LOCUS       NM_175305               3712 bp    mRNA    linear   ROD 15-JAN-2024
DEFINITION  Mus musculus leucine rich repeat containing 19 (Lrrc19), transcript
            variant 1, mRNA.
ACCESSION   NM_175305
VERSION     NM_175305.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3712)
  AUTHORS   Xie R, Gu Y, Li M, Li L, Yang Y, Sun Y, Zhou B, Liu T, Wang S, Liu
            W, Yang R, Su X, Zhong W, Wang B and Cao H.
  TITLE     Desulfovibrio vulgaris interacts with novel gut epithelial immune
            receptor LRRC19 and exacerbates colitis
  JOURNAL   Microbiome 12 (1), 4 (2024)
   PUBMED   38172943
  REMARK    GeneRIF: Desulfovibrio vulgaris interacts with novel gut epithelial
            immune receptor LRRC19 and exacerbates colitis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3712)
  AUTHORS   Su X, Wei J, Qi H, Jin M, Zhang Q, Zhang Y, Zhang C and Yang R.
  TITLE     LRRC19 Promotes Permeability of the Gut Epithelial Barrier Through
            Degrading PKC-zeta and PKCiota/lambda to Reduce Expression of ZO1,
            ZO3, and Occludin
  JOURNAL   Inflamm Bowel Dis 27 (8), 1302-1315 (2021)
   PUBMED   33501933
  REMARK    GeneRIF: LRRC19 Promotes Permeability of the Gut Epithelial Barrier
            Through Degrading PKC-zeta and PKCiota/lambda to Reduce Expression
            of ZO1, ZO3, and Occludin.
REFERENCE   3  (bases 1 to 3712)
  AUTHORS   Sun J, Wang Z and Wang X.
  TITLE     Suppression of LRRC19 promotes cutaneous wound healing in pressure
            ulcers in mice
  JOURNAL   Organogenesis 14 (1), 13-24 (2018)
   PUBMED   29461900
  REMARK    GeneRIF: LRRC19 could be a potential therapeutic target for
            pressure ulcers.
REFERENCE   4  (bases 1 to 3712)
  AUTHORS   Cao S, Su X, Zeng B, Yan H, Huang Y, Wang E, Yun H, Zhang Y, Liu F,
            Li W, Wei H, Che Y and Yang R.
  TITLE     The Gut Epithelial Receptor LRRC19 Promotes the Recruitment of
            Immune Cells and Gut Inflammation
  JOURNAL   Cell Rep 14 (4), 695-707 (2016)
   PUBMED   26776522
  REMARK    GeneRIF: LRRC19 deficiency impairs the gut immune system and
            host-microbiota interactions.
REFERENCE   5  (bases 1 to 3712)
  AUTHORS   Su X, Min S, Cao S, Yan H, Zhao Y, Li H, Chai L, Mei S, Yang J,
            Zhang Y, Zhang Z, Liu F, Sun W, Che Y and Yang R.
  TITLE     LRRC19 expressed in the kidney induces TRAF2/6-mediated signals to
            prevent infection by uropathogenic bacteria
  JOURNAL   Nat Commun 5, 4434 (2014)
   PUBMED   25026888
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3712)
  AUTHORS   Chai L, Dai L, Che Y, Xu J, Liu G, Zhang Z and Yang R.
  TITLE     LRRC19, a novel member of the leucine-rich repeat protein family,
            activates NF-kappaB and induces expression of proinflammatory
            cytokines
  JOURNAL   Biochem Biophys Res Commun 388 (3), 543-548 (2009)
   PUBMED   19679103
  REMARK    GeneRIF: LRRC19 may play an important role in inducing innate
            immune responses in certain tissues such as the kidney.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK033594.1 and AK165421.1.
