LOCUS       NM_013587               2925 bp    mRNA    linear   ROD 12-DEC-2023
DEFINITION  Mus musculus low density lipoprotein receptor-related protein
            associated protein 1 (Lrpap1), mRNA.
ACCESSION   NM_013587
VERSION     NM_013587.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2925)
  AUTHORS   Reid KM and Brown GC.
  TITLE     LRPAP1 is released from activated microglia and inhibits microglial
            phagocytosis and amyloid beta aggregation
  JOURNAL   Front Immunol 14, 1286474 (2023)
   PUBMED   38035103
  REMARK    GeneRIF: LRPAP1 is released from activated microglia and inhibits
            microglial phagocytosis and amyloid beta aggregation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2925)
  AUTHORS   Li H, Wang X, Wang Y, Li Y, Chen Y, Wong YT, He J and He ML.
  TITLE     Secreted LRPAP1 binds and triggers IFNAR1 degradation to facilitate
            virus evasion from cellular innate immunity
  JOURNAL   Signal Transduct Target Ther 8 (1), 374 (2023)
   PUBMED   37743411
  REMARK    GeneRIF: Secreted LRPAP1 binds and triggers IFNAR1 degradation to
            facilitate virus evasion from cellular innate immunity.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2925)
  AUTHORS   Bedogni F and Hevner RF.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2925)
  AUTHORS   Wang H, Xiao L, Wang H and Wang G.
  TITLE     Involvement of chronic unpredictable mild stress-induced
            hippocampal LRP1 up-regulation in microtubule instability and
            depressive-like behavior in a depressive-like adult male rat model
  JOURNAL   Physiol Behav 215, 112749 (2020)
   PUBMED   31770536
  REMARK    GeneRIF: Involvement of chronic unpredictable mild stress-induced
            hippocampal LRP1 up-regulation in microtubule instability and
            depressive-like behavior in a depressive-like adult male rat model.
REFERENCE   5  (bases 1 to 2925)
  AUTHORS   Yook C, Kim K, Kim D, Kang H, Kim SG, Kim E and Kim SY.
  TITLE     A TBR1-K228E Mutation Induces Tbr1 Upregulation, Altered Cortical
            Distribution of Interneurons, Increased Inhibitory Synaptic
            Transmission, and Autistic-Like Behavioral Deficits in Mice
  JOURNAL   Front Mol Neurosci 12, 241 (2019)
   PUBMED   31680851
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2925)
  AUTHORS   Willnow TE, Armstrong SA, Hammer RE and Herz J.
  TITLE     Functional expression of low density lipoprotein receptor-related
            protein is controlled by receptor-associated protein in vivo
  JOURNAL   Proc Natl Acad Sci U S A 92 (10), 4537-4541 (1995)
   PUBMED   7538675
REFERENCE   7  (bases 1 to 2925)
  AUTHORS   Lorent K, Overbergh L, Moechars D, De Strooper B, Van Leuven F and
            Van den Berghe H.
  TITLE     Expression in mouse embryos and in adult mouse brain of three
            members of the amyloid precursor protein family, of the
            alpha-2-macroglobulin receptor/low density lipoprotein
            receptor-related protein and of its ligands apolipoprotein E,
            lipoprotein lipase, alpha-2-macroglobulin and the 40,000 molecular
            weight receptor-associated protein
  JOURNAL   Neuroscience 65 (4), 1009-1025 (1995)
   PUBMED   7542371
REFERENCE   8  (bases 1 to 2925)
  AUTHORS   Van Leuven F, Umans L, Lorent K, Hilliker C, Serneels L, Overbergh
            L, Stas L and Raymakers L.
  TITLE     Molecular analysis of the human and mouse alpha 2M family
  JOURNAL   Ann N Y Acad Sci 737, 163-171 (1994)
   PUBMED   7524394
  REMARK    Review article
REFERENCE   9  (bases 1 to 2925)
  AUTHORS   Lorent K, Overbergh L, Delabie J, Van Leuven F and Van den Berghe
            H.
