LOCUS       NM_138682               3636 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus leucine rich repeat containing 4 (Lrrc4), mRNA.
ACCESSION   NM_138682
VERSION     NM_138682.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3636)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3636)
  AUTHORS   Zhang,Y., Li,D., Zeng,Q., Feng,J., Fu,H., Luo,Z., Xiao,B., Yang,H.
            and Wu,M.
  TITLE     LRRC4 functions as a neuron-protective role in experimental
            autoimmune encephalomyelitis
  JOURNAL   Mol Med 27 (1), 44 (2021)
   PUBMED   33932995
  REMARK    GeneRIF: LRRC4 functions as a neuron-protective role in
            experimental autoimmune encephalomyelitis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3636)
  AUTHORS   Feng,J., Zhang,Y., Ren,X., Li,D., Fu,H., Liu,C., Zhou,W., Liu,Q.,
            Liu,Q. and Wu,M.
  TITLE     Leucine-rich repeat containing 4 act as an autophagy inhibitor that
            restores sensitivity of glioblastoma to temozolomide
  JOURNAL   Oncogene 39 (23), 4551-4566 (2020)
   PUBMED   32372061
  REMARK    GeneRIF: Leucine-rich repeat containing 4 act as an autophagy
            inhibitor that restores sensitivity of glioblastoma to
            temozolomide.
REFERENCE   4  (bases 1 to 3636)
  AUTHORS   Choi,Y., Park,H., Kang,S., Jung,H., Kweon,H., Kim,S., Choi,I.,
            Lee,S.Y., Choi,Y.E., Lee,S.H. and Kim,E.
  TITLE     NGL-1/LRRC4C-Mutant Mice Display Hyperactivity and Anxiolytic-Like
            Behavior Associated With Widespread Suppression of Neuronal
            Activity
  JOURNAL   Front Mol Neurosci 12, 250 (2019)
   PUBMED   31680855
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3636)
  AUTHORS   Um,S.M., Ha,S., Lee,H., Kim,J., Kim,K., Shin,W., Cho,Y.S.,
            Roh,J.D., Kang,J., Yoo,T., Noh,Y.W., Choi,Y., Bae,Y.C. and Kim,E.
  TITLE     NGL-2 Deletion Leads to Autistic-like Behaviors Responsive to NMDAR
            Modulation
  JOURNAL   Cell Rep 23 (13), 3839-3851 (2018)
   PUBMED   29949768
  REMARK    GeneRIF: Mice lacking NGL-2 (Lrrc4(-/-) mice) show suppressed
            N-Methyl-D-aspartate receptor (NMDAR)-dependent synaptic plasticity
            in the hippocampus. NGL-2 associates with NMDARs through both
            PSD-95-dependent and -independent mechanisms.
REFERENCE   6  (bases 1 to 3636)
  AUTHORS   Yoshida,Y., Han,B., Mendelsohn,M. and Jessell,T.M.
  TITLE     PlexinA1 signaling directs the segregation of proprioceptive
            sensory axons in the developing spinal cord
  JOURNAL   Neuron 52 (5), 775-788 (2006)
   PUBMED   17145500
REFERENCE   7  (bases 1 to 3636)
  AUTHORS   Kim,S., Burette,A., Chung,H.S., Kwon,S.K., Woo,J., Lee,H.W.,
            Kim,K., Kim,H., Weinberg,R.J. and Kim,E.
  TITLE     NGL family PSD-95-interacting adhesion molecules regulate
            excitatory synapse formation
  JOURNAL   Nat Neurosci 9 (10), 1294-1301 (2006)
   PUBMED   16980967
REFERENCE   8  (bases 1 to 3636)
  AUTHORS   Zhang,Q.H., Wang,L.L., Cao,L., Peng,C., Li,X.L., Tang,K., Li,W.F.,
            Liao,P., Wang,J.R. and Li,G.Y.
