LOCUS       NM_145616               3000 bp    mRNA    linear   ROD 28-AUG-2024
DEFINITION  Mus musculus leucine rich repeat containing 49 (Lrrc49), transcript
            variant 2, mRNA.
ACCESSION   NM_145616
VERSION     NM_145616.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3000)
  AUTHORS   Tang,Q., Fang,Z., Liao,H., Zhang,Y., Li,C., Zhou,C., Liu,F. and
            Shen,J.
  TITLE     Reduced circ_lrrc49 in trigeminal ganglion contributes to
            neuropathic pain in mice by downregulating Ist1 and impairing
            autophagy
  JOURNAL   J Neurochem 168 (7), 1265-1280 (2024)
   PUBMED   38348636
  REMARK    GeneRIF: Reduced circ_lrrc49 in trigeminal ganglion contributes to
            neuropathic pain in mice by downregulating Ist1 and impairing
            autophagy.
REFERENCE   2  (bases 1 to 3000)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3000)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   4  (bases 1 to 3000)
  AUTHORS   Evsikov,A.V., Graber,J.H., Brockman,J.M., Hampl,A., Holbrook,A.E.,
            Singh,P., Eppig,J.J., Solter,D. and Knowles,B.B.
  TITLE     Cracking the egg: molecular dynamics and evolutionary aspects of
            the transition from the fully grown oocyte to embryo
  JOURNAL   Genes Dev 20 (19), 2713-2727 (2006)
   PUBMED   17015433
REFERENCE   5  (bases 1 to 3000)
  AUTHORS   Janke,C., Rogowski,K., Wloga,D., Regnard,C., Kajava,A.V.,
            Strub,J.M., Temurak,N., van Dijk,J., Boucher,D., van Dorsselaer,A.,
            Suryavanshi,S., Gaertig,J. and Edde,B.
  TITLE     Tubulin polyglutamylase enzymes are members of the TTL domain
            protein family
  JOURNAL   Science 308 (5729), 1758-1762 (2005)
   PUBMED   15890843
REFERENCE   6  (bases 1 to 3000)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CF737193.1, AK049268.1, AK051325.1, DV658343.1 and AW050057.1.
            
            On Mar 26, 2009 this sequence version replaced NM_145616.3.
            
            Transcript Variant: This variant (2) represents the longest
            transcript and encodes the longest isoform (2).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK049268.1, SRR1660817.200923.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139, SAMN01164141
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-54                CF737193.1         25-78
            55-223              CF737193.1         80-248
            224-1827            AK049268.1         3-1606
            1828-2630           AK051325.1         1435-2237
            2631-2983           DV658343.1         247-599
            2984-3000           AW050057.1         1-17                c
FEATURES             Location/Qualifiers
     source          1..3000
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 32.75 cM"
     gene            1..3000
                     /gene="Lrrc49"
                     /gene_synonym="D430025H09Rik; p79; PGs4"
                     /note="leucine rich repeat containing 49"
                     /db_xref="GeneID:102747"
                     /db_xref="MGI:MGI:2442689"
     exon            1..323
                     /gene="Lrrc49"
                     /gene_synonym="D430025H09Rik; p79; PGs4"
                     /inference="alignment:Splign:2.1.0"
     CDS             276..2534
                     /gene="Lrrc49"
                     /gene_synonym="D430025H09Rik; p79; PGs4"
                     /note="isoform 2 is encoded by transcript variant 2;
                     leucine-rich repeat-containing protein 49; tubulin
                     polyglutamylase complex subunit 4"
                     /codon_start=1
                     /product="leucine-rich repeat-containing protein 49
                     isoform 2"
                     /protein_id="NP_663591.3"
                     /db_xref="CCDS:CCDS23257.1"
                     /db_xref="GeneID:102747"