  TITLE     Distribution of mRNA coding for alpha-2-macroglobulin, the
            murinoglobulins, the alpha-2-macroglobulin receptor and the
            alpha-2-macroglobulin receptor associated protein during mouse
            embryogenesis and in adult tissues
  JOURNAL   Differentiation 55 (3), 213-223 (1994)
   PUBMED   7514554
REFERENCE   10 (bases 1 to 2925)
  AUTHORS   Furukawa T, Ozawa M, Huang RP and Muramatsu T.
  TITLE     A heparin binding protein whose expression increases during
            differentiation of embryonal carcinoma cells to parietal endoderm
            cells: cDNA cloning and sequence analysis
  JOURNAL   J Biochem 108 (2), 297-302 (1990)
   PUBMED   2229028
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY771772.1, BC094324.1 and BY642418.1.
            
            On May 11, 2018 this sequence version replaced NM_013587.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK168421.1, SRR1660811.76187.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 BY771772.1         2-3
            3-2909              BC094324.1         1-2907
            2910-2925           BY642418.1         410-425
FEATURES             Location/Qualifiers
     source          1..2925
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 18.01 cM"
     gene            1..2925
                     /gene="Lrpap1"
                     /gene_synonym="HBP44; RAP"
                     /note="low density lipoprotein receptor-related protein
                     associated protein 1"
                     /db_xref="GeneID:16976"
                     /db_xref="MGI:MGI:96829"
     exon            1..221
                     /gene="Lrpap1"
                     /gene_synonym="HBP44; RAP"
                     /inference="alignment:Splign:2.1.0"
     exon            222..366
                     /gene="Lrpap1"
                     /gene_synonym="HBP44; RAP"
                     /inference="alignment:Splign:2.1.0"
     exon            367..488
                     /gene="Lrpap1"
                     /gene_synonym="HBP44; RAP"
                     /inference="alignment:Splign:2.1.0"
     exon            489..609
                     /gene="Lrpap1"
                     /gene_synonym="HBP44; RAP"
                     /inference="alignment:Splign:2.1.0"
     exon            610..768
                     /gene="Lrpap1"
                     /gene_synonym="HBP44; RAP"
                     /inference="alignment:Splign:2.1.0"
     exon            769..851
                     /gene="Lrpap1"
                     /gene_synonym="HBP44; RAP"
                     /inference="alignment:Splign:2.1.0"
     exon            852..1028
                     /gene="Lrpap1"
                     /gene_synonym="HBP44; RAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..2925
                     /gene="Lrpap1"
                     /gene_synonym="HBP44; RAP"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaggaagat ggcgcctcga agagagaggg tctctacgct gccccggctc caactgctag
       61 tgctgttgtt gctgccgctg atgcttgtgc cccagcccat agcaggccat ggcggcaagt
      121 actcgcgaga gaagaacgag ccggagatgg ccgccaagcg cgagtccggg gaggagttcc
      181 gcatggagaa gctgaaccag ctatgggaga aggccaagcg gcttcatctg tctcctgtga
      241 ggctggccga gctgcattct gacctgaaga tacaagagag ggatgaactc aactggaaaa
