LOCUS       NM_028973               5323 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus leucine rich repeat containing 15 (Lrrc15), mRNA.
ACCESSION   NM_028973 XM_148600 XM_358823
VERSION     NM_028973.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5323)
  AUTHORS   Gong,S., Xiang,K., Chen,L., Zhuang,H., Song,Y. and Chen,J.
  TITLE     Integrated bioinformatics analysis identified leucine rich repeat
            containing 15 and secreted phosphoprotein 1 as hub genes for
            calcific aortic valve disease and osteoarthritis
  JOURNAL   IET Syst Biol 18 (3), 77-91 (2024)
   PUBMED   38566328
  REMARK    GeneRIF: Integrated bioinformatics analysis identified leucine rich
            repeat containing 15 and secreted phosphoprotein 1 as hub genes for
            calcific aortic valve disease and osteoarthritis.
REFERENCE   2  (bases 1 to 5323)
  AUTHORS   Wang,Q.W., Jia,Y.L., Li,P. and Yu,G.Y.
  TITLE     Effect of LRRC15 on autophagy in A549 cells
  JOURNAL   Yi Chuan 46 (5), 398-407 (2024)
   PUBMED   38763774
  REMARK    GeneRIF: Effect of LRRC15 on autophagy in A549 cells.
REFERENCE   3  (bases 1 to 5323)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 5323)
  AUTHORS   Wang,Y., Wang,W., Su,L., Ji,F., Zhang,M., Xie,Y., Zhang,T. and
            Jiao,J.
  TITLE     BACH1 changes microglial metabolism and affects astrogenesis during
            mouse brain development
  JOURNAL   Dev Cell 59 (1), 108-124 (2024)
   PUBMED   38101413
REFERENCE   5  (bases 1 to 5323)
  AUTHORS   Roy,T.A., Bubier,J.A., Dickson,P.E., Wilcox,T.D., Ndukum,J.,
            Clark,J.W., Sukoff Rizzo,S.J., Crabbe,J.C., Denegre,J.M.,
            Svenson,K.L., Braun,R.E., Kumar,V., Murray,S.A., White,J.K.,
            Philip,V.M. and Chesler,E.J.
  TITLE     Discovery and validation of genes driving drug-intake and related
            behavioral traits in mice
  JOURNAL   Genes Brain Behav 23 (1), e12875 (2024)
   PUBMED   38164795
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   6  (bases 1 to 5323)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   7  (bases 1 to 5323)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   8  (bases 1 to 5323)
  AUTHORS   Moore,B.A., Gonzalez Aviles,G.D., Larkins,C.E., Hillman,M.J. and
            Caspary,T.
  TITLE     Mitochondrial retention of Opa1 is required for mouse embryogenesis
  JOURNAL   Mamm Genome 21 (7-8), 350-360 (2010)
   PUBMED   20652258
REFERENCE   9  (bases 1 to 5323)
  AUTHORS   Yoshida,Y., Han,B., Mendelsohn,M. and Jessell,T.M.
  TITLE     PlexinA1 signaling directs the segregation of proprioceptive
            sensory axons in the developing spinal cord
  JOURNAL   Neuron 52 (5), 775-788 (2006)
   PUBMED   17145500
REFERENCE   10 (bases 1 to 5323)
  AUTHORS   Reynolds,P.A., Smolen,G.A., Palmer,R.E., Sgroi,D., Yajnik,V.,
            Gerald,W.L. and Haber,D.A.
  TITLE     Identification of a DNA-binding site and transcriptional target for
            the EWS-WT1(+KTS) oncoprotein
  JOURNAL   Genes Dev 17 (17), 2094-2107 (2003)
   PUBMED   12923058
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK017350.1, BC050245.1 and BX522800.1.
