LOCUS       NM_053073               7674 bp    mRNA    linear   ROD 05-DEC-2024
DEFINITION  Mus musculus low density lipoprotein receptor-related protein 8,
            apolipoprotein e receptor (Lrp8), transcript variant 1, mRNA.
ACCESSION   NM_053073 XM_011240457
VERSION     NM_053073.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7674)
  AUTHORS   Whately,K.M., Sengottuvel,N., Edatt,L., Srivastava,S., Woods,A.T.,
            Tsai,Y.S., Porrello,A., Zimmerman,M.P., Chack,A.C., Jefferys,S.R.,
            Yacovone,G., Kim,D.J., Dudley,A.C., Amelio,A.L. and Pecot,C.V.
  TITLE     Spon1+ inflammatory monocytes promote collagen remodeling and lung
            cancer metastasis through lipoprotein receptor 8 signaling
  JOURNAL   JCI Insight 9 (9), e168792 (2024)
   PUBMED   38716730
  REMARK    GeneRIF: Spon1+ inflammatory monocytes promote collagen remodeling
            and lung cancer metastasis through lipoprotein receptor 8
            signaling.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7674)
  AUTHORS   Caracci,M.O., Pizarro,H., Alarcon-Godoy,C., Fuentealba,L.M.,
            Farfan,P., De Pace,R., Santibanez,N., Cavieres,V.A., Pastor,T.P.,
            Bonifacino,J.S., Mardones,G.A. and Marzolo,M.P.
  TITLE     The Reelin receptor ApoER2 is a cargo for the adaptor protein
            complex AP-4: Implications for Hereditary Spastic Paraplegia
  JOURNAL   Prog Neurobiol 234, 102575 (2024)
   PUBMED   38281682
  REMARK    GeneRIF: The Reelin receptor ApoER2 is a cargo for the adaptor
            protein complex AP-4: Implications for Hereditary Spastic
            Paraplegia.
            Erratum:[Prog Neurobiol. 2024 Oct;241:102662. doi:
            10.1016/j.pneurobio.2024.102662. PMID: 39294072]
REFERENCE   3  (bases 1 to 7674)
  AUTHORS   Wasser,C.R., Werthmann,G.C., Hall,E.M., Kuhbandner,K., Wong,C.H.,
            Durakoglugil,M.S. and Herz,J.
  TITLE     Regulation of the hippocampal translatome by Apoer2-ICD release
  JOURNAL   Mol Neurodegener 18 (1), 62 (2023)
   PUBMED   37726747
  REMARK    GeneRIF: Regulation of the hippocampal translatome by Apoer2-ICD
            release.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7674)
  AUTHORS   Wolfkiel,P.R., Haller,A.M., Kirby,J., Jaeschke,A. and Hui,D.Y.
  TITLE     Different sensitivity to diet-induced hyperinsulinemia and
            hyperglycemia between mice with global or bone marrow-specific apoE
            receptor-2 deficiency
  JOURNAL   Am J Physiol Regul Integr Comp Physiol 325 (1), R55-R68 (2023)
   PUBMED   37212552
  REMARK    GeneRIF: Different sensitivity to diet-induced hyperinsulinemia and
            hyperglycemia between mice with global or bone marrow-specific apoE
            receptor-2 deficiency.
REFERENCE   5  (bases 1 to 7674)
  AUTHORS   Oshima,K., Yoshinaga,S., Kitazawa,A., Hirota,Y., Nakajima,K. and
            Kubo,K.I.
  TITLE     A Unique 'Reversed' Migration of Neurons in the Developing
            Claustrum
  JOURNAL   J Neurosci 43 (5), 693-708 (2023)
   PUBMED   36631266
REFERENCE   6  (bases 1 to 7674)
  AUTHORS   Trommsdorff,M., Gotthardt,M., Hiesberger,T., Shelton,J.,
            Stockinger,W., Nimpf,J., Hammer,R.E., Richardson,J.A. and Herz,J.
  TITLE     Reeler/Disabled-like disruption of neuronal migration in knockout
            mice lacking the VLDL receptor and ApoE receptor 2
  JOURNAL   Cell 97 (6), 689-701 (1999)
   PUBMED   10380922
REFERENCE   7  (bases 1 to 7674)
  AUTHORS   Kim,H.J., Kim,D.H., Magoori,K., Saeki,S. and Yamamoto,T.T.
