LOCUS       NM_001013382            1137 bp    mRNA    linear   ROD 06-JUN-2024
DEFINITION  Mus musculus leucine rich repeat containing 52 (Lrrc52), mRNA.
ACCESSION   NM_001013382 XM_136373
VERSION     NM_001013382.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1137)
  AUTHORS   Balbach,M., Hamzeh,H., Jikeli,J.F., Brenker,C., Schiffer,C.,
            Hansen,J.N., Neugebauer,P., Trotschel,C., Jovine,L., Han,L.,
            Florman,H.M., Kaupp,U.B., Strunker,T. and Wachten,D.
  TITLE     Molecular Mechanism Underlying the Action of Zona-pellucida
            Glycoproteins on Mouse Sperm
  JOURNAL   Front Cell Dev Biol 8, 572735 (2020)
   PUBMED   32984353
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1137)
  AUTHORS   Lang,I., Jung,M., Niemeyer,B.A., Ruth,P. and Engel,J.
  TITLE     Expression of the LRRC52 gamma subunit (gamma2) may provide
            Ca2+-independent activation of BK currents in mouse inner hair
            cells
  JOURNAL   FASEB J 33 (11), 11721-11734 (2019)
   PUBMED   31348683
  REMARK    GeneRIF: LRRC52 is a gamma2 subunit of Big conductance and voltage-
            and Ca(2+)-activated K(+) channel complexes
REFERENCE   3  (bases 1 to 1137)
  AUTHORS   Lingle,C.J., Martinez-Espinosa,P.L., Yang-Hood,A., Boero,L.E.,
            Payne,S., Persic,D., V-Ghaffari,B., Xiao,M., Zhou,Y., Xia,X.M.,
            Pyott,S.J. and Rutherford,M.A.
  TITLE     LRRC52 regulates BK channel function and localization in mouse
            cochlear inner hair cells
  JOURNAL   Proc Natl Acad Sci U S A 116 (37), 18397-18403 (2019)
   PUBMED   31451634
  REMARK    GeneRIF: LRRC52 regulates BK channel function and localization in
            mouse cochlear inner hair cells.
REFERENCE   4  (bases 1 to 1137)
  AUTHORS   Zeng,X.H., Yang,C., Xia,X.M., Liu,M. and Lingle,C.J.
  TITLE     SLO3 auxiliary subunit LRRC52 controls gating of sperm KSPER
            currents and is critical for normal fertility
  JOURNAL   Proc Natl Acad Sci U S A 112 (8), 2599-2604 (2015)
   PUBMED   25675513
  REMARK    GeneRIF: These results establish a critical role of LRRC52 in KSPER
            channels and demonstrate that loss of a non-pore-forming auxiliary
            subunit results in severe fertility impairment.
REFERENCE   5  (bases 1 to 1137)
  AUTHORS   Gineste,C., De Winter,J.M., Kohl,C., Witt,C.C., Giannesini,B.,
            Brohm,K., Le Fur,Y., Gretz,N., Vilmen,C., Pecchi,E., Jubeau,M.,
            Cozzone,P.J., Stienen,G.J., Granzier,H., Labeit,S.,
            Ottenheijm,C.A., Bendahan,D. and Gondin,J.
  TITLE     In vivo and in vitro investigations of heterozygous nebulin
            knock-out mice disclose a mild skeletal muscle phenotype
  JOURNAL   Neuromuscul Disord 23 (4), 357-369 (2013)
   PUBMED   23375831
REFERENCE   6  (bases 1 to 1137)
  AUTHORS   Yang,C., Zeng,X.H., Zhou,Y., Xia,X.M. and Lingle,C.J.
  TITLE     LRRC52 (leucine-rich-repeat-containing protein 52), a
            testis-specific auxiliary subunit of the alkalization-activated
            Slo3 channel
  JOURNAL   Proc Natl Acad Sci U S A 108 (48), 19419-19424 (2011)
   PUBMED   22084117
  REMARK    GeneRIF: LRRC52 and LRRC26 define a new family of auxiliary
            subunits capable of critically modifying the gating behavior of Slo
            family channels.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC113970.8.