            
            On Apr 15, 2009 this sequence version replaced NM_028973.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK017350.1, BC050245.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                AK017350.1         1-29
            30-2049             BC050245.1         1-2020
            2050-5306           BC050245.1         2022-5278
            5307-5323           BX522800.1         265-281
FEATURES             Location/Qualifiers
     source          1..5323
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 21.23 cM"
     gene            1..5323
                     /gene="Lrrc15"
                     /gene_synonym="5430427N11Rik; LIB"
                     /note="leucine rich repeat containing 15"
                     /db_xref="GeneID:74488"
                     /db_xref="MGI:MGI:1921738"
     exon            1..87
                     /gene="Lrrc15"
                     /gene_synonym="5430427N11Rik; LIB"
                     /inference="alignment:Splign:2.1.0"
     exon            88..5308
                     /gene="Lrrc15"
                     /gene_synonym="5430427N11Rik; LIB"
                     /inference="alignment:Splign:2.1.0"
     CDS             91..1830
                     /gene="Lrrc15"
                     /gene_synonym="5430427N11Rik; LIB"
                     /note="leucine-rich repeat-containing protein 15"
                     /codon_start=1
                     /product="leucine-rich repeat-containing protein 15
                     precursor"
                     /protein_id="NP_083249.1"
                     /db_xref="CCDS:CCDS28099.1"
                     /db_xref="GeneID:74488"
                     /db_xref="MGI:MGI:1921738"
                     /translation="MPLKHYLLLLVSCQAWAAGLAYYGCPSECTCSRASQVECTGAQI
                     VAMPSPLPWNAMSLQILNTHITELPEDKFLNISALIALKMEKNELANIMPGAFRNLGS
                     LRHLSLANNKLKNLPVRLFQDVNNLETLLLSNNQLVQIQPAQFSQFSNLKELQLYGNN
                     LEYIPEGVFDHLVGLTKLNLGNNGFTHLSPRVFQHLGNLQVLRLYENRLSDIPMGTFD
                     ALGNLQELALQENQIGTLSPGLFHNNRNLQRLYLSNNHISHLPPGIFMQLPHLNKLTL
                     FGNSLKELSPGVFGPMPNLRELWLYNNHITSLPDNAFSHLNQLQVLILSHNQLSYISP
                     GAFNGLTNLRELSLHTNALQDLDGNVFRSLANLRNVSLQNNRLRQLPGSIFANVNGLM
                     TIQLQNNNLENLPLGIFDHLGNLCELRLYDNPWRCDSNILPLHDWLILNRARLGTDTL
                     PVCSSPASVRGQSLVIINVNFPGPSVQGPETPEVSSYPDTSSYPDSTSISSTTEITRS
                     TDDDYTDLNTIEPIDDRNTWGMTDAQSGLAIAAIVIGIIALACSLAACICCCCCKKRS
                     QAVLMQMKAPNEC"
     regulatory      5289..5294
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lrrc15"
                     /gene_synonym="5430427N11Rik; LIB"
                     /note="hexamer: AATAAA"
     polyA_site      5308
                     /gene="Lrrc15"
                     /gene_synonym="5430427N11Rik; LIB"
                     /note="major polyA site"
ORIGIN      
        1 atgctgcagt cttgagccgg tccggtcctc cgcctcctct cctcgccgcc tccttcttat
       61 tgacccggca gcctcgtgga gctgctggcc atgccgctga aacattatct ccttttgctg
      121 gtgagctgcc aggcctgggc tgcaggtttg gcctactatg gctgccccag cgaatgtacc
      181 tgttcccggg cctcccaggt agagtgcaca ggggcacaaa ttgtggcgat gccttcccct