  TITLE     Evolution of the apolipoprotein E receptor 2 gene by exon loss
  JOURNAL   J Biochem 124 (2), 451-456 (1998)
   PUBMED   9685741
REFERENCE   8  (bases 1 to 7674)
  AUTHORS   Brandes,C., Novak,S., Stockinger,W., Herz,J., Schneider,W.J. and
            Nimpf,J.
  TITLE     Avian and murine LR8B and human apolipoprotein E receptor 2:
            differentially spliced products from corresponding genes
  JOURNAL   Genomics 42 (2), 185-191 (1997)
   PUBMED   9192837
REFERENCE   9  (bases 1 to 7674)
  AUTHORS   Novak,S., Hiesberger,T., Schneider,W.J. and Nimpf,J.
  TITLE     A new low density lipoprotein receptor homologue with 8 ligand
            binding repeats in brain of chicken and mouse
  JOURNAL   J Biol Chem 271 (20), 11732-11736 (1996)
   PUBMED   8662771
  REMARK    Erratum:[J Biol Chem 1996 Oct 25;271(43):27188]
REFERENCE   10 (bases 1 to 7674)
  AUTHORS   Rollins,B.J., Stier,P., Ernst,T. and Wong,G.G.
  TITLE     The human homolog of the JE gene encodes a monocyte secretory
            protein
  JOURNAL   Mol Cell Biol 9 (11), 4687-4695 (1989)
   PUBMED   2513477
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ129380.1, D85463.1, AL807828.14 and AL611936.11.
            
            On or before Mar 14, 2019 this sequence version replaced
            XM_011240457.2, NM_053073.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849383,
                              SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-441               CJ129380.1         1-441
            442-3156            D85463.1           440-3154
            3157-6858           AL807828.14        170892-174593
            6859-7674           AL611936.11        2001-2816
FEATURES             Location/Qualifiers
     source          1..7674
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 50.18 cM"
     gene            1..7674
                     /gene="Lrp8"
                     /gene_synonym="4932703M08Rik; ApoER2; Lr8b"
                     /note="low density lipoprotein receptor-related protein 8,
                     apolipoprotein e receptor"
                     /db_xref="GeneID:16975"
                     /db_xref="MGI:MGI:1340044"
     exon            1..260
                     /gene="Lrp8"
                     /gene_synonym="4932703M08Rik; ApoER2; Lr8b"
                     /inference="alignment:Splign:2.1.0"
     exon            261..380
                     /gene="Lrp8"
                     /gene_synonym="4932703M08Rik; ApoER2; Lr8b"
                     /inference="alignment:Splign:2.1.0"
     exon            381..503
                     /gene="Lrp8"
                     /gene_synonym="4932703M08Rik; ApoER2; Lr8b"
                     /inference="alignment:Splign:2.1.0"
     exon            504..632
                     /gene="Lrp8"
                     /gene_synonym="4932703M08Rik; ApoER2; Lr8b"
                     /inference="alignment:Splign:2.1.0"
     exon            633..1013
                     /gene="Lrp8"
                     /gene_synonym="4932703M08Rik; ApoER2; Lr8b"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..1136
                     /gene="Lrp8"
                     /gene_synonym="4932703M08Rik; ApoER2; Lr8b"
                     /inference="alignment:Splign:2.1.0"
     exon            1137..1259
                     /gene="Lrp8"
                     /gene_synonym="4932703M08Rik; ApoER2; Lr8b"
