LOCUS       NM_001302555            1458 bp    mRNA    linear   ROD 01-AUG-2024
DEFINITION  Mus musculus leucine rich repeat containing 23 (Lrrc23), mRNA.
ACCESSION   NM_001302555 XM_006505662
VERSION     NM_001302555.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1458)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1458)
  AUTHORS   Hwang,J.Y., Chai,P., Nawaz,S., Choi,J., Lopez-Giraldez,F.,
            Hussain,S., Bilguvar,K., Mane,S., Lifton,R.P., Ahmad,W., Zhang,K.
            and Chung,J.J.
  TITLE     LRRC23 truncation impairs radial spoke 3 head assembly and sperm
            motility underlying male infertility
  JOURNAL   Elife 12, 90095 (2023)
   PUBMED   38091523
  REMARK    GeneRIF: LRRC23 truncation impairs radial spoke 3 head assembly and
            sperm motility underlying male infertility.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1458)
  AUTHORS   Pina,J.O., Raju,R., Roth,D.M., Winchester,E.W., Chattaraj,P.,
            Kidwai,F., Faucz,F.R., Iben,J., Mitra,A., Campbell,K., Fridell,G.,
            Esnault,C., Cotney,J.L., Dale,R.K. and D'Souza,R.N.
  TITLE     Multimodal spatiotemporal transcriptomic resolution of embryonic
            palate osteogenesis
  JOURNAL   Nat Commun 14 (1), 5687 (2023)
   PUBMED   37709732
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1458)
  AUTHORS   Zhang,X., Sun,J., Lu,Y., Zhang,J., Shimada,K., Noda,T., Zhao,S.,
            Koyano,T., Matsuyama,M., Zhou,S., Wu,J., Ikawa,M. and Liu,M.
  TITLE     LRRC23 is a conserved component of the radial spoke that is
            necessary for sperm motility and male fertility in mice
  JOURNAL   J Cell Sci 134 (20) (2021)
   PUBMED   34585727
  REMARK    GeneRIF: LRRC23 is a conserved component of the radial spoke that
            is necessary for sperm motility and male fertility in mice.
REFERENCE   5  (bases 1 to 1458)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1458)
  AUTHORS   Stauber,M., Weidemann,M., Dittrich-Breiholz,O., Lobschat,K.,
            Alten,L., Mai,M., Beckers,A., Kracht,M. and Gossler,A.
  TITLE     Identification of FOXJ1 effectors during ciliogenesis in the foetal
            respiratory epithelium and embryonic left-right organiser of the
            mouse
  JOURNAL   Dev Biol 423 (2), 170-188 (2017)
   PUBMED   27914912
REFERENCE   7  (bases 1 to 1458)
  AUTHORS   McClintock,T.S., Glasser,C.E., Bose,S.C. and Bergman,D.A.
  TITLE     Tissue expression patterns identify mouse cilia genes
  JOURNAL   Physiol Genomics 32 (2), 198-206 (2008)
   PUBMED   17971504
  REMARK    GeneRIF: Lrrc23 is most abundantly expressed in tissues rich in
            highly ciliated cells, such as olfactory sensory neurons, and is
            predicted to be important to cilia.
REFERENCE   8  (bases 1 to 1458)
  AUTHORS   Ansari-Lari,M.A., Oeltjen,J.C., Schwartz,S., Zhang,Z., Muzny,D.M.,
            Lu,J., Gorrell,J.H., Chinault,A.C., Belmont,J.W., Miller,W. and
            Gibbs,R.A.
  TITLE     Comparative sequence analysis of a gene-rich cluster at human
            chromosome 12p13 and its syntenic region in mouse chromosome 6
  JOURNAL   Genome Res 8 (1), 29-40 (1998)
   PUBMED   9445485
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC049601.1 and AW122764.1.
