LOCUS       NM_028233               4638 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus leucine-rich PPR-motif containing (Lrpprc), mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_028233
VERSION     NM_028233.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4638)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4638)
  AUTHORS   Zhang,K., Yao,E., Chuang,E., Chen,B., Chuang,E.Y. and Chuang,P.T.
  TITLE     mTORC1 signaling facilitates differential stem cell differentiation
            to shape the developing murine lung and is associated with
            mitochondrial capacity
  JOURNAL   Nat Commun 13 (1), 7252 (2022)
   PUBMED   36433959
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4638)
  AUTHORS   Zhang,K., Yao,E., Chen,B., Chuang,E., Wong,J., Seed,R.I.,
            Nishimura,S.L., Wolters,P.J. and Chuang,P.T.
  TITLE     Acquisition of cellular properties during alveolar formation
            requires differential activity and distribution of mitochondria
  JOURNAL   Elife 11, e68598 (2022)
   PUBMED   35384838
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4638)
  AUTHORS   Paulo,E., Zhang,Y., Masand,R., Huynh,T.L., Seo,Y., Swaney,D.L.,
            Soucheray,M., Stevenson,E., Jimenez-Morales,D., Krogan,N.J. and
            Wang,B.
  TITLE     Brown adipocyte ATF4 activation improves thermoregulation and
            systemic metabolism
  JOURNAL   Cell Rep 36 (12), 109742 (2021)
   PUBMED   34551310
REFERENCE   5  (bases 1 to 4638)
  AUTHORS   Cuillerier,A., Ruiz,M., Daneault,C., Forest,A., Rossi,J., Vasam,G.,
            Cairns,G., Cadete,V., Des Rosiers,C. and Burelle,Y.
  CONSRTM   LSFC Consortium
  TITLE     Adaptive optimization of the OXPHOS assembly line partially
            compensates lrpprc-dependent mitochondrial translation defects in
            mice
  JOURNAL   Commun Biol 4 (1), 989 (2021)
   PUBMED   34413467
  REMARK    GeneRIF: Adaptive optimization of the OXPHOS assembly line
            partially compensates lrpprc-dependent mitochondrial translation
            defects in mice.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4638)
  AUTHORS   Calvo,S.E., Pagliarini,D.J. and Mootha,V.K.
  TITLE     Upstream open reading frames cause widespread reduction of protein
            expression and are polymorphic among humans
  JOURNAL   Proc Natl Acad Sci U S A 106 (18), 7507-7512 (2009)
   PUBMED   19372376
  REMARK    GeneRIF: Includes the study of an upstream ORF in this gene, and
            shows that it functions to reduce protein levels by ~74%.
REFERENCE   7  (bases 1 to 4638)
  AUTHORS   Tsuchiya,N., Fukuda,H., Nakashima,K., Nagao,M., Sugimura,T. and
            Nakagama,H.
  TITLE     LRP130, a single-stranded DNA/RNA-binding protein, localizes at the
            outer nuclear and endoplasmic reticulum membrane, and interacts
            with mRNA in vivo
  JOURNAL   Biochem Biophys Res Commun 317 (3), 736-743 (2004)
   PUBMED   15081402
  REMARK    GeneRIF: associates with mRNA/mRNP complexes at the outside of
            nuclear/endoplasmic reticulum, and plays a role in control of mRNA
            metabolisms
REFERENCE   8  (bases 1 to 4638)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   9  (bases 1 to 4638)
  AUTHORS   Tsuchiya,N., Fukuda,H., Sugimura,T., Nagao,M. and Nakagama,H.
  TITLE     LRP130, a protein containing nine pentatricopeptide repeat motifs,
            interacts with a single-stranded cytosine-rich sequence of mouse
            hypervariable minisatellite Pc-1
  JOURNAL   Eur J Biochem 269 (12), 2927-2933 (2002)
   PUBMED   12071956
  REMARK    GeneRIF: LRP130 may function in stabilizing minisatellite DNA
            sequences.
REFERENCE   10 (bases 1 to 4638)
  AUTHORS   Suzuki,Y., Wanaka,A., Tohyama,M. and Takagi,T.
  TITLE     Identification of differentially expressed mRNAs during neuronal
            differentiation of P19 embryonal carcinoma cells
  JOURNAL   Neurosci Res 23 (1), 65-71 (1995)
   PUBMED   7501302
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC165360.3 and BC059862.1.