                     /inference="alignment:Splign:2.1.0"
     exon            1260..1379
                     /gene="Lrp8"
                     /gene_synonym="4932703M08Rik; ApoER2; Lr8b"
                     /inference="alignment:Splign:2.1.0"
     exon            1380..1505
                     /gene="Lrp8"
                     /gene_synonym="4932703M08Rik; ApoER2; Lr8b"
                     /inference="alignment:Splign:2.1.0"
     exon            1506..1680
                     /gene="Lrp8"
                     /gene_synonym="4932703M08Rik; ApoER2; Lr8b"
                     /inference="alignment:Splign:2.1.0"
     exon            1681..1908
                     /gene="Lrp8"
                     /gene_synonym="4932703M08Rik; ApoER2; Lr8b"
                     /inference="alignment:Splign:2.1.0"
     exon            1909..2027
                     /gene="Lrp8"
                     /gene_synonym="4932703M08Rik; ApoER2; Lr8b"
                     /inference="alignment:Splign:2.1.0"
     exon            2028..2167
                     /gene="Lrp8"
                     /gene_synonym="4932703M08Rik; ApoER2; Lr8b"
                     /inference="alignment:Splign:2.1.0"
     exon            2168..2309
                     /gene="Lrp8"
                     /gene_synonym="4932703M08Rik; ApoER2; Lr8b"
                     /inference="alignment:Splign:2.1.0"
     exon            2310..2462
                     /gene="Lrp8"
                     /gene_synonym="4932703M08Rik; ApoER2; Lr8b"
                     /inference="alignment:Splign:2.1.0"
     exon            2463..2687
                     /gene="Lrp8"
                     /gene_synonym="4932703M08Rik; ApoER2; Lr8b"
                     /inference="alignment:Splign:2.1.0"
     exon            2688..2756
                     /gene="Lrp8"
                     /gene_synonym="4932703M08Rik; ApoER2; Lr8b"
                     /inference="alignment:Splign:2.1.0"
     exon            2757..2929
                     /gene="Lrp8"
                     /gene_synonym="4932703M08Rik; ApoER2; Lr8b"
                     /inference="alignment:Splign:2.1.0"
     exon            2930..3106
                     /gene="Lrp8"
                     /gene_synonym="4932703M08Rik; ApoER2; Lr8b"
                     /inference="alignment:Splign:2.1.0"
     exon            3107..7674
                     /gene="Lrp8"
                     /gene_synonym="4932703M08Rik; ApoER2; Lr8b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3544..3549
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lrp8"
                     /gene_synonym="4932703M08Rik; ApoER2; Lr8b"
                     /note="hexamer: AATACA"
     polyA_site      3563
                     /gene="Lrp8"
                     /gene_synonym="4932703M08Rik; ApoER2; Lr8b"
                     /note="major polyA site"
     regulatory      4558..4563
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lrp8"
                     /gene_synonym="4932703M08Rik; ApoER2; Lr8b"
                     /note="hexamer: AATAAA"
     polyA_site      4582
                     /gene="Lrp8"
                     /gene_synonym="4932703M08Rik; ApoER2; Lr8b"
     regulatory      4711..4716
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lrp8"
                     /gene_synonym="4932703M08Rik; ApoER2; Lr8b"
                     /note="hexamer: AATAAA"
     polyA_site      4733
