LOCUS       NM_001369054            6657 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus low density lipoprotein receptor-related protein 8,
            apolipoprotein e receptor (Lrp8), transcript variant 7, mRNA.
ACCESSION   NM_001369054
VERSION     NM_001369054.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6657)
  AUTHORS   Whately,K.M., Sengottuvel,N., Edatt,L., Srivastava,S., Woods,A.T.,
            Tsai,Y.S., Porrello,A., Zimmerman,M.P., Chack,A.C., Jefferys,S.R.,
            Yacovone,G., Kim,D.J., Dudley,A.C., Amelio,A.L. and Pecot,C.V.
  TITLE     Spon1+ inflammatory monocytes promote collagen remodeling and lung
            cancer metastasis through lipoprotein receptor 8 signaling
  JOURNAL   JCI Insight 9 (9), e168792 (2024)
   PUBMED   38716730
  REMARK    GeneRIF: Spon1+ inflammatory monocytes promote collagen remodeling
            and lung cancer metastasis through lipoprotein receptor 8
            signaling.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6657)
  AUTHORS   Caracci,M.O., Pizarro,H., Alarcon-Godoy,C., Fuentealba,L.M.,
            Farfan,P., De Pace,R., Santibanez,N., Cavieres,V.A., Pastor,T.P.,
            Bonifacino,J.S., Mardones,G.A. and Marzolo,M.P.
  TITLE     The Reelin receptor ApoER2 is a cargo for the adaptor protein
            complex AP-4: Implications for Hereditary Spastic Paraplegia
  JOURNAL   Prog Neurobiol 234, 102575 (2024)
   PUBMED   38281682
  REMARK    GeneRIF: The Reelin receptor ApoER2 is a cargo for the adaptor
            protein complex AP-4: Implications for Hereditary Spastic
            Paraplegia.
            Erratum:[Prog Neurobiol. 2024 Oct;241:102662. doi:
            10.1016/j.pneurobio.2024.102662.. PMID: 39294072]
REFERENCE   3  (bases 1 to 6657)
  AUTHORS   Wasser,C.R., Werthmann,G.C., Hall,E.M., Kuhbandner,K., Wong,C.H.,
            Durakoglugil,M.S. and Herz,J.
  TITLE     Regulation of the hippocampal translatome by Apoer2-ICD release
  JOURNAL   Mol Neurodegener 18 (1), 62 (2023)
   PUBMED   37726747
  REMARK    GeneRIF: Regulation of the hippocampal translatome by Apoer2-ICD
            release.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6657)
  AUTHORS   Wolfkiel,P.R., Haller,A.M., Kirby,J., Jaeschke,A. and Hui,D.Y.
  TITLE     Different sensitivity to diet-induced hyperinsulinemia and
            hyperglycemia between mice with global or bone marrow-specific apoE
            receptor-2 deficiency
  JOURNAL   Am J Physiol Regul Integr Comp Physiol 325 (1), R55-R68 (2023)
   PUBMED   37212552
  REMARK    GeneRIF: Different sensitivity to diet-induced hyperinsulinemia and
            hyperglycemia between mice with global or bone marrow-specific apoE
            receptor-2 deficiency.
REFERENCE   5  (bases 1 to 6657)
  AUTHORS   Oshima,K., Yoshinaga,S., Kitazawa,A., Hirota,Y., Nakajima,K. and
            Kubo,K.I.
  TITLE     A Unique 'Reversed' Migration of Neurons in the Developing
            Claustrum
  JOURNAL   J Neurosci 43 (5), 693-708 (2023)
   PUBMED   36631266
REFERENCE   6  (bases 1 to 6657)
  AUTHORS   Trommsdorff,M., Gotthardt,M., Hiesberger,T., Shelton,J.,
            Stockinger,W., Nimpf,J., Hammer,R.E., Richardson,J.A. and Herz,J.
  TITLE     Reeler/Disabled-like disruption of neuronal migration in knockout
            mice lacking the VLDL receptor and ApoE receptor 2
  JOURNAL   Cell 97 (6), 689-701 (1999)
   PUBMED   10380922
REFERENCE   7  (bases 1 to 6657)
  AUTHORS   Kim,H.J., Kim,D.H., Magoori,K., Saeki,S. and Yamamoto,T.T.
