LOCUS       NM_146117               1207 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus leucine rich repeat containing 26 (Lrrc26), mRNA.
ACCESSION   NM_146117
VERSION     NM_146117.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1207)
  AUTHORS   Gonzalez-Perez,V., Martinez-Espinosa,P.L., Sala-Rabanal,M.,
            Bharadwaj,N., Xia,X.M., Chen,A.C., Alvarado,D., Gustafsson,J.K.,
            Hu,H., Ciorba,M.A. and Lingle,C.J.
  TITLE     Goblet cell LRRC26 regulates BK channel activation and protects
            against colitis in mice
  JOURNAL   Proc Natl Acad Sci U S A 118 (3) (2021)
   PUBMED   33431687
  REMARK    GeneRIF: Goblet cell LRRC26 regulates BK channel activation and
            protects against colitis in mice.
REFERENCE   2  (bases 1 to 1207)
  AUTHORS   Noda,S., Suzuki,Y., Yamamura,H., Giles,W.R. and Imaizumi,Y.
  TITLE     Roles of LRRC26 as an auxiliary gamma1-subunit of large-conductance
            Ca2+-activated K+ channels in bronchial smooth muscle cells
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 318 (2), L366-L375 (2020)
   PUBMED   31800260
  REMARK    GeneRIF: Roles of LRRC26 as an auxiliary gamma1-subunit of
            large-conductance Ca(2+)-activated K(+) channels in bronchial
            smooth muscle cells, is reported.
REFERENCE   3  (bases 1 to 1207)
  AUTHORS   Lingle,C.J., Martinez-Espinosa,P.L., Yang-Hood,A., Boero,L.E.,
            Payne,S., Persic,D., V-Ghaffari,B., Xiao,M., Zhou,Y., Xia,X.M.,
            Pyott,S.J. and Rutherford,M.A.
  TITLE     LRRC52 regulates BK channel function and localization in mouse
            cochlear inner hair cells
  JOURNAL   Proc Natl Acad Sci U S A 116 (37), 18397-18403 (2019)
   PUBMED   31451634
REFERENCE   4  (bases 1 to 1207)
  AUTHORS   Yang,C., Gonzalez-Perez,V., Mukaibo,T., Melvin,J.E., Xia,X.M. and
            Lingle,C.J.
  TITLE     Knockout of the LRRC26 subunit reveals a primary role of
            LRRC26-containing BK channels in secretory epithelial cells
  JOURNAL   Proc Natl Acad Sci U S A 114 (18), E3739-E3747 (2017)
   PUBMED   28416688
  REMARK    GeneRIF: LRRC26-containing BK channels are competent to contribute
            to resting K(+) efflux at normal cell membrane potentials with
            resting cytosolic Ca(2+) concentrations and likely play a critical
            physiological role in supporting normal secretory function in all
            secretory epithelial cells.
REFERENCE   5  (bases 1 to 1207)
  AUTHORS   Larsen,C.K., Praetorius,H.A., Leipziger,J. and Sorensen,M.V.
  TITLE     Intact colonic KCa1.1 channel activity in KCNMB2 knockout mice
  JOURNAL   Physiol Rep 5 (5) (2017)
   PUBMED   28292889
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL732309.9.
