LOCUS       NM_175413               3092 bp    mRNA    linear   ROD 09-JUN-2024
DEFINITION  Mus musculus leucine rich repeat containing 39 (Lrrc39), transcript
            variant 2, mRNA.
ACCESSION   NM_175413
VERSION     NM_175413.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3092)
  AUTHORS   Will,R.D., Eden,M., Just,S., Hansen,A., Eder,A., Frank,D., Kuhn,C.,
            Seeger,T.S., Oehl,U., Wiemann,S., Korn,B., Koegl,M., Rottbauer,W.,
            Eschenhagen,T., Katus,H.A. and Frey,N.
  TITLE     Myomasp/LRRC39, a heart- and muscle-specific protein, is a novel
            component of the sarcomeric M-band and is involved in stretch
            sensing
  JOURNAL   Circ Res 107 (10), 1253-1264 (2010)
   PUBMED   20847312
  REMARK    GeneRIF: Reveal myomasp/LRRC39 as a previously unrecognized
            component of an M-band-associated signaling pathway that regulates
            cardiomyocyte gene expression in response to biomechanical stress.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC025622.3 and AC131038.6.
            
            On Apr 10, 2020 this sequence version replaced NM_175413.3.
            
            Transcript Variant: This variant (2) encodes isoform 2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK052159.1, AK039277.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-141               AC025622.3         167259-167399
            142-332             AC025622.3         170006-170196
            333-438             AC025622.3         173035-173140
            439-595             AC025622.3         174275-174431
            596-732             AC025622.3         175114-175250
            733-878             AC025622.3         181695-181840
            879-1031            AC131038.6         31095-31247
            1032-1168           AC131038.6         32355-32491
            1169-3092           AC131038.6         34071-35994
FEATURES             Location/Qualifiers
     source          1..3092
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 50.39 cM"
     gene            1..3092
                     /gene="Lrrc39"
                     /gene_synonym="2010005E21Rik; 9430028I06Rik; Myomasp"
                     /note="leucine rich repeat containing 39"
                     /db_xref="GeneID:109245"
                     /db_xref="MGI:MGI:1924557"
     exon            1..141
                     /gene="Lrrc39"
                     /gene_synonym="2010005E21Rik; 9430028I06Rik; Myomasp"
                     /inference="alignment:Splign:2.1.0"
     exon            142..332
                     /gene="Lrrc39"
                     /gene_synonym="2010005E21Rik; 9430028I06Rik; Myomasp"
                     /inference="alignment:Splign:2.1.0"
     CDS             220..1233
                     /gene="Lrrc39"
                     /gene_synonym="2010005E21Rik; 9430028I06Rik; Myomasp"
                     /note="isoform 2 is encoded by transcript variant 2;
                     leucine-rich repeat-containing protein 39;
                     myosin-interacting M-band-associated stress-responsive
                     protein"
                     /codon_start=1
                     /product="leucine-rich repeat-containing protein 39
                     isoform 2"
                     /protein_id="NP_780622.1"
                     /db_xref="CCDS:CCDS17788.1"
                     /db_xref="GeneID:109245"
                     /db_xref="MGI:MGI:1924557"
                     /translation="MTESAVCTGAVSAVKEVWEERIKKHHEDVKREKEFQHKLVRIWE
