LOCUS       NM_001033346            5931 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Mus musculus leucine rich repeat containing 55 (Lrrc55), mRNA.
ACCESSION   NM_001033346 XM_006499467 XM_141031 XM_914076
VERSION     NM_001033346.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5931)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5931)
  AUTHORS   Hu,S., Han,R., Chen,L., Qin,W., Xu,X., Shi,J., Zhu,X., Zhang,M.,
            Zeng,C., Tang,Z., Bao,H. and Liu,Z.
  TITLE     Upregulated LRRC55 promotes BK channel activation and aggravates
            cell injury in podocytes
  JOURNAL   J Exp Med 218 (3) (2021)
   PUBMED   33346797
  REMARK    GeneRIF: Upregulated LRRC55 promotes BK channel activation and
            aggravates cell injury in podocytes.
REFERENCE   3  (bases 1 to 5931)
  AUTHORS   Makkar,G., Shrivastava,V., Hlavay,B., Pretorius,M., Kyle,B.D.,
            Braun,A.P., Lynn,F.C. and Huang,C.
  TITLE     Lrrc55 is a novel prosurvival factor in pancreatic islets
  JOURNAL   Am J Physiol Endocrinol Metab 317 (5), E794-E804 (2019)
   PUBMED   31526288
  REMARK    GeneRIF: Lrrc55 is a novel prosurvival factor that is upregulated
            specifically in islets during pregnancy, and it prevents conversion
            of adaptive unfolded protein response to unresolved ER stress and
            apoptosis in beta-cells
REFERENCE   4  (bases 1 to 5931)
  AUTHORS   Zhou,Y., Li,M., Xue,Y., Li,Z., Wen,W., Liu,X., Ma,Y., Zhang,L.,
            Shen,Z. and Cao,X.
  TITLE     Interferon-inducible cytoplasmic lncLrrc55-AS promotes antiviral
            innate responses by strengthening IRF3 phosphorylation
  JOURNAL   Cell Res 29 (8), 641-654 (2019)
   PUBMED   31213650
  REMARK    GeneRIF: Interferon-inducible cytoplasmic lncLrrc55-AS promotes
            antiviral innate responses by strengthening IRF3 phosphorylation.
REFERENCE   5  (bases 1 to 5931)
  AUTHORS   Zhang,Y.Y., Han,X., Liu,Y., Chen,J., Hua,L., Ma,Q., Huang,Y.Y.,
            Tang,Q.Y. and Zhang,Z.
  TITLE     +mRNA expression of LRRC55 protein (leucine-rich repeat-containing
            protein 55) in the adult mouse brain
  JOURNAL   PLoS One 13 (1), e0191749 (2018)
   PUBMED   29370300
  REMARK    GeneRIF: LRRC55 mRNA is richly expressed in the adult mouse medial
            habenula nucleus (MHb), cerebellum and pons. However, the potential
            role of LRRC55 in MHb and cerebellum could be different based on
            the function of BK channels in these brain regions
            Erratum:[PLoS One. 2018 May 10;13(5):e0197531. doi:
            10.1371/journal.pone.0197531.. PMID: 29746565]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5931)
  AUTHORS   Quina,L.A., Wang,S., Ng,L. and Turner,E.E.
  TITLE     Brn3a and Nurr1 mediate a gene regulatory pathway for habenula
            development
  JOURNAL   J Neurosci 29 (45), 14309-14322 (2009)
   PUBMED   19906978
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL928793.13.
            
            On Jan 12, 2023 this sequence version replaced NM_001033346.4.
