LOCUS       NM_028838               3657 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus leucine rich repeat containing 2 (Lrrc2), mRNA.
ACCESSION   NM_028838 XM_135172
VERSION     NM_028838.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3657)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3657)
  AUTHORS   Timmermans,S. and Libert,C.
  TITLE     Overview of inactivating mutations in the protein-coding genome of
            the mouse reference strain C57BL/6J
  JOURNAL   JCI Insight 3 (13), 121758 (2018)
   PUBMED   29997285
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3657)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   4  (bases 1 to 3657)
  AUTHORS   Tang,F., Barbacioru,C., Nordman,E., Bao,S., Lee,C., Wang,X.,
            Tuch,B.B., Heard,E., Lao,K. and Surani,M.A.
  TITLE     Deterministic and stochastic allele specific gene expression in
            single mouse blastomeres
  JOURNAL   PLoS One 6 (6), e21208 (2011)
   PUBMED   21731673
REFERENCE   5  (bases 1 to 3657)
  AUTHORS   Tarantino,C., Paolella,G., Cozzuto,L., Minopoli,G., Pastore,L.,
            Parisi,S. and Russo,T.
  TITLE     miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic
            stem cells
  JOURNAL   FASEB J 24 (9), 3255-3263 (2010)
   PUBMED   20439489
REFERENCE   6  (bases 1 to 3657)
  AUTHORS   Kiss,H., Darai,E., Kiss,C., Kost-Alimova,M., Klein,G.,
            Dumanski,J.P. and Imreh,S.
  TITLE     Comparative human/murine sequence analysis of the common eliminated
            region 1 from human 3p21.3
  JOURNAL   Mamm Genome 13 (11), 646-655 (2002)
   PUBMED   12461651
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC118727.7 and AK010252.1.
            
            On May 3, 2007 this sequence version replaced NM_028838.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript from the same
            strain was available for the full length of the gene. The extent of
            this transcript is supported by orthologous human data.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ428068.1, AK010252.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-132               AC118727.7         147317-147448       c
            133-1449            AK010252.1         132-1448
            1450-3657           AC118727.7         114927-117134       c
FEATURES             Location/Qualifiers
     source          1..3657
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 60.79 cM"
     gene            1..3657
                     /gene="Lrrc2"
                     /gene_synonym="2400002D05Rik; 4933431K03Rik"
                     /note="leucine rich repeat containing 2"
                     /db_xref="GeneID:74249"
                     /db_xref="MGI:MGI:1921499"
     exon            1..132
                     /gene="Lrrc2"
                     /gene_synonym="2400002D05Rik; 4933431K03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            133..279
                     /gene="Lrrc2"
                     /gene_synonym="2400002D05Rik; 4933431K03Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             155..1270
                     /gene="Lrrc2"
                     /gene_synonym="2400002D05Rik; 4933431K03Rik"
                     /codon_start=1
                     /product="leucine-rich repeat-containing protein 2"
                     /protein_id="NP_083114.2"
                     /db_xref="CCDS:CCDS23580.1"
