LOCUS       NM_001358891            2238 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus leucine rich repeat containing 14 (Lrrc14), transcript
            variant 3, mRNA.
ACCESSION   NM_001358891 XM_006520785
VERSION     NM_001358891.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2238)
  AUTHORS   Wu,C., Yang,Y., Ou,J., Zhu,L., Zhao,W. and Cui,J.
  TITLE     LRRC14 attenuates Toll-like receptor-mediated NF-kappaB signaling
            through disruption of IKK complex
  JOURNAL   Exp Cell Res 347 (1), 65-73 (2016)
   PUBMED   27426725
  REMARK    GeneRIF: TLR signaling led to lower expression of LRRC14.
REFERENCE   2  (bases 1 to 2238)
  AUTHORS   Uwanogho,D.A., Yasin,S.A., Starling,B. and Price,J.
  TITLE     The intergenic region between the Mouse Recql4 and Lrrc14 genes
            functions as an evolutionary conserved bidirectional promoter
  JOURNAL   Gene 449 (1-2), 103-117 (2010)
   PUBMED   19720120
  REMARK    GeneRIF: we define a small core bidirectional promoter that drives
            expression of the mouse genes Recql4, on one strand, and Lrrc14; a
            novel member of the LRR gene family, on the opposite strand
REFERENCE   3  (bases 1 to 2238)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC156550.5.
            
            On Dec 13, 2017 this sequence version replaced XM_006520785.3.
            
            Transcript Variant: This variant (3) differs in the 5' UTR compared
            to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK149655.1, AK159836.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-287               AC156550.5         87741-88027
            288-641             AC156550.5         89967-90320
            642-1226            AC156550.5         90501-91085
            1227-2238           AC156550.5         91180-92191
FEATURES             Location/Qualifiers
     source          1..2238
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 36.28 cM"
     gene            1..2238
                     /gene="Lrrc14"
                     /gene_synonym="E130306I01Rik; mKIAA0014"
                     /note="leucine rich repeat containing 14"
                     /db_xref="GeneID:223664"
                     /db_xref="MGI:MGI:2445060"
     exon            1..287
                     /gene="Lrrc14"
                     /gene_synonym="E130306I01Rik; mKIAA0014"
                     /inference="alignment:Splign:2.1.0"
     exon            288..641
                     /gene="Lrrc14"
                     /gene_synonym="E130306I01Rik; mKIAA0014"
                     /inference="alignment:Splign:2.1.0"
     CDS             313..1794
                     /gene="Lrrc14"
                     /gene_synonym="E130306I01Rik; mKIAA0014"
                     /codon_start=1
                     /product="leucine-rich repeat-containing protein 14"
                     /protein_id="NP_001345820.1"
                     /db_xref="CCDS:CCDS27589.1"
                     /db_xref="GeneID:223664"
                     /db_xref="MGI:MGI:2445060"
                     /translation="MHTLVFLSTRQVLQCQPAACQALPLLPRELFPLLFKVAFMDKKT
                     LVLRELVHTWPFPLLSFQQLLQECAHCSRALLQERLSTESMQAVILGLTARIHTQETE
                     AGTQPLCRKHALRVLDMTGLLDDGVEQDPETMSMWDCTAAVARTCIAQQQGGTAEPGL
                     SPVPVEIRVDLRVNRASYTFLREALQSSVASPLRLCCRDLRAEDLPMRNTVALLQLLD
                     AGCLRRIDLRFNNLGLRGLSVIIPHVARFQHLASLRLHYVHGDSRQPSVDGEDNFRYF
                     LAQMGRFMCLRELSMGSSLLSGRLDQLLSTLQRPLESLELAFCALLPEDLRFLAQSSH
