LOCUS       NM_153074               1263 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Mus musculus leucine rich repeat containing 25 (Lrrc25), mRNA.
ACCESSION   NM_153074
VERSION     NM_153074.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1263)
  AUTHORS   Zhang,X., Zhang,M.C. and Wang,C.T.
  TITLE     Loss of LRRC25 accelerates pathological cardiac hypertrophy through
            promoting fibrosis and inflammation regulated by TGF-beta1
  JOURNAL   Biochem Biophys Res Commun 506 (1), 137-144 (2018)
   PUBMED   30340835
  REMARK    GeneRIF: LRRC25 as a critical molecular switch whose
            down-regulation resulted in cardiac hypertrophy in a TGF-beta1- and
            NF-kappaB-dependent manner.
REFERENCE   2  (bases 1 to 1263)
  AUTHORS   Rissoan,M.C., Duhen,T., Bridon,J.M., Bendriss-Vermare,N.,
            Peronne,C., de Saint Vis,B., Briere,F. and Bates,E.E.
  TITLE     Subtractive hybridization reveals the expression of
            immunoglobulin-like transcript 7, Eph-B1, granzyme B, and 3 novel
            transcripts in human plasmacytoid dendritic cells
  JOURNAL   Blood 100 (9), 3295-3303 (2002)
   PUBMED   12384430
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC157774.5.
            
            On Jan 5, 2022 this sequence version replaced NM_153074.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK171924.1, SRR7345562.4462219.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-172               AC157774.5         30874-31045         c
            173-975             AC157774.5         29536-30338         c
            976-1263            AC157774.5         27049-27336         c
FEATURES             Location/Qualifiers
     source          1..1263
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 34.15 cM"
     gene            1..1263
                     /gene="Lrrc25"
                     /gene_synonym="Mapa"
                     /note="leucine rich repeat containing 25"
                     /db_xref="GeneID:211228"
                     /db_xref="MGI:MGI:2445284"
     exon            1..172
                     /gene="Lrrc25"
                     /gene_synonym="Mapa"
                     /inference="alignment:Splign:2.1.0"
     exon            173..975
                     /gene="Lrrc25"
                     /gene_synonym="Mapa"
                     /inference="alignment:Splign:2.1.0"
     CDS             182..1075
                     /gene="Lrrc25"
                     /gene_synonym="Mapa"
                     /note="monocyte and plasmacytoid activated molecule;
                     leucine-rich repeat-containing protein 25; monocyte and
                     plasmacytoid-activated protein"
                     /codon_start=1
                     /product="leucine-rich repeat-containing protein 25
                     precursor"
                     /protein_id="NP_694714.1"
                     /db_xref="CCDS:CCDS22375.1"
                     /db_xref="GeneID:211228"
                     /db_xref="MGI:MGI:2445284"
                     /translation="MGSIRTRLLWLCLLMLLALLHKSGSQDLTCMVHPSRVDWTQTFN
                     GTCLNFSGLGLSLPRSPLQASHAQVLDLSKNGLQVLPGAFFDKLEKLQTLIVTHNQLD
                     SVDRSLALRCDLELKADCSCGLASWYALRQNCSGQQQLLCLHPATEAPRNLSTFLQVS
                     CPPSWGPGTIGALVAGTISLAVAVSGSVLAWRLLRRRRRASEHSLSKAQMSPHDIPKP
                     VTDFLPRYSSRRPGPKAPDSPPSRFTMDYENVFIGQPAEDCSWSAARNSPSGDSDCYM
                     NYRSVDQDSQPVYCNLESLGR"
     exon            976..1263
                     /gene="Lrrc25"
                     /gene_synonym="Mapa"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1235..1240
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lrrc25"
                     /gene_synonym="Mapa"
                     /note="hexamer: AATAAA"
     polyA_site      1263
                     /gene="Lrrc25"
                     /gene_synonym="Mapa"
                     /note="major polyA site"
ORIGIN      
        1 gtgagagcct gaggctggca gagggctctc tgctgtcccc tccactccta cacctactcg
       61 tcttcccgtc ttcccgcagg cgtggattaa caggtggaaa gcaccaggag ctgtgaaccc
      121 caacccagac cctaggaccc tgaggcttac gagacatcac gaaggccagg aggttgctgg
      181 gatgggaagc atcagaacta ggttgctgtg gttatgtctc ctgatgctgt tggccctgct
      241 tcacaagtca ggaagtcaag atctcacctg catggttcac ccgagcaggg tagactggac
      301 tcagacattt aatggcacct gcctcaattt cagtggcctt ggcctgtccc tgccaaggag
      361 ccccttgcag gccagccatg ctcaagtcct ggacctgtct aagaatggcc tgcaggtgct
      421 ccctggggct ttcttcgaca agctggaaaa gctgcagacc ctgattgtca cccacaacca
      481 gctggacagt gtggacaggt ccctggcctt gcgctgtgac ctggagctca aggcagactg
      541 cagctgtggg ctggcctcct ggtatgctct ccgccagaac tgctccgggc agcagcagct
      601 actgtgtcta cacccagcca ccgaagctcc aaggaacctc tccaccttcc ttcaggtcag
      661 ctgtcccccc agctggggcc cggggaccat tggagccctt gttgctggga ctatctccct
      721 ggctgtggct gtcagtggat ctgtgctggc ctggagactt cttcgccgcc gccgcagagc
      781 cagtgagcac agcctcagca aagcccagat gtccccacac gatatcccca aaccagtgac
      841 agatttcctg ccaaggtaca gcagccggcg acctggcccc aaggccccag actcaccacc
      901 cagcaggttc acaatggatt atgagaatgt ctttattggc cagccggccg aggactgctc
      961 atggtctgca gccagaaaca gcccttctgg ggacagtgac tgctacatga actacaggag
     1021 tgtcgaccag gactctcagc ccgtctattg caacctggag tccctggggc gatgaggaga
     1081 gtgtggtctc ctggcgctga accagcctcc gacagccccc aggatccagc acgctcaaca
     1141 tcacaggggg tagaggacac cccacccccc cacccccaaa gcagaaggag ggtcagaaac
     1201 aaccctccgg tcagtgtgca tgcatgtgat gctcaataaa agctctggga gcagctgact
     1261 cta
//