                     /db_xref="GeneID:74249"
                     /db_xref="MGI:MGI:1921499"
                     /translation="MGHKVVVFDISVVRALWETRVKKHKAWQKKEAERLEKSALEKIK
                     EEWDFVAECRRKGVPQAEYCKNGFVDTSTRLLEKIERNSVSRQSARVKDRDKRRSPFV
                     FELSGTQWKELPDSLKEQTHLKEWYIHSTLIQIIPTYIELFQAMKILDLPKNQITCLP
                     AEIGRLKNLKELNVSFNHLKSIPPELGDCEHLERLDCSGNLDLMDLPFELSNLKQVTF
                     VDISANKFSSVPICVLRMCRLQWLDISSNNLSDLPQDIDRLEELQGFLLYKNKLTYLP
                     QAMLNLKKLTLLVVSGDHLVEVPTALCDASTPLKFVSLVDNPIDKTGCQDTEDTVESE
                     RDRQHFDKEFMKAYIEDLKEREAVPSYTTKVSFSLQL"
     exon            280..487
                     /gene="Lrrc2"
                     /gene_synonym="2400002D05Rik; 4933431K03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            488..644
                     /gene="Lrrc2"
                     /gene_synonym="2400002D05Rik; 4933431K03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            645..781
                     /gene="Lrrc2"
                     /gene_synonym="2400002D05Rik; 4933431K03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            782..927
                     /gene="Lrrc2"
                     /gene_synonym="2400002D05Rik; 4933431K03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1083
                     /gene="Lrrc2"
                     /gene_synonym="2400002D05Rik; 4933431K03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1220
                     /gene="Lrrc2"
                     /gene_synonym="2400002D05Rik; 4933431K03Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1221..3657
                     /gene="Lrrc2"
                     /gene_synonym="2400002D05Rik; 4933431K03Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3634..3639
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lrrc2"
                     /gene_synonym="2400002D05Rik; 4933431K03Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3657
                     /gene="Lrrc2"
                     /gene_synonym="2400002D05Rik; 4933431K03Rik"
                     /note="major polyA site"
ORIGIN      
        1 ggattttcct ggaagaaagc tttgctgggc gttcatgtga ctcatgttcc agtaagagcc
       61 gcagtctcgg atgacctgag tagagcaggg ttatctggat gtgcttgtgg gtggaacccc
      121 tttggaaggg aggtaacttt atgctgctcc ccaaatggga cacaaagtgg tcgtgtttga
      181 catctctgtt gtcagagcct tatgggaaac tcgtgtcaag aagcacaaag catggcagaa
      241 gaaggaggca gaaaggctgg agaaaagcgc cctggagaag ataaaggagg agtgggactt
      301 tgtggccgag tgcaggagga agggcgtgcc ccaggctgag tactgcaaga atggctttgt
      361 ggacaccagc acaaggctcc tggaaaagat agagaggaac tctgtttcca ggcagagtgc
      421 gcgagtcaag gacagagaca aacggaggag tccatttgtg tttgaacttt cagggacaca
      481 gtggaaggag ctgcctgatt cgctgaagga gcagacacac ctcaaagaat ggtacattca
      541 cagtaccctc attcagatca ttcccacgta catcgagctg tttcaagcca tgaaaatttt
      601 ggatttgcca aaaaaccaaa tcacgtgtct tccagctgaa attggtcgct taaagaacct
      661 gaaagaactc aatgtgagtt ttaaccattt gaagagtatt cccccggagc taggagactg
      721 tgagcatcta gagagactgg actgttctgg gaatctggac ctgatggatc tcccctttga
      781 attaagtaat ttgaagcaag ttacatttgt ggatatctct gcgaacaagt tctccagcgt
      841 tcctatctgt gtcctgcgga tgtgtcgtct gcagtggctg gatatcagca gcaacaatct
      901 gagtgacctg ccacaagata tagacaggct ggaagagcta caaggtttcc tgctgtataa