  TITLE     Evolution of the apolipoprotein E receptor 2 gene by exon loss
  JOURNAL   J Biochem 124 (2), 451-456 (1998)
   PUBMED   9685741
REFERENCE   8  (bases 1 to 6657)
  AUTHORS   Brandes,C., Novak,S., Stockinger,W., Herz,J., Schneider,W.J. and
            Nimpf,J.
  TITLE     Avian and murine LR8B and human apolipoprotein E receptor 2:
            differentially spliced products from corresponding genes
  JOURNAL   Genomics 42 (2), 185-191 (1997)
   PUBMED   9192837
REFERENCE   9  (bases 1 to 6657)
  AUTHORS   Novak,S., Hiesberger,T., Schneider,W.J. and Nimpf,J.
  TITLE     A new low density lipoprotein receptor homologue with 8 ligand
            binding repeats in brain of chicken and mouse
  JOURNAL   J Biol Chem 271 (20), 11732-11736 (1996)
   PUBMED   8662771
  REMARK    Erratum:[J Biol Chem 1996 Oct 25;271(43):27188]
REFERENCE   10 (bases 1 to 6657)
  AUTHORS   Rollins,B.J., Stier,P., Ernst,T. and Wong,G.G.
  TITLE     The human homolog of the JE gene encodes a monocyte secretory
            protein
  JOURNAL   Mol Cell Biol 9 (11), 4687-4695 (1989)
   PUBMED   2513477
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL807828.14 and AL611936.11.
            
            Transcript Variant: This variant (7), as well as variant 6, encodes
            isoform e.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK030143.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-46                AL807828.14        129522-129567
            47-169              AL807828.14        133196-133318
            170-298             AL807828.14        141785-141913
            299-421             AL807828.14        146013-146135
            422-541             AL807828.14        149877-149996
            542-667             AL807828.14        150069-150194
            668-842             AL807828.14        152818-152992
            843-1070            AL807828.14        154147-154374
            1071-1189           AL807828.14        155426-155544
            1190-1329           AL807828.14        155750-155889
            1330-1471           AL807828.14        157191-157332
            1472-1624           AL807828.14        158501-158653
            1625-1849           AL807828.14        159702-159926
            1850-1918           AL807828.14        162578-162646
            1919-2091           AL807828.14        167547-167719
            2092-5843           AL807828.14        170842-174593
            5844-6657           AL611936.11        2001-2814
FEATURES             Location/Qualifiers
     source          1..6657
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 50.18 cM"
     gene            1..6657
                     /gene="Lrp8"
                     /gene_synonym="4932703M08Rik; ApoER2; Lr8b"
                     /note="low density lipoprotein receptor-related protein 8,
                     apolipoprotein e receptor"
                     /db_xref="GeneID:16975"
                     /db_xref="MGI:MGI:1340044"
     exon            1..46
                     /gene="Lrp8"
                     /gene_synonym="4932703M08Rik; ApoER2; Lr8b"
                     /inference="alignment:Splign:2.1.0"
     exon            47..169
                     /gene="Lrp8"
                     /gene_synonym="4932703M08Rik; ApoER2; Lr8b"
                     /inference="alignment:Splign:2.1.0"
     exon            170..298
                     /gene="Lrp8"
