LOCUS       NM_008513               5172 bp    mRNA    linear   ROD 06-OCT-2024
DEFINITION  Mus musculus low density lipoprotein receptor-related protein 5
            (Lrp5), mRNA.
ACCESSION   NM_008513
VERSION     NM_008513.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5172)
  AUTHORS   Luquero,A., Pimentel,N., Vilahur,G., Badimon,L. and
            Borrell-Pages,M.
  TITLE     Unique Splicing of Lrp5 in the Brain: A New Player in
            Neurodevelopment and Brain Maturation
  JOURNAL   Int J Mol Sci 25 (12), 6763 (2024)
   PUBMED   38928468
  REMARK    GeneRIF: Unique Splicing of Lrp5 in the Brain: A New Player in
            Neurodevelopment and Brain Maturation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5172)
  AUTHORS   Tang,W., Luan,Y., Yuan,Q., Li,A., Chen,S., Menacherry,S., Young,L.
            and Wu,D.
  TITLE     LDL receptor-related protein 5 selectively transports unesterified
            polyunsaturated fatty acids to intracellular compartments
  JOURNAL   Nat Commun 15 (1), 3068 (2024)
   PUBMED   38594269
  REMARK    GeneRIF: LDL receptor-related protein 5 selectively transports
            unesterified polyunsaturated fatty acids to intracellular
            compartments.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5172)
  AUTHORS   Kim,G., Chen,Z., Li,J., Luo,J., Castro-Martinez,F., Wisniewski,J.,
            Cui,K., Wang,Y., Sun,J., Ren,X., Crawford,S.E., Becerra,S.P.,
            Zhu,J., Liu,T., Wang,S., Zhao,K. and Wu,C.
  TITLE     Gut-liver axis calibrates intestinal stem cell fitness
  JOURNAL   Cell 187 (4), 914-930 (2024)
   PUBMED   38280375
REFERENCE   4  (bases 1 to 5172)
  AUTHORS   Turkkahraman,H., Flanagan,S., Zhu,T., Bellido,T.M. and Yuan,X.
  TITLE     The LRP5 high-bone-mass mutation causes alveolar bone accrual with
            minor craniofacial alteration
  JOURNAL   J Periodontal Res 58 (4), 723-732 (2023)
   PUBMED   37128744
  REMARK    GeneRIF: The LRP5 high-bone-mass mutation causes alveolar bone
            accrual with minor craniofacial alteration.
REFERENCE   5  (bases 1 to 5172)
  AUTHORS   Geng,S., Paul,F., Kowalczyk,I., Raimundo,S., Sporbert,A., Mamo,T.M.
            and Hammes,A.
  TITLE     Balancing WNT signalling in early forebrain development: The role
            of LRP4 as a modulator of LRP6 function
  JOURNAL   Front Cell Dev Biol 11, 1173688 (2023)
   PUBMED   37091972
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5172)
  AUTHORS   Kato,M., Patel,M.S., Levasseur,R., Lobov,I., Chang,B.H., Glass,D.A.
            2nd, Hartmann,C., Li,L., Hwang,T.H., Brayton,C.F., Lang,R.A.,
            Karsenty,G. and Chan,L.
  TITLE     Cbfa1-independent decrease in osteoblast proliferation, osteopenia,
            and persistent embryonic eye vascularization in mice deficient in
            Lrp5, a Wnt coreceptor
  JOURNAL   J Cell Biol 157 (2), 303-314 (2002)
   PUBMED   11956231
  REMARK    GeneRIF: Cbfa1-independent decrease in osteoblast proliferation,
            osteopenia, and persistent embryonic eye vascularization in mice
            deficient in Lrp5
REFERENCE   7  (bases 1 to 5172)
  AUTHORS   Mao,J., Wang,J., Liu,B., Pan,W., Farr,G.H. 3rd, Flynn,C., Yuan,H.,
            Takada,S., Kimelman,D., Li,L. and Wu,D.
  TITLE     Low-density lipoprotein receptor-related protein-5 binds to Axin
            and regulates the canonical Wnt signaling pathway
  JOURNAL   Mol Cell 7 (4), 801-809 (2001)
   PUBMED   11336703
REFERENCE   8  (bases 1 to 5172)
  AUTHORS   Pinson,K.I., Brennan,J., Monkley,S., Avery,B.J. and Skarnes,W.C.
  TITLE     An LDL-receptor-related protein mediates Wnt signalling in mice
  JOURNAL   Nature 407 (6803), 535-538 (2000)
   PUBMED   11029008
REFERENCE   9  (bases 1 to 5172)
  AUTHORS   Chen,D., Lathrop,W. and Dong,Y.
