LOCUS       NM_001162973             811 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus leucine rich repeat containing 51 (Lrrc51), transcript
            variant 2, mRNA.
ACCESSION   NM_001162973
VERSION     NM_001162973.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 811)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 811)
  AUTHORS   Stauber,M., Weidemann,M., Dittrich-Breiholz,O., Lobschat,K.,
            Alten,L., Mai,M., Beckers,A., Kracht,M. and Gossler,A.
  TITLE     Identification of FOXJ1 effectors during ciliogenesis in the foetal
            respiratory epithelium and embryonic left-right organiser of the
            mouse
  JOURNAL   Dev Biol 423 (2), 170-188 (2017)
   PUBMED   27914912
REFERENCE   3  (bases 1 to 811)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   4  (bases 1 to 811)
  AUTHORS   Ahmed,Z.M., Masmoudi,S., Kalay,E., Belyantseva,I.A., Mosrati,M.A.,
            Collin,R.W., Riazuddin,S., Hmani-Aifa,M., Venselaar,H., Kawar,M.N.,
            Tlili,A., van der Zwaag,B., Khan,S.Y., Ayadi,L., Riazuddin,S.A.,
            Morell,R.J., Griffith,A.J., Charfedine,I., Caylan,R., Oostrik,J.,
            Karaguzel,A., Ghorbel,A., Riazuddin,S., Friedman,T.B., Ayadi,H. and
            Kremer,H.
  TITLE     Mutations of LRTOMT, a fusion gene with alternative reading frames,
            cause nonsyndromic deafness in humans
  JOURNAL   Nat Genet 40 (11), 1335-1340 (2008)
   PUBMED   18953341
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC167240.5.
            
            [WARNING] On May 7, 2024 this sequence was replaced by
            NM_001162973.2.
            
            Transcript Variant: This variant (2) lacks an alternate exon in the
            5' UTR compared to variant 1. Variants 1, 2, and 4 encode the same
            protein (isoform 1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DV061370.1, CA464728.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-94                AC167240.5         91350-91443
            95-232              AC167240.5         104433-104570
            233-438             AC167240.5         109440-109645
            439-587             AC167240.5         111624-111772
            588-811             AC167240.5         111995-112218
FEATURES             Location/Qualifiers
     source          1..811
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 54.69 cM"
     gene            1..811
                     /gene="Lrrc51"
                     /gene_synonym="1700008D07Rik; Lrtomt"
                     /note="leucine rich repeat containing 51"
                     /db_xref="GeneID:69358"
                     /db_xref="MGI:MGI:1916608"
     exon            1..94
                     /gene="Lrrc51"
                     /gene_synonym="1700008D07Rik; Lrtomt"
                     /inference="alignment:Splign:2.1.0"
     exon            95..232
                     /gene="Lrrc51"
                     /gene_synonym="1700008D07Rik; Lrtomt"
                     /inference="alignment:Splign:2.1.0"
     CDS             151..729
                     /gene="Lrrc51"
                     /gene_synonym="1700008D07Rik; Lrtomt"
                     /note="isoform 1 is encoded by transcript variant 2;
                     leucine-rich repeat-containing protein 51"
                     /codon_start=1
                     /product="leucine-rich repeat-containing protein 51
                     isoform 1"
                     /protein_id="NP_001156445.1"
                     /db_xref="CCDS:CCDS52332.1"
                     /db_xref="GeneID:69358"
                     /db_xref="MGI:MGI:1916608"
                     /translation="MSSRDYMNTSVQEPPLDYSFKSVQMVQDLVTEEPRTGLRPVRHS
                     KSGKSLTQSLWLNNNVLNDLKDFNQVVSQLLQHPENLAWIDLSFNDLTTIDPVLTTFF
                     NLSVLYLHGNGIHRLGEVNKLAVLPRLRSLTLHGNPIEEEKGYRQYVLCNLPRITTFD
                     FSGVTRADRSTAEVWKRMNIKPKKVRAKQDVL"
     exon            233..438
                     /gene="Lrrc51"
                     /gene_synonym="1700008D07Rik; Lrtomt"
                     /inference="alignment:Splign:2.1.0"
     exon            439..587
                     /gene="Lrrc51"
                     /gene_synonym="1700008D07Rik; Lrtomt"
                     /inference="alignment:Splign:2.1.0"
     exon            588..811
                     /gene="Lrrc51"
                     /gene_synonym="1700008D07Rik; Lrtomt"
                     /inference="alignment:Splign:2.1.0"
     regulatory      784..789
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lrrc51"
                     /gene_synonym="1700008D07Rik; Lrtomt"
                     /note="hexamer: AATAAA"
     polyA_site      811
                     /gene="Lrrc51"
                     /gene_synonym="1700008D07Rik; Lrtomt"
                     /note="major polyA site"
ORIGIN      
        1 gttcaactga gccgtctagg gcgtgttgac taaggtagtt gctatggggt tgcgctgagt
       61 aactcttcag gtagtgagac gctgaagccg gagggctgaa gccagactcc cagggcccat
      121 gcttccacct gatgaatgat ggcctgaact atgagctcac gggactatat gaacacttcc
      181 gtgcaggagc ctcctcttga ctactccttc aaaagcgtcc aaatggtcca agatctggta
      241 accgaggagc caaggacagg tctacgaccg gtgaggcact caaagtcagg aaagtcactg
      301 acccagtccc tgtggctcaa caacaatgtc ctcaatgatc tgaaagactt caaccaggtg
      361 gtttcacagc ttctacagca tccagagaat ctggcctgga ttgacctctc cttcaatgac
      421 ctgactacca ttgaccctgt cctaacaaca ttcttcaacc taagtgtcct ctaccttcac
      481 ggcaacggca tccatcgcct aggggaggtg aataagctag ctgtcctccc tcgtctccgg
      541 agcctgaccc tccatgggaa ccccatagag gaagaaaagg ggtacaggca gtatgtgctg
      601 tgcaacctgc cccgtatcac cacgtttgac ttcagtggag tcaccagggc cgatcgcagc
      661 acagctgaag tctggaaacg catgaacatc aagcccaaga aggtccgggc caagcaggat
      721 gttctctgag attcgcagga cccagcacac cgaatgccct gaggataatc agcttggttt
      781 gacaataaat gatttgagct gttgaacaga t
//