            
            On Mar 23, 2007 this sequence version replaced NM_028233.1.
            
            CCDS Note: The coding region has been updated to extend the
            N-terminus to one that is more supported by available transcript
            and homology data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC059862.1, SRR7652917.731630.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            regulatory uORF                    :: PMID: 19372376
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-266               AC165360.3         212134-212399       c
            267-4638            BC059862.1         1-4372
FEATURES             Location/Qualifiers
     source          1..4638
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 55.02 cM"
     gene            1..4638
                     /gene="Lrpprc"
                     /gene_synonym="3110001K13Rik; Gp130; Lrp130; Lsfc"
                     /note="leucine-rich PPR-motif containing"
                     /db_xref="GeneID:72416"
                     /db_xref="MGI:MGI:1919666"
     exon            1..422
                     /gene="Lrpprc"
                     /gene_synonym="3110001K13Rik; Gp130; Lrp130; Lsfc"
                     /inference="alignment:Splign:2.1.0"
     regulatory      70..132
                     /regulatory_class="uORF"
                     /gene="Lrpprc"
                     /gene_synonym="3110001K13Rik; Gp130; Lrp130; Lsfc"
                     /experiment="DESCRIPTION:regulatory uORF[PMID:19372376]"
                     /note="this uORF is predicted to encode a 20 aa peptide
                     (PMID:19372376)"
     CDS             274..4452
                     /gene="Lrpprc"
                     /gene_synonym="3110001K13Rik; Gp130; Lrp130; Lsfc"
                     /note="leucine rich protein LRP130; leucine-rich PPR
                     motif-containing protein, mitochondrial; 130 kDa
                     leucine-rich protein"
                     /codon_start=1
                     /product="leucine-rich PPR motif-containing protein,
                     mitochondrial precursor"
                     /protein_id="NP_082509.2"
                     /db_xref="CCDS:CCDS29003.2"
                     /db_xref="GeneID:72416"
                     /db_xref="MGI:MGI:1919666"
                     /translation="MAALLRPARWLLGAAAAPRLPLSLRLPAGVPGRLSSVVRVAAVG
                     SRPAAGERLSQARLYAIVAEKRDLQEEPAPVRKNSSQFDWALMRLDNSVRRTGRITKG
                     LLQRVFESTCSSGSPGSNQALLLLRSCGSLLPELSLAERTEFAHKIWDKLQQLGVVYD
                     VSHYNALLKVYLQNEYKFSPTDFLAKMEGANIQPNRVTYQRLIAAYCNVGDIEGASKI
                     LGFMKTKDLPITEAVFSALVTGHARAGDMENAENILTVMKQAGIEPGPDTYLALLNAH
                     AERGDIGQVRQILEKVEKSDHYFMDRDFLQVIFSFSKAGYPQYVSEILEKITYERRSI
                     PDAMNLILFLATEKLEDTAFQVLLALPLSKDESSDNFGSFFLRHCVTLDLPPEKLIDY
                     CRRLRDAKLHSSSLQFTLHCALQANRTALAKAVMEALREEGFPIRPHYFWPLLAGHQK
                     TKNVQGIIDILKIMNKVGVDPDQETYINYVFPCFDSAQSVRAALQENECLLASSTFAQ
                     AEVKNEAINGNLQNILSFLESNTLPFSFSSLRNSLILGFRRSMNIDLWSKITELLYKD
                     ERYCSKPPGPAEAVGYFLYNLIDSMSDSEVQAKEERLRQYFHQLQEMNVKVPENIYKG
                     ICNLLNTYHVPELIKDIKVLVDREKVDSQKTSQVTSSDLESTLEKLKAEGQPVGSALK
                     QLLLLLCSEENMQKALEVKAKYESDMVIGGYAALINLCCRHDNAEDAWNLKQEVDRLD
                     ASAILDTAKYVALVKVLGKHSRLQDAINILKEMKEKDVVIKDATVLSFFHILNGAALR
                     GEIETVKQLHEAIVTLGLAKPSSNISFPLVTVHLEKGDLPAALEASIACHKKYKVLPR
