LOCUS       NM_001113379            3932 bp    mRNA    linear   ROD 09-JUN-2024
DEFINITION  Mus musculus leucine rich repeat containing 32 (Lrrc32), mRNA.
ACCESSION   NM_001113379 XM_001472523 XM_003689425 XM_006507977 XM_485967
VERSION     NM_001113379.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3932)
  AUTHORS   Xu,J., Liu,H., Lan,Y. and Jiang,R.
  TITLE     Cis-Repression of Foxq1 Expression Affects Foxf2-Mediated Gene
            Expression in Palate Development
  JOURNAL   Front Cell Dev Biol 9, 665109 (2021)
   PUBMED   33898467
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3932)
  AUTHORS   Nasrallah,R., Imianowski,C.J., Bossini-Castillo,L., Grant,F.M.,
            Dogan,M., Placek,L., Kozhaya,L., Kuo,P., Sadiyah,F.,
            Whiteside,S.K., Mumbach,M.R., Glinos,D., Vardaka,P., Whyte,C.E.,
            Lozano,T., Fujita,T., Fujii,H., Liston,A., Andrews,S., Cozzani,A.,
            Yang,J., Mitra,S., Lugli,E., Chang,H.Y., Unutmaz,D., Trynka,G. and
            Roychoudhuri,R.
  TITLE     A distal enhancer at risk locus 11q13.5 promotes suppression of
            colitis by Treg cells
  JOURNAL   Nature 583 (7816), 447-452 (2020)
   PUBMED   32499651
REFERENCE   3  (bases 1 to 3932)
  AUTHORS   Xu,J., Liu,H., Lan,Y., Park,J.S. and Jiang,R.
  TITLE     Genome-wide Identification of Foxf2 Target Genes in Palate
            Development
  JOURNAL   J Dent Res 99 (4), 463-471 (2020)
   PUBMED   32040930
REFERENCE   4  (bases 1 to 3932)
  AUTHORS   Metelli,A., Wu,B.X., Riesenberg,B., Guglietta,S., Huck,J.D.,
            Mills,C., Li,A., Rachidi,S., Krieg,C., Rubinstein,M.P.,
            Gewirth,D.T., Sun,S., Lilly,M.B., Wahlquist,A.H., Carbone,D.P.,
            Yang,Y., Liu,B. and Li,Z.
  TITLE     Thrombin contributes to cancer immune evasion via proteolysis of
            platelet-bound GARP to activate LTGF-beta
  JOURNAL   Sci Transl Med 12 (525) (2020)
   PUBMED   31915300
  REMARK    GeneRIF: Thrombin contributes to cancer immune evasion via
            proteolysis of platelet-bound GARP to activate LTGF-beta.
REFERENCE   5  (bases 1 to 3932)
  AUTHORS   Salem,M., Wallace,C., Velegraki,M., Li,A., Ansa-Addo,E.,
            Metelli,A., Kwon,H., Riesenberg,B., Wu,B., Zhang,Y., Guglietta,S.,
            Sun,S., Liu,B. and Li,Z.
  TITLE     GARP Dampens Cancer Immunity by Sustaining Function and
            Accumulation of Regulatory T Cells in the Colon
  JOURNAL   Cancer Res 79 (6), 1178-1190 (2019)
   PUBMED   30674536
REFERENCE   6  (bases 1 to 3932)
  AUTHORS   Zhou,A.X., Kozhaya,L., Fujii,H. and Unutmaz,D.
  TITLE     GARP-TGF-beta complexes negatively regulate regulatory T cell
            development and maintenance of peripheral CD4+ T cells in vivo
  JOURNAL   J Immunol 190 (10), 5057-5064 (2013)
   PUBMED   23576681
  REMARK    GeneRIF: These findings suggest a role for GARP in natural and
            induced Treg development through activation of bound latent
            TGF-beta and signaling, which negatively regulates GARP expression
            on Tregs.
REFERENCE   7  (bases 1 to 3932)
  AUTHORS   D'Alise,A.M., Ergun,A., Hill,J.A., Mathis,D. and Benoist,C.
