LOCUS       NM_027941               1978 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus leucine rich repeat containing 34 (Lrrc34), mRNA.
ACCESSION   NM_027941
VERSION     NM_027941.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1978)
  AUTHORS   Nolte,J.
  TITLE     Lrrc34 Interacts with Oct4 and Has an Impact on Telomere Length in
            Mouse Embryonic Stem Cells
  JOURNAL   Stem Cells Dev 30 (22), 1093-1102 (2021)
   PUBMED   34549596
  REMARK    GeneRIF: Lrrc34 Interacts with Oct4 and Has an Impact on Telomere
            Length in Mouse Embryonic Stem Cells.
REFERENCE   2  (bases 1 to 1978)
  AUTHORS   Ou,J.H., Li,Y.R., Wang,Z.P., Jin,C., Li,K., Lu,Y., Zou,D.F.,
            Li,P.Y., Li,M.Z., Miao,S.Y., Wang,L.F. and Song,W.
  TITLE     Lrrc34 Is Highly Expressed in SSCs and Is Necessary for SSC
            Expansion In Vitro
  JOURNAL   Chin Med Sci J 35 (1), 20-30 (2020)
   PUBMED   32299535
  REMARK    GeneRIF: Lrrc34 Is Highly Expressed in SSCs and Is Necessary for
            SSC Expansion In Vitro.
REFERENCE   3  (bases 1 to 1978)
  AUTHORS   Nie,D., Dai,Y. and Luo,Z.
  TITLE     The testis-specific expressed gene Spata34 is not required for
            fertility in mice
  JOURNAL   Mol Biol Rep 47 (1), 285-292 (2020)
   PUBMED   31621016
  REMARK    GeneRIF: Authors found that the Spata34 gene KO mice had normal
            fertility compared with wild type mice, and no overt detectable
            difference was found in testis/body weight ratios, testicular
            histology, sperm counts and spermatozoa motility parameters between
            WT and Spata34 KO mice.
REFERENCE   4  (bases 1 to 1978)
  AUTHORS   Luhrig,S., Siamishi,I., Tesmer-Wolf,M., Zechner,U., Engel,W. and
            Nolte,J.
  TITLE     Lrrc34, a novel nucleolar protein, interacts with npm1 and ncl and
            has an impact on pluripotent stem cells
  JOURNAL   Stem Cells Dev 23 (23), 2862-2874 (2014)
   PUBMED   24991885
  REMARK    GeneRIF: LRRC34 is a novel nucleolar protein that is predominantly
            expressed in pluripotent stem cells.
REFERENCE   5  (bases 1 to 1978)
  AUTHORS   Chen,T., Jiang,Z., Xu,W., Wang,Y., Li,Y., Wan,Y., Yuan,W., Mo,X.,
            Wu,X., Deng,Y., Fan,X. and Nie,D.
  TITLE     Expression and identification of a novel gene Spata34 in mouse
            spermatogenic cells
  JOURNAL   Mol Biol Rep 41 (3), 1683-1691 (2014)
   PUBMED   24435972
  REMARK    GeneRIF: Overexpression of Spata34 in COS7 cells inhibited the
            transcriptional activity of AP-1, p53 and p21 which suggested that
            Spata34 protein may act as a transcriptional repressor in p53 and
            p21 pathway
REFERENCE   6  (bases 1 to 1978)
  AUTHORS   Chen,H., Palmer,J.S., Thiagarajan,R.D., Dinger,M.E., Lesieur,E.,
            Chiu,H., Schulz,A., Spiller,C., Grimmond,S.M., Little,M.H.,
            Koopman,P. and Wilhelm,D.
  TITLE     Identification of novel markers of mouse fetal ovary development
  JOURNAL   PLoS One 7 (7), e41683 (2012)
   PUBMED   22844512
REFERENCE   7  (bases 1 to 1978)
  AUTHORS   McClintock,T.S., Glasser,C.E., Bose,S.C. and Bergman,D.A.
