LOCUS       NM_008514               9368 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus low density lipoprotein receptor-related protein 6
            (Lrp6), mRNA.
ACCESSION   NM_008514 XR_105046 XR_105047
VERSION     NM_008514.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 9368)
  AUTHORS   Oh,S.A., Jeon,J., Je,S.Y., Kim,S., Jung,J. and Ko,H.W.
  TITLE     TMEM132A regulates Wnt/beta-catenin signaling through stabilizing
            LRP6 during mouse embryonic development
  JOURNAL   Cell Commun Signal 22 (1), 482 (2024)
   PUBMED   39385148
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9368)
  AUTHORS   de Jaime-Soguero,A., Hattemer,J., Bufe,A., Haas,A., van den
            Berg,J., van Batenburg,V., Das,B., di Marco,B., Androulaki,S.,
            Bohly,N., Landry,J.J.M., Schoell,B., Rosa,V.S., Villacorta,L.,
            Baskan,Y., Trapp,M., Benes,V., Chabes,A., Shahbazi,M., Jauch,A.,
            Engel,U., Patrizi,A., Sotillo,R., van Oudenaarden,A., Bageritz,J.,
            Alfonso,J., Bastians,H. and Acebron,S.P.
  TITLE     Developmental signals control chromosome segregation fidelity
            during pluripotency and neurogenesis by modulating replicative
            stress
  JOURNAL   Nat Commun 15 (1), 7404 (2024)
   PUBMED   39191776
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 9368)
  AUTHORS   Luo,X., Zhang,D., Zheng,J., Liu,H., Sun,L., Guo,H., Wang,L. and
            Cui,S.
  TITLE     Casein kinase 1alpha mediates estradiol secretion via CYP19A1
            expression in mouse ovarian granulosa cells
  JOURNAL   BMC Biol 22 (1), 176 (2024)
   PUBMED   39183304
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 9368)
  AUTHORS   Meng,S., Wang,Z., Liu,X., Shen,K., Gu,Y., Yu,B. and Wang,L.
  TITLE     Uptake of ox-LDL by binding to LRP6 mediates oxidative
            stress-induced BMSCs senescence promoting obesity-related bone loss
  JOURNAL   Cell Signal 117, 111114 (2024)
   PUBMED   38387686
  REMARK    GeneRIF: Uptake of ox-LDL by binding to LRP6 mediates oxidative
            stress-induced BMSCs senescence promoting obesity-related bone
            loss.
REFERENCE   5  (bases 1 to 9368)
  AUTHORS   Tang,W., Luan,Y., Yuan,Q., Li,A., Chen,S., Menacherry,S., Young,L.
            and Wu,D.
  TITLE     LDL receptor-related protein 5 selectively transports unesterified
            polyunsaturated fatty acids to intracellular compartments
  JOURNAL   Nat Commun 15 (1), 3068 (2024)
   PUBMED   38594269
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 9368)
  AUTHORS   Skarnes,W.C., Moss,J.E., Hurtley,S.M. and Beddington,R.S.
  TITLE     Capturing genes encoding membrane and secreted proteins important
            for mouse development
  JOURNAL   Proc Natl Acad Sci U S A 92 (14), 6592-6596 (1995)
   PUBMED   7604039
REFERENCE   7  (bases 1 to 9368)
  AUTHORS   Cole,W.A. and Trasler,D.G.
  TITLE     Gene-teratogen interaction in insulin-induced mouse exencephaly
  JOURNAL   Teratology 22 (1), 125-139 (1980)
   PUBMED   7003792
REFERENCE   8  (bases 1 to 9368)
  AUTHORS   Sofaer,J.A.
  TITLE     Tooth development in the 'crooked' mouse
  JOURNAL   J Embryol Exp Morphol 41, 279-287 (1977)
   PUBMED   591875
REFERENCE   9  (bases 1 to 9368)
  AUTHORS   Gruneberg,H.
  TITLE     Exocrine glands and the Chievitz organ of some mouse mutants
  JOURNAL   J Embryol Exp Morphol 25 (2), 247-261 (1971)
   PUBMED   5088022
REFERENCE   10 (bases 1 to 9368)
  AUTHORS   Gruneberg,H.