                     /db_xref="MGI:MGI:2442689"
                     /translation="MIPGKYRSVSGRAANNVNCGLHLVIQTSSLSDKNKVEFRLNRET
                     PPFPGRLLQHDLERNYSSRQGDGRVISPSPRNKSSCISSTTNVTDLCGLDMRAATTSL
                     SAFGDSSIQTPSKPRIRQGCHSAGPNVSGDHISLVSSSMPAFPILQRSSEEKTLYSDR
                     LTLERQKLTVCPIIDGEEHLRLLNFQHNFITRIQNISNLQRLIFLDLYDNQIEEISGL
                     STLKSLRVLLLGKNRIKKISNLENLKNLDVLDLHGNQITKIENVNHLCDLRVLNLARN
                     LLSHVDNLNGLDSLTELNLRHNQITFVRDVDNLPCLQRLFLSFNNITSFESVSCLAES
                     TSLSDITFDGNPIAQESWYKHTVLQNMMQLRQLDMKRITEEERRVASVVAKKEEEKKR
                     ESHKQSLLKEKKRLTINNVARKWDLQQRVANIASTQDRKDSESPPQESCQLDGGNISA
                     FPEEAGSLDAGLSSALQGLSVTETHLVEIDGETLSLYGSGALECLDRNWSVQTAGMVT
                     TVSFTFIEFDEIVQVLPKLKMKFPNSLHLKFRETNLVMLQQFNALAQLRRVDQLTIDP
                     QGNPVVNFTLWKYYVLFRLSHFSMQKINGTEVTQNDMIMAERLFGILAHVASSELPQY
                     RMISILGDARKKQFRYLLESKGKKPGIICEETSDSKRFLGENTNRATLNYTTREFYHE
                     KLEEIKDKKKFCRLYVEDLVKEATAINMKNEALQKLWPQMFIELVRDAVIEIRSKDSY
                     MKLCLQQITDQK"
     exon            324..380
                     /gene="Lrrc49"
                     /gene_synonym="D430025H09Rik; p79; PGs4"
                     /inference="alignment:Splign:2.1.0"
     exon            381..468
                     /gene="Lrrc49"
                     /gene_synonym="D430025H09Rik; p79; PGs4"
                     /inference="alignment:Splign:2.1.0"
     exon            469..666
                     /gene="Lrrc49"
                     /gene_synonym="D430025H09Rik; p79; PGs4"
                     /inference="alignment:Splign:2.1.0"
     exon            667..769
                     /gene="Lrrc49"
                     /gene_synonym="D430025H09Rik; p79; PGs4"
                     /inference="alignment:Splign:2.1.0"
     exon            770..973
                     /gene="Lrrc49"
                     /gene_synonym="D430025H09Rik; p79; PGs4"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1040
                     /gene="Lrrc49"
                     /gene_synonym="D430025H09Rik; p79; PGs4"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1184
                     /gene="Lrrc49"
                     /gene_synonym="D430025H09Rik; p79; PGs4"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1246
                     /gene="Lrrc49"
                     /gene_synonym="D430025H09Rik; p79; PGs4"
                     /inference="alignment:Splign:2.1.0"
     exon            1247..1394
                     /gene="Lrrc49"
                     /gene_synonym="D430025H09Rik; p79; PGs4"
                     /inference="alignment:Splign:2.1.0"
     exon            1395..1478
                     /gene="Lrrc49"
                     /gene_synonym="D430025H09Rik; p79; PGs4"
                     /inference="alignment:Splign:2.1.0"
     exon            1479..1642
                     /gene="Lrrc49"
                     /gene_synonym="D430025H09Rik; p79; PGs4"
                     /inference="alignment:Splign:2.1.0"
     exon            1643..1880
                     /gene="Lrrc49"
                     /gene_synonym="D430025H09Rik; p79; PGs4"
                     /inference="alignment:Splign:2.1.0"
     exon            1881..2066
                     /gene="Lrrc49"
                     /gene_synonym="D430025H09Rik; p79; PGs4"
                     /inference="alignment:Splign:2.1.0"
     exon            2067..2176
                     /gene="Lrrc49"
                     /gene_synonym="D430025H09Rik; p79; PGs4"
                     /inference="alignment:Splign:2.1.0"
     exon            2177..2330
                     /gene="Lrrc49"
                     /gene_synonym="D430025H09Rik; p79; PGs4"
                     /inference="alignment:Splign:2.1.0"
     exon            2331..2993
                     /gene="Lrrc49"
