LOCUS       NM_001081358            7006 bp    mRNA    linear   ROD 24-SEP-2024
DEFINITION  Mus musculus leucine rich repeat containing 7 (Lrrc7), transcript
            variant 1, mRNA.
ACCESSION   NM_001081358 XM_898867
VERSION     NM_001081358.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7006)
  AUTHORS   Cesari,E., Farini,D., Medici,V., Ehrmann,I., Guerra,M., Testa,E.,
            Naro,C., Geloso,M.C., Pagliarini,V., La Barbera,L., D'Amelio,M.,
            Orsini,T., Vecchioli,S.F., Tamagnone,L., Fort,P., Viscomi,M.T.,
            Elliott,D.J. and Sette,C.
  TITLE     Differential expression of paralog RNA binding proteins establishes
            a dynamic splicing program required for normal cerebral cortex
            development
  JOURNAL   Nucleic Acids Res 52 (8), 4167-4184 (2024)
   PUBMED   38324473
REFERENCE   2  (bases 1 to 7006)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7006)
  AUTHORS   Chong,C.H., Li,Q., Mak,P.H.S., Ng,C.C.P., Leung,E.H.W., Tan,V.H.,
            Chan,A.K.W., McAlonan,G. and Chan,S.Y.
  TITLE     Lrrc7 mutant mice model developmental emotional dysregulation that
            can be alleviated by mGluR5 allosteric modulation
  JOURNAL   Transl Psychiatry 9 (1), 244 (2019)
   PUBMED   31582721
  REMARK    GeneRIF: important role of LRRC7 in mGluR5 signaling; mutant mice
            had inappropriate juvenile aggressive behavior and significant
            anxiety-like behavior and social dysfunction in adulthood
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7006)
  AUTHORS   Gerhardt,B., Leesman,L., Burra,K., Snowball,J., Rosenzweig,R.,
            Guzman,N., Ambalavanan,M. and Sinner,D.
  TITLE     Notum attenuates Wnt/beta-catenin signaling to promote tracheal
            cartilage patterning
  JOURNAL   Dev Biol 436 (1), 14-27 (2018)
   PUBMED   29428562
REFERENCE   5  (bases 1 to 7006)
  AUTHORS   Wang,S., Stanika,R.I., Wang,X., Hagen,J., Kennedy,M.B.,
            Obermair,G.J., Colbran,R.J. and Lee,A.
  TITLE     Densin-180 Controls the Trafficking and Signaling of L-Type
            Voltage-Gated Cav1.2 Ca2+ Channels at Excitatory Synapses
  JOURNAL   J Neurosci 37 (18), 4679-4691 (2017)
   PUBMED   28363979
  REMARK    GeneRIF: We report that the protein densin-180 is highly enriched
            at excitatory synapses in the brain and enhances the cell surface
            trafficking and postsynaptic localization of Cav1.2 L-type Ca(2+)
            channels in neurons. This interaction promotes coupling of Cav1.2
            channels to activity-dependent gene transcription.
REFERENCE   6  (bases 1 to 7006)
  AUTHORS   Jenkins,M.A., Christel,C.J., Jiao,Y., Abiria,S., Kim,K.Y.,
            Usachev,Y.M., Obermair,G.J., Colbran,R.J. and Lee,A.
  TITLE     Ca2+-dependent facilitation of Cav1.3 Ca2+ channels by densin and
            Ca2+/calmodulin-dependent protein kinase II
  JOURNAL   J Neurosci 30 (15), 5125-5135 (2010)
   PUBMED   20392935
REFERENCE   7  (bases 1 to 7006)
  AUTHORS   Sawallisch,C., Berhorster,K., Disanza,A., Mantoani,S.,
            Kintscher,M., Stoenica,L., Dityatev,A., Sieber,S., Kindler,S.,
            Morellini,F., Schweizer,M., Boeckers,T.M., Korte,M., Scita,G. and
            Kreienkamp,H.J.
  TITLE     The insulin receptor substrate of 53 kDa (IRSp53) limits
            hippocampal synaptic plasticity
  JOURNAL   J Biol Chem 284 (14), 9225-9236 (2009)
   PUBMED   19208628
REFERENCE   8  (bases 1 to 7006)
  AUTHORS   Lassila,M., Juhila,J., Heikkila,E. and Holthofer,H.