                     AAHLKKLDLSGNDLSGNQLTPFQGLLQAVATTLLHLELTECQLADAQLLATLPTLTRC
                     ASLRYLGLYGNPLSMAGLKELLRDSVVQAELRTVVHPFPVDCYEGLPWPPPASVLLEA
                     SINEEKFARVEAELHQLLLASGRAHVLWTTDIYGRLAADYFSL"
     exon            642..1226
                     /gene="Lrrc14"
                     /gene_synonym="E130306I01Rik; mKIAA0014"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..2238
                     /gene="Lrrc14"
                     /gene_synonym="E130306I01Rik; mKIAA0014"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2238
                     /gene="Lrrc14"
                     /gene_synonym="E130306I01Rik; mKIAA0014"
                     /note="major polyA site"
ORIGIN      
        1 gcggagctgg gcgaggcttg ctgggcgagg aagggttgca ggccttggta gtcggggagg
       61 cggatgagcg ggggccgcgg ggctgggatt cgagtcgagc tgagagtcaa gcagccgtta
      121 gtggtcaggg cacttggacg gcaggttcga cggggactgg cgcttgaaga ccacggctga
      181 ggcggattct cgggaggtgc cgccggcgcg cggggatggg ccgcaagcga agggagacct
      241 aggggcgggc gaggccggtc tcggcctgtg gctccaggct cgcccgggtg gctgtctgcc
      301 cagtccagca ccatgcacac acttgtgttc ctcagcacgc gtcaggtcct tcagtgccag
      361 ccagctgcat gccaggccct gcccctgctg ccccgggaac tcttccctct gctcttcaag
      421 gtggccttca tggacaaaaa gacgcttgtg ctgcgtgagc tggtgcacac gtggcccttt
      481 cccctgctca gcttccagca gctgctgcag gagtgtgccc actgcagtcg agccctgctg
      541 caggagcggc tcagcacaga aagcatgcag gctgtgatcc tggggctgac agctcggatt
      601 cacactcaag aaacagaggc tggcacgcag cccttgtgca ggaagcatgc attgcgggtt
      661 ctggacatga cgggtctcct ggatgatggt gtggagcagg atcctgaaac catgagcatg
      721 tgggactgta cagccgctgt agccagaacg tgcattgccc agcagcaggg tgggactgcc
      781 gagccagggc tgtcaccagt ccccgtggaa atccgagtag accttcgggt aaaccgggcc
      841 tcgtacacat tccttcgtga ggccctccaa agcagtgtgg ccagcccgct gcggctgtgc
      901 tgccgggacc tgcgggctga ggatctaccc atgcgtaaca ctgtggccct gctacagctt
      961 ttagatgcag gctgtctgcg ccggatagac ctgcgcttca ataacctggg cttgcgtggc
     1021 ctgtctgtca ttatcccaca tgtggcccgc tttcagcact tagctagcct gaggctgcac
     1081 tacgtgcatg gggactcaag acagccttcc gtggacgggg aggacaactt tcgctacttt
     1141 ctggcccaga tgggccggtt tatgtgtctt cgggagctca gcatggggtc ttctctcctt
     1201 tcaggcaggc tggatcaact gctcagcacc ctgcagaggc ccctggaaag cctagaactg
     1261 gccttctgtg cgctcttgcc tgaggaccta cgcttcctgg ctcagagttc tcatgctgcc
     1321 catctcaaaa agttggattt gagtggcaac gacctgtcag gcaaccagtt gacacccttc
     1381 cagggtctgc tgcaggcagt agccaccaca ctgctgcatc ttgagctgac tgagtgccag
     1441 cttgctgatg cccagctgtt ggctaccctg cccaccctca ctcgatgtgc cagtctccgc
     1501 taccttggtc tctatggcaa ccctttgtct atggcaggac ttaaagaact gcttcgggac
     1561 tctgtggtac aggctgagct acgtaccgtg gtacacccct tccctgtgga ctgctatgag
     1621 ggtcttcctt ggccaccacc tgcctctgtc cttctggaag cctccatcaa tgaggagaag
     1681 tttgcccggg tggaagctga gttacaccaa ctgctgttag cttcgggccg tgcccatgtg
     1741 ctctggacca cagacatcta tggccggcta gctgcagact attttagcct ctgatctcca
     1801 gggtcgtagt gaagcctgac acaaaggctc tgtcttaggt tttctgcagt ttgcctttct
     1861 cctgggtata ccttgagtca cttctgcttt ctgcagtacc cttcacctgc tcccagtatc
     1921 tggcagcctg ttgctatctc aggcctgtgc gcccctgttc tgtttgatgt acttgttggc
     1981 tctgttgggt tgtagtctct ctgtagaaaa cgcttcctgg acacatccca tgccctaagc
     2041 aggcatgcag tgcactgagg tagatgtcag ggtgatctgc ttcagggcat tttggggtct
     2101 tacattgtgt accctgcctg gcaccctatt acctggctct ggagggtgtg gataaggtac
     2161 aaacgtgtag tatctggaat gtgaatttat gggctttttt gatgtgtgtc ctaattggat
     2221 gggaaagact tacctgca
//
