LOCUS       NM_145152               4311 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus leucine rich repeat containing 3 (Lrrc3), mRNA.
ACCESSION   NM_145152
VERSION     NM_145152.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4311)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4311)
  AUTHORS   Yoshida,Y., Han,B., Mendelsohn,M. and Jessell,T.M.
  TITLE     PlexinA1 signaling directs the segregation of proprioceptive
            sensory axons in the developing spinal cord
  JOURNAL   Neuron 52 (5), 775-788 (2006)
   PUBMED   17145500
REFERENCE   3  (bases 1 to 4311)
  AUTHORS   Gitton,Y., Dahmane,N., Baik,S., Ruiz i Altaba,A., Neidhardt,L.,
            Scholze,M., Herrmann,B.G., Kahlem,P., Benkahla,A., Schrinner,S.,
            Yildirimman,R., Herwig,R., Lehrach,H. and Yaspo,M.L.
  CONSRTM   HSA21 expression map initiative
  TITLE     A gene expression map of human chromosome 21 orthologues in the
            mouse
  JOURNAL   Nature 420 (6915), 586-590 (2002)
   PUBMED   12466855
REFERENCE   4  (bases 1 to 4311)
  AUTHORS   Reymond,A., Marigo,V., Yaylaoglu,M.B., Leoni,A., Ucla,C.,
            Scamuffa,N., Caccioppoli,C., Dermitzakis,E.T., Lyle,R., Banfi,S.,
            Eichele,G., Antonarakis,S.E. and Ballabio,A.
  TITLE     Human chromosome 21 gene expression atlas in the mouse
  JOURNAL   Nature 420 (6915), 582-586 (2002)
   PUBMED   12466854
REFERENCE   5  (bases 1 to 4311)
  AUTHORS   Reymond,A., Camargo,A.A., Deutsch,S., Stevenson,B.J.,
            Parmigiani,R.B., Ucla,C., Bettoni,F., Rossier,C., Lyle,R.,
            Guipponi,M., de Souza,S., Iseli,C., Jongeneel,C.V., Bucher,P.,
            Simpson,A.J. and Antonarakis,S.E.
  TITLE     Nineteen additional unpredicted transcripts from human chromosome
            21
  JOURNAL   Genomics 79 (6), 824-832 (2002)
   PUBMED   12036297
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY320829.1, AY061858.1, AC158612.7, AC153874.4 and BQ176232.1.
            
            On Jan 4, 2008 this sequence version replaced NM_145152.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments and orthologous data.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BY320829.1, AK043535.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                BY320829.1         1-27
            28-1072             AY061858.1         1-1045
            1073-2381           AC158612.7         69883-71191         c
            2382-4268           AC153874.4         128045-129931       c
            4269-4311           BQ176232.1         1-43                c
FEATURES             Location/Qualifiers
     source          1..4311
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 39.72 cM"
     gene            1..4311
                     /gene="Lrrc3"
                     /gene_synonym="1300011L04Rik; C21orf102"
                     /note="leucine rich repeat containing 3"
                     /db_xref="GeneID:237387"
                     /db_xref="MGI:MGI:2447899"
     exon            1..138
                     /gene="Lrrc3"
                     /gene_synonym="1300011L04Rik; C21orf102"
                     /inference="alignment:Splign:2.1.0"
     exon            139..4296
                     /gene="Lrrc3"
                     /gene_synonym="1300011L04Rik; C21orf102"
                     /inference="alignment:Splign:2.1.0"
     CDS             271..1044
                     /gene="Lrrc3"
