LOCUS       NM_001289743            3644 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus leucine rich repeat containing 4C (Lrrc4c), transcript
            variant 2, mRNA.
ACCESSION   NM_001289743 XM_006499478
VERSION     NM_001289743.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3644)
  AUTHORS   Lopez-Tello,J. and Sferruzzi-Perri,A.N.
  TITLE     Characterization of placental endocrine function and fetal brain
            development in a mouse model of small for gestational age
  JOURNAL   Front Endocrinol (Lausanne) 14, 1116770 (2023)
   PUBMED   36843585
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3644)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3644)
  AUTHORS   Vuong,H.E., Pronovost,G.N., Williams,D.W., Coley,E.J.L.,
            Siegler,E.L., Qiu,A., Kazantsev,M., Wilson,C.J., Rendon,T. and
            Hsiao,E.Y.
  TITLE     The maternal microbiome modulates fetal neurodevelopment in mice
  JOURNAL   Nature 586 (7828), 281-286 (2020)
   PUBMED   32968276
REFERENCE   4  (bases 1 to 3644)
  AUTHORS   Fujita,Y., Nakanishi,T., Ueno,M., Itohara,S. and Yamashita,T.
  TITLE     Netrin-G1 Regulates Microglial Accumulation along Axons and
            Supports the Survival of Layer V Neurons in the Postnatal Mouse
            Brain
  JOURNAL   Cell Rep 31 (4), 107580 (2020)
   PUBMED   32348754
REFERENCE   5  (bases 1 to 3644)
  AUTHORS   Lee,H., Shin,W., Kim,K., Lee,S., Lee,E.J., Kim,J., Kweon,H.,
            Lee,E., Park,H., Kang,M., Yang,E., Kim,H. and Kim,E.
  TITLE     NGL-3 in the regulation of brain development, Akt/GSK3b signaling,
            long-term depression, and locomotive and cognitive behaviors
  JOURNAL   PLoS Biol 17 (6), e2005326 (2019)
   PUBMED   31166939
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3644)
  AUTHORS   Kim,S., Burette,A., Chung,H.S., Kwon,S.K., Woo,J., Lee,H.W.,
            Kim,K., Kim,H., Weinberg,R.J. and Kim,E.
  TITLE     NGL family PSD-95-interacting adhesion molecules regulate
            excitatory synapse formation
  JOURNAL   Nat Neurosci 9 (10), 1294-1301 (2006)
   PUBMED   16980967
REFERENCE   7  (bases 1 to 3644)
  AUTHORS   Delprat,B., Michel,V., Goodyear,R., Yamasaki,Y., Michalski,N.,
            El-Amraoui,A., Perfettini,I., Legrain,P., Richardson,G.,
            Hardelin,J.P. and Petit,C.
  TITLE     Myosin XVa and whirlin, two deafness gene products required for
            hair bundle growth, are located at the stereocilia tips and
            interact directly
  JOURNAL   Hum Mol Genet 14 (3), 401-410 (2005)
   PUBMED   15590698
REFERENCE   8  (bases 1 to 3644)
  AUTHORS   Lin,J.C., Ho,W.H., Gurney,A. and Rosenthal,A.
  TITLE     The netrin-G1 ligand NGL-1 promotes the outgrowth of
            thalamocortical axons
  JOURNAL   Nat Neurosci 6 (12), 1270-1276 (2003)
   PUBMED   14595443
REFERENCE   9  (bases 1 to 3644)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Aizawa,H., Yuasa,S.,
            Nakajima,D., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
REFERENCE   10 (bases 1 to 3644)
  AUTHORS   Sturgis,S.H.
  TITLE     Editorial: Allan Guttmacher, M.D.--a life fulfilled
  JOURNAL   N Engl J Med 290 (19), 1085 (1974)
   PUBMED   4595443
  REMARK    GeneRIF: NGL-1 is most abundant in the striatum and the cerebral
            cortex--the intermediate and final targets, of thalamocortical
            axons; surface-bound NGL-1 stimulates, but soluble NGL-1 disrupts,
            the growth of embryonic thalamic axons.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK034276.1 and AV345568.2.
