LOCUS       NM_001172064            2554 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus leucine rich repeat containing 56 (Lrrc56), transcript
            variant 1, mRNA.
ACCESSION   NM_001172064
VERSION     NM_001172064.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2554)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ092649.1, AK220237.1 and AK017603.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK220237.1, SRR7345562.2104031.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-46                CJ092649.1         1-46
            47-2548             AK220237.1         1-2502
            2549-2554           AK017603.1         2386-2391
FEATURES             Location/Qualifiers
     source          1..2554
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 86.48 cM"
     gene            1..2554
                     /gene="Lrrc56"
                     /gene_synonym="5730427C23Rik; mFLJ00101"
                     /note="leucine rich repeat containing 56"
                     /db_xref="GeneID:70552"
                     /db_xref="MGI:MGI:1917802"
     exon            1..488
                     /gene="Lrrc56"
                     /gene_synonym="5730427C23Rik; mFLJ00101"
                     /inference="alignment:Splign:2.1.0"
     exon            489..559
                     /gene="Lrrc56"
                     /gene_synonym="5730427C23Rik; mFLJ00101"
                     /inference="alignment:Splign:2.1.0"
     exon            560..747
                     /gene="Lrrc56"
                     /gene_synonym="5730427C23Rik; mFLJ00101"
                     /inference="alignment:Splign:2.1.0"
     CDS             571..2229
                     /gene="Lrrc56"
                     /gene_synonym="5730427C23Rik; mFLJ00101"
                     /note="isoform a is encoded by transcript variant 1;
                     leucine-rich repeat-containing protein 56"
                     /codon_start=1
                     /product="leucine-rich repeat-containing protein 56
                     isoform a"
                     /protein_id="NP_001165535.1"
                     /db_xref="CCDS:CCDS22004.1"
                     /db_xref="GeneID:70552"
                     /db_xref="MGI:MGI:1917802"
                     /translation="MDPAWDGSQGSRPGTASIRVRELSWQGLNNPHPQNKRLGSHGDI
                     HRERWVEERLSPARLQALAQVDDLQLVRVLEMCVDTRKNSLGNFGLYLPNLIQLKLNH
                     SYLGSLRDLGTSLGHLQVLWLARCGLTDLDGIGSFLELKELYVSYNNISDLSPLCLLE
                     QLEVLDLEGNNVEDLGQMRYLQLCPRLAMLTLEGNLVCLKPDPGPSNKAPQGYNYRAE
                     VKKLIPQLHVLDEVPTTCTSAPAPQTLSQDWLMVKEAIKEGSVLDILLPRLDDPHGAT
                     IRKFDPTLPVPETQPWALSLLVPGGPLPEGLLSENPATEDHASNLTHGPGQVLCGNPT
                     KGLRKRRNQYQEWAPLEQMPPHRPDLAIRPSTPRPDPAESCDLAMTGLRAWTEPGLRP
                     LLQRQLEFQQERSAQVQAQDPQKDPVEQEDQTGPKTSLTPPRLVSELSRTSGFHLIPS
                     PPKYPMPPESGISSLGRSADLPFRGRRLRVLGSLGPSLGEGSVLGERLAAVTALRALE
                     ASSGPSHRAQGCPDPKPALGPAACPPGLHCLHHLNPIPPAHSLP"
     exon            748..835
                     /gene="Lrrc56"
                     /gene_synonym="5730427C23Rik; mFLJ00101"
                     /inference="alignment:Splign:2.1.0"
     exon            836..896
                     /gene="Lrrc56"
                     /gene_synonym="5730427C23Rik; mFLJ00101"
                     /inference="alignment:Splign:2.1.0"
     exon            897..993
                     /gene="Lrrc56"
                     /gene_synonym="5730427C23Rik; mFLJ00101"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1194
                     /gene="Lrrc56"
                     /gene_synonym="5730427C23Rik; mFLJ00101"
                     /inference="alignment:Splign:2.1.0"
     exon            1195..1378
                     /gene="Lrrc56"
                     /gene_synonym="5730427C23Rik; mFLJ00101"
                     /inference="alignment:Splign:2.1.0"
     exon            1379..1540
                     /gene="Lrrc56"
                     /gene_synonym="5730427C23Rik; mFLJ00101"
                     /inference="alignment:Splign:2.1.0"
     exon            1541..1605
                     /gene="Lrrc56"
                     /gene_synonym="5730427C23Rik; mFLJ00101"
