LOCUS       NM_001033371            2102 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus leucine rich repeat containing 36 (Lrrc36), transcript
            variant 3, mRNA.
ACCESSION   NM_001033371 XM_194421 XM_894895 XM_915427 XM_923734
VERSION     NM_001033371.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2102)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2102)
  AUTHORS   Miyata,H., Castaneda,J.M., Fujihara,Y., Yu,Z., Archambeault,D.R.,
            Isotani,A., Kiyozumi,D., Kriseman,M.L., Mashiko,D., Matsumura,T.,
            Matzuk,R.M., Mori,M., Noda,T., Oji,A., Okabe,M.,
            Prunskaite-Hyyrylainen,R., Ramirez-Solis,R., Satouh,Y., Zhang,Q.,
            Ikawa,M. and Matzuk,M.M.
  TITLE     Genome engineering uncovers 54 evolutionarily conserved and
            testis-enriched genes that are not required for male fertility in
            mice
  JOURNAL   Proc Natl Acad Sci U S A 113 (28), 7704-7710 (2016)
   PUBMED   27357688
REFERENCE   3  (bases 1 to 2102)
  AUTHORS   Stowe,T.R., Wilkinson,C.J., Iqbal,A. and Stearns,T.
  TITLE     The centriolar satellite proteins Cep72 and Cep290 interact and are
            required for recruitment of BBS proteins to the cilium
  JOURNAL   Mol Biol Cell 23 (17), 3322-3335 (2012)
   PUBMED   22767577
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK133042.1 and BC036564.1.
            
            On Jan 1, 2010 this sequence version replaced NM_001033371.2.
            
            Transcript Variant: This variant (3) represents use of an alternate
            promoter and 5' UTR, uses a downstream start codon, and uses an
            alternate in-frame splice site in the central coding region,
            compared to variant 1. The resulting isoform (2) has a shorter
            N-terminus and lacks a 2 residue internal segment, compared to
            isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK133042.1, BC150957.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2075              AK133042.1         1-2075
            2076-2102           BC036564.1         1693-1719
FEATURES             Location/Qualifiers
     source          1..2102
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 53.04 cM"
     gene            1..2102
                     /gene="Lrrc36"
                     /note="leucine rich repeat containing 36"
                     /db_xref="GeneID:270091"
                     /db_xref="MGI:MGI:2448585"
     exon            1..184
                     /gene="Lrrc36"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..1964
                     /gene="Lrrc36"
                     /note="isoform 3 is encoded by transcript variant 3;
                     leucine-rich repeat-containing protein 36"
                     /codon_start=1
                     /product="leucine-rich repeat-containing protein 36
                     isoform 3"
                     /protein_id="NP_001028543.1"
                     /db_xref="CCDS:CCDS22601.1"
                     /db_xref="GeneID:270091"
                     /db_xref="MGI:MGI:2448585"
                     /translation="MLTPWLSPPDDRAVRDSERRAAKLHFSQLGNSENFLLEVEKSSR
                     EKTMKNCVTDEGPASHVSPEVDARMETDANKGLFIPFPNREIKDSLTSICAAQGSGTP
                     AQKLDVFPLGTQMQEATRRETSDLHQEDELRLYPPPQSTVRSPEKMTRDGYRVSFLDT
                     KSSGSSPEKDLIPKPDAYPCTHDASLGKRLDVGDSNQILPCQLPSEVCLDHYGNQYSQ
                     TLCLHGSLVKRAQKGKNYREHSIKPSQDKKATTSHPCGDLLTSLSNPDSSTGRLLRLS
                     SDLYATTHFNSDPALLANVEQQLSSLRDFTPAPGSFPSSPALGNSLRTLLLPPGTPEN
                     REIPTKRSLSPSRRGFKRKDGILANPSLKRGFQDATGSEAQPLSSDLGSLHGLSGNHS
                     PPISARTPHVATVLRQLLELVDKHWNGSGSLLLDKKFLGPARDLLLSLVVPAPSQQWR
                     RSKLDDKAGKALCWRETELKEAGLLVPNDVESLKQKLVKVLEENLVLSEKIQQLEGTA
                     ATSIVSGHPSHTHDELLRKNQQLTIQVACLTQELTQLKRLEETVALLHESQRSLVVTN
                     EYLLQQLHKEQKGYSGKSLLPPEKSHPLGRSSPFGKSTLSSSSPMVHDTGQYLIQSVS
                     EADPEPSLWS"
     exon            185..273
                     /gene="Lrrc36"