  TITLE     A cluster of coregulated genes determines TGF-beta-induced
            regulatory T-cell (Treg) dysfunction in NOD mice
  JOURNAL   Proc Natl Acad Sci U S A 108 (21), 8737-8742 (2011)
   PUBMED   21543717
REFERENCE   8  (bases 1 to 3932)
  AUTHORS   Wang,R., Wan,Q., Kozhaya,L., Fujii,H. and Unutmaz,D.
  TITLE     Identification of a regulatory T cell specific cell surface
            molecule that mediates suppressive signals and induces Foxp3
            expression
  JOURNAL   PLoS One 3 (7), e2705 (2008)
   PUBMED   18628982
  REMARK    GeneRIF: GARP is a regulatory T cell specific cell surface molecule
            that mediates suppressive signals and induces Foxp3 expression
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 3932)
  AUTHORS   Roubin,R., Pizette,S., Ollendorff,V., Planche,J., Birnbaum,D. and
            Delapeyriere,O.
  TITLE     Structure and developmental expression of mouse Garp, a gene
            encoding a new leucine-rich repeat-containing protein
  JOURNAL   Int J Dev Biol 40 (3), 545-555 (1996)
   PUBMED   8840187
REFERENCE   10 (bases 1 to 3932)
  AUTHORS   Ollendorff,V., Szepetowski,P., Mattei,M.G., Gaudray,P. and
            Birnbaum,D.
  TITLE     New gene in the homologous human 11q13-q14 and mouse 7F chromosomal
            regions
  JOURNAL   Mamm Genome 2 (3), 195-200 (1992)
   PUBMED   1543912
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC115069.6.
            
            On or before Apr 30, 2020 this sequence version replaced
            XM_006507977.2, NM_001113379.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR3363660.947052.1,
                                           SRR7652917.50594.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-107               AC115069.6         58276-58382         c
            108-202             AC115069.6         54065-54159         c
            203-3932            AC115069.6         46542-50271         c
FEATURES             Location/Qualifiers
     source          1..3932
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 53.86 cM"
     gene            1..3932
                     /gene="Lrrc32"
                     /gene_synonym="D11S833Eh; D7H11S833E; EG434215; Garp"
                     /note="leucine rich repeat containing 32"
                     /db_xref="GeneID:434215"
                     /db_xref="MGI:MGI:93882"
     exon            1..107
                     /gene="Lrrc32"
                     /gene_synonym="D11S833Eh; D7H11S833E; EG434215; Garp"
                     /inference="alignment:Splign:2.1.0"
     exon            108..202
                     /gene="Lrrc32"
                     /gene_synonym="D11S833Eh; D7H11S833E; EG434215; Garp"
                     /inference="alignment:Splign:2.1.0"
     CDS             116..2107
                     /gene="Lrrc32"
                     /gene_synonym="D11S833Eh; D7H11S833E; EG434215; Garp"
                     /note="glycoprotein A repetitions predominant; garpin;
                     leucine-rich repeat-containing protein 32; transforming
                     growth factor beta activator LRRC32"
                     /codon_start=1
                     /product="transforming growth factor beta activator LRRC32
                     precursor"
                     /protein_id="NP_001106850.1"