                     IHDVLCKLVEKGETDLIQKAMDFVSQEQGEMTMLYDLFFAFLQTGNYKEAKKIIETPG
                     IRARPTRLQWFCDRCIASNQVEALEKLVELTEKLFECDRDQMYYNLLKLYKISSDWQR
                     ADAAWTKMQEENIIPRERTLRLLAEILKTSNQEVPFDVPELWFGDDRPSLSPSSRSAG
                     EDVTEKTLLSNCKLKKSKDAYNIFLKAEKQNVVFSSETYSTLIGLLLSKDDFTQAMHV
                     KDFAETHIKGFTLNDAANSLLIIRQVRRDYLKGALATLRAALDLKQVPSQIAVTRLIQ
                     ALALKGDVESIEAIQRMVAGLDTIGLSKMVFINNIALAQMKNNKLDAAIENIEHLLAS
                     ENQAIEPQYFGLSYLFRKVIEEQMEPALEKLSIMSERMANQFALYKPVTDLFLQLVDS
                     GKVDEARALLERCGAIAEQSSLLSVFCLRTSQKPKKAPVLKTLLELIPELRDNDKVYS
                     CSMKSYALDKDVASAKALYEYLTAKNLKLDDLFLKRYAALLKDVGEPVPFPEPPESFA
                     FYIKQLKEARESPS"
     exon            423..616
                     /gene="Lrpprc"
                     /gene_synonym="3110001K13Rik; Gp130; Lrp130; Lsfc"
                     /inference="alignment:Splign:2.1.0"
     exon            617..739
                     /gene="Lrpprc"
                     /gene_synonym="3110001K13Rik; Gp130; Lrp130; Lsfc"
                     /inference="alignment:Splign:2.1.0"
     exon            740..861
                     /gene="Lrpprc"
                     /gene_synonym="3110001K13Rik; Gp130; Lrp130; Lsfc"
                     /inference="alignment:Splign:2.1.0"
     exon            862..920
                     /gene="Lrpprc"
                     /gene_synonym="3110001K13Rik; Gp130; Lrp130; Lsfc"
                     /inference="alignment:Splign:2.1.0"
     exon            921..1007
                     /gene="Lrpprc"
                     /gene_synonym="3110001K13Rik; Gp130; Lrp130; Lsfc"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1134
                     /gene="Lrpprc"
                     /gene_synonym="3110001K13Rik; Gp130; Lrp130; Lsfc"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1279
                     /gene="Lrpprc"
                     /gene_synonym="3110001K13Rik; Gp130; Lrp130; Lsfc"
                     /inference="alignment:Splign:2.1.0"
     exon            1280..1425
                     /gene="Lrpprc"
                     /gene_synonym="3110001K13Rik; Gp130; Lrp130; Lsfc"
                     /inference="alignment:Splign:2.1.0"
     exon            1426..1531
                     /gene="Lrpprc"
                     /gene_synonym="3110001K13Rik; Gp130; Lrp130; Lsfc"
                     /inference="alignment:Splign:2.1.0"
     exon            1532..1639
                     /gene="Lrpprc"
                     /gene_synonym="3110001K13Rik; Gp130; Lrp130; Lsfc"
                     /inference="alignment:Splign:2.1.0"
     exon            1640..1758
                     /gene="Lrpprc"
                     /gene_synonym="3110001K13Rik; Gp130; Lrp130; Lsfc"
                     /inference="alignment:Splign:2.1.0"
     exon            1759..1852
                     /gene="Lrpprc"
                     /gene_synonym="3110001K13Rik; Gp130; Lrp130; Lsfc"
                     /inference="alignment:Splign:2.1.0"
     exon            1853..1919
                     /gene="Lrpprc"
                     /gene_synonym="3110001K13Rik; Gp130; Lrp130; Lsfc"
                     /inference="alignment:Splign:2.1.0"
     exon            1920..1947
                     /gene="Lrpprc"
                     /gene_synonym="3110001K13Rik; Gp130; Lrp130; Lsfc"
                     /inference="alignment:Splign:2.1.0"
     exon            1948..2005
                     /gene="Lrpprc"
                     /gene_synonym="3110001K13Rik; Gp130; Lrp130; Lsfc"