                     /gene_synonym="1300011L04Rik; C21orf102"
                     /note="leucine-rich repeat-containing protein 3"
                     /codon_start=1
                     /product="leucine-rich repeat-containing protein 3
                     precursor"
                     /protein_id="NP_660134.1"
                     /db_xref="CCDS:CCDS23960.1"
                     /db_xref="GeneID:237387"
                     /db_xref="MGI:MGI:2447899"
                     /translation="MGPRGRQSPSATLAPSQGSCFFILFCLRLGASCPQACQCPDHAG
                     AVAVHCSSRGLQEIPRDIPADTVLLKLDANRISRVPNGAFQHLPQLRELDLSHNAIEA
                     IGPAAFSGLAGGLRLLDLSHNRIRRIPKDALGKLSAKIRLSHNPLHCECALQEALWEL
                     KLDPDSVDEIACHTSAQEQFVGKPLIQVLDSGASFCSTHRKTTDVAMLVTMFGWFTMV
                     IAYVVYYVRHNQEDARRHLEYLKSLPSAPVSKEPLSPVP"
     polyA_site      2062
                     /gene="Lrrc3"
                     /gene_synonym="1300011L04Rik; C21orf102"
     regulatory      4274..4279
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lrrc3"
                     /gene_synonym="1300011L04Rik; C21orf102"
                     /note="hexamer: AATAAA"
     polyA_site      4296
                     /gene="Lrrc3"
                     /gene_synonym="1300011L04Rik; C21orf102"
                     /note="major polyA site"
ORIGIN      
        1 gcccctcccg ccatggcttg cccgcctccc ttctttactg gccgctcggt gggcacgggg
       61 cgggtcgccg cggcgccggg aggactctgg tcaggctccg ggaagctcgg aaggcgctga
      121 gcagcggcgg ccgctcagaa ctgagatcac taggctcttc agcaggcgaa gacacaagag
      181 tttgtgttgg atgactgcct gcaacgtgag gaaggacagt cgcttgcaca tcccagtgga
      241 gaagagctac ctgggtcagg tggaggcaac atgggcccca ggggcaggca gagcccctca
      301 gccacactgg ccccctccca ggggtcttgc ttcttcatcc tcttctgctt acggttaggt
      361 gcctcctgcc cacaggcctg ccagtgccct gaccatgctg gggccgtggc tgtccattgc
      421 agctcaagag ggctgcagga gatccctagg gacatcccag ccgacacggt gcttctgaaa
      481 ctagacgcca acagaatctc ccgagtcccc aatggagcct tccaacacct gcctcagctg
      541 agggagctgg acctgtccca taatgccatt gaggccattg ggccagcagc cttctcaggt
      601 ctggctgggg gcctgcggct gctggactta tcccacaatc gcatccgaag aattccaaag
      661 gacgccctgg gcaagttgag tgccaagatc cgcctgtccc acaatccact gcactgtgag
      721 tgtgccctgc aggaggccct gtgggaacta aagctggacc cggactccgt ggatgaaatt
      781 gcctgccaca cctcagcgca ggagcagttt gtgggcaagc cgctgatcca ggtcctggac
      841 tcaggtgcca gcttctgcag tacccaccgg aagaccaccg atgtcgccat gctggtcacc
      901 atgttcggct ggtttaccat ggtgattgcc tacgtagtgt actacgtacg ccacaaccag
      961 gaggatgcca gacgacacct ggagtacctg aagtccctgc ctagtgctcc agtctccaag
     1021 gagcctctta gccctgtgcc ctagcaccca cctccggtgg gccactgagc ctggctaccc
     1081 tgtctttctg cagcaggtgg aggtgatggt gctcttgtgt ccccagggag gtgcattgca
     1141 gctgttcagc ccaaaaaagc actttcatag ttggtatttg gtccctgcag ccactgccta
     1201 acactgtagc ggggggaggg gggtttgccc atcttaatgg gtaggtaaat ggaggtcgag
     1261 agaaacggaa ctccttgcca aggctggctt cagctgccac ttaaacccag gctgtttgtg
     1321 gtataggtct gtgagccgtc tgatctgcca acctcccttt cccacaccat gctgtgggaa
     1381 gtaaatactt gtgcacgcaa ggatgggggc cctggcaggg aggatggcgc cagcagtttt
     1441 gccaccgggg aatggctcat ttctgtttac ccctgctctc ccagtacatc tgaacacaga
     1501 gatgtttgcc ctttcccaga gcaaagtacc ggcaatctag acctttccag agaggtcagt
     1561 gcaaagtcca gcctgcactg gtctgctctg acctttgtcc tgggagttct ttagttgccc