                     /db_xref="CCDS:CCDS52319.1"
                     /db_xref="GeneID:434215"
                     /db_xref="MGI:MGI:93882"
                     /translation="MSHQILLLLAMLTLGLAISQRREQVPCRTVNKEALCHGLGLLQV
                     PSVLSLDIQALYLSGNQLQSILVSPLGFYTALRHLDLSDNQISFLQAGVFQALPYLEH
                     LNLAHNRLATGMALNSGGLGRLPLLVSLDLSGNSLHGNLVERLLGETPRLRTLSLAEN
                     SLTRLARHTFWGMPAVEQLDLHSNVLMDIEDGAFEALPHLTHLNLSRNSLTCISDFSL
                     QQLQVLDLSCNSIEAFQTAPEPQAQFQLAWLDLRENKLLHFPDLAVFPRLIYLNVSNN
                     LIQLPAGLPRGSEDLHAPSEGWSASPLSNPSRNASTHPLSQLLNLDLSYNEIELVPAS
                     FLEHLTSLRFLNLSRNCLRSFEARQVDSLPCLVLLDLSHNVLEALELGTKVLGSLQTL
                     LLQDNALQELPPYTFASLASLQRLNLQGNQVSPCGGPAEPGPPGCVDFSGIPTLHVLN
                     MAGNSMGMLRAGSFLHTPLTELDLSTNPGLDVATGALVGLEASLEVLELQGNGLTVLR
                     VDLPCFLRLKRLNLAENQLSHLPAWTRAVSLEVLDLRNNSFSLLPGNAMGGLETSLRR
                     LYLQGNPLSCCGNGWLAAQLHQGRVDVDATQDLICRFGSQEELSLSLVRPEDCEKGGL
                     KNVNLILLLSFTLVSAIVLTTLATICFLRRQKLSQQYKA"
     exon            203..3932
                     /gene="Lrrc32"
                     /gene_synonym="D11S833Eh; D7H11S833E; EG434215; Garp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3910..3915
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lrrc32"
                     /gene_synonym="D11S833Eh; D7H11S833E; EG434215; Garp"
                     /note="hexamer: ATTAAA"
     polyA_site      3932
                     /gene="Lrrc32"
                     /gene_synonym="D11S833Eh; D7H11S833E; EG434215; Garp"
                     /note="major polyA site"
ORIGIN      
        1 ggccggctgg agcggcgctg cagcggtccg gcctcggcgg gccagacccc cggggttgcg
       61 cgaacgatgc gcggaggagt caggcggcgg cggcggcgct gagccaggca gagccatgag
      121 ccaccagatc ctgctactcc tggccatgct gaccctgggc ctggctatct ctcagcgtcg
      181 agagcaagtg ccctgtagga cggtgaacaa ggaggccttg tgccacggcc ttggcctgct
      241 ccaggtcccc tcggtgctct cactggacat ccaagctctc tacttgtccg ggaaccaact
      301 gcagagcatc ctggtctccc cactgggctt ctatacagcg cttcgtcacc tggatttaag
      361 tgacaaccag attagcttcc tccaggctgg ggtcttccag gccctgccct acctggagca
      421 ccttaacctg gcccacaatc ggcttgccac aggcatggct ctcaacagtg gtggtctggg
      481 ccgcctgccc cttttggtct ccctggacct gtctgggaac agcctgcatg gcaatctggt
      541 ggagcgactg ttgggtgaga ccccgaggct gcgtacgctc tcactggcgg agaacagcct
      601 cactcgcctg gcacgccaca ccttctgggg tatgccagcg gtggagcaat tagacctcca
      661 cagcaatgtc ctcatggata tcgaggacgg tgcctttgag gccctgcccc acctgactca
      721 cctcaatctc tccagaaact ccctcacctg catctcagac ttcagcctcc agcagctgca
      781 ggtactagac ttgagctgca acagcattga ggccttccag acggccccgg aaccacaggc
      841 ccagttccag ttggcctggc tcgacctccg ggagaacaag ctgctccact tccctgacct
      901 ggccgtgttc ccgagactca tctacctgaa tgtgtctaac aacctcatcc agctccctgc
      961 ggggctgccc cggggcagtg aggacctcca cgcaccctct gaaggctggt cagcctctcc
     1021 actgtccaac cccagccgga atgccagcac ccaccctctc tcccagctcc tgaacctgga
     1081 tctgagttac aatgagatcg aactggtccc tgctagcttt cttgaacacc tgacctccct
     1141 gcgcttcctc aacctcagca gaaactgcct gcgatccttt gaggctcgac aagtggactc
     1201 cctgccctgc ctggtgcttt tggacttgag ccacaatgtg ctggaagcat tagaactggg
     1261 taccaaagtc ctagggtccc tgcagacgtt gcttctgcag gacaatgcct tgcaagaact