                     /gene="Lrp8"
                     /gene_synonym="4932703M08Rik; ApoER2; Lr8b"
                     /note="major polyA site"
     regulatory      7651..7656
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lrp8"
                     /gene_synonym="4932703M08Rik; ApoER2; Lr8b"
                     /note="hexamer: ATTAAA"
     polyA_site      7670
                     /gene="Lrp8"
                     /gene_synonym="4932703M08Rik; ApoER2; Lr8b"
ORIGIN      
        1 ttgaaatgca gccggggagc cggggcgggc ggcagcggtg gtggtggcgg cggcggcagc
       61 ggcagccccg gcgccgcggc aaggacttgg cgggctgagg cgcggcggcg gcgcgggggt
      121 ctcggggcgc ggcggccgga gccccgggcc cgctatgggc cgcccagaac tgggcgcgct
      181 ccggccgctg gcgctgttgc tgttgctgct gctgcagctt cagcatctct ccgcagcgga
      241 tccgctgccg ggcggccaag ggccagtcaa ggagtgtgaa gaggaccagt ttcggtgtcg
      301 gaacgagcgc tgcattccct tggtgtggag atgcgatgag gacaacgact gctcggacaa
      361 cagcgacgag gacgactgcc ccaagaggac ctgcgcggac agcgacttca cctgtgacaa
      421 tggccactgc atcccagagc ggtggaagtg cgacggcgag gaggagtgtc ccgatggctc
      481 tgacgaatcg aaggccacgt gctccagtga agagtgtcct gccgagaagt taagctgcgg
      541 acccaccagc cacaagtgtg tgcctgcctc atggcgctgc gacggagaga aggactgtga
      601 gggtggtgct gacgaggccg gctgtcccac cttgtgcgcc ccgcacgagt tccagtgcag
      661 caaccgctcc tgcctggcct ctgtgttcgt gtgcgatggt gacgatgact gcggcgacgg
      721 cagcgacgag cgtggctgct cggacccggc ctgcccgccc cgcgagttcc gctgtggagg
      781 aggcggcacc tgcatccctg agcgctgggt ctgcgaccgc cagttcgact gcgaggaccg
      841 ctcggatgag gcggccgagc tctgcgggcg agcgggccag gggaccacgg ccacgccagc
      901 agcctgcgcc ccgaccgccc agttcacctg ccgcagcggc gagtgcatac acctgggctg
      961 gcgctgcgac ggcgaccgcg actgcaagga caagtctgac gaggccgact gctcaccagg
     1021 accctgccgc gagaatgagt tccagtgtgg ggatgggact tgcgttcttg ccatcaaacg
     1081 gtgcaaccag gagcgggact gcccggacgg gagtgacgaa gcgggctgcc ttcaggagtc
     1141 aacttgtgag ggtccccgca gatttcagtg taagagtggc gagtgcgtgg acggcgggaa
     1201 agtgtgtgat gatcagaggg actgccggga ctggtcggat gagcctcaga aagtgtgtgg
     1261 gctaaatgag tgtctgcaca ataacggcgg ctgttcccac atctgcactg acctcaagat
     1321 cggctttgag tgcacgtgcc cagcaggctt ccagctcttg gaccagaaga cctgtggtga
     1381 cattgatgaa tgccaggacc cggatgcctg cagccaaatc tgcgtgaatt acaagggcta
     1441 ctttaagtgt gaatgccacc ctggctatga gatggataca ctgaccaaga actgcaaagc
     1501 tgtagccggc aagagcccat ctctgatctt cacgaaccga cacgaggtgc ggaggataga
     1561 cctggtgaag cgggactact cgcgcctcat ccccatgctc aagaatgtcg tggcgctgga
     1621 cgtggaagta gccaccaatc gcatatactg gtgcgacctc tcctaccgca agatctacag
     1681 cgcccacatg gacaaggcca gcatcccgga cgagcaggtg gtcctcattg atgagcagct
     1741 gcactccccg gagggcctgg cggtggactg ggtccataag cacatctact ggacagactc
     1801 aggcaataag accatctcag tggccacaac cgatggacgc cgccgctgta ctctcttcag
     1861 ccgtgagctc agtgagcccc gagccattgc cgttgacccc ctgcgagggt tcatgtactg
     1921 gtctgactgg ggtttccagg caaagattga gaaggctggg ctcaatggtg cagaccggca
     1981 aacactggtt tcagacaaca ttgaatggcc caatggaatc accctggact tgctgagcca
     2041 gcgtttgtac tgggtggact ccaagctgca ccaactatcc agcattgact tcaatggagg
     2101 caacagaaag atgctgatct tctccactga cttcctgagt cacccttttg gggttgctgt
     2161 atttgaggac aaggtattct ggacagacct ggagaatgag gccattttca gcgcaaatcg
     2221 gctcaatggc ctggaaatcg ccatcctggc cgagaacctc aataacccac atgacattgt