            
            On Jan 28, 2014 this sequence version replaced XM_006499478.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 5. All seven variants encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN01164131,
                              SAMN01164132 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3096              AK034276.1         2-3097
            3097-3644           AV345568.2         77-624
FEATURES             Location/Qualifiers
     source          1..3644
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 52.3 cM"
     gene            1..3644
                     /gene="Lrrc4c"
                     /gene_synonym="6430556C10Rik; NGL-1"
                     /note="leucine rich repeat containing 4C"
                     /db_xref="GeneID:241568"
                     /db_xref="MGI:MGI:2442636"
     exon            1..415
                     /gene="Lrrc4c"
                     /gene_synonym="6430556C10Rik; NGL-1"
                     /inference="alignment:Splign:2.1.0"
     exon            416..596
                     /gene="Lrrc4c"
                     /gene_synonym="6430556C10Rik; NGL-1"
                     /inference="alignment:Splign:2.1.0"
     exon            597..685
                     /gene="Lrrc4c"
                     /gene_synonym="6430556C10Rik; NGL-1"
                     /inference="alignment:Splign:2.1.0"
     exon            686..822
                     /gene="Lrrc4c"
                     /gene_synonym="6430556C10Rik; NGL-1"
                     /inference="alignment:Splign:2.1.0"
     exon            823..916
                     /gene="Lrrc4c"
                     /gene_synonym="6430556C10Rik; NGL-1"
                     /inference="alignment:Splign:2.1.0"
     exon            917..968
                     /gene="Lrrc4c"
                     /gene_synonym="6430556C10Rik; NGL-1"
                     /inference="alignment:Splign:2.1.0"
     exon            969..3644
                     /gene="Lrrc4c"
                     /gene_synonym="6430556C10Rik; NGL-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3076..3081
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lrrc4c"
                     /gene_synonym="6430556C10Rik; NGL-1"
                     /note="hexamer: ATTAAA"
     polyA_site      3100
                     /gene="Lrrc4c"
                     /gene_synonym="6430556C10Rik; NGL-1"
                     /note="major polyA site"
ORIGIN      
        1 gcctgcttcc tcgtaaaaga gattgtgtga gtgtccgtac tgtgtgtggg gatttgtgag
       61 acaagcaaag gaggtatacc atacaagagg agatctcaac agcgtgataa aaatctccag
      121 gcactggggc tcacaatctc tagccccccc tcctcacacc gccccttctt tgccctactc
      181 ccccggctcc tttcgtcttt gatgagtttt tggctcactt tttggcggag tctcttggac
      241 atgttctgct gttgctgaag gatcaaataa atggaacctt tgaaagttga ttatttttct
      301 cttatgtgac aaacacacac agagagagcg cgaagaggaa ggaaattaga gtgctgtatg
      361 acaagctaga ggatttaaat ttttccttgg tgaactttga ggatccgctg agaagaaacc
      421 aaatgaagtg tttaccgtca ttatctctat ttgatgaaga ggatactggg gctcaaagag
      481 acttaataac ttgtccaaga tcacctaatg ctgaataatc aagaatgagt gccatgaaag
      541 aacaaagacc agcctggacc agcatatttt tgagaggata agccacaggg tagcagaaat
      601 gattcacttg atggcatgcc tgtttgttta cccagagaga gtggagctga ggaagttgga
      661 gcttccattg acactctaaa ctcatgaatt accgaaggaa cgaagaataa tgcatgtatt
      721 ttgacacaat ggagacatcc tgacacctct tctgaatctc agtaaattaa ctggattcaa
      781 gcttggcaaa caggaaaact ggtacaagac aacttgctac aggtgtgaag aaacatcacc