            
            On Sep 28, 2017 this sequence version replaced NM_175305.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK033594.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2156              AK033594.1         2-2157
            2157-3712           AK165421.1         1365-2920
FEATURES             Location/Qualifiers
     source          1..3712
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 43.34 cM"
     gene            1..3712
                     /gene="Lrrc19"
                     /gene_synonym="9130022A01Rik"
                     /note="leucine rich repeat containing 19"
                     /db_xref="GeneID:100061"
                     /db_xref="MGI:MGI:2140219"
     exon            1..105
                     /gene="Lrrc19"
                     /gene_synonym="9130022A01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            106..189
                     /gene="Lrrc19"
                     /gene_synonym="9130022A01Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             115..1209
                     /gene="Lrrc19"
                     /gene_synonym="9130022A01Rik"
                     /note="leucine-rich repeat-containing protein 19"
                     /codon_start=1
                     /product="leucine-rich repeat-containing protein 19
                     precursor"
                     /protein_id="NP_780514.1"
                     /db_xref="CCDS:CCDS18360.1"
                     /db_xref="GeneID:100061"
                     /db_xref="MGI:MGI:2140219"
                     /translation="MKVTRFMFWLFSMLLPSVKSQASETEVPCNFSRRNYTLIPEGIS
                     TNVTILDLSYNRITLNAADSRVLQMYSLLTELYLMENNIIALYNSSFRNLLNLEILNI
                     CGNSISVIQQGSFVGLNELKQLFLCQNKILQLNPDTFVPLNNLKVLNLQGNLIRLFDA
                     PQLPHLEILTLDGNPWNCTCGLLELHNWLNTSNVTLENENMTMCSYPDELKHDSIKSA
                     PFTTECHSTFISTITEDFQSTRNSSFNSSSHNLTWTSEHEPLGKSWAFLVGVVATVLL
                     TSLLIFIAIKCPVWYNILLSYNHHRLEEHEAETYENGLTRNPSSLSQITDTNSEDTTV
                     IFEQLHAFVVDDDGFIEDRYIDINEVHEEK"
     exon            190..703
                     /gene="Lrrc19"
                     /gene_synonym="9130022A01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            704..880
                     /gene="Lrrc19"
                     /gene_synonym="9130022A01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            881..3712
                     /gene="Lrrc19"
                     /gene_synonym="9130022A01Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaacagtga aatgagacct tctgacacag gcttttctaa tggtgtagaa gaagcagagt
       61 aaactcgcac acactgctct cagatacaaa aaggagaaag gaaaggcctt cgatatgaaa
      121 gtcacacgct tcatgttttg gctcttctcc atgctactac catctgtcaa aagccaagct
      181 tctgaaacag aagtcccatg taatttcagc agaaggaatt acactttgat tccagagggt
      241 atcagtacca atgttaccat tcttgatctc agttataacc gaattactct gaatgctgca
      301 gatagcaggg tgctgcagat gtactcttta ctcactgagc tctacctgat ggagaataac
      361 atcattgcct tatataacag cagtttcagg aatcttctca acctagaaat tttaaatatc
      421 tgtggaaatt caatcagtgt aattcaacag ggttcatttg ttggcttaaa tgaactaaaa
      481 caattatttc tttgccaaaa caaaatatta caactgaatc ccgatacatt tgtgcctcta
      541 aataacctaa aagttctgaa tctgcaaggc aatttgatac gcctcttcga tgcaccacag
      601 ctacctcatc tggagatact aactctggat ggaaatccat ggaactgtac ctgtggtcta
      661 cttgagttgc acaactggct gaacacgtct aatgtgacat tagaaaacga gaacatgacc
      721 atgtgtagct acccagatga gctaaagcac gacagcatca agtcagcgcc cttcacaact
      781 gaatgccact ctacatttat ttccactata actgaagact ttcagtccac taggaattca