     2281 aatcttccac gagctgaagc agccaaaggc tgcagatgcc tgtgacctga gtgcccagcc
     2341 caacggcggc tgtgaatacc tgtgccttcc tgctcctcaa atctccagcc actcccccaa
     2401 gtacacgtgt gcctgtcctg acacgatgtg gctgggccca gacatgaaga gatgctaccg
     2461 agcacctcag tctacctcaa ctacaacctt agcctctgcc atgacaagga cagtacctgc
     2521 taccacaaga gctcctggga caaccatcca cgaccctacc taccagaacc atagcacaga
     2581 gacgccaagc cagacagctg ccgcccctca ctcggttaac gtccctaggg ctcccagcac
     2641 cagcccatcc accccgagcc ctgctaccag caaccactcc cagcattatg ggaatgaagg
     2701 cagccagatg ggctcaacag tcaccgctgc tgtcattggg gtcatcgtgc ccatagtggt
     2761 aatagccctg ctatgtatga gtgggtacct catctggagg aactggaagc ggaagaacac
     2821 caagagcatg aatttcgaca acccagtgta caggaaaacg acagaagagg aagaggaaga
     2881 tgagcttcac atagggagga cagctcagat tggccacgtc taccccgcag caatcagcaa
     2941 ctatgatcgc ccactgtggg cagagccctg tcttggggag accagagacc tggaagaccc
     3001 agcccctgcc ctcaaggagc tttttgtctt gccgggagaa ccaaggtcac agcttcacca
     3061 actcccgaag aaccctcttt ccgagctgcc tgtcgtcaag tgcaagcgag tggcattaag
     3121 tcttgaagat gatggactgc cctgaggatg ggcccaccca cttcgtgcct catggagttc
     3181 agtcctatgc actactctct ctggatggtg tgtgattgga tgagtgccat ttctatatat
     3241 gggtctgtgt gagtgtgtgt gtgtgtgtgt gtgagtgtgt gtgtgtgtgt gtgtgtgtgt
     3301 gtgtgtgtgt gtgtgtgtgt gtatgtgact ttttttaaat ttatgttgcg gaaaggtaac
     3361 cacaaagtta tgatgaactg caaacatcca aaggatgtga aagtttttat atgtataatg
     3421 ttttatacac tttttaactg gttgcactac ccgtgaagaa ttcatgggac agccactgct
     3481 gagtgactaa catgatgcac ataaccaaac ggggccaatg gtacaaactt cactcatcat
     3541 ttgaatacag tatttacaga ggatgtttga gttgagagct tttttaggtt tgaggggctt
     3601 gatttttttg taaataaaat tatgctttgt ggctatccat caacataagt ataaaaagaa
     3661 agaacgcttc aacccccttc cccatttaga ttatttatta acatatttcg aaagtaaggt
     3721 tagctctata aataatttag agaggtgaga gtatttattt ttggtatggc tggctcactg
     3781 cacagactct gtgtttatgt gtgtgtgtct gtgtgagaga agaaaaatct gtagagaaga
     3841 ggcacgctta tgactattgt tcaaatacat aaaaacagtt attttaaaac agtccacaag
     3901 aggggtgtct agttttcaga gacacttcag aaactttgct cagaaaacag atgctacagt
     3961 ttgtgcaggc atgcggtagg aaaggtagat cacctctggc tactcctgag gccctgctga
     4021 gccagcaaaa tgctttccag ttcctctttg gctctcacga tgcccaccta ggctttctgg
     4081 ccagtgtact gaacagtgct acaagccctc aggagctcaa gatagcagag tccttctttc
     4141 aaagcccagc ttagtgagga cttgggtcaa cttcagtaag cttcctctga agcaactgaa
     4201 ggccgagcct ttagagcaac cattgtcaac ctttgtgggt cgcctaagag catcgcaaac
     4261 cagatattta cattatgatt cataacagtg acaatcacag ttatgaggta gaaaggaaag
     4321 ggattttatg gttgggggtt agtccaacaa gagggacagt gttaatgctt ctgaagcatc
     4381 aggaaggttg aaagccactg ctctagagcc aagtgagtgc atgtctaggg ttcccatgtt
     4441 tacagtaagg accggctcag gcactgaccc tctgagtcac gtgaatgagg acgaagaatt
     4501 tggaataggt ttggttacat ctatttctca tccccttatt ttccaccatt taaaaataat
     4561 aaacatgttt cttaccaccg tatgttcata tggataagac taagtccaaa aaggtgacta
     4621 catccaaatt tatatttcgg ggaaatacca tgagataatt atagcatact gggcatgtgt
     4681 ccacacacgg attggtttca ctgctttata aataaaagga acaactctgg gtatttgtat
     4741 agaattttct tcatatgtaa catctttcca tttcctgagc cttgggggtg gggtgggaga
     4801 atgccacttg ctgtctgtga agtccactgt tggaaacata attccatagt cccagaagga
     4861 attcagtccc caccaactta ctctttcaaa gtgtggtctt cccgcgactc tgcagctctg
     4921 cagttcactc cagctgaacg accagggaca agtacaacac aggagtttgg cttaagtggc