                     /gene_synonym="4932703M08Rik; ApoER2; Lr8b"
                     /inference="alignment:Splign:2.1.0"
     exon            299..421
                     /gene="Lrp8"
                     /gene_synonym="4932703M08Rik; ApoER2; Lr8b"
                     /inference="alignment:Splign:2.1.0"
     exon            422..541
                     /gene="Lrp8"
                     /gene_synonym="4932703M08Rik; ApoER2; Lr8b"
                     /inference="alignment:Splign:2.1.0"
     exon            542..667
                     /gene="Lrp8"
                     /gene_synonym="4932703M08Rik; ApoER2; Lr8b"
                     /inference="alignment:Splign:2.1.0"
     CDS             634..2130
                     /gene="Lrp8"
                     /gene_synonym="4932703M08Rik; ApoER2; Lr8b"
                     /note="isoform e is encoded by transcript variant 7; low
                     density lipoprotein receptor relative, 8 ligand binding
                     repeats, brain; low-density lipoprotein receptor-related
                     protein 8; apolipoprotein E receptor 2"
                     /codon_start=1
                     /product="low-density lipoprotein receptor-related protein
                     8 isoform e"
                     /protein_id="NP_001355983.1"
                     /db_xref="GeneID:16975"
                     /db_xref="MGI:MGI:1340044"
                     /translation="MDTLTKNCKAVAGKSPSLIFTNRHEVRRIDLVKRDYSRLIPMLK
                     NVVALDVEVATNRIYWCDLSYRKIYSAHMDKASIPDEQVVLIDEQLHSPEGLAVDWVH
                     KHIYWTDSGNKTISVATTDGRRRCTLFSRELSEPRAIAVDPLRGFMYWSDWGFQAKIE
                     KAGLNGADRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFNGGNRKMLIFS
                     TDFLSHPFGVAVFEDKVFWTDLENEAIFSANRLNGLEIAILAENLNNPHDIVIFHELK
                     QPKAADACDLSAQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQS
                     TSTTTLASAMTRTVPATTRAPGTTIHDPTYQNHSTETPSQTAAAPHSVNVPRAPSTSP
                     STPSPATSNHSQHYGNEGSQMGSTVTAAVIGVIVPIVVIALLCMSGYLIWRNWKRKNT
                     KSMNFDNPVYRKTTEEEEEDELHIGRTAQIGHVYPARVALSLEDDGLP"
     exon            668..842
                     /gene="Lrp8"
                     /gene_synonym="4932703M08Rik; ApoER2; Lr8b"
                     /inference="alignment:Splign:2.1.0"
     exon            843..1070
                     /gene="Lrp8"
                     /gene_synonym="4932703M08Rik; ApoER2; Lr8b"
                     /inference="alignment:Splign:2.1.0"
     exon            1071..1189
                     /gene="Lrp8"
                     /gene_synonym="4932703M08Rik; ApoER2; Lr8b"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..1329
                     /gene="Lrp8"
                     /gene_synonym="4932703M08Rik; ApoER2; Lr8b"
                     /inference="alignment:Splign:2.1.0"
     exon            1330..1471
                     /gene="Lrp8"
                     /gene_synonym="4932703M08Rik; ApoER2; Lr8b"
                     /inference="alignment:Splign:2.1.0"
     exon            1472..1624
                     /gene="Lrp8"
                     /gene_synonym="4932703M08Rik; ApoER2; Lr8b"
                     /inference="alignment:Splign:2.1.0"
     exon            1625..1849
                     /gene="Lrp8"
                     /gene_synonym="4932703M08Rik; ApoER2; Lr8b"
                     /inference="alignment:Splign:2.1.0"
     exon            1850..1918
                     /gene="Lrp8"
