LOCUS       NM_153568               3100 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus leucine rich repeat containing 66 (Lrrc66), mRNA.
ACCESSION   NM_153568
VERSION     NM_153568.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3100)
  AUTHORS   Skarnes,W.C., Rosen,B., West,A.P., Koutsourakis,M., Bushell,W.,
            Iyer,V., Mujica,A.O., Thomas,M., Harrow,J., Cox,T., Jackson,D.,
            Severin,J., Biggs,P., Fu,J., Nefedov,M., de Jong,P.J., Stewart,A.F.
            and Bradley,A.
  TITLE     A conditional knockout resource for the genome-wide study of mouse
            gene function
  JOURNAL   Nature 474 (7351), 337-342 (2011)
   PUBMED   21677750
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC140429.2.
            
            On Sep 30, 2022 this sequence version replaced NM_153568.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC031901.1, AK051875.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-38                AC140429.2         105482-105519       c
            39-518              AC140429.2         102622-103101       c
            519-688             AC140429.2         88570-88739         c
            689-878             AC140429.2         83853-84042         c
            879-3100            AC140429.2         79733-81954         c
FEATURES             Location/Qualifiers
     source          1..3100
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 38.89 cM"
     gene            1..3100
                     /gene="Lrrc66"
                     /note="leucine rich repeat containing 66"
                     /db_xref="GeneID:231296"
                     /db_xref="MGI:MGI:2387634"
     exon            1..38
                     /gene="Lrrc66"
                     /inference="alignment:Splign:2.1.0"
     exon            39..518
                     /gene="Lrrc66"
                     /inference="alignment:Splign:2.1.0"
     CDS             44..2662
                     /gene="Lrrc66"
                     /note="leucine-rich repeat-containing protein 66"
                     /codon_start=1
                     /product="leucine-rich repeat-containing protein 66
                     precursor"
                     /protein_id="NP_705796.1"
                     /db_xref="CCDS:CCDS19343.1"
                     /db_xref="GeneID:231296"
                     /db_xref="MGI:MGI:2387634"
                     /translation="MRDFYVRVTILVTGLCFVETVTTPSRKSSVSFNPEYQRNGDLLV
                     NWSSIRHVSQNTDAMDRSFYFFRVLFQPHTQKERHIKPPDRTHHRISKVTLDPLAHLH
                     ALEILNLSNKAIHYFSLDQPLPPSSHQKRHGGHSHSRLPRLQVLILQRNQLSGTPKGL
                     WKLKSLRSLDLSFNRIVHIGLSDFHGCLQLESIYLKSNKICTIHPKAFKGLKKLQVVD
                     LRSNALTTLVPIVTIALELPHLELGLADNQWQCSESNVNFQNITSSSWREIWKAICNM
                     SVENKRPNAETHQIRKSRDTHLLLSPPSDLKSLIQSKAERPQAGMDMHLSALGKEAKD
                     GYGDLRGMWPQSPVELRDSQDEQVTDRKDDKPPALELAICLSVFITFVVAFCLGAFAR
                     PYIDRLRQQRCSNKRPGSDNAYSNKGFHGDIEGAQHMEYQGTDLHQTTHHLHLSENQN
                     PSWVAEPIPHSAVQSEQMLGSNGTDPGHQQSPEQLKDSNESRSGDSIVLPSGPVAHLA
                     LHGLPNADAHKAISPVQHHHDFLEEAHYDTVAQEYSLIDDVMDRSSITGPLGTFPSSV
                     ESRRDDLHPSQPRDVVASFSKTLAHANTREAEGSMETGCPEPLGAMDSQMGSSEERQV
                     SNSIRELATQQPSFQGVDAEERLSHVYSEVLHNDPPSLRPRWGSGHYVIPATGEPVER
                     DAPFDPHYDLVTNYESDSDEGSLFTLSSEGSEDTRSLAEEQASVENDGTSQPLPSRNL
                     GEYKDSVTSAESVEDLTSQRIPEKCEAQEAHLRNTLISGPDSCVCETNQENDSSSLDP
                     ENRSTWPQLPGHKLSHHETLGTYGDIEPQSEAVDWHYSLRDLESPNVDSSPSPPYSDE
                     DLSGPEDRARKRSKHW"
     exon            519..688
                     /gene="Lrrc66"
                     /inference="alignment:Splign:2.1.0"
     exon            689..878
                     /gene="Lrrc66"
                     /inference="alignment:Splign:2.1.0"
     exon            879..3100
                     /gene="Lrrc66"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3078..3083
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lrrc66"
                     /note="hexamer: AGTAAA"