      241 ctgccctgga atgctatgag cctgcagatc cttaacacac acatcaccga actccccgag
      301 gacaagttcc tcaacatttc agccctcatc gccctgaaga tggagaagaa cgagctggcc
      361 aacatcatgc caggtgcctt ccgcaatctg ggctcgctgc gtcacctcag ccttgccaac
      421 aacaaactaa agaacctgcc cgttaggctc ttccaggatg tgaacaatct ggagaccctc
      481 ctgctgtcca ataaccagct ggtgcagatc cagccggccc agttctccca gtttagtaat
      541 cttaaggaac tccagttgta tggcaacaat ctggaataca tccccgaagg agtctttgac
      601 cacctggtag gtctcaccaa actcaacctg ggcaacaacg gcttcaccca cctatcccct
      661 agggtctttc agcatctggg caacctccag gtgcttcggc tatatgagaa caggctttca
      721 gacatcccca tgggcacttt tgatgcactt ggcaacctcc aggagctggc cctccaagag
      781 aaccagattg gcaccctctc ccctggcttg ttccacaata accgtaacct ccagagactg
      841 tatctatcca acaaccacat ctcacatctg ccccctggca tcttcatgca gctgccccac
      901 cttaacaagc tcacactctt tgggaattcc ctgaaggagc tttccccggg ggtctttggg
      961 cccatgccca acctgaggga gctttggctc tacaacaatc acattacctc cctccctgac
     1021 aatgccttca gccacctgaa ccagttgcag gttctgattc ttagtcacaa ccagctcagt
     1081 tacatctccc caggagcctt caatgggctg acgaatctcc gagaactgtc cctccacacc
     1141 aatgctctac aggacctgga tgggaatgtc ttccgatcac tggccaacct gaggaacgtc
     1201 tcactccaga ataaccgcct tcgacagctc cctggcagca tcttcgccaa cgtcaatggt
     1261 ctcatgacca tccaactgca gaacaacaat ctagagaact tgcctctggg catctttgat
     1321 cacttaggga acctgtgtga gcttcgtctc tatgacaacc cctggagatg tgactcaaac
     1381 atcctcccac ttcatgactg gctcattctc aacagagcca ggttggggac agacactctt
     1441 ccagtgtgtt ccagtccagc cagtgtccga ggccagtccc ttgtcatcat caatgtcaat
     1501 ttccctggac ccagtgtcca gggcccagaa acccctgaag tatctagcta cccagataca
     1561 tccagctatc ctgacagcac atccatttct tctaccacag agatcaccag gtctaccgat
     1621 gatgactaca ccgatctaaa caccatcgaa cccattgatg accgcaatac atggggcatg
     1681 actgatgccc agagtgggct ggccattgct gccattgtga ttggcatcat agctttggcc
     1741 tgttccctcg ctgcctgtat ctgctgctgc tgctgcaaaa agaggagcca ggcagtcctg
     1801 atgcagatga aggctcccaa tgagtgctag ggaggcaagc tcgaacaggg tgggggaagg
     1861 aggaggtcag aggatccgag aaggtgatca ttcaacttcc aaacctgggg ccacataacc
     1921 aggccctggt ggccccaggg gaaatgtgcc ccatcttgtc ctgtgcccct gaatcttcta
     1981 tagagaagca ggtgtttcag gaccttttac tcccagagaa atctaattgg tcattaaaaa
     2041 aaaaaaaaag caagcaagca agaaaccaat caaccaaggg gtttctcggt cagtgcctag
     2101 gcaactttct gaggggccct ctgccaaatc ctcacttctt tcaagaacaa gcttccccgt
     2161 gcccagcccc tcccaacctc tgtagactta atgatgacaa ggcctgctca catggtgaga
     2221 tagttctctg ctggcacagc tgtgcctcaa agtattatag atgctgcttt cttttttttc
     2281 ccctctcgct tctccttttt gtgccacggc ttgactctgt ctcttccagt gagaggtccc
     2341 ccttttgttt atctgctgct gaagacagac tatattctct ctccgagagg gtttgaatct
     2401 tttagctcac tgcactggct ttggagggtg ttctgcaaga caggaagaca tctgtgccat
     2461 ctgatccaag gcagtgttat tgtcagcatc tgctgtgcca agctcagcct ttcagaggag
     2521 catgtttaaa gcctcaagct ttccttcaaa gagcctggcc cttgatggta tagaatcatg
     2581 ccaaatggct aagttctcaa aacacaaaaa tcagctcact gaaagtggct gaagaatgtg
     2641 acccgctgcc tggggtcctt gcacaccctg ctgcctttgc ctcttctgat tttgtattga
     2701 agcatcacac acatacccgt gtgattggca tgataccaag aaatggtatt gtagtgactc