      841 tctttcaata gctcttcaca caacttaaca tggacctcag agcatgagcc tcttgggaaa
      901 agctgggctt tcctggttgg tgttgttgcc actgtactgc taacttcact gcttatcttc
      961 attgctatca agtgcccagt atggtacaat attctgctga gttacaacca ccatcgcctg
     1021 gaagagcatg aggcagaaac ctatgaaaat ggtcttacaa gaaacccaag ttctctttca
     1081 caaataacag atacgaactc tgaagacacc acagtgatat ttgaacagtt gcatgcattt
     1141 gtggtagatg atgatgggtt tattgaagac agatacatag atatcaatga ggtacatgaa
     1201 gaaaagtaat tttatcgtgt ttaaattctg aaaaatactt tcagactatt tacagcttag
     1261 acagagattt ttatttggca aacaaaacta taaacagcaa accttcatat taattagtac
     1321 cttatgttaa tatcacagtt attacttttt tctatatgtc acaaggaagt ctaaatgcaa
     1381 ttactcatac actggttagc tgtaagttta atgatttatc tatactacca gcatttacta
     1441 gtgtcagcag tgttcgggaa actacagact gctaaaaaca aggcctaagg acaattattt
     1501 atcaactaaa atgagcagat tcttatatta aaaaatacac atgctgtgat gtcttaaatt
     1561 atactaaaat tgtaatcaat aaagaaatac aaattttagg cttatattat caaagtgagg
     1621 aacaggcagc tttaactata taaagtgatc ttatgttcac aaatgaattc acagaattaa
     1681 agaatatgct gcctaaactt aaaaacaaaa tttcctcaaa aatttgtagc actttaaagc
     1741 acagatgtag tgatttggaa taatccctac taaccactac tgcatttgac agtggttgtt
     1801 aggaagaatt ccatatacaa ctgccatgat tgatattaca atggctccta aaatgggcat
     1861 cataacaatt atgaattttc tttaaaagac taaacgtttc tctatttctt ttgggagatt
     1921 atttttaaaa ttattgtgag ctagaactga gaatatttaa gtaatccaca cacatctatc
     1981 tctgtttcaa taaacagagc aatgtttccc aaattgattt gtagaacact gattttctat
     2041 aatgacactg acaaccattt atagaggaag aaaaaggcaa ctggtcaaat tactgaagga
     2101 atctaaatct aaacatagtt aaagattttt ttcctttagt acttatagat tttactaagt
     2161 tcaggtgttc tctgataact caagagtaca gtactaagtt tttgaagggc atctatatag
     2221 catgttcagg tccctgggtt catttctctc tctctcctct cctctctctc tctctctctc
     2281 tctctctctc tctgtatgtg tattccatac acacacagaa acattaaaat ttatttgata
     2341 aacaaaccct ttcttggaag aatagctaat agctcacaac atattaatag attaaaagac
     2401 acattctgaa aaaatagccc taacatagga agggtctatc taaagtgaaa tgtttgccaa
     2461 ttctcttata atagctaagc cgcaaatatt attttaacaa cttaacagtt taaagaatga
     2521 aattaaaaac cagcaaaata tgtattttac cattgtatac atggaaaaac taagtgtatt
     2581 tacttgcatc tgtaaaacac tgaacattta tggatgaagt agtgtaacac attttctgtg
     2641 attttctttg tatacatgag aaggaaaaga gttgaagatg gaacacaggt agaaatgtga
     2701 caacagacct tggtacatga tacacgagca tacaatgctc tgacattcca atttctcttt
     2761 aataaagata ttcaaaagaa tgtacatgat accttcttac aaaaaaagac taataatgaa
     2821 gatcttttca taattttcaa ataatgctca tcaaggacaa tgtacaaagc ctactgattg
     2881 ataacttctt tcactgaagt ggaactaaac gatcatagtt caatctactt aaaagcctag
     2941 gttaaaattc taagtgctag atataaagac ataattcgtc ttagagttta agtctttaga
     3001 agcagaaatc ttcttataaa ctgggtagac cttccctttg tatagaattt agctccttgg
     3061 gagtaaataa aacagcatat atttgacatt tagataaatt taatattaag atgttatggt
     3121 aaattaagaa atgatgatac attttctatt acaaatatgt actttaaatg taaggtttca
     3181 gtaagatgcc agttgtggtt cttgttagta atcccagcac ttgggagaca gagtcagaga
     3241 tactgacaaa cttctgggtt tgagtacgat atcaactcat aagaatccaa caattaaggg
     3301 ctggagagat ggctcagtgg ttgggagcac tgaatactct tccagaggcc ccagattcgg
     3361 ttctcagcac ccacatggca gctcacagct ctctgtggct ccagtttcag gtgctccaat
     3421 gcccttgcaa gacatatacg caggaagaat gtcagtgcac atgaaataaa aacaaataaa
     3481 agtttaatcc aacaattaac aaaatcaaaa taagagaaaa agttaaaatt gtataaggaa
     3541 ataaatgact cacaagttaa gtcacatacc aaaattcatt tatgcatatg tacttacgct
     3601 tgtctttcag taaatatgac atccatactt tgtgtttctc tgtcattttg agctttaagc
     3661 tgtgtaaaca gttaacacag acattattca ttaaaaataa agggtaagca cc
//