                     DRVSLTKLKEKVTREDGRVILRIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLKIPEFI
                     GRFQHLIVLDLSRNTISEIPRGIGLLTRLQELILSYNKIKTVPKELSNCTSLEKLELA
                     VNRDISDLPPELSKLLKLTHLDLSMNQFTTIPHAVLDMPALEWLDMGSNSLQQLPDSL
                     DRMRSLHTLWLQRNEITCLPETIKNMKNLGTLVLSNNKLQDIPGCMEEMTNLRFVNFR
                     DNPLRLEVTLPPSDNTDGEEEQELFGLQFMHAYIQESRRTEDQVNCLTQMPSSIHSDG
                     ESN"
     exon            333..438
                     /gene="Lrrc39"
                     /gene_synonym="2010005E21Rik; 9430028I06Rik; Myomasp"
                     /inference="alignment:Splign:2.1.0"
     exon            439..595
                     /gene="Lrrc39"
                     /gene_synonym="2010005E21Rik; 9430028I06Rik; Myomasp"
                     /inference="alignment:Splign:2.1.0"
     exon            596..732
                     /gene="Lrrc39"
                     /gene_synonym="2010005E21Rik; 9430028I06Rik; Myomasp"
                     /inference="alignment:Splign:2.1.0"
     exon            733..878
                     /gene="Lrrc39"
                     /gene_synonym="2010005E21Rik; 9430028I06Rik; Myomasp"
                     /inference="alignment:Splign:2.1.0"
     exon            879..1031
                     /gene="Lrrc39"
                     /gene_synonym="2010005E21Rik; 9430028I06Rik; Myomasp"
                     /inference="alignment:Splign:2.1.0"
     exon            1032..1168
                     /gene="Lrrc39"
                     /gene_synonym="2010005E21Rik; 9430028I06Rik; Myomasp"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..3092
                     /gene="Lrrc39"
                     /gene_synonym="2010005E21Rik; 9430028I06Rik; Myomasp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1293..1298
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lrrc39"
                     /gene_synonym="2010005E21Rik; 9430028I06Rik; Myomasp"
                     /note="hexamer: AATATA"
     regulatory      1306..1311
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lrrc39"
                     /gene_synonym="2010005E21Rik; 9430028I06Rik; Myomasp"
                     /note="hexamer: AATAAT"
     polyA_site      1310
                     /gene="Lrrc39"
                     /gene_synonym="2010005E21Rik; 9430028I06Rik; Myomasp"
                     /note="major polyA site"
     polyA_site      1339
                     /gene="Lrrc39"
                     /gene_synonym="2010005E21Rik; 9430028I06Rik; Myomasp"
     regulatory      2130..2135
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lrrc39"
                     /gene_synonym="2010005E21Rik; 9430028I06Rik; Myomasp"
                     /note="hexamer: AATGAA"
     polyA_site      2150
                     /gene="Lrrc39"
                     /gene_synonym="2010005E21Rik; 9430028I06Rik; Myomasp"
     regulatory      3065..3070
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lrrc39"
                     /gene_synonym="2010005E21Rik; 9430028I06Rik; Myomasp"
                     /note="hexamer: AATAAA"
     polyA_site      3092
                     /gene="Lrrc39"
                     /gene_synonym="2010005E21Rik; 9430028I06Rik; Myomasp"
ORIGIN      
        1 gacatgactt ttcacttggt cacagcccga cagagtttta gtcatttgga gccacactgg
       61 gggaaaaaaa aatcaccttg gatctgattc tagctgagaa tcagggagct ctgggcatgt
      121 tggctgcagc aaccccctat ggtctttact gaggtgtcct gtgactcagc tcttcagaac
      181 gtaatgaagt agatgacttg actacaatgt gggaaaatca tgacagaaag tgcggtttgt
      241 accggggccg tcagtgctgt aaaggaagtc tgggaagaaa gaataaagaa acaccatgaa