                     /gene_synonym="4932703M08Rik; ApoER2; Lr8b"
                     /inference="alignment:Splign:2.1.0"
     exon            1919..2091
                     /gene="Lrp8"
                     /gene_synonym="4932703M08Rik; ApoER2; Lr8b"
                     /inference="alignment:Splign:2.1.0"
     exon            2092..6657
                     /gene="Lrp8"
                     /gene_synonym="4932703M08Rik; ApoER2; Lr8b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2529..2534
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lrp8"
                     /gene_synonym="4932703M08Rik; ApoER2; Lr8b"
                     /note="hexamer: AATACA"
     polyA_site      2548
                     /gene="Lrp8"
                     /gene_synonym="4932703M08Rik; ApoER2; Lr8b"
                     /note="major polyA site"
     regulatory      3543..3548
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lrp8"
                     /gene_synonym="4932703M08Rik; ApoER2; Lr8b"
                     /note="hexamer: AATAAA"
     polyA_site      3567
                     /gene="Lrp8"
                     /gene_synonym="4932703M08Rik; ApoER2; Lr8b"
     regulatory      3696..3701
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lrp8"
                     /gene_synonym="4932703M08Rik; ApoER2; Lr8b"
                     /note="hexamer: AATAAA"
     polyA_site      3718
                     /gene="Lrp8"
                     /gene_synonym="4932703M08Rik; ApoER2; Lr8b"
                     /note="major polyA site"
     regulatory      6636..6641
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lrp8"
                     /gene_synonym="4932703M08Rik; ApoER2; Lr8b"
                     /note="hexamer: ATTAAA"
     polyA_site      6655
                     /gene="Lrp8"
                     /gene_synonym="4932703M08Rik; ApoER2; Lr8b"
ORIGIN      
        1 tgactatgta tcactcctgc ggcgtggagt acagggactc acagagccaa gaggacctgc
       61 gcggacagcg acttcacctg tgacaatggc cactgcatcc cagagcggtg gaagtgcgac
      121 ggcgaggagg agtgtcccga tggctctgac gaatcgaagg ccacgtgctc cagtgaagag
      181 tgtcctgccg agaagttaag ctgcggaccc accagccaca agtgtgtgcc tgcctcatgg
      241 cgctgcgacg gagagaagga ctgtgagggt ggtgctgacg aggccggctg tcccacctca
      301 ccaggaccct gccgcgagaa tgagttccag tgtggggatg ggacttgcgt tcttgccatc
      361 aaacggtgca accaggagcg ggactgcccg gacgggagtg acgaagcggg ctgccttcag
      421 gggctaaatg agtgtctgca caataacggc ggctgttccc acatctgcac tgacctcaag
      481 atcggctttg agtgcacgtg cccagcaggc ttccagctct tggaccagaa gacctgtggt
      541 gacattgatg aatgccagga cccggatgcc tgcagccaaa tctgcgtgaa ttacaagggc
      601 tactttaagt gtgaatgcca ccctggctat gagatggata cactgaccaa gaactgcaaa
      661 gctgtagccg gcaagagccc atctctgatc ttcacgaacc gacacgaggt gcggaggata
      721 gacctggtga agcgggacta ctcgcgcctc atccccatgc tcaagaatgt cgtggcgctg
      781 gacgtggaag tagccaccaa tcgcatatac tggtgcgacc tctcctaccg caagatctac
      841 agcgcccaca tggacaaggc cagcatcccg gacgagcagg tggtcctcat tgatgagcag
      901 ctgcactccc cggagggcct ggcggtggac tgggtccata agcacatcta ctggacagac
      961 tcaggcaata agaccatctc agtggccaca accgatggac gccgccgctg tactctcttc
     1021 agccgtgagc tcagtgagcc ccgagccatt gccgttgacc ccctgcgagg gttcatgtac
     1081 tggtctgact ggggtttcca ggcaaagatt gagaaggctg ggctcaatgg tgcagaccgg
     1141 caaacactgg tttcagacaa cattgaatgg cccaatggaa tcaccctgga cttgctgagc