  TITLE     Densin is a novel cell membrane protein of Sertoli cells in the
            testis
  JOURNAL   Mol Reprod Dev 74 (5), 641-645 (2007)
   PUBMED   17039495
  REMARK    GeneRIF: Densin is a novel testicular protein expressed in the cell
            membranes of Sertoli cells.
REFERENCE   9  (bases 1 to 7006)
  AUTHORS   Munton,R.P., Tweedie-Cullen,R., Livingstone-Zatchej,M.,
            Weinandy,F., Waidelich,M., Longo,D., Gehrig,P., Potthast,F.,
            Rutishauser,D., Gerrits,B., Panse,C., Schlapbach,R. and Mansuy,I.M.
  TITLE     Qualitative and quantitative analyses of protein phosphorylation in
            naive and stimulated mouse synaptosomal preparations
  JOURNAL   Mol Cell Proteomics 6 (2), 283-293 (2007)
   PUBMED   17114649
REFERENCE   10 (bases 1 to 7006)
  AUTHORS   Trinidad,J.C., Specht,C.G., Thalhammer,A., Schoepfer,R. and
            Burlingame,A.L.
  TITLE     Comprehensive identification of phosphorylation sites in
            postsynaptic density preparations
  JOURNAL   Mol Cell Proteomics 5 (5), 914-922 (2006)
   PUBMED   16452087
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC102540.7, AC118595.6, AC134449.3 and AC145301.4.
            
            On Mar 2, 2021 this sequence version replaced NM_001081358.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMN00849374, SAMN00849377
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-656               AC102540.7         122120-122775
            657-754             AC118595.6         76789-76886
            755-830             AC118595.6         116373-116448
            831-1033            AC118595.6         176111-176313
            1034-1151           AC118595.6         211026-211143
            1152-1230           AC118595.6         226163-226241
            1231-1320           AC134449.3         174392-174481       c
            1321-1377           AC134449.3         171439-171495       c
            1378-1441           AC134449.3         122908-122971       c
            1442-1516           AC134449.3         92149-92223         c
            1517-1661           AC134449.3         84809-84953         c
            1662-1734           AC134449.3         80576-80648         c
            1735-1864           AC134449.3         69435-69564         c
            1865-1980           AC134449.3         67837-67952         c
            1981-2050           AC134449.3         64000-64069         c
            2051-2150           AC134449.3         62224-62323         c
            2151-2275           AC134449.3         59668-59792         c
            2276-2524           AC134449.3         57562-57810         c
            2525-2725           AC145301.4         2024-2224
            2726-2837           AC145301.4         8394-8505
            2838-3018           AC145301.4         8708-8888
            3019-4699           AC145301.4         10867-12547
            4700-4840           AC145301.4         15852-15992
            4841-4960           AC145301.4         24081-24200
            4961-5182           AC145301.4         37371-37592
            5183-5275           AC145301.4         45473-45565
            5276-5350           AC145301.4         68278-68352
            5351-7006           AC145301.4         88234-89889
FEATURES             Location/Qualifiers
     source          1..7006
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3"
     gene            1..7006
                     /gene="Lrrc7"
                     /gene_synonym="B230334C09Rik; densin; mKIAA1365"