  TITLE     Study of a novel brain relatively specific gene LRRC4 involved in
            glioma tumorigenesis suppression using the Tet-on system
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 37 (8), 532-540 (2005)
   PUBMED   16077900
  REMARK    GeneRIF: Together, these findings provide clues to the function of
            LRRC4 as a negative regulator of cell growth and underscore a link
            between the above-mentioned cyclins, cyclin-associated molecules
            and tumorigenicity.
REFERENCE   9  (bases 1 to 3636)
  AUTHORS   Zhang,Q., Wang,J., Fan,S., Wang,L., Cao,L., Tang,K., Peng,C.,
            Li,Z., Li,W., Gan,K., Liu,Z., Li,X., Shen,S. and Li,G.
  TITLE     Expression and functional characterization of LRRC4, a novel
            brain-specific member of the LRR superfamily
  JOURNAL   FEBS Lett 579 (17), 3674-3682 (2005)
   PUBMED   15967442
  REMARK    GeneRIF: LRRC4 may play an important role in maintaining normal
            function and suppressing tumorigenesis in the central nervous
            system.
REFERENCE   10 (bases 1 to 3636)
  AUTHORS   Lin,J.C., Ho,W.H., Gurney,A. and Rosenthal,A.
  TITLE     The netrin-G1 ligand NGL-1 promotes the outgrowth of
            thalamocortical axons
  JOURNAL   Nat Neurosci 6 (12), 1270-1276 (2003)
   PUBMED   14595443
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC068662.5 and BE945283.1.
            
            On Jan 31, 2007 this sequence version replaced NM_138682.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: DQ177325.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3548              AC068662.5         84850-88397         c
            3549-3636           BE945283.1         1-88                c
FEATURES             Location/Qualifiers
     source          1..3636
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 12.05 cM"
     gene            1..3636
                     /gene="Lrrc4"
                     /gene_synonym="MBAG1; Nag14; NGL-2; NGL2; NLG-2"
                     /note="leucine rich repeat containing 4"
                     /db_xref="GeneID:192198"
                     /db_xref="MGI:MGI:2182081"
     exon            1..3622
                     /gene="Lrrc4"
                     /gene_synonym="MBAG1; Nag14; NGL-2; NGL2; NLG-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             134..2092
                     /gene="Lrrc4"
                     /gene_synonym="MBAG1; Nag14; NGL-2; NGL2; NLG-2"
                     /note="leucine-rich repeat-containing protein 4; LIBG-like
                     protein; netrin-G2 ligand; brain tumor-associated protein
                     MBAG1; LRRC4-like protein"
                     /codon_start=1
                     /product="leucine-rich repeat-containing protein 4
                     precursor"
                     /protein_id="NP_619623.2"
                     /db_xref="CCDS:CCDS39448.1"
                     /db_xref="GeneID:192198"
                     /db_xref="MGI:MGI:2182081"