     1201 cagcgtttgt actgggtgga ctccaagctg caccaactat ccagcattga cttcaatgga
     1261 ggcaacagaa agatgctgat cttctccact gacttcctga gtcacccttt tggggttgct
     1321 gtatttgagg acaaggtatt ctggacagac ctggagaatg aggccatttt cagcgcaaat
     1381 cggctcaatg gcctggaaat cgccatcctg gccgagaacc tcaataaccc acatgacatt
     1441 gtaatcttcc acgagctgaa gcagccaaag gctgcagatg cctgtgacct gagtgcccag
     1501 cccaacggcg gctgtgaata cctgtgcctt cctgctcctc aaatctccag ccactccccc
     1561 aagtacacgt gtgcctgtcc tgacacgatg tggctgggcc cagacatgaa gagatgctac
     1621 cgagcacctc agtctacctc aactacaacc ttagcctctg ccatgacaag gacagtacct
     1681 gctaccacaa gagctcctgg gacaaccatc cacgacccta cctaccagaa ccatagcaca
     1741 gagacgccaa gccagacagc tgccgcccct cactcggtta acgtccctag ggctcccagc
     1801 accagcccat ccaccccgag ccctgctacc agcaaccact cccagcatta tgggaatgaa
     1861 ggcagccaga tgggctcaac agtcaccgct gctgtcattg gggtcatcgt gcccatagtg
     1921 gtaatagccc tgctatgtat gagtgggtac ctcatctgga ggaactggaa gcggaagaac
     1981 accaagagca tgaatttcga caacccagtg tacaggaaaa cgacagaaga ggaagaggaa
     2041 gatgagcttc acatagggag gacagctcag attggccacg tctaccccgc acgagtggca
     2101 ttaagtcttg aagatgatgg actgccctga ggatgggccc acccacttcg tgcctcatgg
     2161 agttcagtcc tatgcactac tctctctgga tggtgtgtga ttggatgagt gccatttcta
     2221 tatatgggtc tgtgtgagtg tgtgtgtgtg tgtgtgtgag tgtgtgtgtg tgtgtgtgtg
     2281 tgtgtgtgtg tgtgtgtgtg tgtgtgtatg tgactttttt taaatttatg ttgcggaaag
     2341 gtaaccacaa agttatgatg aactgcaaac atccaaagga tgtgaaagtt tttatatgta
     2401 taatgtttta tacacttttt aactggttgc actacccgtg aagaattcat gggacagcca
     2461 ctgctgagtg actaacatga tgcacataac caaacggggc caatggtaca aacttcactc
     2521 atcatttgaa tacagtattt acagaggatg tttgagttga gagctttttt aggtttgagg
     2581 ggcttgattt ttttgtaaat aaaattatgc tttgtggcta tccatcaaca taagtataaa
     2641 aagaaagaac gcttcaaccc ccttccccat ttagattatt tattaacata tttcgaaagt
     2701 aaggttagct ctataaataa tttagagagg tgagagtatt tatttttggt atggctggct
     2761 cactgcacag actctgtgtt tatgtgtgtg tgtctgtgtg agagaagaaa aatctgtaga
     2821 gaagaggcac gcttatgact attgttcaaa tacataaaaa cagttatttt aaaacagtcc
     2881 acaagagggg tgtctagttt tcagagacac ttcagaaact ttgctcagaa aacagatgct
     2941 acagtttgtg caggcatgcg gtaggaaagg tagatcacct ctggctactc ctgaggccct
     3001 gctgagccag caaaatgctt tccagttcct ctttggctct cacgatgccc acctaggctt
     3061 tctggccagt gtactgaaca gtgctacaag ccctcaggag ctcaagatag cagagtcctt
     3121 ctttcaaagc ccagcttagt gaggacttgg gtcaacttca gtaagcttcc tctgaagcaa
     3181 ctgaaggccg agcctttaga gcaaccattg tcaacctttg tgggtcgcct aagagcatcg
     3241 caaaccagat atttacatta tgattcataa cagtgacaat cacagttatg aggtagaaag
     3301 gaaagggatt ttatggttgg gggttagtcc aacaagaggg acagtgttaa tgcttctgaa
     3361 gcatcaggaa ggttgaaagc cactgctcta gagccaagtg agtgcatgtc tagggttccc
     3421 atgtttacag taaggaccgg ctcaggcact gaccctctga gtcacgtgaa tgaggacgaa
     3481 gaatttggaa taggtttggt tacatctatt tctcatcccc ttattttcca ccatttaaaa
     3541 ataataaaca tgtttcttac caccgtatgt tcatatggat aagactaagt ccaaaaaggt
     3601 gactacatcc aaatttatat ttcggggaaa taccatgaga taattatagc atactgggca
     3661 tgtgtccaca cacggattgg tttcactgct ttataaataa aaggaacaac tctgggtatt
     3721 tgtatagaat tttcttcata tgtaacatct ttccatttcc tgagccttgg gggtggggtg
     3781 ggagaatgcc acttgctgtc tgtgaagtcc actgttggaa acataattcc atagtcccag
     3841 aaggaattca gtccccacca acttactctt tcaaagtgtg gtcttcccgc gactctgcag
     3901 ctctgcagtt cactccagct gaacgaccag ggacaagtac aacacaggag tttggcttaa