                     /note="leucine rich repeat containing 7"
                     /db_xref="GeneID:242274"
                     /db_xref="MGI:MGI:2676665"
     exon            1..656
                     /gene="Lrrc7"
                     /gene_synonym="B230334C09Rik; densin; mKIAA1365"
                     /inference="alignment:Splign:2.1.0"
     exon            657..754
                     /gene="Lrrc7"
                     /gene_synonym="B230334C09Rik; densin; mKIAA1365"
                     /inference="alignment:Splign:2.1.0"
     exon            755..830
                     /gene="Lrrc7"
                     /gene_synonym="B230334C09Rik; densin; mKIAA1365"
                     /inference="alignment:Splign:2.1.0"
     CDS             830..5458
                     /gene="Lrrc7"
                     /gene_synonym="B230334C09Rik; densin; mKIAA1365"
                     /note="isoform 1 is encoded by transcript variant 1;
                     densin 180; leucine-rich repeat-containing protein 7"
                     /codon_start=1
                     /product="leucine-rich repeat-containing protein 7 isoform
                     1"
                     /protein_id="NP_001074827.1"
                     /db_xref="GeneID:242274"
                     /db_xref="MGI:MGI:2676665"
                     /translation="MQCLEMTTKRKLIGRLVPCRCFRGEEEIISVLDYSHCSLQQVPK
                     EVFNFERTLEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSSLPTSIASLVNLKEL
                     DISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQLYLNDAFLEFLPA
                     NFGRLVKLRILELRENHLKTLPKSMHKLAQLERLDLGNNEFSELPEVLDQIQNLRELW
                     MDNNALQVLPGSIGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNMLQQLPDS
                     IGLLKKLTTLKVDDNQLTMLPNTIGNLSLLEEFDCSCNELESLPPTIGYLHSLRTLAV
                     DENFLPELPREIGSCKNVTVMSLRSNKLEFLPEEIGQMQRLRVLNLSDNRLKNLPFSF
                     TKLKELAALWLSDNQSKALIPLQTEAHPETKQRVLTNYMFPQQPRGDEDFQSDSDSFN
                     PTLWEEQRQQRMTVAFEFEDKKEDDESAGKVKALSCQAPWDRGQRGITLQPARLSGDC
                     CTPWARCDQQIQDMPVPQSDPQLAWGCISGLQQERSMCAPLPVAAQSTTLPSLSGRQV
                     EINLKRYPTPYPEDLKNMVKSVQNLVGKPSHGVRVENSNPTANTEQTVKEKFEHKWPV
                     APKEITVEDSFVHPANEMRIGELHPSLAETPLYPPKLVLLGKDKKESTDESEVDKTHC
                     LNNSVSSGTYSDYSPSQASSASSNTRMKVGSLQATAKDAVHNSLWGNRIAPPFPQPLD
                     AKPLLSQREAVPPGNIPQRPDRLPMSDAFPDNWTDGSHYDNTGFVSEEAAGENANNNP
                     LLSSKARSVPAHGRRPLIRQERIVGVPLELEQSTHRHTPETEVPPSNPWQNWTRTPSP
                     FEDRTAFPSKLETTPTTSPLPERKDHMKEPTETPGPFSPGVPWEYHDPTPNRSLGNVF
                     SQIHCRPDSSKGVIAISKSTERLSPLMKDIKSNKFKKSQSIDEIDVGTYKVYNIPLEN
                     YASGSDHLGSHERPDKFLGPEHGMSSMSRSQSVPMLDDEMLMYGSSKGPPQQKASMTK
                     KVYQFDQSFNPQGAVEVKAEKRIPPPFAHNSEYVQQPSKNIAKDLVSPRAYRGYPPME
                     QMFSFSQPSVNEDAMVNAQFASQGPRAGFLRRADSLASSTEMAMFRRVSEPHELPPGD
                     RYGRATYRGGLEGQSSISMTDPQFLKRNGRYEDEHPSYQEVKAQAGSFPAKNLTQRRP
                     LSARSYSTESYGASQTRPVSARPTMAALLEKIPSDYNLGNYGDKTSDNSDIKTRPTPV
                     KGEESCGKMPADWRQQLLRHIEARRLDRNAAYKHNTVNLGMLPYGGISAMHAGRSMTL
                     NLQTKSKFDLQDLPLQKTPSQQSNILDNGQEDVSPSGQWNPYPLGRRDVPPDTITKKA
                     GSHIQTLMGSQSLQHRSREQQPYEGNINKVTIQQFQSPLPIQIPSSQATRGPQPGRCL
                     IQTKGQRSMDGYPEQFCVRIEKNPGLGFSISGGISGQGNPFKPSDKGIFVTRVQPDGP
                     ASNLLQPGDKILQANGHSFVHMEHEKAVLLLKSFQNTVDLVIQRELTV"