  TITLE     Tissue expression patterns identify mouse cilia genes
  JOURNAL   Physiol Genomics 32 (2), 198-206 (2008)
   PUBMED   17971504
  REMARK    GeneRIF: Lrrc34 is most abundantly expressed in tissues rich in
            highly ciliated cells, such as olfactory sensory neurons, and is
            predicted to be important to cilia.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC100519.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC100519.1, AK005720.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1978
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 14.27 cM"
     gene            1..1978
                     /gene="Lrrc34"
                     /gene_synonym="1700007J06Rik; SPATA34"
                     /note="leucine rich repeat containing 34"
                     /db_xref="GeneID:71827"
                     /db_xref="MGI:MGI:1919077"
     exon            1..149
                     /gene="Lrrc34"
                     /gene_synonym="1700007J06Rik; SPATA34"
                     /inference="alignment:Splign:2.1.0"
     exon            150..270
                     /gene="Lrrc34"
                     /gene_synonym="1700007J06Rik; SPATA34"
                     /inference="alignment:Splign:2.1.0"
     CDS             161..1408
                     /gene="Lrrc34"
                     /gene_synonym="1700007J06Rik; SPATA34"
                     /note="spermatogenesis associated SPATA34"
                     /codon_start=1
                     /product="leucine-rich repeat-containing protein 34"
                     /protein_id="NP_082217.1"
                     /db_xref="CCDS:CCDS38405.1"
                     /db_xref="GeneID:71827"
                     /db_xref="MGI:MGI:1919077"
                     /translation="MEKLQAQYCYLCSENIRKTNPFILNILQKLDEEIEKRPKEKFTV
                     NIAGNNRLDSGQRITGEDFWLLSKTLRNQPCISGVDVRYNLIGDVGAFYAAKLLQKQP
                     SITYLNLMFNDIGPEGGELIAKALHKNKTLKYLRMTGNKIENTGGMLFAAMLQMNSSL
                     EKLDLGDCDLGLQCVIAFSTVLTQNQAIKGINLNRPILYGEQEESTVHIGHMLKENHV
                     LVELHMCKHGMKNYGLQQLCNALYLNSSLRYLDVSCNKITRDGMVFLADVLKSNTTLE
                     VLDLSFNRIETAGAKYLSETLTSHNRSLKALSVVSNKIEGEGLVALSQSMKTNLVLSN
                     IYIWGNKFDEDTCVAYSDLIKSGRLKPDNTDVEPYMVDEHIYLSEVSNGLKRHYYWAP
                     TYGETYMPSSSAGFALVPVGEHL"
     exon            271..392
                     /gene="Lrrc34"
                     /gene_synonym="1700007J06Rik; SPATA34"
                     /inference="alignment:Splign:2.1.0"
     exon            393..457
                     /gene="Lrrc34"
                     /gene_synonym="1700007J06Rik; SPATA34"
                     /inference="alignment:Splign:2.1.0"
     exon            458..541
                     /gene="Lrrc34"
                     /gene_synonym="1700007J06Rik; SPATA34"
                     /inference="alignment:Splign:2.1.0"
     exon            542..670
                     /gene="Lrrc34"
                     /gene_synonym="1700007J06Rik; SPATA34"
                     /inference="alignment:Splign:2.1.0"
     exon            671..766
                     /gene="Lrrc34"
                     /gene_synonym="1700007J06Rik; SPATA34"
                     /inference="alignment:Splign:2.1.0"
     exon            767..921
                     /gene="Lrrc34"
                     /gene_synonym="1700007J06Rik; SPATA34"
