LOCUS       NM_153521               3146 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus leucine rich repeat containing 41 (Lrrc41), mRNA.
ACCESSION   NM_153521
VERSION     NM_153521.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3146)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3146)
  AUTHORS   He,Y., Chen,Q., Dai,J., Cui,Y., Zhang,C., Wen,X., Li,J., Xiao,Y.,
            Peng,X., Liu,M., Shen,B., Sha,J., Hu,Z., Li,J. and Shu,W.
  TITLE     Single-cell RNA-Seq reveals a highly coordinated transcriptional
            program in mouse germ cells during primordial follicle formation
  JOURNAL   Aging Cell 20 (7), e13424 (2021)
   PUBMED   34174788
REFERENCE   3  (bases 1 to 3146)
  AUTHORS   Schenkova,K., Lutz,J., Kopp,M., Ramos,S. and Rivero,F.
  TITLE     MUF1/leucine-rich repeat containing 41 (LRRC41), a substrate of
            RhoBTB-dependent cullin 3 ubiquitin ligase complexes, is a
            predominantly nuclear dimeric protein
  JOURNAL   J Mol Biol 422 (5), 659-673 (2012)
   PUBMED   22709582
  REMARK    GeneRIF: The authors identified MUF1 as the first substrate for
            RhoBTB-Cul3 ubiquitin ligase complexes.
REFERENCE   4  (bases 1 to 3146)
  AUTHORS   Kamura,T., Maenaka,K., Kotoshiba,S., Matsumoto,M., Kohda,D.,
            Conaway,R.C., Conaway,J.W. and Nakayama,K.I.
  TITLE     VHL-box and SOCS-box domains determine binding specificity for
            Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases
  JOURNAL   Genes Dev 18 (24), 3055-3065 (2004)
   PUBMED   15601820
REFERENCE   5  (bases 1 to 3146)
  AUTHORS   Kile,B.T., Schulman,B.A., Alexander,W.S., Nicola,N.A., Martin,H.M.
            and Hilton,D.J.
  TITLE     The SOCS box: a tale of destruction and degradation
  JOURNAL   Trends Biochem Sci 27 (5), 235-241 (2002)
   PUBMED   12076535
  REMARK    Review article
REFERENCE   6  (bases 1 to 3146)
  AUTHORS   Kamura,T., Burian,D., Yan,Q., Schmidt,S.L., Lane,W.S., Querido,E.,
            Branton,P.E., Shilatifard,A., Conaway,R.C. and Conaway,J.W.
  TITLE     Muf1, a novel Elongin BC-interacting leucine-rich repeat protein
            that can assemble with Cul5 and Rbx1 to reconstitute a ubiquitin
            ligase
  JOURNAL   J Biol Chem 276 (32), 29748-29753 (2001)
   PUBMED   11384984
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY033356.1, BB619031.1, AK052762.1 and BQ032399.1.