            
            On Aug 22, 2018 this sequence version replaced NM_001013382.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC087947.1, SRR5189685.43431.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-688               AC113970.8         226515-227202       c
            689-1137            AC113970.8         206097-206545       c
FEATURES             Location/Qualifiers
     source          1..1137
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 74.83 cM"
     gene            1..1137
                     /gene="Lrrc52"
                     /gene_synonym="4930413P14Rik"
                     /note="leucine rich repeat containing 52"
                     /db_xref="GeneID:240899"
                     /db_xref="MGI:MGI:1924118"
     exon            1..688
                     /gene="Lrrc52"
                     /gene_synonym="4930413P14Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             67..1011
                     /gene="Lrrc52"
                     /gene_synonym="4930413P14Rik"
                     /note="leucine-rich repeat-containing protein 52; BK
                     channel auxilliary gamma subunit LRRC52; BK channel
                     auxiliary gamma subunit LRRC52"
                     /codon_start=1
                     /product="leucine-rich repeat-containing protein 52
                     precursor"
                     /protein_id="NP_001013400.1"
                     /db_xref="CCDS:CCDS15458.1"
                     /db_xref="GeneID:240899"
                     /db_xref="MGI:MGI:1924118"
                     /translation="MSLASGPSSKLLLFSLGMGLVSGSKCPNKCVCQDQEVACIDLHL
                     TEYPADIPLNTRRLYLNNNKITSLPALQLGFLSDLVYLDCQNNRIREVMDYTFIGIFR
                     LIYLDLSSNNLTSISPFSFSVLTNLVRLNISHNPHLLYLDKYVFANTTSLRYLDLRNT
                     GLHIIDHNGFHHLVVLQTLYLSGNPWICNCSFLDFTIHLLVSHMDHPDAQNATCTEPA
                     ELKGWPITKVGNPLQYMCITHLDQQDYIFLLLIGFCIFAAGTVAAWLTGVCAVLYQNA
                     LRTSSGDDTEDETGSRFANQIFRSNTHLGPIRRFPELI"
     exon            689..1137
                     /gene="Lrrc52"
                     /gene_synonym="4930413P14Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agatcagaag gacagcttgt acccgccctc aggaaggtag aaggagggga accttggctt
       61 cttactatgt cccttgcttc aggccctagc tccaagttgt tactcttttc tcttggaatg
      121 gggttggtat cagggtccaa gtgtccaaac aagtgtgtgt gtcaagacca agaagtagcc
      181 tgcatagatt tgcacctaac ggaataccca gctgatattc ctctgaacac ccggagacta
      241 tacctgaaca ataacaaaat cactagttta ccagctttgc agctgggatt cctcagtgac
      301 ctcgtttact tggactgtca gaacaaccgg attcgagagg tgatggatta taccttcatc
      361 gggatcttca gactcatcta ccttgacctc agctccaaca acctaacttc catctcccct
      421 ttcagcttct cagtgctcac caacctggtg cggctgaaca tttcacacaa ccctcacctg
      481 ttgtatcttg acaaatacgt ctttgccaac accacgtctt tgaggtacct ggacctcaga
      541 aacaccggat tgcacatcat cgaccataat ggcttccacc acctggtggt gctccagact
      601 ctgtacctaa gtgggaaccc ctggatatgc aactgctcct tcctggactt caccatccac
      661 ttattagtgt cccatatgga ccacccagat gcccagaacg ccacgtgtac ggagcctgct
      721 gagctgaaag ggtggcccat cacgaaggtg gggaatccac tccagtacat gtgcatcaca
      781 cacctggacc agcaggacta catcttctta ctgctcatcg gcttctgcat cttcgctgcc
      841 ggcacggtgg ctgcctggct cacgggtgta tgtgctgtgc tgtaccagaa tgccctccga
      901 acgtcgagcg gggatgatac cgaagatgaa actgggagta gattcgccaa ccagattttt
      961 cgaagcaaca cacacttggg ccccattcgt cggttccctg aactgatcta gctgtcagag
     1021 agcaccaccg actgtgcctt ccctggtctg gctccctgat ttctctcttg ccctcccatt
     1081 ttaccatcac tgtcttggag actgaagccc tctagtaaaa taaaatattt ggtggtt
//