                     /inference="alignment:Splign:2.1.0"
     exon            274..401
                     /gene="Lrrc36"
                     /inference="alignment:Splign:2.1.0"
     exon            402..450
                     /gene="Lrrc36"
                     /inference="alignment:Splign:2.1.0"
     exon            451..891
                     /gene="Lrrc36"
                     /inference="alignment:Splign:2.1.0"
     exon            892..1184
                     /gene="Lrrc36"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1350
                     /gene="Lrrc36"
                     /inference="alignment:Splign:2.1.0"
     exon            1351..1499
                     /gene="Lrrc36"
                     /inference="alignment:Splign:2.1.0"
     exon            1500..1623
                     /gene="Lrrc36"
                     /inference="alignment:Splign:2.1.0"
     exon            1624..1738
                     /gene="Lrrc36"
                     /inference="alignment:Splign:2.1.0"
     exon            1739..2082
                     /gene="Lrrc36"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2057..2062
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lrrc36"
                     /note="hexamer: AAGAAA"
     polyA_site      2077
                     /gene="Lrrc36"
                     /note="major polyA site"
ORIGIN      
        1 gagttctggg cttcagtttt tcctccgcaa acatggtttt ctgactctga aaaagaaaca
       61 tgctcacgcc gtggctttcg cctccagatg accgagccgt ccgtgacagc gagaggagag
      121 cggccaagct acatttcagt cagttgggca acagtgaaaa ttttctctta gaggtggaaa
      181 aaagctctag ggagaagaca atgaaaaact gtgtgacaga tgagggcccc gcgtcacacg
      241 tcagtcctga ggttgatgcc aggatggaaa cagacgcaaa caaaggactt tttattccct
      301 tccccaaccg ggaaataaag gattccctaa ccagcatttg tgcagcccag ggcagtggca
      361 caccagctca gaaattagac gtttttccgc tggggacaca gatgcaggaa gcaacaagaa
      421 gggagacaag tgaccttcac caggaagatg aactcaggct ctacccgcct cctcagagca
      481 cagtccgatc tccagagaag atgacgagag atggataccg agtgtctttc ctagacacta
      541 agtcttcagg ttcttctcca gaaaaggact tgataccaaa acctgatgcc tatccatgta
      601 cccatgatgc ctccttgggt aaacgcctgg atgtgggtga ttctaaccag atccttccct
      661 gtcagttacc ttctgaggtt tgtctggacc actatggtaa tcaatattct caaactcttt
      721 gcctgcacgg aagtcttgtc aaaagggctc agaagggcaa gaactaccga gaacatagca
      781 taaagccttc acaggacaaa aaggccacca catcccatcc ctgtggagac ttactaacat
      841 ccctgtcaaa ccccgactcc agcacgggaa ggctgctgag gcttagctca gatctctatg
      901 ccacaaccca tttcaacagt gaccccgctc tgctggccaa cgtggagcaa cagctttcca
      961 gcctccgtga ctttacacca gcacctggtt ctttcccaag cagccctgcc ctaggaaatt
     1021 ctctgcggac actgctgctg cctcctggga ctccagaaaa cagggagatt ccgactaaga
     1081 ggtcattaag cccttcaagg agaggattca agcggaagga cggtatcctt gccaacccga
     1141 gtctgaagcg tggtttccaa gatgctacag gcagcgaggc gcaacctctc tctagtgacc
     1201 tgggcagttt gcatggttta tcaggaaacc acagtcctcc gatctctgcc agaacccccc
     1261 acgtggccac tgtcctcaga cagctcctgg agctggtgga caagcactgg aatggctctg
     1321 gctccctcct cctggacaag aagtttctcg gtcccgccag agacttgctc ctgtcattgg
     1381 tggtccctgc accctctcag cagtggcggc gctcgaagct tgacgataag gcagggaaag
     1441 ccttgtgctg gagggagacc gagctaaagg aagcagggct gctagttcct aacgatgtgg
     1501 aaagtctgaa gcaaaaactg gtcaaagtgc tggaggaaaa ccttgttctg tcagaaaaaa
     1561 ttcagcagtt ggagggaacc gctgccacct cgattgtgag tgggcaccca tcacacacac
     1621 acgatgagct tctgcgcaaa aaccaacagc tgaccataca ggtggcttgc ctgacccagg
     1681 agctgactca gctgaaaaga ctggaggaga cagttgctct tctccatgag agtcagaggt
     1741 ccctggtggt aactaatgag tatctgctgc agcagctgca taaagagcag aaaggttatt
     1801 ccgggaaatc tctcctgcct cccgagaaga gtcatccttt ggggagatcg tcgccctttg
     1861 ggaaaagcac gctgtcttcc tcctcaccaa tggtacacga cacgggtcag tacctaatac
     1921 agagtgtctc agaagccgac ccagagccta gtttgtggag ctagcaccgc agcccgcccc
     1981 accagctccc tcgcccacgg aggacgctca gggccgctgt ccctgtggtg ggtactggtg
     2041 tttaccccca aagattaaga aaaacgtatt atgatgactt tcaaaaaaaa aaaaaaaaaa
     2101 aa
//