            
            Sequence Note:.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219380.33608.1,
                                           SRR17784651.448226.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on conservation,
                                                expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-323               AL928793.13        46445-46767         c
            324-1852            AL928793.13        43980-45508         c
            1853-5931           AL928793.13        36068-40146         c
FEATURES             Location/Qualifiers
     source          1..5931
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 49.53 cM"
     gene            1..5931
                     /gene="Lrrc55"
                     /gene_synonym="A330097E02Rik; Gm351"
                     /note="leucine rich repeat containing 55"
                     /db_xref="GeneID:241528"
                     /db_xref="MGI:MGI:2685197"
     exon            1..323
                     /gene="Lrrc55"
                     /gene_synonym="A330097E02Rik; Gm351"
                     /inference="alignment:Splign:2.1.0"
     exon            324..1852
                     /gene="Lrrc55"
                     /gene_synonym="A330097E02Rik; Gm351"
                     /inference="alignment:Splign:2.1.0"
     CDS             1192..2088
                     /gene="Lrrc55"
                     /gene_synonym="A330097E02Rik; Gm351"
                     /note="leucine-rich repeat-containing protein 55; BK
                     channel auxilliary gamma subunit LRRC55; BK channel
                     auxiliary gamma subunit LRRC55"
                     /codon_start=1
                     /product="leucine-rich repeat-containing protein 55
                     precursor"
                     /protein_id="NP_001028518.2"
                     /db_xref="CCDS:CCDS38167.2"
                     /db_xref="GeneID:241528"
                     /db_xref="MGI:MGI:2685197"
                     /translation="MGDTWAQLPWPGPPHSALLLVFFLLAAGVMHSDAGTSCPVLCTC
                     RNQVVDCSNQRLFSVPPDLPMDTRNLSLAHNRIAAVPPGYLTCYMELRVLDLRNNSLM
                     ELPPGLFLHAKRLAHLDLSYNNLSHVPADMFREAHGLVHIDLSHNPWLRRVHPQAFQG
                     LVHLRDLDLSYGGLAFLSLEALEGLPGLVTLQIGGNPWVCGCTMEPLLKWLRNRIQRC
                     TADSQLAECRGPPEVEGAPLFSLTEESFKACHLTLTLDDYLFIAFVGFVVSIASVATN
                     FLLGITANCCHRWSKANEEEEI"
     exon            1853..5931
                     /gene="Lrrc55"
                     /gene_synonym="A330097E02Rik; Gm351"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2303..2308
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lrrc55"
                     /gene_synonym="A330097E02Rik; Gm351"
                     /note="hexamer: AATAAA"
     polyA_site      2327
                     /gene="Lrrc55"
                     /gene_synonym="A330097E02Rik; Gm351"
                     /note="major polyA site"
     regulatory      5906..5911
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lrrc55"
                     /gene_synonym="A330097E02Rik; Gm351"
                     /note="hexamer: AATAAA"
     polyA_site      5931
                     /gene="Lrrc55"
                     /gene_synonym="A330097E02Rik; Gm351"
                     /note="major polyA site"
ORIGIN      
        1 ggctctggcg gaagccacac accaaggcag cctcggcacc agctgagttt cccaagaggc
       61 attcagattc tgtgaacttt ctaagcatcc tctctcaaat ttcctttcag cgtaaaagaa
      121 ggggcacagg gaccacagga caggaaaccg cagaagatgc tggcctggga tgcaggagac
      181 atggaagagg agagtcgggg gaggggaaga gccggatagg caatctgttc ggaagctagc