     exon            831..1033
                     /gene="Lrrc7"
                     /gene_synonym="B230334C09Rik; densin; mKIAA1365"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..1151
                     /gene="Lrrc7"
                     /gene_synonym="B230334C09Rik; densin; mKIAA1365"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1230
                     /gene="Lrrc7"
                     /gene_synonym="B230334C09Rik; densin; mKIAA1365"
                     /inference="alignment:Splign:2.1.0"
     exon            1231..1320
                     /gene="Lrrc7"
                     /gene_synonym="B230334C09Rik; densin; mKIAA1365"
                     /inference="alignment:Splign:2.1.0"
     exon            1321..1377
                     /gene="Lrrc7"
                     /gene_synonym="B230334C09Rik; densin; mKIAA1365"
                     /inference="alignment:Splign:2.1.0"
     exon            1378..1441
                     /gene="Lrrc7"
                     /gene_synonym="B230334C09Rik; densin; mKIAA1365"
                     /inference="alignment:Splign:2.1.0"
     exon            1442..1516
                     /gene="Lrrc7"
                     /gene_synonym="B230334C09Rik; densin; mKIAA1365"
                     /inference="alignment:Splign:2.1.0"
     exon            1517..1661
                     /gene="Lrrc7"
                     /gene_synonym="B230334C09Rik; densin; mKIAA1365"
                     /inference="alignment:Splign:2.1.0"
     exon            1662..1734
                     /gene="Lrrc7"
                     /gene_synonym="B230334C09Rik; densin; mKIAA1365"
                     /inference="alignment:Splign:2.1.0"
     exon            1735..1864
                     /gene="Lrrc7"
                     /gene_synonym="B230334C09Rik; densin; mKIAA1365"
                     /inference="alignment:Splign:2.1.0"
     exon            1865..1980
                     /gene="Lrrc7"
                     /gene_synonym="B230334C09Rik; densin; mKIAA1365"
                     /inference="alignment:Splign:2.1.0"
     exon            1981..2050
                     /gene="Lrrc7"
                     /gene_synonym="B230334C09Rik; densin; mKIAA1365"
                     /inference="alignment:Splign:2.1.0"
     exon            2051..2150
                     /gene="Lrrc7"
                     /gene_synonym="B230334C09Rik; densin; mKIAA1365"
                     /inference="alignment:Splign:2.1.0"
     exon            2151..2275
                     /gene="Lrrc7"
                     /gene_synonym="B230334C09Rik; densin; mKIAA1365"
                     /inference="alignment:Splign:2.1.0"
     exon            2276..2524
                     /gene="Lrrc7"
                     /gene_synonym="B230334C09Rik; densin; mKIAA1365"
                     /inference="alignment:Splign:2.1.0"
     exon            2525..2725
                     /gene="Lrrc7"
                     /gene_synonym="B230334C09Rik; densin; mKIAA1365"
                     /inference="alignment:Splign:2.1.0"
     exon            2726..2837
                     /gene="Lrrc7"
                     /gene_synonym="B230334C09Rik; densin; mKIAA1365"
                     /inference="alignment:Splign:2.1.0"
     exon            2838..3018
                     /gene="Lrrc7"
                     /gene_synonym="B230334C09Rik; densin; mKIAA1365"
                     /inference="alignment:Splign:2.1.0"
     exon            3019..4699
                     /gene="Lrrc7"