                     /inference="alignment:Splign:2.1.0"
     exon            2006..2112
                     /gene="Lrpprc"
                     /gene_synonym="3110001K13Rik; Gp130; Lrp130; Lsfc"
                     /inference="alignment:Splign:2.1.0"
     exon            2113..2190
                     /gene="Lrpprc"
                     /gene_synonym="3110001K13Rik; Gp130; Lrp130; Lsfc"
                     /inference="alignment:Splign:2.1.0"
     exon            2191..2235
                     /gene="Lrpprc"
                     /gene_synonym="3110001K13Rik; Gp130; Lrp130; Lsfc"
                     /inference="alignment:Splign:2.1.0"
     exon            2236..2349
                     /gene="Lrpprc"
                     /gene_synonym="3110001K13Rik; Gp130; Lrp130; Lsfc"
                     /inference="alignment:Splign:2.1.0"
     exon            2350..2480
                     /gene="Lrpprc"
                     /gene_synonym="3110001K13Rik; Gp130; Lrp130; Lsfc"
                     /inference="alignment:Splign:2.1.0"
     exon            2481..2566
                     /gene="Lrpprc"
                     /gene_synonym="3110001K13Rik; Gp130; Lrp130; Lsfc"
                     /inference="alignment:Splign:2.1.0"
     exon            2567..2774
                     /gene="Lrpprc"
                     /gene_synonym="3110001K13Rik; Gp130; Lrp130; Lsfc"
                     /inference="alignment:Splign:2.1.0"
     exon            2775..2899
                     /gene="Lrpprc"
                     /gene_synonym="3110001K13Rik; Gp130; Lrp130; Lsfc"
                     /inference="alignment:Splign:2.1.0"
     exon            2900..3006
                     /gene="Lrpprc"
                     /gene_synonym="3110001K13Rik; Gp130; Lrp130; Lsfc"
                     /inference="alignment:Splign:2.1.0"
     exon            3007..3075
                     /gene="Lrpprc"
                     /gene_synonym="3110001K13Rik; Gp130; Lrp130; Lsfc"
                     /inference="alignment:Splign:2.1.0"
     exon            3076..3166
                     /gene="Lrpprc"
                     /gene_synonym="3110001K13Rik; Gp130; Lrp130; Lsfc"
                     /inference="alignment:Splign:2.1.0"
     exon            3167..3309
                     /gene="Lrpprc"
                     /gene_synonym="3110001K13Rik; Gp130; Lrp130; Lsfc"
                     /inference="alignment:Splign:2.1.0"
     exon            3310..3418
                     /gene="Lrpprc"
                     /gene_synonym="3110001K13Rik; Gp130; Lrp130; Lsfc"
                     /inference="alignment:Splign:2.1.0"
     exon            3419..3545
                     /gene="Lrpprc"
                     /gene_synonym="3110001K13Rik; Gp130; Lrp130; Lsfc"
                     /inference="alignment:Splign:2.1.0"
     exon            3546..3634
                     /gene="Lrpprc"
                     /gene_synonym="3110001K13Rik; Gp130; Lrp130; Lsfc"
                     /inference="alignment:Splign:2.1.0"
     exon            3635..3836
                     /gene="Lrpprc"
                     /gene_synonym="3110001K13Rik; Gp130; Lrp130; Lsfc"
                     /inference="alignment:Splign:2.1.0"
     exon            3837..3976
                     /gene="Lrpprc"
                     /gene_synonym="3110001K13Rik; Gp130; Lrp130; Lsfc"
                     /inference="alignment:Splign:2.1.0"
     exon            3977..4092
                     /gene="Lrpprc"
                     /gene_synonym="3110001K13Rik; Gp130; Lrp130; Lsfc"
