LOCUS       NM_001170788            2431 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus leucine rich repeat containing 36 (Lrrc36), transcript
            variant 1, mRNA.
ACCESSION   NM_001170788
VERSION     NM_001170788.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2431)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2431)
  AUTHORS   Miyata,H., Castaneda,J.M., Fujihara,Y., Yu,Z., Archambeault,D.R.,
            Isotani,A., Kiyozumi,D., Kriseman,M.L., Mashiko,D., Matsumura,T.,
            Matzuk,R.M., Mori,M., Noda,T., Oji,A., Okabe,M.,
            Prunskaite-Hyyrylainen,R., Ramirez-Solis,R., Satouh,Y., Zhang,Q.,
            Ikawa,M. and Matzuk,M.M.
  TITLE     Genome engineering uncovers 54 evolutionarily conserved and
            testis-enriched genes that are not required for male fertility in
            mice
  JOURNAL   Proc Natl Acad Sci U S A 113 (28), 7704-7710 (2016)
   PUBMED   27357688
REFERENCE   3  (bases 1 to 2431)
  AUTHORS   Stowe,T.R., Wilkinson,C.J., Iqbal,A. and Stearns,T.
  TITLE     The centriolar satellite proteins Cep72 and Cep290 interact and are
            required for recruitment of BBS proteins to the cilium
  JOURNAL   Mol Biol Cell 23 (17), 3322-3335 (2012)
   PUBMED   22767577
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY084860.1, AC090480.11, BC172120.1 and BC036564.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849384
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-345               BY084860.1         2-346
            346-410             AC090480.11        67774-67838         c
            411-2369            BC172120.1         80-2038
            2370-2431           BC036564.1         1658-1719
FEATURES             Location/Qualifiers
     source          1..2431
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 53.04 cM"
     gene            1..2431
                     /gene="Lrrc36"
                     /note="leucine rich repeat containing 36"
                     /db_xref="GeneID:270091"
                     /db_xref="MGI:MGI:2448585"
     exon            1..89
                     /gene="Lrrc36"
                     /inference="alignment:Splign:2.1.0"
     CDS             20..2293
                     /gene="Lrrc36"
                     /note="isoform 1 is encoded by transcript variant 1;
                     leucine-rich repeat-containing protein 36"
                     /codon_start=1
                     /product="leucine-rich repeat-containing protein 36
                     isoform 1"
                     /protein_id="NP_001164259.1"
                     /db_xref="CCDS:CCDS52658.1"
                     /db_xref="GeneID:270091"
                     /db_xref="MGI:MGI:2448585"
                     /translation="MAEQWDLDEECLRRLGALTLEQPELVESLSLQGSYAGKIHSIGD
                     AFRNFKSLRSLDLSRNLITSLKGIQYLCSLQELNLYYNNIPSLVEVSRLQPLPFLKEL
                     DLRLNPVVRKDTDYRLFAVYTLQTLEKLDDRAVRDSERRAAKLHFSQLGNSENFLLEV
                     EKSSREKTMKNCVTDEGPASHVSPEVDARMETDANKGLFIPFPNREIKDSLTSICAAQ
                     GSGTPAQKLDVFPLGTQMQEATRRETSDLHQEDGLELRLYPPPQSTVRSPEKMTRDGY
                     RVSFLDTKSSGSSPEKDLIPKPDAYPCTHDASLGKRLDVGDSNQILPCQLPSEVCLDH
                     YGNQYSQTLCLHGSLVKRAQKGKNYREHSIKPSQDKKATTSHPCGDLLTSLSNPDSST
                     GRLLRLSSDLYATTHFNSDPALLANVEQQLSSLRDFTPAPGSFPSSPALGNSLRTLLL
                     PPGTPENREIPTKRSLSPSRRGFKRKDGILANPSLKRGFQDATGSEAQPLSSDLGSLH
                     GLSGNHSPPISARTPHVATVLRQLLELVDKHWNGSGSLLLDKKFLGPARDLLLSLVVP
                     APSQQWRRSKLDDKAGKALCWRETELKEAGLLVPNDVESLKQKLVKVLEENLVLSEKI
                     QQLEGTAATSIVSGHPSHTHDELLRKNQQLTIQVACLTQELTQLKRLEETVALLHESQ
                     RSLVVTNEYLLQQLHKEQKGYSGKSLLPPEKSHPLGRSSPFGKSTLSSSSPMVHDTGQ
                     YLIQSVSEADPEPSLWS"
     exon            90..217
                     /gene="Lrrc36"
                     /inference="alignment:Splign:2.1.0"
     exon            218..410
                     /gene="Lrrc36"
                     /inference="alignment:Splign:2.1.0"
     exon            411..507
                     /gene="Lrrc36"
                     /inference="alignment:Splign:2.1.0"
     exon            508..596
                     /gene="Lrrc36"
                     /inference="alignment:Splign:2.1.0"
     exon            597..724
                     /gene="Lrrc36"