      241 aagcaaagga gcgggggatt ccaggatgag ggaggcagag ccgttcgtct gcgtaagatt
      301 gatgtctgtg tccttggaac agaagtgact tctgcctccg cctgctgagt gcacagctga
      361 gcatggtgac agcttgaaga catagataat gcttttgtaa ctgaccctta cctgtgcctc
      421 cagactcatg gtgttttcca catttcgtgg tccagacagt gggtgtcact tgggactcac
      481 ccctctctgg gaagcaaaga gcatcccttg agaatccaga gaccactgag actgaatgtt
      541 caggcttcta ggagacccat gggaacatac ttctccccca tcctaaatct ctggccccag
      601 gtctcttgtg aactcatgcc cactgggcca ccaggagaaa tggcctctgg gaccttgaat
      661 gttggagatc aaggtgccgt tctgacttcc taatcagtcc cagacctagg acagggctta
      721 agttttctta gatgaagtgc caggaccttt aaagggcacc tttcatcccc ctcacatcct
      781 cccctgcccc acccacctgt cagacacagc acaagaggaa gcatccagca ggcatgggtg
      841 acagaagcac aaaagatcta cagggaccct tccagggcct gctgacagct gttccagctc
      901 catccttgtt cccctagttt cttaagcttt gatcatcctt tcagaccctg gggtacctca
      961 actgggtcca tgctccccag ggtctacaaa gggacatcct atgaatctta ggaagtcctt
     1021 gggtgttgag aggctctcaa ggaagtgttg agccatgata gcactctcgc aaaagcccca
     1081 ccttccagac tcaggcctct aatgtagcag catccctgta acttgactgt tggacctagg
     1141 gacaccgctc tcatgggctc cctacagcac tgctgctgcc agctgccaaa gatgggtgac
     1201 acctgggccc aacttccctg gcctgggcct ccccactcag ccttgttgct ggtcttcttc
     1261 ctcttggcag ctggggtgat gcactctgat gcgggtacca gttgcccagt cctttgtaca
     1321 tgtcgtaacc aagtagtgga ctgcagcaac cagcggctgt tctctgtacc cccggacctg
     1381 ccaatggaca cccgcaacct cagcctagcc cacaatcgca ttgcagctgt accgccaggc
     1441 tatctcacat gctacatgga actccgcgtg ctggatttgc gaaacaactc cttgatggag
     1501 ctgccccctg gcctctttct ccacgccaag cgcttagcac acctggatct aagctacaac
     1561 aacctcagtc atgtgccagc tgacatgttc cgggaagctc atggactggt acatatcgac
     1621 ctgagccaca acccctggct gcggagggtg cacccccagg ccttccaggg ccttgtgcat
     1681 ctcagagacc tggacctcag ctatggcggc ctggcttttc tgagccttga agcccttgag
     1741 ggcctcccag ggctggtgac cctacagatc gggggtaacc catgggtatg tggctgcacc
     1801 atggagccct tgctgaagtg gctgcggaat cggatacagc gctgtacagc ggattctcag
     1861 cttgctgagt gtcggggacc ccctgaagtt gagggtgccc ccctcttttc actcactgaa
     1921 gagagcttca aggcctgcca cctgactctg accctggatg attacctctt catcgcattt
     1981 gtgggctttg tggtctccat cgcttctgta gccaccaact tcctcctggg catcacggcc
     2041 aactgttgtc accgttggag caaggctaat gaagaagaag agatttgaca caggtgcctc
     2101 tcatccctcc atgctgctgc cactgctgct gaccgctgga caccctgtat cacggtgccc
     2161 tggccatctc catcatagct caaacaaggt tggaaagcta actttgtatg agcatccatc
     2221 cactttgggc caggcactgt gctagcaact gagaatgaaa gacaaattca atccggttcc
     2281 tgcccttgag gtacttactt ctaataaagg aaaacaattc caaaacatcc tcttatgaca
     2341 aaatgccaat actctgagca tagagtgagg gaagccaagc ggagggtcca tcatctgtgc
     2401 ctcacaaagt ccaagaagaa ttgcaggaat tatctgctaa gtagataggg aagggtggac
     2461 atagcaaatg ataggacctt gtatgcaggt cgtgttaaga gcagcagacc ttgtggccta
     2521 agtacataga agaagtaggt gcaaaagtaa atctctccct ctgacaccca atttttcagt
     2581 tcccactgct gcctgccact gccctctagg agtgagatag cctccatgcc agacaccttg
     2641 accttctccc attagcagaa aggggagtga aaggacctcc cagcgacttc ccaattgtag
     2701 tctagttgtg aagtaatcac cctcagcacc cttcctcctc tccctgtctc tgcttctgac
     2761 ttaagccttg tcttcaaaga aaaggcagga agcctcacaa ggaggcagca aaagtcttgg
     2821 caccctggga ccccaattta tgtgactgtt ctttccatgg tgctcacacc aaaggaactc
     2881 accaggaaag tgcactgtag ggtgcagatc ctagcatggc agtaaccggg gcaggaggac
     2941 aaagccacca cattcatccc cacaggacgg tatgtcttct ctccttagta acttgttcat
     3001 tggagcataa agaaagaata gctattaatt gctggttctt gctagtgtcg ggcagtataa