  TITLE     Genes and genotypes affecting the teeth of the mouse
  JOURNAL   J Embryol Exp Morphol 14 (2), 137-159 (1965)
   PUBMED   5893447
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC060704.1 and AC155838.7.
            
            On or before Dec 16, 2010 this sequence version replaced
            XR_105047.1, XR_105046.1, NM_008514.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC060704.1, AF074265.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5428              BC060704.1         1-5428
            5429-9368           AC155838.7         80421-84360
FEATURES             Location/Qualifiers
     source          1..9368
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 65.37 cM"
     gene            1..9368
                     /gene="Lrp6"
                     /gene_synonym="C030016K15Rik; Cd; Gw; ska26; ska<m26Jus>;
                     skax26"
                     /note="low density lipoprotein receptor-related protein 6"
                     /db_xref="GeneID:16974"
                     /db_xref="MGI:MGI:1298218"
     exon            1..271
                     /gene="Lrp6"
                     /gene_synonym="C030016K15Rik; Cd; Gw; ska26; ska<m26Jus>;
                     skax26"
                     /inference="alignment:Splign:2.1.0"
     CDS             217..5058
                     /gene="Lrp6"
                     /gene_synonym="C030016K15Rik; Cd; Gw; ska26; ska<m26Jus>;
                     skax26"
                     /note="crooked; LRP-6; low density lipoprotein-related
                     protein 6; low density lipoprotein receptor-related
                     protein 6; low density lipoprotein-related protein 6"
                     /codon_start=1
                     /product="low-density lipoprotein receptor-related protein
                     6 precursor"
                     /protein_id="NP_032540.2"
                     /db_xref="CCDS:CCDS39678.1"
                     /db_xref="GeneID:16974"
                     /db_xref="MGI:MGI:1298218"
                     /translation="MGAVLRSLLACSFCVLLRAAPLLLYANRRDLRLVDATNGKENAT
                     IVVGGLEDAAAVDFVFGHGLIYWSDVSEEAIKRTEFNKTESVQNVVVSGLLSPDGLAC
                     DWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRAIALDPSSGFMYWTDWGEV
                     PKIERAGMDGSSRFVIINTEIYWPNGLTLDYQERKLYWADAKLNFIHKSNLDGTNRQA
                     VVKGSLPHPFALTLFEDTLYWTDWNTHSILACNKYTGEGLREIHSNIFSPMDIHAFSQ
                     QRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCKDGATELLLLA
                     RRTDLRRISLDTPDFTDIVLQLEDIRHAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGS
                     GSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRA
                     IVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGTIYWGD
                     AKTDKIEVMNTDGTGRRVLVEDKIPHIFGFTLLGDYVYWTDWQRRSIERVHKRSAERE
                     VIIDQLPDLMGLKATSVHRIIGSNPCAEDNGGCSHLCLYRPQGLRCACPIGFELISDM
                     KTCIVPEAFLLFSRRADIRRISLETNNNNVAIPLTGVKEASALDFDVTDNRIYWTDIS
                     LKTISRAFMNGSALEHVVEFGLDYPEGMAVDWLGKNLYWADTGTNRIEVSKLDGQHRQ