                     /inference="alignment:Splign:2.1.0"
     exon            922..1077
                     /gene="Lrrc34"
                     /gene_synonym="1700007J06Rik; SPATA34"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..1204
                     /gene="Lrrc34"
                     /gene_synonym="1700007J06Rik; SPATA34"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..1840
                     /gene="Lrrc34"
                     /gene_synonym="1700007J06Rik; SPATA34"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1817..1822
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lrrc34"
                     /gene_synonym="1700007J06Rik; SPATA34"
                     /note="hexamer: AATAAA"
     polyA_site      1840
                     /gene="Lrrc34"
                     /gene_synonym="1700007J06Rik; SPATA34"
                     /note="major polyA site"
ORIGIN      
        1 gtgaggactg agcaggggca gactgttgaa aaagctcagc cacggcggcc ttcctcttta
       61 gaggtcgagg tccgcaaagc gagctgggta aggggcaccg ggctctaggc gaaggaaagg
      121 gcagcggatc ccgcctgcag aagccccagc tccagagtcg atggagaagc tccaggccca
      181 gtactgttac ttatgttcag aaaacatacg gaaaactaat cctttcatac tgaatatact
      241 ccaaaaactg gatgaagaaa ttgaaaagcg acccaaagaa aaatttaccg taaatattgc
      301 tggtaacaat cgcttagact ccggacaaag aataacaggg gaagactttt ggcttctttc
      361 caaaacttta aggaaccagc catgtatcag tggtgtggat gtgaggtata acctcatcgg
      421 cgatgtcggt gccttctatg ctgcgaaact acttcagaaa caaccaagta tcacttattt
      481 aaaccttatg tttaatgata ttggacctga aggtggagaa ttgattgcta aagcactaca
      541 taaaaacaaa actcttaagt atttgagaat gacgggaaat aagattgaga acacaggagg
      601 catgcttttt gctgcaatgc tgcagatgaa ctcaagcctg gagaaactgg atctgggcga
      661 ctgtgacctg ggactgcaat gtgtgatcgc attttctacg gtactaactc aaaaccaagc
      721 aatcaaggga ataaacctga accggcctat actgtacgga gaacaggaag agtctactgt
      781 ccacattggc cacatgttga aagaaaatca tgtccttgtt gagctacata tgtgcaaaca
      841 tggcatgaaa aattatggtt tacagcagtt atgcaatgca ctgtatttga acagtagcct
      901 acgctacctt gatgtcagct gcaataaaat aactcgtgat ggaatggtgt ttttggctga
      961 tgtcctaaaa agcaatacta ctctggaagt actagatctt tcttttaaca gaatagaaac
     1021 tgcaggcgca aagtacctca gtgaaactct aacttcccac aacaggagtc ttaaagcatt
     1081 gtctgtagtc agcaacaaga tagaaggaga ggggcttgtt gcactttccc agtcaatgaa
     1141 aaccaacctc gtactgtcca atatctacat ttggggaaac aaatttgatg aggatacctg
     1201 tgtggcatat tcagatttga taaagagtgg ccgactaaag ccagataata cagatgtgga
     1261 accgtatatg gtggacgaac atatttacct ttcagaagtc tccaacggcc ttaaaaggca
     1321 ttattactgg gcaccgactt atggagaaac ttacatgccg tcatcttccg caggctttgc
     1381 tcttgttcct gtgggcgaac atctataaga agcttgaaaa cagttttcat acattcatct
     1441 caacactttt ggagactaat attttgtaga ctattttttt cttttgtaaa tcagaacaaa
     1501 ttatttttat caaagtataa aattttgtgt acttgttctc gagaaaaagc tgattcttaa
     1561 catagagact aaaatatcaa ccctgaaaca agccacagaa ctatagtagt tctttttgta
     1621 atgaaaaacg aacacaaaaa ccaaagaaaa gtaaagtcac tacagatatc ttaaccaaat
     1681 gatatggcag atttgctttg cagctggcaa gtttacagtg gattttgaga gagatcaaag
     1741 ttcagaagtc aaaaagtatt ccacatagac gtttagacat tacagacagg tgctaataat
     1801 ttcacaaaag caagaaaata aagcttcctt gaacagacaa aaaaaaaaaa aaaaaaaaaa
     1861 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1921 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa
//