     3061 gctccctcct ccgacattcc tttcacacat acaacagccc tttgggggga tttattgttc
     3121 ccatttggca gataaggtca tcaggctcag agaaggtagc atgcctgcta tgtcatgttc
     3181 aagataaaat cagtattctt catcacagtt ctttctaaag ctatgaaaat tcaagttcaa
     3241 gccacactaa tgaagttgcc gataaggacc aggcactcct ctgggcatgg ttctatttgc
     3301 tgattcatct cttgctattc ttactgccag atagtcttta tcattcccac tttccagttg
     3361 aattcattgt ggagagctgg gatgcttatc caaattatct gcatgaacaa agagtatgac
     3421 aggtgactcc tctgaggaaa tatgaatcta atcagttaga agccaaggac tctgtgggaa
     3481 acacaatgct caccgtcttt gtcatcatct tcattttcct catccatgtc acctgcttca
     3541 tcatgatctt ccctgtctcc ttgggcactg gaaagtctag gatgcttctt ttgtattctc
     3601 ttcctgtgtg ggaaccaaat caagatgatg tcctggagaa tggaaagtag aggctaaagg
     3661 ttgggtatgc cttcagccta agactagact cagttctgtc agggttctct ttccagtgct
     3721 tcctcgggta cctgatggaa gagaatgtcc tggaagcctg catagcagga ccccagaatt
     3781 cagcactcat cataacaata ataatcacaa aaaccaataa aaggcagcag taaagcccag
     3841 ctgtgcacag actatgctcc cagtggggca actccagcct ctgaaacaga ggcaccacaa
     3901 gtgacatcta aacagaagac gccaccttaa cagtatatga gcacatcatt agaactagtg
     3961 gctgtgatgt cttttttttt tttaatcaga tctttggaaa acaggagatg tacctctact
     4021 gtgttgtgtt gcaagagaaa ctgaaggatc tgagaaaatg ataggtgaga acccctgaac
     4081 aggagatggg gagatccatc tgggtagtcc cagtcctgtt agcaaggctg gcttggtaag
     4141 aaaatgaaac aagagctttc tatcttggct ccaaccctgg caagcatcca tcatacaccc
     4201 tgccacccag ctgacttaca atgcatggag aaggggaacg tgtcgtaatc caactcatct
     4261 gcattgatct aatcagccaa aacagaccct ggaagctttc ccccccaccc ccactcttgc
     4321 tttcaatgcc taggccacag ctctgctcct ataaaatatg acatagaact atgccctgct
     4381 ctccctgacc actcaactgt ggccaacaat ggtagactct agctagtctc cataagctaa
     4441 gcttcttgcc taaagtgttt ttggaaagga acttttagaa atagtattcc tgattttaaa
     4501 aaaaaaatca tttaactttc cttagaagaa catcatgctc actgatagta atctcctgga
     4561 caccactgtt tactgaatta tagttaccat attttaagat ctactactct gttttacata
     4621 gaattagaac aagacaagac accaaatgcc tcttgagatc aagtgttctt ttgagtggca
     4681 caatttgatc tccattaatg gcgaagactt ctaagcaagc tatatcaaga caatgtttct
     4741 ccagcgtcta aaaggtcccc agttaactaa ggcacaagaa gaggaacatt cagcctccac
     4801 acgaacatgg aattctaatg ccaccatcac cagttcaggc tttcagaatt aagtgtctcg
     4861 aaatagtcta ataatccttg cgacaaatgt ttacatgtcc tggtgaggac aagcccatta
     4921 tgatgtttcc atgaagtttt gttcagtttt tttccacact ggctaatgtg ggatcatttg
     4981 tttgtctata tgtgtatcta tggttcattt atgttggttg tatactgact tggagaatat
     5041 tcctttagaa cttgggttca aacctctaac acagtccact cagttatcaa gttgataaac
     5101 aaataagcac cctgcccatt tgtctagctg ctcaggaaat atgaaaagag ccaatgctat
     5161 agtggaaaca atctaatgag acctggctcc tccctacttt cctctgtcct cctctatcct
     5221 ctagagactt gtacctatca cagaagtttt ctttatactg tgtctgaaga tatcaggtca
     5281 tacataacta accaacaagc ttatgctggt caagggctag ccaataaaat tcttttcaga
     5341 aaagatccca catatgcacc acaccattct ggaccatgcc cctatggttg tcctctagat
     5401 accaccttct tttccatttt caccaggatt cccatggaaa cttgaagaaa tacattgccc
     5461 agagatgcta tagagtttca tggtctcagt taggggcttg atgtaatgta tttgaagaga
     5521 tcaggacttg aatttcattc caacctttga aaaaggtcaa gagctccatt ttctccatgc
     5581 acatacttgc caccattctt tccagctgta gaagagcaca aaaagatacc tttgttcatt
     5641 cctccaagct agggaacctt gtcttgtttt gtatactccg aaaggaggca aaaggaagta
     5701 aaggaggcaa gacccaagga ccttttgtaa atcatggcac tggttgggag ttgggtccat
     5761 agacctctca gtgttcctaa gccctgatgt ctggtggtgg gagggttagg ggaggaattg
     5821 ggaagatgcc aacctttgta tggaaattat tttataacca tgcacttttg taactgtgaa
     5881 gaatttttca taaacgcaca ttaataataa aaaagtgtat agtttaacga a
//