                     VLVWKDLDSPRALALDPAEGFMYWTEWGGKPKIDRAAMDGSERTTLVPNVGRANGLTI
                     DYAKRRLYWTDLDTNLIESSDMLGLNREVIADDLPHPFGLTQYQDYIYWTDWSRRSIE
                     RANKTSGQNRTIIQGHLDYVMDILVFHSSRQAGWNECASSNGHCSHLCLAVPVGGFVC
                     GCPAHYSLNADNRTCSAPTTFLLFSQKSAINRMVIDEQQSPDIILPIHSLRNVRAIDY
                     DPLDKQLYWIDSRQNSIRKAHEDGGQGFNVVANSVANQNLEIQPYDLSIDIYSRYIYW
                     TCEATNVIDVTRLDGRSVGVVLKGEQDRPRAIVVNPEKGYMYFTNLQERSPKIERAAL
                     DGTEREVLFFSGLSKPIALALDSKLGKLFWADSDLRRIESSDLSGANRIVLEDSNILQ
                     PVGLTVFENWLYWIDKQQQMIEKIDMTGREGRTKVQARIAQLSDIHAVKELNLQEYRQ
                     HPCAQDNGGCSHICLVKGDGTTRCSCPMHLVLLQDELSCGEPPTCSPQQFTCFTGDID
                     CIPVAWRCDGFTECEDHSDELNCPVCSESQFQCASGQCIDGALRCNGDANCQDKSDEK
                     NCEVLCLIDQFRCANGQCVGKHKKCDHSVDCSDRSDELDCYPTEEPAPQATNTVGSVI
                     GVIVTIFVSGTIYFICQRMLCPRMKGDGETMTNDYVVHSPASVPLGYVPHPSSLSGSL
                     PGMSRGKSMISSLSIMGGSSGPPYDRAHVTGASSSSSSSTKGTYFPAILNPPPSPATE
                     RSHYTMEFGYSSNSPSTHRSYSYRPYSYRHFAPPTTPCSTDVCDSDYAPSRRMTSVAT
                     AKGYTSDVNYDSEPVPPPPTPRSQYLSAEENYESCPPSPYTERSYSHHLYPPPPSPCT
                     DSS"
     exon            272..665
                     /gene="Lrp6"
                     /gene_synonym="C030016K15Rik; Cd; Gw; ska26; ska<m26Jus>;
                     skax26"
                     /inference="alignment:Splign:2.1.0"
     exon            666..863
                     /gene="Lrp6"
                     /gene_synonym="C030016K15Rik; Cd; Gw; ska26; ska<m26Jus>;
                     skax26"
                     /inference="alignment:Splign:2.1.0"
     exon            864..1060
                     /gene="Lrp6"
                     /gene_synonym="C030016K15Rik; Cd; Gw; ska26; ska<m26Jus>;
                     skax26"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1192
                     /gene="Lrp6"
                     /gene_synonym="C030016K15Rik; Cd; Gw; ska26; ska<m26Jus>;
                     skax26"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1589
                     /gene="Lrp6"
                     /gene_synonym="C030016K15Rik; Cd; Gw; ska26; ska<m26Jus>;
                     skax26"
                     /inference="alignment:Splign:2.1.0"
     exon            1590..1761
                     /gene="Lrp6"
                     /gene_synonym="C030016K15Rik; Cd; Gw; ska26; ska<m26Jus>;
                     skax26"
                     /inference="alignment:Splign:2.1.0"
     exon            1762..1978
                     /gene="Lrp6"
                     /gene_synonym="C030016K15Rik; Cd; Gw; ska26; ska<m26Jus>;
                     skax26"
                     /inference="alignment:Splign:2.1.0"
     exon            1979..2268
                     /gene="Lrp6"
                     /gene_synonym="C030016K15Rik; Cd; Gw; ska26; ska<m26Jus>;
                     skax26"
                     /inference="alignment:Splign:2.1.0"
     exon            2269..2495
                     /gene="Lrp6"