  TITLE     Molecular cloning of mouse Lrp7(Lr3) cDNA and chromosomal mapping
            of orthologous genes in mouse and human
  JOURNAL   Genomics 55 (3), 314-321 (1999)
   PUBMED   10049586
REFERENCE   10 (bases 1 to 5172)
  AUTHORS   Hey,P.J., Twells,R.C., Phillips,M.S., Yusuke,Nakagawa., Brown,S.D.,
            Kawaguchi,Y., Cox,R., Guochun,Xie., Dugan,V., Hammond,H.,
            Metzker,M.L., Todd,J.A. and Hess,J.F.
  TITLE     Cloning of a novel member of the low-density lipoprotein receptor
            family
  JOURNAL   Gene 216 (1), 103-111 (1998)
   PUBMED   9714764
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK081025.1, AK147330.1 and BB070734.1.
            
            On Jul 9, 2009 this sequence version replaced NM_008513.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147068.1, BC011374.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AK081025.1         1-3
            4-805               AK147330.1         2-803
            806-4119            AK147330.1         917-4230
            4120-5166           AK147330.1         7848-8894
            5167-5172           BB070734.1         257-262
FEATURES             Location/Qualifiers
     source          1..5172
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 3.33 cM"
     gene            1..5172
                     /gene="Lrp5"
                     /gene_synonym="BMND1; HBM; LR3; LRP7; mKIAA4142; OPPG"
                     /note="low density lipoprotein receptor-related protein 5"
                     /db_xref="GeneID:16973"
                     /db_xref="MGI:MGI:1278315"
     exon            1..210
                     /gene="Lrp5"
                     /gene_synonym="BMND1; HBM; LR3; LRP7; mKIAA4142; OPPG"
                     /inference="alignment:Splign:2.1.0"
     exon            211..607
                     /gene="Lrp5"
                     /gene_synonym="BMND1; HBM; LR3; LRP7; mKIAA4142; OPPG"
                     /inference="alignment:Splign:2.1.0"
     exon            608..805
                     /gene="Lrp5"
                     /gene_synonym="BMND1; HBM; LR3; LRP7; mKIAA4142; OPPG"
                     /inference="alignment:Splign:2.1.0"
     exon            806..1002
                     /gene="Lrp5"
                     /gene_synonym="BMND1; HBM; LR3; LRP7; mKIAA4142; OPPG"
                     /inference="alignment:Splign:2.1.0"
     exon            1003..1134
                     /gene="Lrp5"
                     /gene_synonym="BMND1; HBM; LR3; LRP7; mKIAA4142; OPPG"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1531
                     /gene="Lrp5"
                     /gene_synonym="BMND1; HBM; LR3; LRP7; mKIAA4142; OPPG"
                     /inference="alignment:Splign:2.1.0"
     exon            1532..1703
                     /gene="Lrp5"
                     /gene_synonym="BMND1; HBM; LR3; LRP7; mKIAA4142; OPPG"
                     /inference="alignment:Splign:2.1.0"
     exon            1704..1920
                     /gene="Lrp5"
                     /gene_synonym="BMND1; HBM; LR3; LRP7; mKIAA4142; OPPG"
                     /inference="alignment:Splign:2.1.0"
     exon            1921..2210
                     /gene="Lrp5"
                     /gene_synonym="BMND1; HBM; LR3; LRP7; mKIAA4142; OPPG"
                     /inference="alignment:Splign:2.1.0"
     exon            2211..2437
                     /gene="Lrp5"
                     /gene_synonym="BMND1; HBM; LR3; LRP7; mKIAA4142; OPPG"
                     /inference="alignment:Splign:2.1.0"
     exon            2438..2622
                     /gene="Lrp5"
                     /gene_synonym="BMND1; HBM; LR3; LRP7; mKIAA4142; OPPG"
                     /inference="alignment:Splign:2.1.0"
     exon            2623..2946
                     /gene="Lrp5"
                     /gene_synonym="BMND1; HBM; LR3; LRP7; mKIAA4142; OPPG"
                     /inference="alignment:Splign:2.1.0"
     exon            2947..3146
                     /gene="Lrp5"
                     /gene_synonym="BMND1; HBM; LR3; LRP7; mKIAA4142; OPPG"