            
            On Apr 22, 2010 this sequence version replaced NM_146117.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC004853.1, AK137758.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-751               AL732309.9         182543-183293
            752-1207            AL732309.9         183370-183825
FEATURES             Location/Qualifiers
     source          1..1207
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 17.14 cM"
     gene            1..1207
                     /gene="Lrrc26"
                     /note="leucine rich repeat containing 26"
                     /db_xref="GeneID:227618"
                     /db_xref="MGI:MGI:2385129"
     exon            1..751
                     /gene="Lrrc26"
                     /inference="alignment:Splign:2.1.0"
     CDS             79..1074
                     /gene="Lrrc26"
                     /note="leucine-rich repeat-containing protein 26; BK
                     channel auxilliary gamma subunit LRRC26; BK channel
                     auxiliary gamma subunit LRRC26"
                     /codon_start=1
                     /product="leucine-rich repeat-containing protein 26
                     precursor"
                     /protein_id="NP_666229.1"
                     /db_xref="CCDS:CCDS15763.1"
                     /db_xref="GeneID:227618"
                     /db_xref="MGI:MGI:2385129"
                     /translation="MRGSFFSRLPPQLSLLLLLSLRRVWTQEDIGTAPSKSPVAPECP
                     EACSCSLGGKANCSALALPAVPADLSWQVRSLLLDHNRVSALPPGAFANAGALLYLDL
                     RENRLRSVHARAFWGLGVLQWLDLSSNQLETLPPGTFAPLRALSFLSLAGNRLALLEP
                     SILGPLPLLRVLSLQDNSLSAIEAGLLNNLPALDVLRLHGNPWTCNCALRPLCTWLRK
                     HPRPASETETLLCVSPRLQTLSLLTAFPDAAFKQCTQSLAARDLAVVYALGPVSFLAS
                     LAICLALGSVLTACGARRRRRRRTTVRHLLRRQLDPEGPPSLEDAGSPVTAAIQA"
     exon            752..1207
                     /gene="Lrrc26"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1176..1181
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lrrc26"
                     /note="hexamer: AATAGA"
     polyA_site      1194
                     /gene="Lrrc26"
                     /note="major polyA site"
ORIGIN      
        1 gggcaggaga gttaatactt gtgcaggtga ggctgagacg gctttggggc accttgactc
       61 caaagcccga agccgcacat gcggggttct tttttctcgc ggcttccgcc gcaactctct
      121 ctgctgctgc tgctgtcgtt gaggcgagtc tggacccagg aggatattgg aactgcccct
      181 tctaaatccc cggtggcccc cgaatgcccc gaggcatgtt catgttcact aggcggcaag
      241 gccaattgct ccgcactcgc gctgcctgcg gtaccagcgg acctgagctg gcaagtacgc
      301 tcactgctgc tggatcacaa tcgcgtgagc gcgctgcctc cgggtgcctt cgccaatgca
      361 ggcgcgctgc tatacctaga tctgagggag aaccggcttc ggtcggtgca cgcacgagct
      421 ttctggggtc tgggagtgtt gcaatggctg gacctgagct ccaaccagct ggaaactctg
      481 cctcctggca ccttcgcgcc gctgcgcgcg cttagtttcc tctccctagc gggtaaccgg
      541 ctggcactcc tggagccttc gatcctgggc ccgcttccat tactgcgagt gctcagcctg
      601 caggacaatt cactatcggc aatcgaggcg ggtttgctga ataacttgcc tgccctcgat
      661 gtgttgcgct tgcatggcaa cccctggacg tgcaactgtg cgctgcgtcc cctttgcact
      721 tggctgcgta agcacccgcg tccagcctca gaaactgaga ccctgctctg cgtgtctcca
      781 agactccaga cgctcagcct actgacagct tttccggatg ccgccttcaa acagtgcact
      841 cagtcactag cagcgcgaga cctggcggtg gtctacgctc tcgggccggt ctctttcctt
      901 gctagtttgg ccatctgcct ggcattgggc tccgtgctca ctgcttgtgg tgcacggcgc
      961 cgccgccgcc gccgcaccac ggtgcgccac ttactaagga gacagctaga ccccgagggc
     1021 ccaccctccc tggaggatgc tgggagccct gtaacagcag ctatccaagc ctaaggggac
     1081 tgcaggttgt ttctagtgct cctgaagtgc ctccgtactt tgagaactct ccccaaatcc
     1141 ctgatcctcc cttcacattc cctgtaggcg tcaacaatag acaaaacccg gaaattttct
     1201 gacattc
//