                     /gene_synonym="B230334C09Rik; densin; mKIAA1365"
                     /inference="alignment:Splign:2.1.0"
     exon            4700..4840
                     /gene="Lrrc7"
                     /gene_synonym="B230334C09Rik; densin; mKIAA1365"
                     /inference="alignment:Splign:2.1.0"
     exon            4841..4960
                     /gene="Lrrc7"
                     /gene_synonym="B230334C09Rik; densin; mKIAA1365"
                     /inference="alignment:Splign:2.1.0"
     exon            4961..5182
                     /gene="Lrrc7"
                     /gene_synonym="B230334C09Rik; densin; mKIAA1365"
                     /inference="alignment:Splign:2.1.0"
     exon            5183..5275
                     /gene="Lrrc7"
                     /gene_synonym="B230334C09Rik; densin; mKIAA1365"
                     /inference="alignment:Splign:2.1.0"
     exon            5276..5350
                     /gene="Lrrc7"
                     /gene_synonym="B230334C09Rik; densin; mKIAA1365"
                     /inference="alignment:Splign:2.1.0"
     exon            5351..7006
                     /gene="Lrrc7"
                     /gene_synonym="B230334C09Rik; densin; mKIAA1365"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6981..6986
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lrrc7"
                     /gene_synonym="B230334C09Rik; densin; mKIAA1365"
                     /note="hexamer: ATTAAA"
     polyA_site      7006
                     /gene="Lrrc7"
                     /gene_synonym="B230334C09Rik; densin; mKIAA1365"
                     /note="major polyA site"
ORIGIN      
        1 gtctgccaat cctggcacct gtgcgccaag ccgcggcacc acggaggacc ccgttccggg
       61 ccaaccctgg gctccaagcc acggccaccc agcctctggg caagcgcgac ctgcagccgc
      121 ccacccagga cccccgccgc cacccgcaac tgcgggagcg caagagccca gccagtgctt
      181 gctgcgcccc gggccacggg gtccctcgcc tcttcagagg cgtcgcggcc agccggggca
      241 gcagccgagt tgggtacacg attcgcccgc gctgcctttc tcttctccac ccaggattta
      301 ttgtctgtgg agccttctgg gggcggggag ggagctgcgc ctccgccgcc gccgccgcca
      361 ctgctgctgc tacggtcgct agcgcggcgc tctgggcggg cggaggccgg ggactggccg
      421 cagtggtgct ccgggcgggc tcccggctcc ccaggggcgc ctctcctctc ctgcacctga
      481 agggcagtgg caccatggtc tgacaccgca tctgcctgga gtcccctctg cctttgcttc
      541 ggaggactcc cctactggct tcactgcgga ccccagagca ctttaaggag taaccctcag
      601 cagctgcaag gccttcactc cttggaccct catgggtagt ttctgcttcc ggcgatgatg
      661 gagagcctaa tacggggaag gaatccccca caatatcaga gaagtccttg taaggaggct
      721 cgtgcagcac ttcggaagag gcctgaagag gagtgagccc gctacatgaa aagaatgcaa
      781 gtcaaagtgc ccacagccta gaagtcttca gagacaggag tgactagcaa tgcagtgctt
      841 ggagatgacc accaaacgga agctcattgg ccgcctggtg ccatgccgct gcttccgtgg
      901 agaggaagag atcatctcag tgttggatta ctcccactgc agcctgcaac aggtgcccaa
      961 ggaggtcttc aacttcgaac gcacactaga agagctctat ctggatgcca atcagattga
     1021 ggagctacct aagcaattgt tcaactgtca agctctacgg aaactaagca ttcctgataa
     1081 tgacctctca agtctgccaa cctccattgc tagcctagtt aacctgaaag aactcgacat
     1141 cagtaaaaac ggtgtacaag aatttccaga aaacataaag tgctgtaagt gtttaaccat
     1201 aattgaagcc agtgtcaatc ccatttctaa actacccgat ggcttcacgc agcttcttaa
     1261 cctgacccag ctctacctga atgacgcatt cctcgaattt cttccagcta attttggaag
     1321 acttgtcaaa ttgcgaatac tggagttaag agaaaatcac ttgaaaactc taccaaagtc
     1381 aatgcacaag ttagcccagc tggaaagact tgacctaggc aataatgaat tcagcgagct