                     /gene_synonym="C030016K15Rik; Cd; Gw; ska26; ska<m26Jus>;
                     skax26"
                     /inference="alignment:Splign:2.1.0"
     exon            2496..2680
                     /gene="Lrp6"
                     /gene_synonym="C030016K15Rik; Cd; Gw; ska26; ska<m26Jus>;
                     skax26"
                     /inference="alignment:Splign:2.1.0"
     exon            2681..3007
                     /gene="Lrp6"
                     /gene_synonym="C030016K15Rik; Cd; Gw; ska26; ska<m26Jus>;
                     skax26"
                     /inference="alignment:Splign:2.1.0"
     exon            3008..3210
                     /gene="Lrp6"
                     /gene_synonym="C030016K15Rik; Cd; Gw; ska26; ska<m26Jus>;
                     skax26"
                     /inference="alignment:Splign:2.1.0"
     exon            3211..3422
                     /gene="Lrp6"
                     /gene_synonym="C030016K15Rik; Cd; Gw; ska26; ska<m26Jus>;
                     skax26"
                     /inference="alignment:Splign:2.1.0"
     exon            3423..3613
                     /gene="Lrp6"
                     /gene_synonym="C030016K15Rik; Cd; Gw; ska26; ska<m26Jus>;
                     skax26"
                     /inference="alignment:Splign:2.1.0"
     exon            3614..3823
                     /gene="Lrp6"
                     /gene_synonym="C030016K15Rik; Cd; Gw; ska26; ska<m26Jus>;
                     skax26"
                     /inference="alignment:Splign:2.1.0"
     exon            3824..3949
                     /gene="Lrp6"
                     /gene_synonym="C030016K15Rik; Cd; Gw; ska26; ska<m26Jus>;
                     skax26"
                     /inference="alignment:Splign:2.1.0"
     exon            3950..4186
                     /gene="Lrp6"
                     /gene_synonym="C030016K15Rik; Cd; Gw; ska26; ska<m26Jus>;
                     skax26"
                     /inference="alignment:Splign:2.1.0"
     exon            4187..4297
                     /gene="Lrp6"
                     /gene_synonym="C030016K15Rik; Cd; Gw; ska26; ska<m26Jus>;
                     skax26"
                     /inference="alignment:Splign:2.1.0"
     exon            4298..4528
                     /gene="Lrp6"
                     /gene_synonym="C030016K15Rik; Cd; Gw; ska26; ska<m26Jus>;
                     skax26"
                     /inference="alignment:Splign:2.1.0"
     exon            4529..4665
                     /gene="Lrp6"
                     /gene_synonym="C030016K15Rik; Cd; Gw; ska26; ska<m26Jus>;
                     skax26"
                     /inference="alignment:Splign:2.1.0"
     exon            4666..4763
                     /gene="Lrp6"
                     /gene_synonym="C030016K15Rik; Cd; Gw; ska26; ska<m26Jus>;
                     skax26"
                     /inference="alignment:Splign:2.1.0"
     exon            4764..9368
                     /gene="Lrp6"
                     /gene_synonym="C030016K15Rik; Cd; Gw; ska26; ska<m26Jus>;