     2761 cccactccaa gcttgttctg ggggactttc tggggatgct ggagagtttc tagcttcccc
     2821 atggtctggg gaaggattct tacaacctcc cctacctctc catgggaagg aagcctttgc
     2881 ataggcccag ctgttaggag taaaagagat gtaggtgcag tcaggacaaa aagcagccac
     2941 gctggccaga ccagaagcat agaaacgaca gtggcctgtg caagcacttc ttccctgaca
     3001 gtgagccccg tgttgctcat tggcagcccc tctactaatc cttttatggg cattctaggc
     3061 ctgtatctgt ttctaatttt tgttccccac ttggggggaa gcaaaattgc taagagatga
     3121 gatcttccag ctgaacgacc aagtgtaatg gaaaccagga atcagtctat actgtggtca
     3181 aattctccat cagcattagt cagctgtagc tagagtgcag cgtgtttaca gacagcagat
     3241 atcggggcac gctggaaggt cacacgaggg tatggggtgc tctgcagaac tttctgcctg
     3301 gggtctggtt gtgaactgag tggtttagtt tagagttttc tctttgggtg acagtcacac
     3361 tatatctgcc ttagctctgt ttcctgctac aaactatttc tgcacattaa acagttctga
     3421 taagacaaca cagctttctc aggacgacta atacaccaat ccatgcagaa gtaaaagctt
     3481 caaaataagc agacatggtg ggtcatgtct ttagtgagtt caagagtagc ctgtctacag
     3541 agcaagttcc aggatggcca gggctatgca gaaagaccct ccctcaaaaa caacacagga
     3601 aacaaagaat ttcaggtttc tctgtaagtg agggaaagac cccagctaag cacagggatt
     3661 tgtgaagtga ctctatctcc aacctgaggt gacactcata aggcaaatca gaaacccctc
     3721 tgggtcttgg caatgtggaa cttacactat gtccaggtcc ccgacagaat acttcataag
     3781 gaacgcttgt gagaaccaac acactcgatg gcccagggaa gctgatgttg gtcaaaagac
     3841 atcatctttc caaggccaat ctgggtcgtc aaagtgtttg taaagtatct ctagcaactg
     3901 gcacacacga accaaagttg tctccagccc cagagtgagt gtgagcttgg ttctgctggc
     3961 tgtggcttgc tggtaggtcc tggggcgaag agaaggagct gggcctgctt tacagcagat
     4021 ggaagcttga cacagtaccg tgctcccaga actatcaggc gctccttgtg agctatgccc
     4081 atcctcagtg ggctaaggat agagagaggt agcatccata gtatccagtg tcccctgcca
     4141 atcataacct ggaaacacag gctacatctg acattgacca tggcagtggt gtacctcact
     4201 ggctcaaagg ctggcctgag gacagctgtc ctctaatgac atgcccagga gctcccaggc
     4261 agtgagcgaa ggcacagttc ctcaaaatca cattttctag tcagggagag agttggcaga
     4321 acactgggtg gagggtcctt tccaataagg taatccattt tgctcagttc ttgggctgga
     4381 aaaagctctg tggtccctag aagtctgtga tagggtgcag agttcaatcc actcgcctca
     4441 tctgttcagt gctttctaga ctgccatccc agccttgtgc agagtgggga gaacagttga
     4501 ctctagaagg ctaataaagg ccaaccagaa ctagcatggt aaagatgttc agggcctggg
     4561 tgtccttcaa agctcttccc ctaaccctct tggcacctta ggaaactagt tccaccatta
     4621 tcttttgtga gtcttttctg cacagtgccc aacttacaat ccctgtagag gcttcatggg
     4681 ctgtctaggg ctttcatcag gagactgtag gaaacagctc gcagtacagt tacagctggc
     4741 ttcttggagc atctcaccca cagccataca gtttccacag gcatcgagat ggtggaatgg
     4801 aagtgtggaa gccggttcca gccttgggag agcatgaaga acagaatgat aacatgagtc
     4861 aggaagcagg ccttgcatgt gtcctagact tagctataaa ctacttaaag atctgtcccc
     4921 agactccgaa gtcagagcca gatctggctg tggaagagaa tctggctgtt gatgattgca
     4981 ggagggaagc cattagtgtt gtctgagaga gtgtgcagca ggtaacttcc atgtggagcc
     5041 ccaccgagtc agggcccttc tcctaaggag agattgttct tgcctcccac tgtctttgct
     5101 ctgccttcta gaacaatcat gcttgactta ctagacagtc tccgcaagta gtcccagttg
     5161 cttggcagtg catttagaga tttctaggct cccagggttc tgtagaatgt gagccctgct
     5221 gggcaggttt aggggaatct gtcctttgct agatgcggct tgtaacagat ttggtgtaca
     5281 ggatcaacaa taaacggtat acaaagggaa aaaaaaaaaa aaa
//
