LOCUS       NP_001164259             757 aa            linear   ROD 10-FEB-2025
DEFINITION  leucine-rich repeat-containing protein 36 isoform 1 [Mus musculus].
ACCESSION   NP_001164259
VERSION     NP_001164259.1
DBSOURCE    REFSEQ: accession NM_001170788.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 757)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 757)
  AUTHORS   Miyata,H., Castaneda,J.M., Fujihara,Y., Yu,Z., Archambeault,D.R.,
            Isotani,A., Kiyozumi,D., Kriseman,M.L., Mashiko,D., Matsumura,T.,
            Matzuk,R.M., Mori,M., Noda,T., Oji,A., Okabe,M.,
            Prunskaite-Hyyrylainen,R., Ramirez-Solis,R., Satouh,Y., Zhang,Q.,
            Ikawa,M. and Matzuk,M.M.
  TITLE     Genome engineering uncovers 54 evolutionarily conserved and
            testis-enriched genes that are not required for male fertility in
            mice
  JOURNAL   Proc Natl Acad Sci U S A 113 (28), 7704-7710 (2016)
   PUBMED   27357688
REFERENCE   3  (residues 1 to 757)
  AUTHORS   Stowe,T.R., Wilkinson,C.J., Iqbal,A. and Stearns,T.
  TITLE     The centriolar satellite proteins Cep72 and Cep290 interact and are
            required for recruitment of BBS proteins to the cilium
  JOURNAL   Mol Biol Cell 23 (17), 3322-3335 (2012)
   PUBMED   22767577
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY084860.1, AC090480.11, BC172120.1 and BC036564.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849384
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..757
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 53.04 cM"
     Protein         1..757
                     /product="leucine-rich repeat-containing protein 36
                     isoform 1"
                     /note="leucine-rich repeat-containing protein 36"
                     /calculated_mol_wt=83802
     Region          26..51
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          <50..141
                     /region_name="PPP1R42"
                     /note="protein phosphatase 1 regulatory subunit 42;
                     cl42388"
                     /db_xref="CDD:455733"
     Region          51..72
                     /region_name="LRR 1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3V0M2.2)"
     Region          52..73
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          73..94
                     /region_name="LRR 2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3V0M2.2)"
     Region          74..98
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          356..376
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3V0M2.2)"
     Region          450..519
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3V0M2.2)"
     Region          703..757
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3V0M2.2)"
     CDS             1..757
                     /gene="Lrrc36"
                     /coded_by="NM_001170788.1:20..2293"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS52658.1"
                     /db_xref="GeneID:270091"
                     /db_xref="MGI:MGI:2448585"
ORIGIN      
        1 maeqwdldee clrrlgaltl eqpelvesls lqgsyagkih sigdafrnfk slrsldlsrn
       61 litslkgiqy lcslqelnly ynnipslvev srlqplpflk eldlrlnpvv rkdtdyrlfa
      121 vytlqtlekl ddravrdser raaklhfsql gnsenfllev ekssrektmk ncvtdegpas
      181 hvspevdarm etdankglfi pfpnreikds ltsicaaqgs gtpaqkldvf plgtqmqeat
      241 rretsdlhqe dglelrlypp pqstvrspek mtrdgyrvsf ldtkssgssp ekdlipkpda
      301 ypcthdaslg krldvgdsnq ilpcqlpsev cldhygnqys qtlclhgslv kraqkgknyr
      361 ehsikpsqdk kattshpcgd lltslsnpds stgrllrlss dlyatthfns dpallanveq
      421 qlsslrdftp apgsfpsspa lgnslrtlll ppgtpenrei ptkrslspsr rgfkrkdgil
      481 anpslkrgfq datgseaqpl ssdlgslhgl sgnhsppisa rtphvatvlr qllelvdkhw
      541 ngsgsllldk kflgpardll lslvvpapsq qwrrsklddk agkalcwret elkeagllvp
      601 ndveslkqkl vkvleenlvl sekiqqlegt aatsivsghp shthdellrk nqqltiqvac
      661 ltqeltqlkr leetvallhe sqrslvvtne yllqqlhkeq kgysgksllp pekshplgrs
      721 spfgkstlss sspmvhdtgq yliqsvsead pepslws
//