                     /translation="MKLLWQVTVHHTWNAVLLPVVYLTAQVWILCAAIAAAASAGPQN
                     CPSVCSCSNQFSKVVCTRRGLSEVPQGIPSNTRYLNLMENNIQMIQADTFRHLHHLEV
                     LQLGRNSIRQIEVGAFNGLASLNTLELFDNWLTVIPSGAFEYLSKLRELWLRNNPIES
                     IPSYAFNRVPSLMRLDLGELKKLEYISEGAFEGLFNLKYLNLGMCNIKDMPNLTPLVG
                     LEELEMSGNHFPEIRPGSFHGLSSLKKLWVMNSQVSLIERNAFDGLASLVELNLAHNN
                     LSSLPHDLFTPLRYLVELHLHHNPWNCDCDILWLAWWLREYIPTNSTCCGRCHAPMHM
                     RGRYLVEVDQAAFQCSAPFIMDAPRDLNISEDRMAELKCRTPPMSSVKWLLPNGTVLS
                     HASRHPRISVLNDGTLNFSRVLLIDTGVYTCMVTNVAGNSNASAYLNVSSAELNTPNF
                     SFFTTVTVETTEISPEDITRKYKPVPTTSTGYQPAYTTSTTVLIQTTRVPKQVPVPST
                     DTTDKMQTSLDEVMKTTKIIIGCFVAVTLLAAAMLIVFYKLRKRHQQRSTVTAARTVE
                     IIQVDEDIPAAAPAAATAAPSGVSGEGAVVLPTIHDHINYNTYKPAHGAHWTENSLGN
                     SLHPTVTTISEPYIIQTHTKDKVQETQI"
     regulatory      3595..3600
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lrrc4"
                     /gene_synonym="MBAG1; Nag14; NGL-2; NGL2; NLG-2"
                     /note="hexamer: AATAAA"
     polyA_site      3617
                     /gene="Lrrc4"
                     /gene_synonym="MBAG1; Nag14; NGL-2; NGL2; NLG-2"
                     /note="major polyA site"
ORIGIN      
        1 ctctaatcgc cccctcccca cctccttctc cagatggaaa gaggagctcc tagctcactt
       61 aagccggggt aaggctggtt ctcttttcca agccaaaatc ccaggcgatg gtgaattatg
      121 aacgtgccac accatgaagc tcttgtggca ggtaactgtg caccacacct ggaatgccgt
      181 cctgcttccc gtcgtctacc tcacggcgca agtgtggatt ctgtgtgcag ccatcgctgc
      241 tgccgcttca gccgggcccc aaaactgccc ctccgtctgt tcctgcagta accagttcag
      301 caaggtggtg tgcacccgcc ggggactctc tgaggtccca cagggtattc cttccaacac
      361 ccggtatctc aacctcatgg aaaacaacat ccagatgatt caggccgaca ccttcaggca
      421 cctccatcac ctggaggtcc tgcagctggg caggaactcc atcaggcaga tagaggtggg
      481 ggccttcaat ggcctcgcca gtctcaacac tctggaactg ttcgacaact ggctgacagt
      541 catccccagt ggggcctttg agtacctgtc caaactgcgg gagctctggc tgcgaaacaa
      601 tcccattgag agcatccctt cttatgcctt caaccgggtg ccctccctca tgcgtctgga
      661 cttgggggaa ctcaagaagc tggagtatat ctctgagggg gcttttgagg ggctgttcaa
      721 cctcaagtac ctgaacttgg gcatgtgcaa cattaaggat atgcccaatc ttacacccct
      781 ggtggggctc gaggagcttg agatgtcagg gaaccacttt cctgagatca ggcctgggtc
      841 cttccatggc ctaagctccc tcaaaaaact gtgggtgatg aactcacagg tcagcctgat
      901 tgagcggaat gcttttgacg gactggcttc cctcgtggaa ctcaacttag cccacaataa
      961 cctctcatct ttgccccatg acctcttcac acccctgaga tacctggtgg agttgcacct
     1021 acaccacaat ccttggaact gtgattgtga tattctgtgg ctggcttggt ggcttcggga
     1081 gtatatccca accaattcca cctgctgtgg ccgctgtcat gctcccatgc acatgcgagg
     1141 ccgctacctg gtagaggtgg accaggctgc ctttcagtgc tctgcccctt tcatcatgga
     1201 tgcaccccgg gacctcaata tctctgagga tcggatggca gaactgaagt gtcggactcc