      301 gacgtgaagc gggagaagga atttcagcat aagctagtgc ggatctggga agaccgagta
      361 agtttaacta agctgaaaga gaaggtgacc agggaagatg gaagagtcat tttaaggata
      421 gagaaagaag aatggaagac tctcccttct tctttactga aactgaatca gctacaggaa
      481 tggcaacttc acaggaccgg attgttgaag attcctgaat tcattggaag attccagcat
      541 ctcattgtgc tagatttatc tcggaacaca atttcagaga tcccccgagg gattggactg
      601 ctcactagac ttcaggaact gattcttagc tacaacaaaa tcaagactgt ccccaaagaa
      661 ctgagcaact gtaccagctt ggagaagcta gaactggctg tgaacagaga tataagtgac
      721 ctcccaccag agctcagcaa actgttaaaa ctcactcacc ttgacctgag tatgaatcag
      781 ttcactacga tccctcatgc tgtgttggac atgcctgccc tcgagtggct ggatatggga
      841 agcaacagcc tgcaacagct tcctgactca ctagacagaa tgcgaagttt acatacactg
      901 tggctgcaga ggaatgaaat aacatgcctg ccagagacaa tcaaaaatat gaaaaacttg
      961 ggtactcttg ttctcagcaa caacaaacta caagatatcc caggctgcat ggaagaaatg
     1021 acgaatctga ggtttgtcaa cttccgagac aacccactaa gactggaggt gacgcttcct
     1081 cccagcgaca acacagatgg agaggaagaa caggagttat ttgggctgca gtttatgcac
     1141 gcatacatac aagagtcccg gagaacagaa gaccaagtca actgtctgac tcaaatgcca
     1201 agctctatac attctgatgg agaaagtaat tgaaagagcc ctgctgaaaa ggaatacttt
     1261 gactacttgg tgaatatttt tgtgaatatc gaaatataat ttaaaaataa tttaaatttt
     1321 tttgtttgtg gaagacaaac gtcacgttca tgtttccttt cattgatgat gtttttcctg
     1381 cgatgacgga tgagctggta cggcagttaa taatacgttt tccagagaca ccaatgggtc
     1441 cgtatagtac tgtaaggcag gactgaagcc tttctgctgt aaatactgga gtctgccttg
     1501 gtcaatcagc agtttacaaa gatgtcctat tttcttcttt tcttcaacag taagaatcct
     1561 acatggaata agcacacaaa aatttaaagt ttggtaaaag ttcataccaa gtttggccac
     1621 tgccatttac gaagctgcta actagccaac agcacgtact aggcgctatg tctgatgctt
     1681 ctaagacgcc ttttcttctt tttaagattt atttatttat tttgtttata tgaataactg
     1741 tcttcagaca caccagaaga gggcatcaga tcccattaca gatggttgtg agccaccatg
     1801 tgcttgctgg gaattgaact cagaaactct ggatgaccag tcggtgctct tgaccactga
     1861 gtcatctctc cagccccatc taagactttt ctttatgatc acaattaaaa tatgttttag
     1921 tttattctaa aattagaatg taagctatat tttctaaatt tttgataaca gtcatctaag
     1981 gaaaaaaaaa aagaatcctt ctccttcagt tttactttgt atacttgatc tcagccaaaa
     2041 gactaagaaa caaccattcg gttttatttg ctatggtttc tcctggccaa ggtcaatcag
     2101 tgtgaaaata ttcaatggaa aattctgaaa atgaaccatt ggtagtggca ttctgagtag
     2161 catggtgaat catgggccac ccactccttc ctatccgggg aatgaacctg tgcctcacac
     2221 atgagcatcc ttagcacagc cacaccgtgc tgcccacttg ctagacgttg tgcagccatc
     2281 ttgactacca gatggacaga gtaggtaagt gcaatgctag tgtgtggggt tctgttttat
     2341 ctacggttcg aggcatctgt gcagtctcac ccacaggagg actagtttac ggggataaag
     2401 tatctccctg tagcatggtg tttgtagctg tcgtcactta cccaggcaaa ctgtcagtgt
     2461 tgccatctgt gagtctgtct cctccatcat cgtgctcttc attctcatcc ctttgagcat
     2521 cttttctctc tggagtaaca tccgagcctt ccaacgatgt cctcattcca cacgttgccc
     2581 aactactcat tctctggaaa tagtagaact ctaccgcccc aagtccaaga gccttgaaat
     2641 actctttgcc cacataatgt ctccagtcac acctgtggtg acaacagagc gcaatcacaa
     2701 tgccagccac cggggtccat gtctctggga catctttttc acttccttcc ttggccaaag
     2761 tgttactttc tttttctgtc ttatcattct ttatgcgttt ggctaaaggt tcttcatcct
     2821 tttcctcaaa actggcagca taggtttcaa ccaaacatcg taatgcaaca tctgcaaaca
     2881 caatcatgtg cccccaccaa accgcatcat ctttaaagtt cagtaagcag tatggctagt
     2941 gcaaaacatt cttaacacac aaaccagcaa aaatctactt agctatatac tgtaacaatt
     3001 ctaccagata ttatacattt ttctcaaatt ttccatctta atttttctag tgatttattt
     3061 gcccaataaa attattttaa ataaaattaa aa
//