            
            On Oct 29, 2014 this sequence version replaced XM_006505662.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC049601.1, AK015011.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN00849387
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1441              BC049601.1         1-1441
            1442-1458           AW122764.1         1-17                c
FEATURES             Location/Qualifiers
     source          1..1458
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 59.17 cM"
     gene            1..1458
                     /gene="Lrrc23"
                     /gene_synonym="4921537K05Rik; B7; Lrpb7"
                     /note="leucine rich repeat containing 23"
                     /db_xref="GeneID:16977"
                     /db_xref="MGI:MGI:1315192"
     exon            1..78
                     /gene="Lrrc23"
                     /gene_synonym="4921537K05Rik; B7; Lrpb7"
                     /inference="alignment:Splign:2.1.0"
     exon            79..213
                     /gene="Lrrc23"
                     /gene_synonym="4921537K05Rik; B7; Lrpb7"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..1119
                     /gene="Lrrc23"
                     /gene_synonym="4921537K05Rik; B7; Lrpb7"
                     /note="leucine-rich protein B7"
                     /codon_start=1
                     /product="leucine-rich repeat-containing protein 23"
                     /protein_id="NP_001289484.1"
                     /db_xref="CCDS:CCDS20528.1"
                     /db_xref="GeneID:16977"
                     /db_xref="MGI:MGI:1315192"
                     /translation="MSDEDDVDDVDAEQDEVESDKEIEEWEDYRKETEEASEEWLPTP
                     ITEAMMKEGLSLLCKIGSGLAHAYIKLEAKDRDLTDISLLRSYIHLRYVDISENHITD
                     ISPLNSLTHLLWLKADGNQLRSARMNELPYLQIASFSYNQIIDTEGIFHPRLGSLDLK
                     GNRIHQVTGLDPERLSSLHTLELRGNQLESTKGIYLPKLKNLYLAQNLLKKVEGLENL
                     SNLTTLHLRDNQIETLNGFSQEMKSLQYLNLRSNMISDLAELAKLRDLPKLRALVLLD
                     NPCADETDYRQEALVQMAHLERLDKEFYEDDDRAEAEEIRQRLKEEQDQDLDPDQDME
                     PYLPPV"
     exon            214..323
                     /gene="Lrrc23"
                     /gene_synonym="4921537K05Rik; B7; Lrpb7"
                     /inference="alignment:Splign:2.1.0"
     exon            324..577
                     /gene="Lrrc23"
                     /gene_synonym="4921537K05Rik; B7; Lrpb7"
                     /inference="alignment:Splign:2.1.0"
     exon            578..708
                     /gene="Lrrc23"
                     /gene_synonym="4921537K05Rik; B7; Lrpb7"
                     /inference="alignment:Splign:2.1.0"
     exon            709..845
                     /gene="Lrrc23"
                     /gene_synonym="4921537K05Rik; B7; Lrpb7"
                     /inference="alignment:Splign:2.1.0"
     exon            846..1149
                     /gene="Lrrc23"
                     /gene_synonym="4921537K05Rik; B7; Lrpb7"
                     /inference="alignment:Splign:2.1.0"
     exon            1150..1444
                     /gene="Lrrc23"
                     /gene_synonym="4921537K05Rik; B7; Lrpb7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1423..1428
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lrrc23"
                     /gene_synonym="4921537K05Rik; B7; Lrpb7"
                     /note="hexamer: AATAAA"
     polyA_site      1444
                     /gene="Lrrc23"
                     /gene_synonym="4921537K05Rik; B7; Lrpb7"
                     /note="major polyA site"
ORIGIN      
        1 gcgtcttcca aaaaaacagt cttggcgtct cagcacaaag atcctctcct taactacttc
       61 tagaggagca gagtcaggag cgcagggcag agaaagatgt cggatgaaga tgatgtggat
      121 gacgttgatg cagaacagga tgaagtggaa agtgacaagg agatagagga atgggaagac
      181 tacaggaaag agacagaaga agcctctgag gaatggctgc ccacccccat cacggaggcc
      241 atgatgaagg aagggctctc attactctgc aagattggca gtggactggc tcacgcttat
      301 attaagctgg aggctaagga cagggacctc acagacatct ccttactgcg ctcctatatc
      361 catcttcgct atgtggatat ttctgagaac catattacag acatatcgcc gctcaacagt
      421 ctcactcacc tcctatggct caaggccgat ggcaatcagc ttcggagtgc taggatgaat
      481 gaacttccct acctgcagat cgccagcttt tcctacaacc agatcataga cactgaaggc
      541 atctttcacc cccgtctggg aagcctggat ctcaaaggga accgcatcca ccaggtgact
      601 ggtctggacc ccgagagact gtcgagcctg cacaccctgg agcttcgagg gaaccagctg
      661 gaatccacaa agggaatcta ccttcctaag ctgaagaatc tctacctggc tcaaaacctg
      721 ctgaagaagg tagagggcct ggagaacctg agcaacttga ccaccctgca tctgcgagac
      781 aaccagattg aaactttgaa tggcttctcc caggaaatga agtcgctgca gtacctcaac
      841 ttgaggagca atatgattag tgatctggca gagctggcca aactgcggga cctgcccaaa
      901 cttcgagccc tggtgctgct ggacaaccca tgtgcggatg agaccgacta ccgccaggag
      961 gccctggtgc agatggcgca ccttgagcgc ctggacaaag aattctatga ggatgatgac
     1021 cgggcagagg ccgaggagat ccgtcagagg ctgaaggagg aacaggatca agatctcgat
     1081 ccggaccagg acatggaacc gtacttgcca ccagtttagt ggctcttcca gcctgcaggg
     1141 acagtaaagg aagccatgga cactggcccc aagaactgat aagactccag tgggggacca
     1201 ccacattcat agccccgtca caggaagtgg gagatgctcc tttttgtccc agactggaaa
     1261 tccatcacat cccaaggctc cttggcagtc atctgtctgt gtggcttgtt ctgtgggcct
     1321 gaactcctaa gcacaggtcg ggggtaaaac taggatgcta gtaggtgttg tctatagaga
     1381 ggcgctgagg aagtgagctg tgatgggcca gttgaggttt caaataaaaa ggcatttttt
     1441 tataaaaaaa aaaaaaaa
//