      841 agtagagatc caggacacgt gttttacttc tttgaattct ctcaggaaga gaagagccag
      901 aaagacccac attaaggttg gcaaacacgt tgcctattta cttcatagag accccaatgg
      961 agaacaagac tgtttgaact ccagaaggac caacaccaga taaattatga atgttgaaca
     1021 agatgacctt acatccacag cagataatga taggtcctag gtttaacagg gccctatttg
     1081 accccctgct tgtggtgctg ttggctcttc aacttcttgt ggtggctggt ttggttcgtg
     1141 ctcaaacctg cccttcagtg tgctcttgta gcaaccagtt cagcaaggtg atttgtgttc
     1201 ggaaaaacct tcgtgaagtt ccggatggca tctccaccaa cacaaggctg ctgaacctcc
     1261 atgagaacca aatccagatc attaaagtga acagcttcaa gcatttgagg cacttagaaa
     1321 tcctccagtt gagcaggaac catattcgaa ccattgaaat cggggccttc aatggtctgg
     1381 ccaacctcaa caccctggaa ctctttgaca atcgtcttac taccataccg aatggagctt
     1441 ttgtatattt gtctaaactg aaggagctct ggttgaggaa caaccctatt gaaagcatcc
     1501 cttcctatgc ttttaacaga atcccttctt tgcgccgcct ggacttaggg gaattgaaaa
     1561 ggctttcata catctcagaa ggtgcctttg aaggtctgtc caacttgagg tatttgaacc
     1621 ttgccatgtg caaccttcgg gaaatcccta acctcacacc actcatcaaa cttgacgagc
     1681 tagatctttc tgggaaccat ttgtctgcaa tcaggcctgg ctcttttcag gggttgatgc
     1741 accttcaaaa actgtggatg atacagtctc agattcaagt gattgaacgg aatgcctttg
     1801 ataaccttca gtcactagtg gagataaact tggcacacaa caatctaaca ttattgcctc
     1861 atgacctctt cacacccttg catcatctag agaggataca cctccatcac aacccgtgga
     1921 actgtaactg tgatatcctg tggctcagct ggtggataag agacatggcc ccctccaaca
     1981 cagcttgctg tgccaggtgt aacactcccc ccaacctgaa agggaggtac atcggagagc
     2041 tggaccagaa ttactttaca tgctatgctc ccgtaattgt ggagccccct gcagacctca
     2101 atgtcactga aggcatggca gctgagctga aatgtcgggc ttctacgtcc ctgacttccg
     2161 tatcttggat tactccaaat ggaacagtca tgacccacgg ggcatacaaa gtgcggatag
     2221 ctgtgctcag cgacggtact ttaaatttca caaatgtaac tgtgcaagac acaggcatgt
     2281 acacatgtat ggtgagtaat tctgttggca acaccactgc ttctgccacc ttgaatgtta
     2341 ctgcggcaac cactactccg ttctcgtact tttcaactgt aacagtagag actatggaac
     2401 cttctcagga tgaggcacgg accacagata acaatgtggg ccccactcca gtgatcgatt
     2461 gggagaccac caatgtaacc acatctctta cgccacagag cacaaggtcg acagaaaaaa
     2521 cattcaccat cccagtaact gacatcaaca gcggaatccc aggaattgat gaggtcatga
     2581 aaacaactaa aatcattatt gggtgttttg tggccatcac actcatggct gccgtgatgc
     2641 tggtcatttt ctacaagatg aggaaacagc accatcggca aaaccaccat gctccaacaa
     2701 ggactgttga aatcattaac gtggatgatg agatcactgg ggacacgccc atggaaagcc
     2761 acctgcccat gcctgcgatt gagcatgagc acctaaacca ctataactct tacaaatctc
     2821 ccttcaacca cacaacaaca gtaaacacaa taaattcaat acacagttca gtgcatgaac
     2881 cgttattgat ccgaatgaac tctaaagaca atgtacaaga gactcagata taaaacattt
     2941 acagttacag aaaacaaaca atcaaaaaac aaaagacagt ttattaaaaa aaaatgacac
     3001 aaatgactgg gctaaatcta ctgtttcaaa aaagtgtctt tacaaaaaaa aaacaaaaag
     3061 aaaagaaatt tatttattaa aaattctatt gtgatctaaa gcagacaaaa ttatgtgtat
     3121 tcctcagaac ctgtttttgc tgcacttact attttcccac acctcctccc tcccctcccc
     3181 aattgccata tttttcatag atctcaactc ccccaaagaa ctggtctagg aaattttgta
     3241 agaattctgt tacactttga gatttttatg gtgaattcta gtggtgagat ccagtctatt
     3301 ttgtctcttt ctctctctct ctctctctct ctcttttttt catttttttc tttttccttc
     3361 atgcccttat gaaatagtca aatggggaat gcaatattag aaatagattt ttaagaaaga
     3421 acgaggtaaa aatgcaagat cttatatttt tcatgtaatg acctgttctg tatttatgag
     3481 gaggacattc tgtggagaaa gacaaaaagt aagcaaacaa cagattaatt tacatatgag
     3541 catctataaa acccatgact tttaaaaagc aaacctctag aaccagaatt tgtagttcaa
     3601 aagcttaaaa taagattata aataaaatat tgttggtttt tctg
//
