggg agaagctgcg gccactgggc ctcaggcaga gaccctggag
      121 gccgaaaggt cctggactgc agattcacac tctgctctgg aagcagaagg cacccatggg
      181 cttggagaac gggtcatggc taccctctat ctgaagtctt gccgggccaa tagtgttgtg
      241 ccagtttctt gtcttctgcg ccaagagggt gcctctgaat tgaaccttcg gcaccgtggc
      301 ctggggcccc agggggtccg ggcattggct tccgtattga cctctaatcc ctacatcaag
      361 cgtctggatc ttcgggacaa tgggctctgt ggtgctggag cagaggctct ggctgatgtc
      421 ctgcgtaaga acagcattat ctctgatgtg gacctgtcag agaatcagat tggagctgca
      481 gggctccagg cgatctgcac tgcccttgcc ttaaacccaa ctgttgagaa gatgcagctg
      541 caagggaaca ggctggagga acaagcagcc cagcacctcg ctgctcttct gctgcatcac
      601 aggggcctga aatctctaga cctcagctat aatcagctca atgacctggc aggagagata
      661 cttggacctg ctgtggcaga aaacacagga ctcacagagc ttaacctcag ttggaatcac
      721 ctgcgaggtc tgggagccac cgcgtttgcc cgaggcctgg aggcaaatat attcttgaaa
      781 gtcctagaca tctctcataa tggctttgga gactctggtg ccagtgcgat tggtgatgcc
      841 ctcagggtca acaatgtttt agaagaactg aatatgagga acaaccgaat ctccgtgtca
      901 ggagccctga agttgggatt gggtctgcaa gtcaatcaga cgctgcggat tcttattatt
      961 tccaagaatc ctattcgcag tgacggctgt gttggcctcc ttaagtctgt ccggaacaac
     1021 aaatcatctg ccctagaact gctggatgtg tctgatatcc aagtaagcag agaatgtgag
     1081 gacctcgcta gctccatgag tgaaattctt ccaggactct gtataaagcg ttatacttct
     1141 agaagaaaag actggccaca agcctctaca ccatcccagc cagcatctgc accaagtgac
     1201 tctggtctct aatatgctac tttaacattc acagtgctgg ccatttaata cacaacatgt
     1261 gtatcttcct ttctgctctc tggcatcttc cataatctgg cttcatttgc tgtggttcat
     1321 tcattcaacc aaaaagctgc ccatgaacaa cactgaacac aaggtccatg acattcttgt
     1381 catccagatc ttcatgttct ggtgactcag ttcaacaaaa cataaaggag atatgcaaat
     1441 ggatctccca agctctcttg caagaagaca gtcataactc attggaaggc aactgatcat
     1501 tacattctga attataaaat cacccatgtg cttctggttt ccatctgtgc cccagagctg
     1561 actctgtgcc atagctctcc atacccaaat cccgctggga gagagctggt ctcccaggag
     1621 tgctgacaca cctgagagca taggtgaaac caccacttct gctcaaattc ctggttgaag
     1681 agggaccaag gaacagccag tgaacagatc cttccagttt ccgtctacat ccagagctga
     1741 gcctgtgcca cagctcctca tacccaaatc ccaccgggag agaactggtc tcccaggagt
     1801 gctgacacac aggcttatag gaggaacaag tcacagtcag agacagcaaa accagctaac
     1861 actacagata accagatttt gagagtcaag ggcaataacg taagcaacag aaaacacggc
     1921 tacttggcat catcagaacc cagttctccc accacagcta gccctggata ccccaataca
     1981 ctggaaaagc aagattctaa tttaaaataa catctcatga tgataataga ggactttaag
     2041 aaggacataa atagggctga agagatagct cagtggttaa gagcactgac tgttctttca
     2101 gaggtcctga gttcaatttc cagcaaccac atggtggccc acaaccatat gtaatgggat
     2161 ccaatgccct cttctggtgt gtctgaagat aaccacagtg tacttatata cataaaataa
     2221 atgaataaat c
//