     1441 gcctgaagtt ctggatcaaa tacagaattt gagggagctg tggatggata acaatgcatt
     1501 gcaagtgctg cctgggtcta tagggaagtt aaagatgttg gtatacctgg atatgtcaaa
     1561 aaacaggata gaaacggttg atatggatat ttctggatgt gaagccctcg aggacctctt
     1621 actatcatcc aatatgttgc aacagctgcc tgactcaata ggattgctga aaaagttaac
     1681 aactctaaaa gtagatgaca atcaacttac aatgctaccc aacacaattg gaaacttatc
     1741 tttattagaa gaatttgact gcagctgcaa cgagctggag tccctccctc ccaccattgg
     1801 ttacctgcac agccttcgaa cattagcggt tgacgagaat ttcctcccag agttgccaag
     1861 agaaattgga agctgtaaga atgtcaccgt tatgtctcta cgctccaata agctagaatt
     1921 tcttcctgaa gaaattgggc agatgcagag actgcgtgtc ttaaatctaa gtgataatag
     1981 gttgaagaat ttgccattct ctttcaccaa actcaaagag cttgcagcat tgtggctttc
     2041 tgacaatcag tccaaggccc ttatccctct gcaaacagaa gcccacccag aaaccaagca
     2101 aagggtacta accaactaca tgtttcccca gcagccccgt ggtgacgaag atttccagtc
     2161 agacagcgac agcttcaacc ccaccctgtg ggaggagcag agacaacagc gcatgactgt
     2221 tgcctttgaa tttgaggata aaaaagaaga tgacgaaagt gctgggaaag ttaaggctct
     2281 ctcctgccaa gccccctggg acaggggcca gcgtgggatt actctccaac ctgccaggct
     2341 gtctggcgat tgctgcacac catgggccag gtgtgatcag cagatccaag atatgcccgt
     2401 cccccagagt gacccccagc tggcatgggg ttgtataagt ggcctccagc aggagaggag
     2461 catgtgtgct ccattgccag tggcagcaca gtccaccact cttccctctc taagtggcag
     2521 acaggttgaa ataaacctaa aacgatatcc aactccttac ccggaggatt taaagaatat
     2581 ggtaaaatct gttcaaaatc tggtgggtaa gccaagccat ggagtgcgtg ttgagaactc
     2641 aaatccaaca gctaacacgg agcaaactgt gaaagaaaag tttgaacaca agtggccggt
     2701 ggccccaaag gagattacag tggaggattc ttttgttcat ccagctaatg aaatgaggat
     2761 tggggaactt cacccttcat tagctgagac ccctctgtac ccacccaaac ttgttctgct
     2821 agggaaggac aaaaaagaat caactgatga gtctgaagtt gacaaaactc actgtctgaa
     2881 taacagtgtc tcctcaggca cctactcaga ctactcgccc tcccaagctt cctcggcatc
     2941 ctctaacacc cggatgaaag tggggtcctt gcaggcaaca gctaaagatg ccgtccataa
     3001 ctctttgtgg ggtaacagga ttgcaccacc tttcccacag cctctagatg caaagccatt
     3061 actcagccaa cgggaggctg tccctccagg gaacatcccc cagcgtcctg ataggctgcc
     3121 aatgagtgat gctttccctg acaactggac tgatggctcc cattacgaca acactggttt
     3181 tgtctccgag gaagccgcag gcgaaaatgc caacaataac cctctcttaa gttccaaggc
     3241 tagaagcgta cctgctcatg ggcgcaggcc tttaattagg caagaaagga ttgtcggtgt
     3301 tcccctggaa ctggagcagt ccacacacag acacacacca gaaacagaag tgcctccttc
     3361 caatccctgg cagaattgga ccagaactcc cagtccattt gaagatagga ctgcttttcc
     3421 ttccaaatta gaaacaaccc ctactaccag tcccttgcct gaaagaaaag accacatgaa
     3481 ggagcctaca gagacaccag gtcccttttc tccgggagtg ccatgggaat accacgaccc
     3541 cacccctaac aggagtctcg gtaatgtctt ttctcaaatc cactgccgcc cagattcgtc
     3601 taaaggtgtt atcgcaatta gcaaaagcac agagaggctt tccccgctca tgaaagatat
     3661 aaagtccaac aagttcaaaa agtcccagag tattgatgag attgacgtcg gtacctacaa
     3721 ggtctataac attccactag aaaactatgc ctctgggagc gatcacttag gaagccatga
     3781 gcggccagac aagttcttgg gaccagagca tggcatgtcc agtatgtcca ggagccagtc
     3841 agtacccatg ttggatgacg agatgctcat gtatggaagt agtaaaggcc caccccaaca
     3901 aaaagcgtct atgactaaga aggtctatca gtttgaccaa agcttcaacc cacaaggagc
     3961 ggtggaagta aaagccgaga agaggattcc accccctttt gcacacaatt ctgagtatgt
     4021 acagcagccc agtaaaaaca tcgccaagga tctggtcagc cccagagcct acagaggata
     4081 cccacccatg gaacagatgt tctccttttc ccagccatct gtaaatgagg atgccatggt
     4141 gaatgctcag ttcgccagcc aggggcccag ggcaggcttc ctaaggaggg ctgactccct
     4201 ggccagctcc accgagatgg ccatgttcag aagggtcagt gagccccacg agctgccccc