     3961 gtggcagcag actaatatct aaagttgaca taactgaaat ctgacatttg aggcatatgt
     4021 ctccgcgtcc ccacacaccg gcttgagtgg ctcacctgct tgatgtcctt tcaacttccg
     4081 gggagaccgt ctggagacct gtcatcctgt catcctgttc ctaggagctt gctctatgtc
     4141 actcatgttt tcctaacctt taaaaaatgg ctgtgttcca agcctggcca ttatgtctga
     4201 caatgcacgt gttgatggtc ttgagatata cagtgactaa atgcagctga cccctgaccc
     4261 attccaaaca gtctcaagga caggcagctg agtcccctgc agctcgcctg tcactgttca
     4321 tccaggaatg gagaggagaa atcaagttta ctaaagaaaa aggttagaag tgaaatcatc
     4381 aaaatttaca caagataggc agggtttttc cctttaatct gcctccaagg aaactgaagc
     4441 agtgatagtg tatagtttct gaacaaacgt tcatagccta gccttcacaa caaggctgaa
     4501 acataccgtc tagggtttcc gaaagatgaa agaattcata tcagaaatac catgtttcct
     4561 gaatgtgcca cagctgcagt ctaaaagcag cctacagtaa acagatgggc aaatccaggg
     4621 acggccggag agcggaagca ctctgaggga ccagaccgac ctccttctat ccttggaaac
     4681 tttttgagcc tcattctgag gtgtaattca gacttctgtt gcctttcgcc tctgcctatg
     4741 tatccacagc caataacagc tgaaaggaaa ctcagtaata aaccaaaagg acagaaaatt
     4801 caacaaacgt tacttattaa aacgaagcca accccttcct tctctagaag acaactctga
     4861 gcagcctgaa caaggtctca gacctgcatc ctctccacag ctatctgccc agtggattga
     4921 aggcactaac agaaacgact ttcctgaaac aagaaactac agctttgttt actcttcaga
     4981 atgtgtgtat gtgtgtgcac agagggacag gatgagacgg cttctgacaa ggagtaagaa
     5041 gaatgagaca ggatttaaac tgatgtcagt gaacactgtt gaagccctcc agttatcctc
     5101 atgtcttagt aacatactca gagtattcac tcgctgctgt gtgccaggct ttgcagacat
     5161 tgcaggtcaa ttcaacagtt ttcacccttt ccaaactcac agcagtacat atggatacaa
     5221 aaagaaaaaa aaattttccc atagatttca cctagactac tcccaaggca caacaaaaga
     5281 gatgggccat tttacctgaa gaggtggaaa taggtctaca taggaatgac ccaaagcaat
     5341 gtcttaaaac ttaaaaagtg gtgttcaggc tgcttctatg agaagaggct gggctcagac
     5401 tgggagtgaa tcagcagcag gaatttcaag gaaaacatgg agttccttac acctggaata
     5461 aagaacttta gcagggttgg caagatgtga aactggatgg aaagacaagt tcaacacaag
     5521 cactttataa aatagtctga tgtaagtaag cagacatttg tttggtcgtc ggttcctgtg
     5581 tgcaaggcat catgggaaac tccctgccag cacttggcag gcattattcc acctcaagct
     5641 ttccagagac cacagggaaa tgactgtttt ctttatttga gccagaggtt ttgatatggt
     5701 tcctgaaggc taacagaagg gcggtgggct tgtcaacaga agcacgccat gttgccgagc
     5761 acctgtgagg tcctcacgtg ggaggaagag aacaaggtgg ttaagataga gaatctggag
     5821 agggtacccc aatcacacta cagtcgggtg ctactgggtg gaggagaaaa ccatcctaac
     5881 cccacagcac tgcaaagacg ctcctgtccc gccacactcc caccatcacg aacatcagta
     5941 agtcagcagt ttcagattct gccatttcct tccccataaa agcatgaaga tagggagtcg
     6001 gtgtccttac gctttatttt tagggtattt gggagtttcc aggatgtgaa gaagttaggt
     6061 ggaggaaatt acggcttcaa tttttttcag ttaactacag gacgcttcat tcaggccggg
     6121 caccatgtgc acagtcttaa gaagcagcag gaactgcatt tgcaaacacg tgttgtaaaa
     6181 aattaatttt aaaaaagcta cctgtataaa tataaatata tatatttaaa gacaaggttt
     6241 tgatactttt tttttaaaaa acaaaaacta caagagaaga ctgtacaaac cacgggcttt
     6301 taaaatagca ttttgctctc tacaagctgt taatgtcagg ggtgaggggt gagggactgg
     6361 tttgcaaaca cactatccaa atggatttgc ttgttttgtc aagccaccct ccaaattacc
     6421 atatttggtg taatagtagg gcatgtaaag ttattgggtc ccattaacca tttctgctct
     6481 tgtcatgtca ttccgggttc cgttagctcc cgtactcggc aatccagctt cttccagagg
     6541 cagaggggct gaaggaagtg tgctccattt cactagctgt actgacatca tccacatgtg
     6601 gacatttgta atatcagtac actatttcta gagagattaa attcattttt taaaatc
//