                     skax26"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9332..9337
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lrp6"
                     /gene_synonym="C030016K15Rik; Cd; Gw; ska26; ska<m26Jus>;
                     skax26"
                     /note="hexamer: AATAAA"
     polyA_site      9368
                     /gene="Lrp6"
                     /gene_synonym="C030016K15Rik; Cd; Gw; ska26; ska<m26Jus>;
                     skax26"
                     /note="major polyA site"
ORIGIN      
        1 ggcggcggca tgggggcagg cgctggcgtc gcgcgagccc gggccggagc ggcgcgctag
       61 agccctgacg tgcgcccttt tctttcttct cgcggccgcg gaaagcatga gcgtgcagac
      121 ccgccgctgc ggcggccgcc ccggctcctc gcccgcgcgt cccctggccg ccgggcgccg
      181 gtgagggccg cgagcgcgcg cggtggtggg gggaagatgg gggccgtgct gaggagcctc
      241 ctggcctgca gcttctgcgt gctgctgaga gcggcccctt tgttgcttta tgcaaacaga
      301 cgggacttga gattggttga tgctacaaat ggcaaagaga atgcaacgat tgtagttgga
      361 ggcttggagg atgcagctgc ggtggacttt gtgtttggtc atggcttgat atactggagt
      421 gatgtcagcg aagaagccat taaacgaaca gaatttaaca aaactgaaag tgtacagaat
      481 gttgttgttt ctggattatt gtccccggat gggctggcat gtgattggct tggagaaaaa
      541 ttgtactgga cagattctga aactaatcgt attgaagttt ctaatttaga tggatcttta
      601 cgaaaagttt tattttggca agagttggat caacccagag ctattgcctt agatccatca
      661 agtgggttca tgtactggac agactgggga gaagtgccaa agatagaacg tgctgggatg
      721 gatggctcaa gtcgcttcgt tataataaac acagagattt actggccaaa cggactgact
      781 ctggactatc aggagcggaa gctttactgg gccgatgcaa aacttaattt catccataaa
      841 tcaaacctgg atggaacaaa ccggcaggca gtggttaaag gttcccttcc acatcctttt
      901 gccttgacgt tatttgagga cacattgtac tggactgact ggaatacaca ctctattttg
      961 gcttgcaaca aatatactgg cgagggtctg cgtgaaattc attctaacat cttctctccc
     1021 atggatatac atgctttcag ccaacagagg cagccaaatg ctacaaatcc atgtggaatt
     1081 gataatggtg gttgttccca tttgtgtttg atgtctccag tcaagccttt ttatcagtgt
     1141 gcttgcccaa ctggggtcaa gctgctggag aatggaaaga cctgcaaaga tggtgccact
     1201 gaactattgc tgttagcccg acggacagac ttgaggcgaa tttctttgga tacacccgat
     1261 tttactgaca ttgttctgca gttagaagat atccggcatg ccattgccat agactatgac
     1321 cctgtagaag gctacatata ctggacggat gacgaagtga gggctatccg tcgctccttc
     1381 atagatggat ctggcagtca gtttgtggtc acggcccaga ttgctcatcc tgatggtatt
     1441 gctgttgact gggttgcaag gaacctgtac tggacagaca ctggcacgga tcgtatagaa
     1501 gtgacaaggc tcaatgggac catgaggaag atcttgattt cagaggactt agaggagccc
     1561 cgggctatcg tgttagatcc catggttggg tacatgtatt ggacagactg gggagaaatc
     1621 ccaaaaatag agcgagctgc tctggacgga tctgaccgag tagttcttgt caacacttcc
     1681 cttggttggc caaacggctt agccctggat tatgatgaag gcacaatata ctggggagat
     1741 gccaaaacag acaaaattga ggttatgaat accgatggca ccgggaggcg agtgctggtg
     1801 gaagacaaga tccctcacat atttgggttt accttgctgg gtgactatgt ttactggact
     1861 gactggcaga ggcggagcat cgagagagta cacaaacgga gcgcagagag ggaggtcatc
     1921 atagatcagc tgccagacct catgggactg aaggccacaa gtgttcacag aatcattggt
     1981 tctaacccct gtgctgagga caatggagga tgtagccatc tttgcctgta caggcctcag