     1261 ccctatgtcc tctgtgaagt ggttgctgcc caatgggaca gtgctcagcc acgcctcccg
     1321 gcatccccgg atctctgttc tcaatgatgg caccttgaac ttttctcgtg tgctgctcat
     1381 agacactgga gtatacacat gcatggtgac caatgtggca ggcaactcca atgcctcggc
     1441 ctacctcaat gtgagctcgg ccgagctcaa cacccccaac ttcagcttct tcaccactgt
     1501 aacagtggaa accacagaga tatcacctga ggacataaca cggaagtaca agcctgttcc
     1561 caccacatcc actggttacc agccggcata taccacctct accacggtgc tcattcagac
     1621 cacccgtgtg cccaagcagg tgccagtacc ctccacagat accactgaca agatgcagac
     1681 cagcctggat gaagtcatga agaccaccaa gatcatcatt ggctgctttg tggcagtgac
     1741 tctcctagct gctgccatgt tgattgtctt ctataaactt cgcaagcggc accagcagcg
     1801 gagtacagtc acagctgcca ggacagtaga gattatccag gtggatgaag acatcccagc
     1861 agcagcacct gcagcagcaa cagcagctcc gtccggtgta tcaggtgagg gggcagtagt
     1921 gttgcccaca atacatgacc atattaacta caacacctac aaaccagcac atggggccca
     1981 ctggacagaa aacagcctgg ggaactctct gcaccccaca gtcaccacta tctctgaacc
     2041 ttatataatt cagacccata ccaaggacaa ggtacaggaa actcaaatat gactccccct
     2101 ccctcaaaaa cttataaaat gcaatagaat gcacaaaaaa gagcaacttt tgtacagagt
     2161 ggggagagac tttttcttgt atatgcttat atattaaatc tatgggctgg ttaaaaaaga
     2221 ttatattaaa atttaaaaac aaaaaaatga aaacaaaact attttctaac ttgtaagttc
     2281 tatttaaagg ggagggaagg ggttcttggc aatgttgtgg gtaggagcct caagtcaact
     2341 gctgtaaggt ggaaactgct aagacaaaac aaactaaaac aaccaacacc cctaaagtgg
     2401 cagggtgtgg gctgctgggg gcagggagga tagcctgcat ctgtcaattt ttagaagatg
     2461 ctttacagga tctaggaata ccatttctat agacaccttt cttaagctga gagctgtctt
     2521 tacagatcta tcttattaaa caaaataatt ttaaaaagca tcacaaattt gtactgtgcc
     2581 caaaggttga gcggtgattt tttttcccct acagagacaa tggggaagat agatctgtaa
     2641 atgtatttta agtaggaaaa ccaccaaaat tccaactaat ccttccagag gttgtttctt
     2701 tgtacgtgtg cgcaaatcct ctgggtttgt gccttcagac tggcatgtgt ctcccctgac
     2761 aatgcttcaa gacagcttgg aaggaaggga gctggcgtag ctctccatca aatgctttca
     2821 cattgcacca gattcctgca gttgggcata acccactctg caaggcatgt gtctattcag
     2881 ggtttcccgg gaggaggagg cggcctgaag ggggtgcggc cggcccagga ggaagggaag
     2941 cagagcagca gcagcagagg gaatgattca caggaggcca taaatcagca ttgtgcagtg
     3001 gccacctgtt gttccgggta tctgacaaat gattgtagac aatgatgaca ttttatgatt
     3061 tttcaaaaaa gatcttgctt gttttgaggt ggaaaggagg ataggctggg aatgggggga
     3121 acttggggga gtggaagctt ttctcttgct taggatttgg tgactattct aaatgctgat
     3181 tcattaggga ttattgcagc tgatgccaac tagttgtggt gatagagtga gtgggggcag
     3241 aacatgagta gagaggggaa ggagagctaa aaagggcaca ggctcaattt aaagaagcct
     3301 tcgccaacca ggatgttaca agaacactga caaggggaac acacaaatga gttgggcatg
     3361 aaattctgtt gaatgggcac cattggggga agcttccctc ccctaggcta cctccagtag
     3421 ttacaagcaa gggcaaggtc tcttattctg gtccatttaa tgatgtaact ttcagttatt
     3481 attttagctt taagagaaaa ttaagggttc agatttgaaa gggggtggta tgggtgggag
     3541 atgccaacaa aagaacactg attgtaatgt gagaaaagtg tatttttgta ttttaataaa
     3601 tattgttcaa tttttaattc aaaaaaaaaa aaaaaa
//