     polyA_site      3100
                     /gene="Lrrc66"
                     /note="major polyA site"
ORIGIN      
        1 ggagacagac cagttagaaa ctacctaagg accctcaggc attatgagag acttctacgt
       61 cagagttact atcctagtta caggtctttg ctttgtggaa acagtgacaa ccccatcaag
      121 aaaaagcagc gtttccttca atcccgagta ccagaggaat ggggaccttc tggtaaactg
      181 gtcttctata agacacgtgt cacagaacac agacgccatg gatagaagtt tctacttctt
      241 tagagttctc ttccagcctc acacacaaaa agaacggcac ataaaacctc cggaccgcac
      301 tcaccatcgc atatcgaaag tgaccctcga ccctctggcg catttacatg ctttggagat
      361 actaaacctc agcaacaaag ctatccacta cttctcgctg gatcagcccc tgcctccttc
      421 ctcacaccaa aagcgccacg gaggccactc ccacagccgg ctccccaggc tccaggtgct
      481 gatccttcaa aggaatcaac tcagtggtac tcctaaagga ctgtggaagc tgaagtcatt
      541 gcggagtctg gatctgtcat tcaacaggat agttcacatt gggctgtctg attttcatgg
      601 ctgcctgcag ctggaaagca tctatttaaa gagcaacaag atctgcacga ttcaccccaa
      661 agccttcaaa gggctcaaaa aattacaggt ggtagacctc agaagcaatg cactgaccac
      721 tctggtaccg attgtgacca ttgctctaga attgccccac ctggaacttg gcttggctga
      781 taaccagtgg cagtgtagtg aaagcaatgt caacttccaa aacattacct cttcatcctg
      841 gagggaaata tggaaagcca tctgcaacat gtctgtggag aacaagaggc caaatgcaga
      901 gactcaccag atcagaaaat ccagggatac acaccttctt ctgtctcctc caagtgactt
      961 gaaaagcctc atccagagca aggcagagag gccccaggca gggatggaca tgcacctttc
     1021 tgctctgggg aaggaggcga aggatggcta tggtgatctc agagggatgt ggccacagtc
     1081 cccagtagaa ctcagagatt ctcaggatga acaggtcact gacagaaagg atgacaagcc
     1141 cccagccctt gagctggcca tctgcctgtc ggtgttcatc acgtttgtgg tggctttctg
     1201 cctgggggct tttgcaaggc cctacattga caggctacgg caacagagat gctcgaataa
     1261 aaggcccggc tcagataatg cctactcaaa caagggcttc catggcgaca ttgaaggtgc
     1321 tcaacacatg gagtaccaag ggacagatct acaccaaact acccaccacc tacatctttc
     1381 tgagaaccag aacccttcgt gggtggcaga gccaatccca cacagtgctg tccaatcaga
     1441 acagatgctg ggaagcaacg gaacagaccc cggtcatcag cagagcccag agcaactcaa
     1501 ggacagcaat gaatcaagaa gtggagatag catcgtgctt ccaagtggcc ctgtagccca
     1561 tcttgcgctc catggccttc caaacgctga tgcacacaag gcgatttcac cagtgcagca
     1621 tcaccatgat tttcttgaag aagcacatta tgacacagtg gcccaggaat attctctcat
     1681 tgacgatgtg atggacaggt cttccatcac tggccctctg ggaactttcc ccagctctgt
     1741 cgagagtagg cgggatgacc tgcacccatc acagccaaga gatgttgtgg cttctttctc
     1801 caaaactcta gcacatgcaa acactagaga ggctgagggg agtatggaaa cggggtgccc
     1861 tgaacctttg ggagccatgg actcacagat gggatcttct gaggaaaggc aagtgagcaa
     1921 ttccattagg gaactggcca cacagcagcc aagcttccag ggggttgatg ctgaggagag
     1981 actttcccat gtctacagcg aggtcctaca caatgaccca ccctctctta ggccaagatg
     2041 gggcagtggc cattatgtca tccctgctac tggggagcct gtggagagag atgctccttt
     2101 tgaccctcat tatgacttgg tgaccaacta cgagtctgat tccgacgagg gttctttgtt
     2161 tacccttagt tctgagggtt ctgaagacac aaggagcttg gctgaggaac aggcatctgt
     2221 ggagaatgat gggaccagcc agcccctccc aagcaggaac ttgggggaat acaaggacag
     2281 tgtgacatca gcagaaagtg ttgaggacct cacatcgcaa aggattccag agaaatgtga
     2341 agcgcaggaa gctcacctta gaaacactct tatttctggt ccagactctt gtgtgtgtga
     2401 gacaaatcag gaaaatgact ctagctccct tgaccctgag aatagatcaa cgtggcccca
     2461 actcccagga cataagttat cacatcatga gactctgggc acatatggtg acatagaacc
     2521 ccagtctgag gcagtagact ggcactactc ccttagagac ctggaatccc caaatgtaga
     2581 tagttcacca tcaccaccat attctgatga agatctctca ggtcctgagg atcgtgcccg
     2641 caagagaagt aagcattggt aaatggcaac cttccaaggc tggggacaga gctctgttgg
     2701 tagagcattt gctcaccatg cacaaacccc tgggttcaaa cctcagcact gtataaattg
     2761 ggcacactgg cacattctgt cagcccagcc cttgggaggc aaaggcagga aacaggcatg
     2821 agactgaaac agcttttgtg gggtagatga tggaatgctc tgacaaatgt gggctctatt
     2881 gctccaagca tcagctcgtg agagatgtca gttctaccat gacaagaccc agtctcccac
     2941 ccagattcca ggatcacacc ctcaaccaca gttgctcgaa tctgcaccat cctgggacct
     3001 aaaagtcata atttctcttc acaaatatga gctccaaaat tcactttttt tagtcaacac
     3061 tgtcacagtg tcaacccagt aaacccgttt atagattgta
//