     2041 gggcttcgat gcgcctgtcc cattggcttt gagctcatca gtgacatgaa gacatgcatt
     2101 gtccccgagg ctttccttct gttctcgagg agagcggata tcagacgcat atctttggaa
     2161 acaaacaaca acaatgtggc cattcctctc actggtgtca aagaagcctc tgctttggat
     2221 tttgatgtca cagacaacag gatttactgg actgatatat cactgaagac tattagcaga
     2281 gcctttatga atggcagtgc actggaacat gtggtagagt ttggcttaga ttatccagaa
     2341 ggcatggcag tggactggct tgggaagaac ttatactggg cagacacagg aacaaatcgc
     2401 attgaggtat cgaagttgga cggacagcac cgacaggttt tggtatggaa agaccttgac
     2461 agtcctcgag ctctggcact ggatcctgct gaagggttta tgtattggac tgagtgggga
     2521 ggcaagccta agattgacag ggctgctatg gatggaagtg aacgcactac attagttcca
     2581 aatgtaggcc gagcaaatgg tctcaccatc gactatgcta aaaggcggct ttactggaca
     2641 gacctggaca ctaacctaat agaatcctca gatatgctcg gactcaaccg tgaagttata
     2701 gcagatgact tgcctcatcc ttttggctta actcagtacc aagattacat ctactggaca
     2761 gactggagcc gacgcagcat tgaacgtgcc aacaaaacca gtggccaaaa ccgcaccatc
     2821 atccagggcc atttggacta tgtgatggac atcctggtct tccactcttc ccggcaggca
     2881 gggtggaatg agtgtgcctc cagcaacggg cactgctccc acctctgctt ggctgtgccc
     2941 gtcggaggtt ttgtgtgtgg atgccctgcc cactactccc tgaatgctga caacaggacc
     3001 tgcagtgctc ccaccacctt cctgctcttc agtcagaaga gcgccatcaa ccgcatggtg
     3061 attgatgaac aacagagccc tgacatcatc cttcctatcc acagccttcg gaacgtccgg
     3121 gccattgact atgacccttt ggacaagcag ctctactgga ttgactctcg acaaaactcc
     3181 atacgaaagg cacatgaaga tggtggccag ggttttaatg tagttgcaaa ctcagtcgca
     3241 aatcagaacc ttgaaataca gccctatgat ctcagcattg atatttatag ccgttacatc
     3301 tactggacct gtgaagctac caatgtcatt gatgtgacga gattagatgg acgatcagtt
     3361 ggagtggttc taaaaggcga gcaagacaga cctcgagcca ttgtggtaaa ccccgagaaa
     3421 gggtatatgt attttaccaa tcttcaggaa agatctccta aaattgaacg ggctgcattg
     3481 gatggtacag aacgagaggt cctctttttc agtggcttaa gtaaaccaat tgctttggct
     3541 cttgatagca agctgggcaa gctcttctgg gctgactcag atctccggcg aattgaaagc
     3601 agtgatctct caggtgccaa caggatcgtg ctagaagact ctaatatatt acagcctgtg
     3661 ggcctgaccg tgtttgaaaa ctggctctat tggattgata aacagcagca gatgattgaa
     3721 aaaattgaca tgactggtcg agaaggaaga accaaggtcc aggctcgaat tgctcagctg
     3781 agtgacatcc atgcagtaaa ggagctgaac cttcaggagt acagacagca cccttgtgcc
     3841 caggataatg gtggctgttc acatatctgc cttgtaaaag gagatggtac gacaagatgc
     3901 tcctgcccca tgcacttagt tctgcttcag gatgagctgt cctgtggaga gcctccaacg
     3961 tgttctcctc agcagtttac ctgcttcact ggggacattg actgcatccc tgtggcttgg
     4021 cggtgtgatg ggttcactga gtgcgaagac cacagcgatg aactcaattg tcccgtgtgc
     4081 tcagagtctc agttccagtg tgccagcggg cagtgcattg atggtgccct tcgatgcaat
     4141 ggcgatgcga actgccagga caaatcagat gagaagaact gtgaagtgct ttgtttaatt
     4201 gatcagttcc gctgtgccaa tggtcagtgc gttggaaagc acaagaaatg tgaccacagt
     4261 gtggactgca gtgacagatc tgacgagctg gactgttatc caactgagga gccagcacca
     4321 caagccacca acacagttgg ttctgttatt ggagtaattg tcaccatttt tgtgtctgga
     4381 accatatact ttatctgcca gaggatgctg tgtcctcgta tgaagggaga cggggagacc
     4441 atgactaacg actatgtggt tcacagcccg gcgtctgtgc cccttggtta tgttcctcac