      961 aaacaagctg acctaccttc ctcaagccat gctcaacctc aaaaagctca ccttgctggt
     1021 tgtcagtggg gatcacctgg tggaggtccc gaccgccctc tgcgatgcct ccacgccttt
     1081 gaaatttgta agccttgtgg acaatcccat tgataagacc ggatgtcaag acactgaaga
     1141 cacagtagag agcgagcggg accgccagca ttttgataag gaatttatga aagcatatat
     1201 tgaagacctt aaagaaagag aagctgttcc cagttatacg accaaagtgt catttagtct
     1261 tcagctttga ttcggttcac cagaagatga caaaaatctt actgccccgt gctctaaatc
     1321 tttgaatatg tgttacctct tattggaatt gcggcttgtg cttaaggaca aagtctagaa
     1381 actactacca tcatcactgt taagaaagat aacattcaaa ttattgataa acttgcttat
     1441 atattaatgt tagcagacga atgcacatac ttgtcctaaa tactgcatat ttaataattt
     1501 aggaaacaca tcacttaaaa attacaacat ttaaaaaaat tacaacacct agaacaagtt
     1561 ttgaaattgg atgcattatg ttcaggaatc aagggctaga gggttgtggg tgaaatggag
     1621 aatttaccac cttgaaaatg tttcaggggg ctggctcagt ggttaagaga gcctgttctt
     1681 ccgaaggtcc agagttcaaa tcccagcaac cacatggtgg ctcacaacca tccgtaacaa
     1741 aatctgatgc cctcttctgg agtgtctgaa gacaactaca gagtacttac atatagtaaa
     1801 taaataaatc taaaaaaaaa aaaaaaaaga aaaagaaaat atttcagtat actgtttatt
     1861 tttattgaga acaacgctcc ttgagtctaa acaacttcct acttccatat ttcaaattta
     1921 ttttggcaag tacattttaa gttgtacttt gactctcagg agagcctgat ggtataactt
     1981 gggtctcgag ggtggaaaga aagactggca ttatgtagag catccagcac tagacactca
     2041 gacagtgtga gctgggaaga tccaaatact ctgcttgttc tgtcctgaat ggtcacctgg
     2101 tggtcctcag aacaaagagc ggaggaatgc cttcagggtt cactcctgta ggtgctgggg
     2161 agagtgtgga caccacactg cggcttccat atgggagtga caggagggtt ctgcctactg
     2221 gagtgcagct gtgggctggc aggagcctcc gggatgtcaa tttgcattgg taaaggtatc
     2281 actctctggg gggtgggggg gtgggggggg gagctctgtg ttcctgaatc atgcttacat
     2341 cactggagga actatataaa gcttctattt ttatacggtg tcttaggcta aaacaagcag
     2401 gaagtggctg ttctgaagag aagagggaga tacacatgta ttgctggttt gtgtatgagt
     2461 ggtctccttt cggaggtagt ccagtgcagc ccactacagc cctcgcagtg gttaaacagc
     2521 ctgtgtctgt gttgttagat gccacagcgt ccagggatgg agtacgtgat gtctgccaaa
     2581 tctcaaaaac tacattttaa atgcaattta cttaaatagt cacttgtggc taccatactg
     2641 cacagcaagg cctaacctgt tacgctgggg caggaggaca ttgtctgtga ttataaacaa
     2701 acaaatgaac gaacaaatga atgaatgaat taataaatgg gtaatttttc cttttttttt
     2761 taacccaaag aactgatttg ccctcagaat catataattt aaaaaggtta ccacataaca
     2821 cacaattaaa acaaacaaac aaacaaacaa acacaaccta aaacaaaagg gttactaagg
     2881 ctgggagatg gctcagtggt taaagctgtt gctatccaaa tctaagaacc aggtggctca
     2941 cctgccattc cagtctgggt acccagtgca aactggctag ctagccaggc ctaccggaag
     3001 ctgttgtctt gaataggaga tagagcctcg gtcaataaag tgggaagatg ctagagtagg
     3061 agtcaaactc tggcctctcc atggggacac acacaggtgc accccacaca catgcaaaac
     3121 cacgcaacac atccgcgcac tcacagaaaa tggaaagaag aaagattaat attggcattt
     3181 cagtattttc agcgtttttt ttcctatctc agtagcgtca cttcaacaga aagcaaactg
     3241 tccagaggca ggcgaaagga cgaaacatct ttcttcctca cacttaaaac tgtttcatcc
     3301 gggcgtggtg gcgcacacct ttaatcccag cactcgggag gcagaggcgg gcggatttct
     3361 gagttcgagg ccaacctggt ctacaaagtg aattccagga cagccaaggc tacacagaga
     3421 aaccctgttt caaaataaac aaacaaacaa aaaaaaccaa aacaaaacaa aaaaacctgt
     3481 ttcaaattga tgattagtcc taaacaaatg actaagattg tatttcatac tcaagtacag
     3541 gctttatatc aagatttgaa aactaaaatg tgaaaagatg gaagggtaga atttcataca
     3601 aatggacttc ttaatgtatg taaattctat tttaataaaa ccagcctttg cgtaaaa
//