     4261 tggtgacagg tatggccgag caacctatag gggtgggctg gaaggccaga gcagcatttc
     4321 aatgactgat ccccaattcc tcaagaggaa tggcaggtac gaagatgagc acccttcata
     4381 tcaagaagtg aaagcgcagg cgggaagttt tcctgctaaa aaccttaccc agaggaggcc
     4441 gctgtctgcc aggagctaca gcacagagag ttatggggcc tcccaaacca ggccagtttc
     4501 agctaggcct accatggcag ccctcctgga aaaaatacca tctgactata acttgggtaa
     4561 ctatggtgac aagacatcag ataacagtga tataaagaca aggcccaccc ctgtgaaggg
     4621 agaggagagc tgtggcaaaa tgccggcaga ctggagacag cagctgctta gacatataga
     4681 agctagaagg ttagacagga atgctgctta caaacacaac acagttaacc ttggcatgct
     4741 gccctatgga ggtatttcag caatgcatgc aggcagaagc atgactttaa acttgcagac
     4801 taagtctaaa tttgaccttc aagacctacc tcttcagaaa accccgtccc agcaaagcaa
     4861 cattttagac aatggacaag aagatgtctc tcctagtggc caatggaatc cttacccact
     4921 tgggaggcgg gatgtacctc cggacaccat tactaaaaag gcaggcagcc acattcagac
     4981 cctgatgggg tcacagagcc ttcagcaccg cagccgggag cagcagccat atgaagggaa
     5041 catcaacaaa gtgaccattc agcagttcca atcgccattg cccatccaga tcccctcatc
     5101 acaggctacc cggggacctc agcctggacg gtgcttaatt caaacgaaag ggcagaggag
     5161 tatggacggt tatcccgagc agttctgtgt gaggatagaa aagaatcctg ggcttggatt
     5221 tagtatcagc ggtggaatta gtgggcaagg aaatcctttc aaaccttctg acaagggtat
     5281 ctttgttact agggttcagc ctgatggacc agcatccaac ctactacagc ccggggataa
     5341 aatccttcag gcaaatggac acagttttgt gcatatggaa catgaaaagg ctgttttact
     5401 actgaagagc ttccagaaca cagtagacct agttattcaa cgtgagctca ctgtctaaat
     5461 gttttttata aatagtgaag atatgtcagg ccagaactaa tgtttaaaaa taaatttata
     5521 catagaaaca aattttgcca gttgctggac caatggcaaa catcagtgcc aggtgtataa
     5581 tagtgtatgt tagccttcca ccctgaaaaa tgttacttat aaacatggcg tttgcgcgca
     5641 gttctgtatc agttccagcg gcagcctctg gctgtgcatt ggtgcagttt tatttctgtt
     5701 tttgtttttt aatcaaataa gttgtcctct caaagtggat ttcctataat ttcggagcac
     5761 ggaagcacac acaagctctt tacaaattct gctctccatc agaaatactg cctcaaaaaa
     5821 tgtatataaa gagttgtaat ccccataaag tatttctagc acaaggtata tgttggcata
     5881 tatacaaaaa agaatataga aaaacgatat tttcgtaaac atcttggatt gagaaagaaa
     5941 atatatctta aaataagact ttactatatt gaatcttttt caataaaaat tacatgatta
     6001 cgccttatgg aagcaactgt acataaagta taaagtattt atatttggtt ccatagccat
     6061 ttgctaaatt cccatagtag agtgaaatga ttcataaatt atccattaat ctctgggacc
     6121 tgagtaaaaa aaccggagaa ggtaaatctg ttcaatgcct ttagctaatt aagaggacac
     6181 aagctgactt cagagacaga ccacaggtgg ctgcgggtca gtctcttcag caaaaccacg
     6241 tgcagtgagc gatgggtggc gggaaaggct taatgcttta atgttctgtt tcctcgggtt
     6301 atgttgacta taaactgtgg cccctgtgat tcctttactg taaatgtgga acttatctgt
     6361 gtgctgattt aattaatttg ctacttttaa atcattttaa atgaattttg ggaattgata
     6421 acatttatta tagagaaaga cttgttggaa cgctatggtg gtttcaaaac tttggtattg
     6481 aaatatgaaa cttcagatat aatttctcag agctgtggtc tactgatatc attaatctta
     6541 attcctgggg gttttttttg tggacagaaa tagacaaaat gttttttctc caaataaaaa
     6601 gttttaagga acataaacat gaattcattc atactagaca gtgaaaacag cctagttaat
     6661 gcacttttac aatctgtttt cctttgtaag aattcaaaat ttattttaca atcctttaaa
     6721 atatttcttt ttatattagt catcaatttg attaaaatat taatttgaaa ttttagatca
     6781 actttccata attggttgta taaactccct catatatcta catcactttt tatacaataa
     6841 atttatctca tatagtagtg tttaaatatt ctatagaatt ttacaataaa atcacatgtg
     6901 gatgtcacca gagctctgag gataatattt gtaagtttgt tttatgagga cattgaaaat
     6961 attgtatttt tgtaggatct attaaaatga gtgccactta ttagaa
//