     4501 ccaagctctc tctctggatc tcttccagga atgtctcgag gcaaatcaat gatcagttcc
     4561 ctcagtatca tggggggaag cagtgggccc ccctatgatc gagcgcacgt cacgggagcc
     4621 tcctcaagca gttcttccag taccaaaggc acttacttcc ctgcaatttt gaacccacca
     4681 ccatcgcctg ccacagaaag atcccattat accatggaat ttggttattc ttccaacagt
     4741 ccttccacac ataggtccta cagctatagg ccgtacagct accggcactt tgcaccgccc
     4801 accacaccct gcagcactga tgtctgtgac agtgactatg ctcctagccg gaggatgacc
     4861 tcggtggcaa cagccaaggg ctacaccagt gacgtgaact atgactcaga acctgtgccc
     4921 ccaccgccca caccccgaag ccagtacttg tcagcggagg agaactatga aagctgcccc
     4981 ccttccccat acacggagag gagttactcc caccacctct acccgccacc accctccccc
     5041 tgcacggact cctcctgagg agggcccctc ctcctctgac tgcctccacc gggacatgta
     5101 aatacacatc tggttgagat ctggaggggg ggagggagct atagagaaga gtgaggcaga
     5161 ctctgtacag ttaacattat aaagtgggtg ggtgctggag atatttgtac agaagaaaag
     5221 aatatttata tattttctta aaacagcagt tttgctgctt gtgccataaa agtttgtata
     5281 aaaaataaat ttgtactaaa agttttattt ttgcaaacta aatacacaga gcatgcctta
     5341 agcccagtga agagactgag tacaaaggaa acaggaaaag aaaggcatca ctgaccagga
     5401 gtgtctgggt tttaacgata ccaaaaaata aaaaggagaa agtaattcca tcttagagta
     5461 gcaaacttgg aagtagccaa attgcctttg ggttaactaa catttgaggg ccgacaagtc
     5521 gagaacccat gaaagaagaa ataacagtac taactttgga cacagggctt tgttttctcc
     5581 aggaatccag caattttcac gaggaaaata gatagttgtg agatccgttt tgagtgctgc
     5641 tgttgtagga gctgaagcgt ctctcgcggg agctgctgag agctctcgcc tgtcacagtc
     5701 catggtaaca ccagctgttc tcacggtctg cctcccaaca ccttggagac tgttttgcca
     5761 agagccatga tttatttaag ctttttaatc tgaggagttg attaaatgga atttactaaa
     5821 cacgaaattg aattgatttc agtataccta ctctgttcgt tcagcaattg gctgagtttt
     5881 taagttgttg gctgtttttg cataatcaaa agttagccat attattggtc ttccacaatt
     5941 gttttaatgc tcattaaagt gtctttttag aacatataag aatgcttaaa aatcacaaat
     6001 ctaactgtta tattcttgta aattagcttt gtatccttgc agcatacaat atcacagtgt
     6061 gaaatcattt tatgtatttt gttagtaaaa catttcaatg tgctctcgtt agaaacagtc
     6121 tgtttaaaca gaaattctta ttgttagtag gcgtccccta gatgaactgt ttgtgacatt
     6181 ttcactttct gtggaccagc ttttctcaga gtgatgtttg caggcatagc tctgccgatg
     6241 tgctgtgagg tagcttctcg gtatgcgctg tgaatgagtg tgttcacacg gcccacagtc
     6301 tgtccttagt ctcctcctgt gtctctctgt gtgctctctc ctaccccatt atggattaag
     6361 ataatttcac agatttaaca gtgggattaa atgagaagac accgtgaact tctcagctgc
     6421 agaaatttga gcagtggaga caatggaagt ctcctgtcac atgcctgacc tactgtcaca
     6481 taccgggccg ctatgtctgt cactgttggg gctggctgtg ggatgaccct gctggggact
     6541 agtttcctgc tttcacatgt gcctagcact cctctcctaa agctgaactt tttttaagct
     6601 agtatgattt ttaccttaac aggtgtcgat taattattga atacatttta aaaattatat
     6661 attgaattgt agctatgaat ttcagagcct aaggggaaac aatgaaagaa ttgatttcag
     6721 aatttggcag agtttgagcg actttaaaaa aacaaaacaa aacgcctaag aacgttttta
     6781 aagagaaaaa actcctttct gactaatgcg tagttgttgt ggacagctta gtgagaatca
     6841 ggggccttgc atctaagtaa agggcaatct acctgtgtcc tgcatttcag tcagataagc
     6901 attaactctt cctgttactg agacgaagtg cacagagcct taagacagac tggacactga