     1621 ttgtgccaaa atgtcagtcc atcgagaggg agaaaatgga gaaacgtgag aaaggtccag
     1681 catgggctca ccatggccgt gtcagctgct agaccactta tgggctgcct cagcttctgc
     1741 cacttctatc cattcctggg cagtggaaac ctgtcaacct cggtggctct tgtgccttgc
     1801 tttctactgc caatatctaa agcagctgtt ttttcagaaa gaggagggac tgaagtttga
     1861 ggttgccatg ccagtcaaca ggaactgctt ttctctagca acaagaacct tctcttcacc
     1921 tcgctgaaat cccagagctc actgatcaac tttcttacct gtaattactt catcttcagg
     1981 ggtagatgtt ctagccacct aactagactt gacttccagt tttgttattt actgtccttt
     2041 tgtataagtg tttataccct aagctatgtc gtcatcgagt atctgggaga agtaaatgag
     2101 catagtgtgt gtgtctgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgctgagta
     2161 tagggtctag atgccgctct gagcagaaat tgaatgtggc ttctgtgtgt gctgggaatt
     2221 ttcttgtgat ctgcaggggc aaggtgagac tatgttgggg gcctggcctg acttggtcct
     2281 taccgtcagt gtgacccaca gttctgtcac catgtgacac acttgcctga ggctacatgg
     2341 ctgtcagctg caaaagtata tggaagagaa aaacactcat gaattccaga ctttccccac
     2401 tgctgaatgc ccacacctac atggtgaccg tggggccacc atgcctggca tctgcagggt
     2461 gaacagagcc ctggatgagc tcccaagctg tccactattc ttccacagcc ctgggccaag
     2521 ctacactgtc ttcagggtca gaccctggcg gagctagtag gaccattccc attcccatga
     2581 gaattggaac ctcgaagcag cctccttagg gacaccagtc aacgttgtga tgctgcctgg
     2641 cccccattgg cacagacatg ctcaataccc agtacccagt taagtgttca gaggaggcag
     2701 gtgctgaggg ctgtatgatt tggaccctgg agggtgctgt gccaaggaaa agaggttaaa
     2761 aagccagagc tgagccaggc agtggtggcg cacgccttta atcccagcac ttgagaggca
     2821 gaggcaggca gatttctgag ttcaaggcca gcctggtcta cagagtgagt tccagaacag
     2881 ccagggctac acagagaaac cctgtctcga aaaaaccaaa ccaaaccaaa caaacaaaca
     2941 aaaaaaagcc agagctgagg gcttggatta aggaccaggt accaccctgg tgctgtggca
     3001 gtgctgaagt agctatctat gtatgtccca tggacaggga cacctctagc ctgacacata
     3061 ctctgggagg tgccagtgca gagggtatgg cttgcattcc tattaccatg tggtggggac
     3121 ggtagctgct tccaggcagg ggcacaagtt gggaggtagc tggcccctgc ggcctttcta
     3181 ccatcctact cagtagaggg accctgtttc tggagcttgc cactatccag catgtctgtc
     3241 ccatcgacaa aaccaggtca aaaaagaaca tgggtggagg cctggtggtg aagtctgtag
     3301 ctgctcttgt cccagaaaca ccctattggg tcttttagat acaccggtgt aggtagggct
     3361 ccgtcccagg ctgctcaacc cactgccagg cttgctgctc ttaacctagg gcttagccct
     3421 acctggttgc acatctatac agctcctgct cagcccttgc tggaaagagg agatgggaga
     3481 ctcaggagag tatggaccct ggagagagca tgccctgtcc tcctataagg aggacctcag
     3541 agacctcagc actctcctgc tcatccaagc ttccaaccct gctgcctcag agtcttatct
     3601 ccctgtcgtc ccattccatg tcattcattc atgtatatag atacccttcc cttccttccc
     3661 atgaccaact cacaggctaa gtgtatgagg ctggagcctc tgctggagac ttgcagatgt
     3721 ggatggttgc attgaaactg tctttctccc tggatcccac ctgcttccac cagcttcacc
     3781 ttccttctct ccttgaatga gatattctcc tcccccaact ctgcacagac cctctagatc
     3841 tccaggactc tgggtcagtc ctcccctact ctgcgcatct ccacccccac cccaccccga
     3901 cttgagtgtt cctcaggcac agtgggcggg gttttttttt gttgttttta tttttgccac
     3961 atggctcagt gtcctgcccc atcctcaccc ccatcagtat aaacctatca tcccaggtcc
     4021 cacccactgg ctcctttggg cactttccct cccactagtt acatgtgatt gcctaagaca
     4081 cggtttaaat tgaaatcctt gggtggggtt agaggttgag gggtggtaag tcacagactg
     4141 agatggaatg ttctgagcct gtggcagctc tcaggactag gactaggctc ctaggatggc
     4201 ttctatgttg cctttcttgg aagctcagcc ccgaacctga ttctgtcctc tcccagcctc
     4261 tctgtgagcc ctcaataaaa ctttttgtgc aggaaaaaaa aaaaaaaaaa a
//