            
            On May 8, 2015 this sequence version replaced NM_153521.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK154613.1, BC022976.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-105               BY033356.1         3-107
            106-275             BB619031.1         25-194
            276-2712            AK052762.1         2-2438
            2713-3146           BQ032399.1         1-434               c
FEATURES             Location/Qualifiers
     source          1..3146
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 53.1 cM"
     gene            1..3146
                     /gene="Lrrc41"
                     /gene_synonym="D630045E04Rik; D730026A16Rik; MUF1"
                     /note="leucine rich repeat containing 41"
                     /db_xref="GeneID:230654"
                     /db_xref="MGI:MGI:2441984"
     exon            1..339
                     /gene="Lrrc41"
                     /gene_synonym="D630045E04Rik; D730026A16Rik; MUF1"
                     /inference="alignment:Splign:2.1.0"
     exon            340..426
                     /gene="Lrrc41"
                     /gene_synonym="D630045E04Rik; D730026A16Rik; MUF1"
                     /inference="alignment:Splign:2.1.0"
     exon            427..497
                     /gene="Lrrc41"
                     /gene_synonym="D630045E04Rik; D730026A16Rik; MUF1"
                     /inference="alignment:Splign:2.1.0"
     exon            498..1620
                     /gene="Lrrc41"
                     /gene_synonym="D630045E04Rik; D730026A16Rik; MUF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1621..1881
                     /gene="Lrrc41"
                     /gene_synonym="D630045E04Rik; D730026A16Rik; MUF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1882..2046
                     /gene="Lrrc41"
                     /gene_synonym="D630045E04Rik; D730026A16Rik; MUF1"
                     /inference="alignment:Splign:2.1.0"
     exon            2047..2145
                     /gene="Lrrc41"
                     /gene_synonym="D630045E04Rik; D730026A16Rik; MUF1"
                     /inference="alignment:Splign:2.1.0"
     exon            2146..2268
                     /gene="Lrrc41"
                     /gene_synonym="D630045E04Rik; D730026A16Rik; MUF1"
                     /inference="alignment:Splign:2.1.0"
     exon            2269..2344
                     /gene="Lrrc41"
                     /gene_synonym="D630045E04Rik; D730026A16Rik; MUF1"
                     /inference="alignment:Splign:2.1.0"
     exon            2345..3131
                     /gene="Lrrc41"
                     /gene_synonym="D630045E04Rik; D730026A16Rik; MUF1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3044..3049
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lrrc41"
                     /gene_synonym="D630045E04Rik; D730026A16Rik; MUF1"
                     /note="hexamer: AATAAA"
     polyA_site      3065
                     /gene="Lrrc41"
                     /gene_synonym="D630045E04Rik; D730026A16Rik; MUF1"
                     /note="major polyA site"
     regulatory      3097..3102
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lrrc41"
                     /gene_synonym="D630045E04Rik; D730026A16Rik; MUF1"
                     /note="hexamer: AATAAA"
     polyA_site      3130
                     /gene="Lrrc41"
                     /gene_synonym="D630045E04Rik; D730026A16Rik; MUF1"
ORIGIN      
        1 agtcatctgc tcctctgttt gacgatcttt taatgttgtt tctgttcttc cccatatccc
       61 ttatggagcg gtcctaaaag ctgacctctt caagatggcg gcccgcgggt gtcattctcg
      121 ggctcgcgca cctccccaag atggcggcgc ccgaggcctg gcgcgcccgg agttgctggt