     6961 acttgcctcc tgtgacgcac aggctactca acacttacgt gaagatggga gggtagcaat
     7021 actgggtatc ggtcagaatt ggagaattct ttatgtttac attttcaatg tgcgtcttta
     7081 tctggtgggc ttcccatgta ggagagactt gcactgtcgt gtgccgggaa cggtgtggct
     7141 tgtttcatct cagtccaagt gcttgtgctg agtggcagtg gcctcttgca aaatactaac
     7201 ttgtgtgcca gtttgttgaa atgatttgaa ggcggttcag gtcagtctca gtagcctctt
     7261 tctggggccg ctcagccgca gtgaagattg ctcagggtac gtcttagtga gggtcgttaa
     7321 atcaaaagtt aggaagatga tgatactcaa gttacatgga cagttacgtt taaataaact
     7381 gtgtctcaat tattgaacat aagagaaaat gagggaaaag acagttttaa attaggctgc
     7441 atctagattc attactcaag aggaaacatg aataaatttg attagatttc atagttacaa
     7501 gggtatttac tttgaacgca tatcttaaag tgtgcctgct cactgatcgg agagggtatg
     7561 aggtgagctt ttgtctagct tgcttttgta cactgcagta agcttttctg ccgtgcagtc
     7621 ttctagaact aagactcaga cttgactcat ttggagccca agtcttctaa ccaaggccca
     7681 agagttcttg cttaggtcag ataaatggca caggaagata aggtttaatt tagagtcggt
     7741 gggtagaatg ttattagtat tttccttctg ttttaaaatt ttacaatctt tttcgcaatg
     7801 aatactaact tgtaaaaaaa tggccatcta ttttaggtaa cagtttttgg gggacaacat
     7861 gtttttgtct tgtcaaaaag gcccgtcagt gaaaacagtt gagttcatag ctgtgttagt
     7921 tacctcacca gttaattgag atttgtctag tgaccaagaa ggctttctgc agggaagtcg
     7981 gcttccctgc aaggcacaga aacaaaagtc ttgttcagtt ccaatagttc tgctttcagt
     8041 gactacagtg cttagtgtag cccttataac tttatagaaa caattaccaa ctgatttctt
     8101 actcaaaatt agactataga taggagtttg ggtatcagtt ggttggcagt atttaagaat
     8161 tcacaaatga gagccgtgca tgagtgtggg tacagactga gtcctaaaca agtttgccat
     8221 taagcattag ttaaaatgtc agaatccctg tttaatctcc tggggtttcc tcaccccagg
     8281 cctaaaacag gctgtgagaa gagacgtgct ttgaggaccc ggaaggcact gctttgtaag
     8341 aatgtcaaga ttaggctttt gaaaccttag attttcaagt caaggacttt gggcctcaaa
     8401 tacaaaacga cacatttgtg acctaaatac tgtgcctcac agatccatac agcccgtggc
     8461 tttctccgac tgaacagctc actgaactca gcttacacct gagtaagggc ggtggggagg
     8521 tggcagatgc gcgggtttac cttgatgacc taagagtcac ctccttcagg gaaggaaact
     8581 gtcattttaa acattgttta acattttcac aaggcgttta gaaagcactc ctgattttat
     8641 tcctagggaa tttttaggat tacaaattga tgtcttgtac tcagaatatg gcccgacaca
     8701 ctcatcattg ggtttttccc ttcttccctt agagtgctag acagcttgct tctgcttcac
     8761 tgtccacttg gggcttgctt tggtttttgt ttgtttgttt tgttttttgt ttttgttttt
     8821 ttgttttttt gtttttccat caaatacgag aaagttgagg gagtggtata gctacatata
     8881 tccatgtggc tgtgtatctg tatcgatgcc taaatatgag tattcagagg aaaggaaggc
     8941 aagggactgc tcccatcagt ccggtgagag gaggctggag agaggataca ggaggctgaa
     9001 cctgaccggc cttgttgcaa gtgaaggatc tggtgctgct tttgctgttt gtcctttttg
     9061 agtctgaacg ttttcttaag ctttaatctt tatcattgtc ttaaagtcag ctggtgtttc
     9121 ttgtacatcg actttggaat gatggtgctt tgcaaggatg tatttatatt ataatggcca
     9181 acatttggtc agcccttgtc cgcttattca cttcccccct tttgtaaaat aagtgcttta
     9241 attataaact gtataaatac cttgtataac ccccccccct tttgattatt acaaacagct
     9301 gaattgtaac aaatgaaatg ttgattttta taataaaaca gtggaaaaat cagtggaaaa
     9361 aatgaaaa
//