      301 agctgaaggt ggaaggcttg gataaggatg gggagaaaga agcaaaactg atccacaacc
      361 tcaacgtcat cctggccaga tacggactgg atgggaggaa ggacgcccag atggtgcaca
      421 gcaacgccct caatgaagac acccaggatg agctggggga ccccaggctg gaaaagctgt
      481 ggcacaaggc aaagacatca gggaaattct ccagtgaaga gctggacaag ctgtggagag
      541 agtttctgca ttacaaagag aagatccagg agtacaatgt gctgctagac acactgagca
      601 gagctgaaga aggttatgag aaccttctca gtccctcgga catggcccac atcaagagcg
      661 acaccctgat cagcaagcac agtgagctga aggacagact gcgcagtatc aaccagggct
      721 tggaccgcct gcggaaggtc agccaccagg gctatggctc caccactgag tttgaagagc
      781 cccgggtgat agatctgtgg gacctggctc agtctgccaa cttcactgag aaggaactgg
      841 agtcattcag ggaggagctc aagcactttg aggccaaaat tgaaaagcac aaccactacc
      901 agaagcagct ggagatttcc caccagaagc tgaagcacgt ggagagcatc ggcgaccccg
      961 agcacatcag ccgcaacaag gagaaatacg tgctgctgga ggagaagacc aaggagctgg
     1021 gctacaaggt gaagaagcat ctacaggacc tgtctagcag ggtctcaagg gctcggcaca
     1081 atgagctctg aggaccagaa gccaccagca gcagcctaga gagaacactt gaagacaccg
     1141 ggagctgtca gcatgtcatc ggcttgcata gacctgaggt gactggtgtg gctgaccacc
     1201 gtggcaagga ggatcccttg aaataccaag ctgatcctac agtggctggc aaggacttat
     1261 tttctttcaa gcaagtgtag ttgtcaccac cctggacgag ggccttgggt accgctacca
     1321 gtgagatagg actggactcc gagctgcagc acaacagttt atattgaaat cacataaacc
     1381 tgcctgccac tggaaacatt ctgtacagag tccttaaata catggcagag ttttgagccc
     1441 tcgagtcctt gcctggtatc tcgaaggatg ggtccattga gccatggcaa attaagttac
     1501 agatgaaggg ggaaggcgaa gactagtcta cccactggaa gcatttccct ccctgcttca
     1561 cgcaccctct ccctctctgg ggatctggcc ccagacagtt ttaaatcaag agatttcagg
     1621 acaaagatgg cagaggtgaa agcctgcagg tcttgcaggg cgaacgtttt ctggccccct
     1681 ccacccccaa agaccctgat cagcttccag atccagtctc tgttccctca cacagaatag
     1741 ccaaaatttt gtctgacccc agcagctgat cctggaagat caggccattg agtttgttag
     1801 ccgctgaatc tcagcccaga aattggaatc tgcctatcag gggtgcgcag ttaaccatgt
     1861 ttaagaatat cacagccgga aagaggctca gtgagtaaaa tgttcataca gcaagcttga
     1921 ggtctacagt ttggatctgc agagccttgc tgtgtttact tacctgcagt cccagcactt
     1981 gagaggcaga gaaagtttat cccagccaaa taaacaaagg tggagtatat gggagaaggc
     2041 actctcccac tctctgatgt gtgcatacac ttacatgtgt acctgtacac aggtgaccac
     2101 tcatagatac tcatatatgg gtgaaactcc cagggcatca tcgtgcaaga agcccatggg
     2161 ttaaggacag cagccgcaag gaacagtagg cagtgtggtt ccctcaccca tgctgtgtct
     2221 gccaccatcc aggccagctg ggatgtgtcc ctctgagcac tagtagatat cttcccagaa
     2281 ccctcagcag tgtctgaggc tcagagaaat tcttgttgct agggtctcag ctctgccttt
     2341 ctggttcagc ccaacaccaa agcctcctgt gcctcacagc ccaggggact caggctcaga
     2401 gtcaactgct gggggagtgc ctggctgtca gatgcacctt cactaatgtt tgtctccatc
     2461 cctagagcca gaggccatgg ctgcatgcta aggcttagaa atgggcacgt tgaagtaaca
     2521 tagcagtata cagcccagtg aaccatctca gagtgagtga tagagagccc acagctatgt
     2581 tagggagagg tgtgacctgt gtgggagctg cctgcttctg gagcagatct ctagtcagga
     2641 ggccactcct gactaagctc tcagatatca gatcctgcaa acttccctgg gtgagtgtga
     2701 ctcccaccgc aagggaacct caagctacaa acttagatgc ggttctggct agcaggctct
     2761 gccacctagc aacagtgact gaaagtcctc aggctgacag gtcaccagtc acattatggt
     2821 aaaggagaac aggttcatgc aagttgtcct ctcactatgc gtgctacggc acatgggttc
     2881 acacaatgaa taaaatatct tttaaagcat tctttctggg gaaaa
//