      181 tctgtgaggt agcggcagca acgaccatgg aggccacgtc ccgggaggcg gcgccagcga
      241 agagctcggc ctcgggcccc agcgctcccc ccgccctgtt cgagctgtgc gggcgggcag
      301 tgagcgccca tatgggggtt ctggagagcg gggtgtgggc cctcccaggc ccaatacttc
      361 aaagcatctt acctctgctc aatatatatt acttggagag gattgaggaa actgctctca
      421 aaaaaggtct ctctactcaa gccatctggc gccgactctg ggatgaactg atgaagacaa
      481 ggccttccag tttggagagt gtgacttgct ggcgagccaa gtttatggag gccttttttt
      541 cccatgttct acgtggaacc attgatgtgt cttctgataa acgtctttgt gatcagcgct
      601 tctcacctct cctgcacagc tcccgtcatg tccgacagct aaccatctgc aacatgctgc
      661 agggagcaac tgagctagtg gcagagccca accgtagggt tctagagacc ctggccagtt
      721 ctctgcatac cctcaagttc cgccacctgc tgttctctga tgtggctgct cagcagtcac
      781 ttcgacagct gctgcatcag ctcatccacc atggggctgt tagccaagtg tcgctgtact
      841 cctggcctgt gcccgagtca gcccttttca tccttattct taccatgagt gctggctttt
      901 ggcaaccagg cccaggtagc ttgccttgcc gcctctgtgg tgaagcctcc cgaggccggg
      961 ccccatctag agatgaaggg tccttattgc taggctctcg caggcctcgg cgtgatgcag
     1021 cagagcgatg tgctgctgca ctaatggcca cccggcggaa gagtgaagtc aagcagatgc
     1081 ccagggctgt acctcccact cgtgtaacac gccgcagcac acaagagagc ctggcaatag
     1141 gtggaacaga ctctaagttg tacctcccag ccacctctta tgaggcttct ggcacaaaac
     1201 agccatctgc tccagctgca gcctctgcct cctcttccac atcatccaaa cgggctccag
     1261 ctagctcagc ctcacagcct aagcccttaa agcgtttcaa acgagctgca gggaagaaag
     1321 ggccccgcac ccgtcagggg tctggtgcag agtctgaaga cctgtatgac tttgttttta
     1381 ttgtggctgg tgagaaggag gatggtgaag agatggagat tggggaagta gcttgtggag
     1441 ctctggatgg gtcagatccc agctgtttgg ggctcccagc actagaggca tcccagcgat
     1501 tccgcagcat ttccaccttg gagctattca cagttcctct ctccacggag gcagctctga
     1561 cactgtgcca tcttctgagt tcctgggtat cactggagag ccttacactt tcctacaatg
     1621 gtctgggctc taatatcttc cgcctcctgg acagcctacg ggccctgtca ggccaggctg
     1681 gatgtcgcct ccgtgccctg catctcagtg accttttctc accactgccc atcctggaat
     1741 tgacccgtgc cattgtgcga gccttgcccc tgttgcgggt cctgtctatt cgtgttgacc
     1801 acccaagcca gagggacaac cctgctgtac cagagaatgc tgggccccct ggacacatag
     1861 ttggggatga agaaatacca gaaaactgcc tcgagcagtt ggaaatggga tttccacgag
     1921 gagcccagcc agccccactg ctctgctctg tcctcaaggc ctcaggttct ctacagcagc
     1981 tgtcactgga cagtgccacc tttgcctcgc ctcaagattt tgggcttgtg ttgcaaacac
     2041 tcaaagaaca caacctatcc ctgaagaggc tgagcttcca tgatatgaat cttgcagact
     2101 gtcagagtga agtgcttttt ttgctaaaga atctgaccct tcaagagatt accttctcct
     2161 tctgccgtct gtttgagaag cgcccagtcc aatttcttcc tgagatggtt gctgctatga
     2221 agggcaactc tacactgaag ggccttcgac taccagggaa ccgcctgggg aacgctggcc
     2281 tattagccct agcagatgtt ttctcagagg attcttcctc ttctctctgt cagctggaca
     2341 tcagttccaa ctgcatcaag ccagatgggc ttttggagtt tgccaaacga ctggagcgct
     2401 ggggccgagg agcctttggt cacctacgcc tcttccagaa ctggctggac caggatgcag
     2461 tcacagcaag agaagcaatc cggcgactcc gggctacctg ccacgtggtt agcgactcat
     2521 gggactcaac ccaggccttt gcagattatg tcagcaccat gtgatggggc ccatacctca
     2581 caggcccatc ctcagtacca tcagcttgca gggactgagc cgtgggctgc ccagaatccc
     2641 caaccactga ttctgtcatc ctctttctgc cactttgtct atttctgttt ccttttcatc
     2701 ttcccttgca ctgaggtcct ggaggccttg atgaggccca gcaaaggcat tcccaccgct
     2761 gagttcagag gctttgggcc acttactcag tactctggga accccaggcc aggaggttac
     2821 gggtctctat cgtcactgag gaaaacaccc cctacccctg ctctggggtt tcctgcttca
     2881 ttcctcaagc aggcacccag gctttagaga agtataggaa tgcctaacac caggcctctt
     2941 ccctcctggg cttaccaatg tgttcccagg cctcagtccc tttcatgcct ttattccttt
     3001 ctttttcttt ttttttttta aaccaaaaaa gtttttctta taaaataaat tttgggcaaa
     3061 catcatgcag cccttcttga tgattttctc ccagagaata aaactgagca gagcctcatg
     3121 aggcagagaa caaaaaaaaa aaaaaa
//