     1321 tccaccctat acctttgcca gcctggccag cctgcagagg ctaaacctac aggggaacca
     1381 ggtcagtccc tgtggggggc cagcagaacc aggtcccccg ggctgtgtgg acttctctgg
     1441 gatccccacc cttcatgttc ttaacatggc agggaactcg atgggaatgc tcagggcggg
     1501 cagcttcctt cacaccccac ttacagagct ggacctctcc accaatcctg gtctggatgt
     1561 ggccacggga gccctggtgg gcctggaggc atccttagag gtactggagc ttcaaggcaa
     1621 cgggctgact gtcttgagag tggacttgcc ctgctttctc cgtctcaagc gccttaacct
     1681 tgctgagaac cagttaagcc acctgcccgc ttggacgcgg gctgtgtccc tggaggtgct
     1741 agatctgcgg aacaacagct tcagcctcct gccaggcaat gccatgggtg gcctggagac
     1801 cagtctccgg cggctgtact tgcagggaaa tccactcagc tgctgtggca atggctggct
     1861 ggcggcccag ctgcaccagg gcagagtgga tgtggatgct actcaggacc taatctgccg
     1921 ctttggctcc caggaggagt tgtccctgag cctagtgcgt ccagaggatt gcgagaaggg
     1981 agggctgaag aatgtcaacc tcatcctcct cctcagcttc acactggtct ctgccatcgt
     2041 cctcaccacg ctggccacca tctgcttcct ccgccggcag aagctcagcc aacaatacaa
     2101 agcctgacag gctcgggaag ccagaggggc agagaagttg gggtccaact caggttactc
     2161 agtgaccagg gacttggtgt cctgcacact gccgcgtggg caggttcctt cccaggctgc
     2221 atctgtgggc cagctgtgca gctcgaagtg gggcagttta ctgcacagag gatgccaacc
     2281 gacagctcga cgctgagtat ctgtttcagg ccacacccgt ctccgggtac tagtaaatga
     2341 aacacatgcc tatcctcagg caagagaggc cgtcactgaa ccacacagtg accacatagg
     2401 cttgaggtgg ggaagcagta ggctggacat ggagaaccca ccctgactta gagcaggaga
     2461 gccagcccgt gagaggattt gtctgagtcc tttccacccc gagctctgtc gcatctgctg
     2521 ataatgactt tcagcctctc tggaaatgaa gaacttgtga cctgaagaga gagccagaac
     2581 ctctccccag aggtcttaag tctaggctcc taggctaggg gctgcaccag cttaaagtgt
     2641 gatcacctag gcttccacgc aggcctgggc cgtcctgtgt cctgctttgg acaggccttc
     2701 tctccagtgc actcttgtat cacacacaca ctgaccctgg tgctgcctgt tccccaaccc
     2761 cctgctcagg cctccttcta tcccagcccc accctgactt ttgagccaag agggagagcc
     2821 tcagctatct ggttcagctt agcagctgca gaggcaaagt caagccaact ctcagaggtt
     2881 tctgtgttat ctgggttata cacaagaaga aaacaaattt ccttatgcat tctcctttga
     2941 gagcctcatg gctcagagag ctgacgaagc caaaatgaat caagtccatg tcctcccatc
     3001 tctggggcca aagctttgcc agtgcggtac ctgcaggctg tcaagtggac aggaagtggc
     3061 cctgccctaa ccaggatcca agcacacttg ctacatatac cccctccctc tcagacaggc
     3121 gcccacagac cctctgcctc tctgcctcag tgtcccttct ttgcagaaga gtatgaattc
     3181 ttcctttctc tttctgctcc ccaaaatctc attgagtgta atctccccac tgaacagata
     3241 gggaaagtta ggtgcaggcc ttgctcagaa tcacgcaagt caatggaaga aaactgggaa
     3301 caaaagtagc tgggcggttg cgccaaggca gagggtttgc tttgtgtgct caaggccctg
     3361 agctggatgc cagcggctgt acccgtgttt ccctacgctc agcagtcaca gcacgagaca
     3421 aggccagcta ccatgccagt cctcaccagg catggaaaaa taatagggac acacacacac
     3481 acacacacac acacacacac acactgtctc cactcattct ccaggcttgt gggctgcagg
     3541 gaggaagggg agtcctggac ccagtcacag agcctgctgc atcagatccc tgtgctcggc
     3601 ccacagtcag ccagagcttc cgtaatgtac aagaagacga aaacgccatt ctctctaccc
     3661 cactctacag gtgaggggac tgaggcccag agaaggttaa aggctccgag gaccaatagg
     3721 cagatccaga cctagaacct tccctcactg gtgctgctgc gcacacagct cttctcctcg
     3781 gcctggaggc caaggcgtgg tggcccctgg gcctgaactc tgaaaacact aatcaatgct
     3841 gctctcacct cccaggactg gcctctaccg ggccctggga cccgctcttt gtataactca
     3901 catgaatgta ttaaagtata attttggaga aa
//
