LOCUS       NM_001081406            1503 bp    mRNA    linear   ROD 01-MAY-2024
DEFINITION  Mus musculus leucine rich repeat protein 1 (Lrr1), transcript
            variant 1, mRNA.
ACCESSION   NM_001081406 XM_979374
VERSION     NM_001081406.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1503)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1503)
  AUTHORS   Kamura,T., Maenaka,K., Kotoshiba,S., Matsumoto,M., Kohda,D.,
            Conaway,R.C., Conaway,J.W. and Nakayama,K.I.
  TITLE     VHL-box and SOCS-box domains determine binding specificity for
            Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases
  JOURNAL   Genes Dev 18 (24), 3055-3065 (2004)
   PUBMED   15601820
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC099934.14.
            
            On Mar 29, 2018 this sequence version replaced NM_001081406.1.
            
            Transcript Variant: This variant (1) encodes the functional
            protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK144741.1, BC075711.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-249               AC099934.14        77066-77314
            250-348             AC099934.14        80114-80212
            349-1070            AC099934.14        82644-83365
            1071-1503           AC099934.14        86832-87264
FEATURES             Location/Qualifiers
     source          1..1503
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 28.73 cM"
     gene            1..1503
                     /gene="Lrr1"
                     /gene_synonym="2410005L11Rik; LRR-1; Ppil5"
                     /note="leucine rich repeat protein 1"
                     /db_xref="GeneID:69706"
                     /db_xref="MGI:MGI:1916956"
     exon            1..249
                     /gene="Lrr1"
                     /gene_synonym="2410005L11Rik; LRR-1; Ppil5"
                     /inference="alignment:Splign:2.1.0"
     CDS             43..1311
                     /gene="Lrr1"
                     /gene_synonym="2410005L11Rik; LRR-1; Ppil5"
                     /note="peptidylprolyl isomerase (cyclophilin) like 5"
                     /codon_start=1
                     /product="leucine-rich repeat protein 1"
                     /protein_id="NP_001074875.1"
                     /db_xref="CCDS:CCDS36462.1"
                     /db_xref="GeneID:69706"
                     /db_xref="MGI:MGI:1916956"
                     /translation="MRLPCEVEVRSCHLPTLGLKSRGKGVRAVVSLCQAPGRNELQPE
                     ARAEPGGHACLLVSTMKDRQGTSYKLRENIEQLFTKFVDEGKATVRLKEPPVDICLSK
                     ANPGNLKTLLSAMRLAHRGCDVNTPLSTLKPVKTSEFEKYKTKMVITSKKDYPLSKNF
                     PYFLEHLQASYCSLARVDMRMLCLKNLTKLDLSHNCIKKLPATIGDLTHLQELNLNDN
                     QLETFSVPLCTSTLQKSLHSLDLSKNKIKALPVQFCQFRELTNLNLNDNELIHLPFKI
                     GQLTNLRFLSAARNKLRNLPSEFKMLSLEYLDLFGNTFEKPEVIPIIKLQVPLTLLES
                     CEQAVLFYRIPYGPDIIPYHLCQDLDTAKTCVCGRFCLQSFIQGTTTMNLHSVAHTVV
                     LVDSMGRTEAPVVSYFCSLTCFVKSSDMLN"
     exon            250..348
                     /gene="Lrr1"
                     /gene_synonym="2410005L11Rik; LRR-1; Ppil5"
                     /inference="alignment:Splign:2.1.0"
     exon            349..1070
                     /gene="Lrr1"
                     /gene_synonym="2410005L11Rik; LRR-1; Ppil5"
                     /inference="alignment:Splign:2.1.0"
     exon            1071..1503
                     /gene="Lrr1"
                     /gene_synonym="2410005L11Rik; LRR-1; Ppil5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1473..1478
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lrr1"
                     /gene_synonym="2410005L11Rik; LRR-1; Ppil5"
                     /note="hexamer: ATTAAA"
     polyA_site      1500
                     /gene="Lrr1"
                     /gene_synonym="2410005L11Rik; LRR-1; Ppil5"
                     /note="major polyA site"
ORIGIN      
        1 aagttttaaa gcctgcgggc cagcgggcga cttagctgca agatgaggct gccctgcgag
       61 gtggaggtcc gtagctgtca tttgccaacc ttagggctca agagccgagg caagggcgtg
      121 cgagcggtgg tgagcctgtg ccaggccccg ggcaggaatg agctgcagcc tgaggcaaga
      181 gcagagccgg gcggccacgc ctgcctgctg gtctccacca tgaaggacag gcagggaacc
      241 agctacaagc taagagagaa cattgagcag ctcttcacca aatttgtgga tgaggggaaa
      301 gccactgtcc ggctaaagga gcctcctgtg gacatctgtc tgagtaaggc caatcctggc
      361 aatttaaaga ctttactttc agctatgaga ctggctcata gaggctgtga cgtcaacaca
      421 ccactctcaa cactaaaacc agtgaagact tcagaatttg aaaaatataa aaccaaaatg
      481 gttatcacat ccaaaaagga ttatcctcta agcaagaact ttccatattt tctggaacac
      541 cttcaggctt cttactgtag ccttgcccga gttgatatgc gtatgctgtg cttaaaaaat
      601 cttacgaagt tagacctgag tcacaactgt ataaaaaaac ttccagctac aattggagac
      661 ctcacccacc ttcaagagct taaccttaat gacaatcagc tggagacctt tagtgtgccc
      721 ttgtgtactt ccacactcca gaagtcactt cacagtttgg atctcagcaa gaacaaaatc
      781 aaagcgctcc ctgtgcagtt ttgtcaattc cgggaactta ctaacttaaa ccttaatgat
      841 aatgaattga ttcaccttcc tttcaagata ggacagctaa caaacctccg ttttctatca
      901 gcagctcgaa acaaacttag aaatctaccc tctgaattta aaatgttatc cctggagtac
      961 ttggatcttt ttgggaatac ttttgaaaaa ccagaagtca ttccaattat aaagcttcaa
     1021 gtaccattaa ctttactgga atcatgtgaa caagctgtgc tattctatag gattccatat
     1081 ggccctgata taattcctta ccatctttgt caagatttgg atactgccaa aacctgtgtc
     1141 tgtggaagat tttgtctcca atctttcatt caaggaacga ctacaatgaa cctacactct
     1201 gttgcgcaca ctgtggtctt agtagatagt atgggaagaa cggaagctcc tgttgtctct
     1261 tacttttgtt ctctaacctg ttttgtaaag tcctctgata tgttgaacta attaatgtaa
     1321 tatcagaaag gtttctagat gtatatcagt tgagtattca tttatgcttt accagtaaca
     1381 aattagagaa aggaaagcat tttgtatatt tgtatggtaa gaaaatgtat attatgttag
     1441 cattttcaac atttgactcg aattttaatt taattaaagc tgaatttagt tttggaagta
     1501 tat
//