                     /gene_synonym="D430025H09Rik; p79; PGs4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atcctcctcc ggatcctccc gctgttttca agcggcctgg aaaaaaaaaa aaaatccaga
       61 acgaggaagt gctgacgcac ggggccccac agatactccc cgaggctagc cgcccggacg
      121 gcccaaagat ctagggcgag gaccagaccg gaaatggtgg tttctatggt aacccctgag
      181 cgggttgcct gggagatgac cccttttggt ctctttgaat cttagctgta ggattacctc
      241 gaaggaggat tgaacatcct ggactgtctc ctgccatgat tcccggaaaa tatcgctccg
      301 tttctggccg agctgcaaat aacgtgaact gtggacttca tctggttatt caaacgtcgt
      361 cactttctga caaaaacaaa gttgaattca ggcttaacag agaaacacca ccatttcctg
      421 gtagactgtt acagcatgac ctggagagga actactcaag caggcaagga gacggaagag
      481 taataagtcc ttcgcctcgt aataagtcat catgcatctc atccacaact aacgtgacag
      541 acctctgtgg gctggacatg agagctgcca caacctcctt gtcagcattt ggagactctt
      601 ccattcagac accttcaaag ccgagaatcc ggcagggctg tcatagtgct ggccccaatg
      661 tatctggtga ccacattagt ctggtgagct catccatgcc ggcgtttcct attctccagc
      721 gctcttctga agagaaaaca ctttactcag acaggctgac cctagaaaga caaaagttga
      781 ctgtgtgccc tatcatcgac ggggaagagc accttcgttt gttgaacttt cagcacaatt
      841 ttataactcg gatccaaaat atttctaatc tacagaggct aatattcttg gacttatatg
      901 ataaccagat tgaagaaatt agtggacttt ctactctgaa atcccttcgt gtcctcctgt
      961 tagggaaaaa cagaatcaag aaaatctcaa atctggagaa tctaaaaaat ttagatgtct
     1021 tggaccttca tggaaatcag attaccaaaa ttgaaaatgt taatcatttg tgtgatttga
     1081 gagttctaaa ccttgccagg aatctcttga gtcatgttga caatctcaac ggcctggatt
     1141 cactaacgga acttaacctt cggcacaacc agatcacctt tgtgagagat gtggataatt
     1201 tgccctgcct ccaacgcctc ttcctcagct tcaacaatat aactagcttt gaaagtgttt
     1261 cctgccttgc cgagtcaact tccctctcgg acatcacctt tgatggcaac ccaatagctc
     1321 aagagtcatg gtacaaacac acggtccttc agaatatgat gcagctgcgc cagctagaca
     1381 tgaagagaat cacggaagaa gaaagacgcg tggcatctgt tgtggccaaa aaagaggagg
     1441 agaagaagag ggagagtcac aagcagtcct tgctgaagga gaagaaaagg ttaaccatta
     1501 acaatgtcgc tcgaaagtgg gacttgcagc agcgagtagc caacattgcc agcactcagg
     1561 acagaaagga ctcggagtct ccgcctcagg aatcctgtca gctcgacgga ggcaacatct
     1621 ctgcctttcc agaggaagca gggtctctag atgcagggct cagcagtgcg ttacaaggct
     1681 tgtctgtcac agaaacacac ttggtggaga tagacggaga aaccctctca ctgtacggct
     1741 caggggcgct ggaatgcctg gatcgaaact ggagtgttca aacagccggc atggtcacca
     1801 cggtctcatt cacgttcatc gagtttgatg aaattgtcca agtacttccc aaactgaaga
     1861 tgaagtttcc aaattctctg caccttaaat tcagggagac caaccttgtg atgctgcagc
     1921 agttcaatgc cctggcacag ctgcgtcggg ttgaccagtt gacaatcgat cctcagggaa
     1981 acccagtggt caactttaca ctctggaagt actacgtgct gttcaggctc agccacttca
     2041 gcatgcagaa aataaatgga acagaggtga ctcaaaatga catgataatg gctgaaaggc
     2101 tctttggaat cttagcacat gtagcatcct ccgagctgcc ccagtaccgc atgatttcaa
     2161 ttctgggtga tgccaggaaa aagcaattcc gatatctact ggaaagcaaa ggtaaaaagc
     2221 ctggcatcat ctgtgaggag accagtgaca gcaagaggtt cttgggggaa aacacgaacc
     2281 gcgctaccct gaattacacc acccgagaat tctaccacga gaagctggaa gaaataaagg
     2341 acaagaagaa gttctgcagg ttgtatgtag aagacctggt gaaggaagcc acagccatca
     2401 acatgaaaaa cgaggctctg cagaagctgt ggccacagat gttcatcgag cttgtgagag
     2461 acgctgtcat agagatccgc agcaaggatt cctacatgaa actctgcctg cagcagatca
     2521 ctgaccagaa atagggatgg ctgctacttc agacttgggc aattggagct ttttcgaagt
     2581 ttggtaagat gcaggttaga catgatgaga caccaccact accgcacagt ctagaaagag
     2641 tggcatcaaa gcctgccccc cccccccccc cgcactgtgg agaaaggagg gaggcaggag
     2701 agagggggac tctttcccgt gcatgctgac cacacaacct tgggaaacca agcagcgact
     2761 ggaggaggcc tggctgctgg gtcagaaatg cttcttcggc tcccgctctg actggtgagt
     2821 ctgccccagt cccaagctcg ctgtgtgctg atgggctagc atgagatgcc tccaccaacc
     2881 tccagctgag actttcctct ttttttgcct ttttatttta tgtcatgatt tcaaagccaa
     2941 gcatatgtct ttttttaatg agtgaagaat aaatacatta gttaaaaaaa aaaaaaaaaa
//