                     /inference="alignment:Splign:2.1.0"
     exon            725..773
                     /gene="Lrrc36"
                     /inference="alignment:Splign:2.1.0"
     exon            774..1220
                     /gene="Lrrc36"
                     /inference="alignment:Splign:2.1.0"
     exon            1221..1513
                     /gene="Lrrc36"
                     /inference="alignment:Splign:2.1.0"
     exon            1514..1679
                     /gene="Lrrc36"
                     /inference="alignment:Splign:2.1.0"
     exon            1680..1828
                     /gene="Lrrc36"
                     /inference="alignment:Splign:2.1.0"
     exon            1829..1952
                     /gene="Lrrc36"
                     /inference="alignment:Splign:2.1.0"
     exon            1953..2067
                     /gene="Lrrc36"
                     /inference="alignment:Splign:2.1.0"
     exon            2068..2411
                     /gene="Lrrc36"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2386..2391
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lrrc36"
                     /note="hexamer: AAGAAA"
     polyA_site      2406
                     /gene="Lrrc36"
                     /note="major polyA site"
ORIGIN      
        1 aggtgagcgg cgggcgcgaa tggcggagca gtgggatctg gacgaggagt gcctccgccg
       61 cctgggggcg ctgaccctgg agcagccgga actggtggag tctctctcat tgcagggatc
      121 ttatgccgga aaaatccact ctattggtga tgccttcaga aatttcaaaa gtctccgatc
      181 cttagattta tcaaggaatt tgatcactag tctaaaggga atccagtatt tatgctcact
      241 ccaagagctg aacttatatt ataacaacat tccttcatta gtggaggtgt cccgactaca
      301 gcccttaccc ttcctcaaag aactagattt gagactcaat cctgttgtaa ggaaagatac
      361 agattatagg ctctttgccg tgtacacgct gcaaacgctg gaaaaactgg atgaccgagc
      421 cgtccgtgac agcgagagga gagcggccaa gctacatttc agtcagttgg gcaacagtga
      481 aaattttctc ttagaggtgg aaaaaagctc tagggagaag acaatgaaaa actgtgtgac
      541 agatgagggc cccgcgtcac acgtcagtcc tgaggttgat gccaggatgg aaacagacgc
      601 aaacaaagga ctttttattc ccttccccaa ccgggaaata aaggattccc taaccagcat
      661 ttgtgcagcc cagggcagtg gcacaccagc tcagaaatta gacgtttttc cgctggggac
      721 acagatgcag gaagcaacaa gaagggagac aagtgacctt caccaggaag atggattaga
      781 actcaggctc tacccgcctc ctcagagcac agtccgatct ccagagaaga tgacgagaga
      841 tggataccga gtgtctttcc tagacactaa gtcttcaggt tcttctccag aaaaggactt
      901 gataccaaaa cctgatgcct atccatgtac ccatgatgcc tccttgggta aacgcctgga
      961 tgtgggtgat tctaaccaga tccttccctg tcagttacct tctgaggttt gtctggacca
     1021 ctatggtaat caatattctc aaactctttg cctgcacgga agtcttgtca aaagggctca
     1081 gaagggcaag aactaccgag aacatagcat aaagccttca caggacaaaa aggccaccac
     1141 atcccatccc tgtggagact tactaacatc cctgtcaaac cccgactcca gcacgggaag
     1201 gctgctgagg cttagctcag atctctatgc cacaacccat ttcaacagtg accccgctct
     1261 gctggccaac gtggagcaac agctttccag cctccgtgac tttacaccag cacctggttc
     1321 tttcccaagc agccctgccc taggaaattc tctgcggaca ctgctgctgc ctcctgggac
     1381 tccagaaaac agggagattc cgactaagag gtcattaagc ccttcaagga gaggattcaa
     1441 gcggaaggac ggtatccttg ccaacccgag tctgaagcgt ggtttccaag atgctacagg
     1501 cagcgaggcg caacctctct ctagtgacct gggcagtttg catggtttat caggaaacca
     1561 cagtcctccg atctctgcca gaacccccca cgtggccact gtcctcagac agctcctgga
     1621 gctggtggac aagcactgga atggctctgg ctccctcctc ctggacaaga agtttctcgg
     1681 tcccgccaga gacttgctcc tgtcattggt ggtccctgca ccctctcagc agtggcggcg
     1741 ctcgaagctt gacgataagg cagggaaagc cttgtgctgg agggagaccg agctaaagga
     1801 agcagggctg ctagttccta acgatgtgga aagtctgaag caaaaactgg tcaaagtgct
     1861 ggaggaaaac cttgttctgt cagaaaaaat tcagcagttg gagggaaccg ctgccacctc
     1921 gattgtgagt gggcacccat cacacacaca cgatgagctt ctgcgcaaaa accaacagct
     1981 gaccatacag gtggcttgcc tgacccagga gctgactcag ctgaaaagac tggaggagac
     2041 agttgctctt ctccatgaga gtcagaggtc cctggtggta actaatgagt atctgctgca
     2101 gcagctgcat aaagagcaga aaggttattc cgggaaatct ctcctgcctc ccgagaagag
     2161 tcatcctttg gggagatcgt cgccctttgg gaaaagcacg ctgtcttcct cctcaccaat
     2221 ggtacacgac acgggtcagt acctaataca gagtgtctca gaagccgacc cagagcctag
     2281 tttgtggagc tagcaccgca gcccgcccca ccagctccct cgcccacgga ggacgctcag
     2341 ggccgctgtc cctgtggtgg gtactggtgt ttacccccaa agattaagaa aaacgtatta
     2401 tgatgacttt caaaaaaaaa aaaaaaaaaa a
//