                     /inference="alignment:Splign:2.1.0"
     exon            4093..4167
                     /gene="Lrpprc"
                     /gene_synonym="3110001K13Rik; Gp130; Lrp130; Lsfc"
                     /inference="alignment:Splign:2.1.0"
     exon            4168..4252
                     /gene="Lrpprc"
                     /gene_synonym="3110001K13Rik; Gp130; Lrp130; Lsfc"
                     /inference="alignment:Splign:2.1.0"
     exon            4253..4395
                     /gene="Lrpprc"
                     /gene_synonym="3110001K13Rik; Gp130; Lrp130; Lsfc"
                     /inference="alignment:Splign:2.1.0"
     exon            4396..4621
                     /gene="Lrpprc"
                     /gene_synonym="3110001K13Rik; Gp130; Lrp130; Lsfc"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4601..4606
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lrpprc"
                     /gene_synonym="3110001K13Rik; Gp130; Lrp130; Lsfc"
                     /note="hexamer: AATAAA"
     polyA_site      4621
                     /gene="Lrpprc"
                     /gene_synonym="3110001K13Rik; Gp130; Lrp130; Lsfc"
                     /note="major polyA site"
ORIGIN      
        1 gccaggctcg ctgagagccg gggcgctgga caagggaaca gggacactgt gaacggaaga
       61 caaaaaacaa tgtatagtaa aacagaaggc ggatccaggg tatcccgcga actcggcttg
      121 cctctcccgt gagccttggc ggggatctgc ctcctcctcc gctggacgcc ctcggtcctt
      181 agtttgtccc actaggggcg accgggtcgt cacgtgctcc tccaggtcct ctgcaggagc
      241 gtgcatccta tcctgccttg ggtacgctga gccatggcag ccctgctgag acccgcgcgt
      301 tggctgctcg gggccgcggc ggccccgcgc ctcccgctgt ccctgcgcct ccctgcgggc
      361 gtcccgggcc ggctgtcctc cgtcgtccgg gtcgcggctg ttggtagccg gccggctgca
      421 ggagagcgtc tgagccaagc cagattgtat gccatcgttg ctgagaaaag ggatcttcaa
      481 gaggagcctg ctcctgtgag aaagaacagc agtcaatttg actgggctct gatgagactg
      541 gataattctg tccggagaac aggccgcatc acaaaggggc ttctgcagag agtctttgag
      601 agcacgtgta gctcaggtag cccagggagc aatcaagctc tgcttctgct gcgcagctgt
      661 ggctcgctcc tgcccgaact gagtctcgcc gagaggacag agtttgctca caagatctgg
      721 gacaaacttc agcagttagg tgtcgtatat gatgtcagtc attacaatgc tttacttaaa
      781 gtatatcttc aaaatgaata caaattttca cctactgact tcctggcaaa gatggaggga
      841 gcaaacatcc aaccaaatcg agtaacatac cagaggctga tagctgccta ctgtaatgtt
      901 ggggacattg aaggtgccag caagatcctt ggatttatga aaacgaaaga ccttccgatc
      961 acagaggccg tgttcagtgc tctcgtcaca gggcatgcga gagctgggga tatggaaaat
     1021 gcagaaaata ttctcacagt gatgaaacag gccggcattg agcctggccc agacacgtat
     1081 ctggccttgt tgaatgcaca tgctgagagg ggtgacattg gccaggttag gcagattctg
     1141 gagaaagtgg agaagtcaga ccattacttc atggaccgcg acttcttgca ggttattttt
     1201 agcttcagta aggctggcta ccctcagtat gtctcagaaa tactggagaa gattacctat
     1261 gagagacggt ctattccaga tgcaatgaac ctcattttgt ttttagccac tgagaagtta
     1321 gaagacactg cgttccaggt tttattggca ttacccctgt ccaaggacga gagctccgat
     1381 aactttggca gtttcttttt gcggcactgt gtgactctgg atttgccccc tgagaagctg
     1441 atagactact gtcggaggct gagggacgcc aagctgcaca gctcctcact gcagttcacg
     1501 ctgcactgtg ctcttcaagc caataggaca gctttggcaa aagcagtgat ggaggctttg
     1561 agggaagaag ggtttcctat ccgaccgcac tatttctggc cgttgcttgc tgggcatcag
     1621 aaaacaaaaa atgttcaagg aataatagat atcctcaaaa taatgaacaa agtgggagtg
     1681 gatcctgatc aggaaacata tataaactat gtgtttccgt gctttgatag tgcacagtca
     1741 gttcgagctg ctttgcagga aaatgaatgt ctcctcgcaa gtagtacctt tgctcaagct
     1801 gaagtgaaga atgaagcaat aaatgggaac ttacagaaca ttttgtcatt tttggaatcg