     4981 agcagactaa tatctaaagt tgacataact gaaatctgac atttgaggca tatgtctccg
     5041 cgtccccaca caccggcttg agtggctcac ctgcttgatg tcctttcaac ttccggggag
     5101 accgtctgga gacctgtcat cctgtcatcc tgttcctagg agcttgctct atgtcactca
     5161 tgttttccta acctttaaaa aatggctgtg ttccaagcct ggccattatg tctgacaatg
     5221 cacgtgttga tggtcttgag atatacagtg actaaatgca gctgacccct gacccattcc
     5281 aaacagtctc aaggacaggc agctgagtcc cctgcagctc gcctgtcact gttcatccag
     5341 gaatggagag gagaaatcaa gtttactaaa gaaaaaggtt agaagtgaaa tcatcaaaat
     5401 ttacacaaga taggcagggt ttttcccttt aatctgcctc caaggaaact gaagcagtga
     5461 tagtgtatag tttctgaaca aacgttcata gcctagcctt cacaacaagg ctgaaacata
     5521 ccgtctaggg tttccgaaag atgaaagaat tcatatcaga aataccatgt ttcctgaatg
     5581 tgccacagct gcagtctaaa agcagcctac agtaaacaga tgggcaaatc cagggacggc
     5641 cggagagcgg aagcactctg agggaccaga ccgacctcct tctatccttg gaaacttttt
     5701 gagcctcatt ctgaggtgta attcagactt ctgttgcctt tcgcctctgc ctatgtatcc
     5761 acagccaata acagctgaaa ggaaactcag taataaacca aaaggacaga aaattcaaca
     5821 aacgttactt attaaaacga agccaacccc ttccttctct agaagacaac tctgagcagc
     5881 ctgaacaagg tctcagacct gcatcctctc cacagctatc tgcccagtgg attgaaggca
     5941 ctaacagaaa cgactttcct gaaacaagaa actacagctt tgtttactct tcagaatgtg
     6001 tgtatgtgtg tgcacagagg gacaggatga gacggcttct gacaaggagt aagaagaatg
     6061 agacaggatt taaactgatg tcagtgaaca ctgttgaagc cctccagtta tcctcatgtc
     6121 ttagtaacat actcagagta ttcactcgct gctgtgtgcc aggctttgca gacattgcag
     6181 gtcaattcaa cagttttcac cctttccaaa ctcacagcag tacatatgga tacaaaaaga
     6241 aaaaaaaatt ttcccataga tttcacctag actactccca aggcacaaca aaagagatgg
     6301 gccattttac ctgaagaggt ggaaataggt ctacatagga atgacccaaa gcaatgtctt
     6361 aaaacttaaa aagtggtgtt caggctgctt ctatgagaag aggctgggct cagactggga
     6421 gtgaatcagc agcaggaatt tcaaggaaaa catggagttc cttacacctg gaataaagaa
     6481 ctttagcagg gttggcaaga tgtgaaactg gatggaaaga caagttcaac acaagcactt
     6541 tataaaatag tctgatgtaa gtaagcagac atttgtttgg tcgtcggttc ctgtgtgcaa
     6601 ggcatcatgg gaaactccct gccagcactt ggcaggcatt attccacctc aagctttcca
     6661 gagaccacag ggaaatgact gttttcttta tttgagccag aggttttgat atggttcctg
     6721 aaggctaaca gaagggcggt gggcttgtca acagaagcac gccatgttgc cgagcacctg
     6781 tgaggtcctc acgtgggagg aagagaacaa ggtggttaag atagagaatc tggagagggt
     6841 accccaatca cactacagtc gggtgctact gggtggagga gaaaaccatc ctaaccccac
     6901 agcactgcaa agacgctcct gtcccgccac actcccacca tcacgaacat cagtaagtca
     6961 gcagtttcag attctgccat ttccttcccc ataaaagcat gaagataggg agtcggtgtc
     7021 cttacgcttt atttttaggg tatttgggag tttccaggat gtgaagaagt taggtggagg
     7081 aaattacggc ttcaattttt ttcagttaac tacaggacgc ttcattcagg ccgggcacca
     7141 tgtgcacagt cttaagaagc agcaggaact gcatttgcaa acacgtgttg taaaaaatta
     7201 attttaaaaa agctacctgt ataaatataa atatatatat ttaaagacaa ggttttgata
     7261 cttttttttt aaaaaacaaa aactacaaga gaagactgta caaaccacgg gcttttaaaa
     7321 tagcattttg ctctctacaa gctgttaatg tcaggggtga ggggtgaggg actggtttgc
     7381 aaacacacta tccaaatgga tttgcttgtt ttgtcaagcc accctccaaa ttaccatatt
     7441 tggtgtaata gtagggcatg taaagttatt gggtcccatt aaccatttct gctcttgtca
     7501 tgtcattccg ggttccgtta gctcccgtac tcggcaatcc agcttcttcc agaggcagag
     7561 gggctgaagg aagtgtgctc catttcacta gctgtactga catcatccac atgtggacat
     7621 ttgtaatatc agtacactat ttctagagag attaaattca ttttttaaaa tctg
//