                     /inference="alignment:Splign:2.1.0"
     exon            1606..1742
                     /gene="Lrrc56"
                     /gene_synonym="5730427C23Rik; mFLJ00101"
                     /inference="alignment:Splign:2.1.0"
     exon            1743..1882
                     /gene="Lrrc56"
                     /gene_synonym="5730427C23Rik; mFLJ00101"
                     /inference="alignment:Splign:2.1.0"
     exon            1883..2554
                     /gene="Lrrc56"
                     /gene_synonym="5730427C23Rik; mFLJ00101"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2530..2535
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lrrc56"
                     /gene_synonym="5730427C23Rik; mFLJ00101"
                     /note="hexamer: AATAAA"
     polyA_site      2554
                     /gene="Lrrc56"
                     /gene_synonym="5730427C23Rik; mFLJ00101"
                     /note="major polyA site"
ORIGIN      
        1 ggggcttcct ggagccgcgg ggaaggcagt gccggaactt gggtcctgca ctcaacagtg
       61 atgtctagtg cctaggtgca gaagagacag accgagaccg tgcttacgag cccgggattt
      121 ctccggagag aaactggtgc acgctcgggt tgcgttgagg acctactaca gagcctccac
      181 cctgcagcct caccaaaggc ccaaaggccc acgagtggaa aggtcatccc gaccgggtat
      241 tggtgtcggg gacagtcagc accgcggacg cggaataaca gaggaagaca gagttcgccg
      301 gaacccctag ctgcctgttc tcgtaggtcg aggtggagca aaggctccat cctggggcag
      361 cgtcggccca tcacaccgcg ctcttcgtgt tttggagaag acccccctac cgctctcaaa
      421 ctcgaggtcc caacactgca gaagctcata ctgcgtccat ttgaagaacg accccgaaag
      481 tcagaaaagt gttacatgta gacacatgtg gcccccttgc ccggatgttt gacctacagc
      541 aggagccggc taccttcagg ttggacttgg atggacccag cctgggatgg atcccagggg
      601 tctcgaccag gcacagctag tatccgggta cgggagctga gctggcaggg cctaaacaac
      661 ccccacccac aaaacaagag actgggcagc catggggata tccataggga gcggtgggtg
      721 gaggagcgcc tatcccctgc tcgactgcag gccctggccc aggtagatga cctccaactg
      781 gtgagggtgc tggagatgtg tgtggacacc cgtaagaaca gcctggggaa cttcggattg
      841 tacctcccta acctgatcca actgaagctg aaccacagct acctgggctc cctcagagac
      901 ctgggcactt cgctgggcca cctgcaggtg ctgtggctgg ctcgctgtgg cctgactgac
      961 ttggatggca ttggctcctt cttggaactg aaggaacttt atgtctccta caacaacatc
     1021 tcggacctga gcccactgtg cctgctcgag cagctagagg tgctggacct ggagggcaac
     1081 aatgtggagg acctggggca gatgcggtac ctgcagctgt gcccacgctt ggccatgctc
     1141 acactggagg ggaatctggt gtgcctgaag ccagatcctg gcccttccaa caaggcgccc
     1201 cagggctaca actacagagc agaggtaaag aagctcatcc cccagctgca cgtccttgac
     1261 gaggtgccca ctacatgcac cagtgcgcct gcgccccaga cgctgagcca ggactggctg
     1321 atggtgaagg aagccatcaa ggaaggcagc gtgcttgaca ttctcctccc tcggctggat
     1381 gatccccatg gagccaccat tcggaaattt gacccaacct tgcctgtgcc tgagacccag
     1441 ccatgggcct tgtccctgct ggtccctggg ggccccttgc ctgaaggtct gctttctgag
     1501 aacccagcca cagaagacca tgccagcaac ctcacccatg gtcctggtca agttctctgt
     1561 gggaacccca ccaaaggcct tcggaaacgt agaaaccagt accaggaatg ggcacccctg
     1621 gaacagatgc ccccacatag gccagatctg gccatcagac cctccacccc aaggcctgac
     1681 cctgcagaaa gctgtgacct ggccatgact gggcttcggg cttggacgga gcctggcctg
     1741 cgtcctcttc tccaaagaca gctggagttc cagcaggaaa gatctgctca ggtccaagcc
     1801 caggacccac agaaggatcc tgtagaacag gaagaccaga ctggacccaa gacttcccta
     1861 accccgccac gcctggtctc agaactttcc aggacatcag gctttcattt gatcccttct
     1921 cccccaaagt acccaatgcc acctgagtca ggcatcagct ccttggggag atctgcagac
     1981 ctgcccttca gaggacgtag gcttagagtt ctgggcagct tggggcctag cctgggtgag
     2041 gggtctgtcc tgggtgagag gttggctgca gtgactgcct tgagagccct ggaggcgtcc
     2101 tcaggcccca gccatcgagc ccagggatgt ccagacccaa agccagcact aggtccagca
     2161 gcttgccctc cagggctcca ctgccttcat cacctgaacc ctatccctcc agcccattct
     2221 ctcccttagt gtaaccttcc cttgctgata tctcttggcc taggtggggc cacagtgaag
     2281 taggtggagc tggggctgga ccctttagat atcccaggac tctgggtcat ctatatggcc
     2341 caaattctga gcctgcttat cctagggttc aaaattgcgc aagcatcctg ggaagatttg
     2401 caggtttcct tatgtggggg cagttccttt ctgttgggac accatatacc ctctgtaaaa
     2461 gccaagcgaa tcattttcaa ctctcaggta tgcagaaatg tgctttactt tgcaagcaat
     2521 ggttggttca ataaattatg aagttgtcac tgcc
//