     1861 aatacattgc ctttctcgtt tagttctttg agaaacagcc taatcctagg cttcaggagg
     1921 tcgatgaaca tagatctttg gagcaagata acagaattgt tgtacaagga tgaacgctat
     1981 tgctcaaagc ctccgggacc agcggaagct gttggctatt ttctttataa cttgattgac
     2041 agcatgagtg actcagaggt acaggccaag gaggagcgtt tgagacaata cttccatcag
     2101 ctgcaggaga tgaatgttaa agttcctgaa aacatctaca aaggcatttg taatttgctg
     2161 aatacctacc atgttcctga attgattaag gatattaagg ttctggttga cagagagaag
     2221 gtagattctc aaaaaacttc tcaagttacc tcatctgatt tggaatcaac acttgagaaa
     2281 ctcaaagctg aaggccaacc tgtaggatct gccctgaagc agctcctgct gctgctctgc
     2341 tcagaggaga atatgcaaaa ggcccttgag gtgaaagcaa aatatgagtc agacatggtt
     2401 attggtggct atgcagcatt aataaatttg tgctgtcgac atgataatgc agaagatgcg
     2461 tggaacttga aacaagaagt tgaccgctta gatgcttcgg ctattcttga cactgccaag
     2521 tacgtagccc ttgtaaaagt actgggaaag cacagcagac tccaagatgc tattaacatt
     2581 ctaaaggaga tgaaagagaa ggatgttgtt atcaaagatg caacagtctt gtcctttttc
     2641 cacatcctca atggtgcagc tttaagaggt gaaattgaaa cagtaaaaca gctgcatgaa
     2701 gccatcgtga ctcttgggtt ggcaaagccg tccagcaaca taagcttccc gttggtcact
     2761 gtgcacctgg aaaagggtga cttacctgct gctcttgaag ccagcattgc ctgccataaa
     2821 aaatataaag tgttacccag gattcatgat gtcttatgta agctagtaga gaaaggcgag
     2881 actgatttga tccagaaagc aatggacttt gtgagccaag aacaagggga gatgacgatg
     2941 ctctacgacc tcttctttgc tttcctgcag acggggaatt acaaagaagc taagaagatc
     3001 attgagactc caggcattag agctcggcct acaagactcc agtggttttg tgatcgatgc
     3061 attgccagta atcaggttga agctcttgag aagttggtag agctgactga gaagctgttt
     3121 gagtgtgaca gagaccagat gtactacaac ttactgaagc tatacaaaat aagcagtgac
     3181 tggcaaagag cggatgctgc gtggaccaaa atgcaagaag agaacattat ccctcgagag
     3241 cggacactgc ggctcttagc cgagatcttg aaaaccagca accaggaagt tcctttcgac
     3301 gttccggagt tgtggtttgg agatgacaga ccttccctga gtccatcctc acgctcagca
     3361 ggagaggacg ttactgagaa gacgttgttg tctaactgca aactaaagaa gagtaaagat
     3421 gcatataata tcttccttaa agccgaaaag caaaacgttg tatttagcag tgaaacttat
     3481 agcaccttga taggcttgct gctgagtaag gacgacttca cccaagcaat gcacgtgaag
     3541 gatttcgctg agacccacat caagggcttc acactgaacg atgctgccaa cagcctcctc
     3601 atcataaggc aagttaggcg ggattatttg aaaggggctc tggcaactct gagagcagcc
     3661 ttggatttga agcaggttcc gtcccagatc gccgtgaccc gcctcatcca ggcgttggcc
     3721 ttgaagggtg atgtggaaag catagaggcc attcagagaa tggtggctgg acttgacacg
     3781 attggactct caaaaatggt ttttatcaat aacatcgctt tggcccagat gaagaataat
     3841 aaacttgatg ctgccataga aaacattgag cacctgcttg cttccgagaa ccaagccata
     3901 gaacctcagt actttggctt gtcgtatcta ttcagaaaag tgatcgaaga gcagatggaa
     3961 ccagcgctag agaagttaag catcatgtct gagagaatgg cgaatcagtt tgcactttac
     4021 aagcccgtca ctgatctatt cctgcagctt gtggattcag gcaaggtgga tgaggccaga
     4081 gctctcttag agagatgcgg tgccattgcc gagcagagct cgcttctgtc ggtgttctgt
     4141 ctgaggactt ctcagaaacc gaaaaaggca ccagttctga agactttgtt agaactgatt
     4201 cctgagttac gtgataacga taaagtatat tcttgcagca tgaaaagcta tgccttagac
     4261 aaagatgtgg cctcggctaa agcactgtat gagtatttga cagccaagaa cttgaagcta
     4321 gatgacctgt ttctcaagcg ctatgcagct ttgctcaagg atgtcggcga accagtcccc
     4381 ttccccgagc cccctgaaag ctttgcattt tatataaagc aactaaagga agcaagggaa
     4441 agcccttcat gagagaagca gcgcggctgt gtgtgtgtct atgtgtgtgt gtgtctgtgt
     4501 gtgtgtctgt gtgtgtgtct gtgtgtgtgt gtctatgtgt gtatatgcgc gcgcacatgc
     4561 ctatgtctaa atgttatttc taaaatgtac ttgagaggaa aataaaccaa tgaaaatgta
     4621 aaaaaaaaaa aaaaaaaa
//