                     /inference="alignment:Splign:2.1.0"
     exon            3147..3355
                     /gene="Lrp5"
                     /gene_synonym="BMND1; HBM; LR3; LRP7; mKIAA4142; OPPG"
                     /inference="alignment:Splign:2.1.0"
     exon            3356..3546
                     /gene="Lrp5"
                     /gene_synonym="BMND1; HBM; LR3; LRP7; mKIAA4142; OPPG"
                     /inference="alignment:Splign:2.1.0"
     exon            3547..3756
                     /gene="Lrp5"
                     /gene_synonym="BMND1; HBM; LR3; LRP7; mKIAA4142; OPPG"
                     /inference="alignment:Splign:2.1.0"
     exon            3757..3882
                     /gene="Lrp5"
                     /gene_synonym="BMND1; HBM; LR3; LRP7; mKIAA4142; OPPG"
                     /inference="alignment:Splign:2.1.0"
     exon            3883..4119
                     /gene="Lrp5"
                     /gene_synonym="BMND1; HBM; LR3; LRP7; mKIAA4142; OPPG"
                     /inference="alignment:Splign:2.1.0"
     exon            4120..4230
                     /gene="Lrp5"
                     /gene_synonym="BMND1; HBM; LR3; LRP7; mKIAA4142; OPPG"
                     /inference="alignment:Splign:2.1.0"
     exon            4231..4467
                     /gene="Lrp5"
                     /gene_synonym="BMND1; HBM; LR3; LRP7; mKIAA4142; OPPG"
                     /inference="alignment:Splign:2.1.0"
     exon            4468..4607
                     /gene="Lrp5"
                     /gene_synonym="BMND1; HBM; LR3; LRP7; mKIAA4142; OPPG"
                     /inference="alignment:Splign:2.1.0"
     exon            4608..4705
                     /gene="Lrp5"
                     /gene_synonym="BMND1; HBM; LR3; LRP7; mKIAA4142; OPPG"
                     /inference="alignment:Splign:2.1.0"
     exon            4706..5172
                     /gene="Lrp5"
                     /gene_synonym="BMND1; HBM; LR3; LRP7; mKIAA4142; OPPG"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5145..5150
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lrp5"
                     /gene_synonym="BMND1; HBM; LR3; LRP7; mKIAA4142; OPPG"
                     /note="hexamer: TATAAA"
     polyA_site      5169
                     /gene="Lrp5"
                     /gene_synonym="BMND1; HBM; LR3; LRP7; mKIAA4142; OPPG"
                     /note="major polyA site"
ORIGIN      
        1 gtcgtcttgg gccgcggcgc ccgaggcggg agcaagaggc gccgggagcc gcgaggatcc
       61 accgccgccg cgcgcgccat ggagcccgag tgagcgcgcg gcgctcccgg ccgccggacg
      121 acatggaaac ggcgccgacc cgggcccctc cgccgccgcc gccgccgctg ctgctgctgg
      181 tgctgtactg cagcttggtc cccgccgcgg cctcaccgct cctgttgttt gccaaccgcc
      241 gggatgtgcg gctagtggat gccggcggag tgaagctgga gtccaccatt gtggccagtg
      301 gcctggagga tgcagctgct gtagacttcc agttctccaa gggtgctgtg tactggacag
      361 atgtgagcga ggaggccatc aaacagacct acctgaacca gactggagct gctgcacaga
      421 acattgtcat ctcgggcctc gtgtcacctg atggcctggc ctgtgactgg gttggcaaga
      481 agctgtactg gacggactcc gagaccaacc gcattgaggt tgccaacctc aatgggacgt
      541 cccgtaaggt tctcttctgg caggacctgg accagccaag ggccattgcc ctggatcctg
      601 cacatgggta catgtactgg actgactggg gggaagcacc ccggatcgag cgggcaggga
      661 tggatggcag tacccggaag atcattgtag actccgacat ttactggccc aatgggctga
      721 ccatcgacct ggaggaacag aagctgtact gggccgatgc caagctcagc ttcatccacc
      781 gtgccaacct ggacggctcc ttccggcaga aggtggtgga gggcagcctc actcaccctt
      841 ttgccctgac actctctggg gacacactct actggacaga ctggcagacc cgctccatcc
      901 acgcctgcaa caagtggaca ggggagcaga ggaaggagat ccttagtgct ctgtactcac
      961 ccatggacat ccaagtgctg agccaggagc ggcagcctcc cttccacaca ccatgcgagg
     1021 aggacaacgg tggctgttcc cacctgtgcc tgctgtcccc gagggagcct ttctactcct
     1081 gtgcctgccc cactggtgtg cagttgcagg acaatggcaa gacgtgcaag acaggggctg
     1141 aggaagtgct gctgctggct cggaggacag acctgaggag gatctctctg gacacccctg
     1201 acttcacaga catagtgctg caggtgggcg acatccggca tgccattgcc attgactacg
     1261 atcccctgga gggctacgtg tactggaccg acgatgaggt gcgggctatc cgcagggcgt
     1321 acctagatgg ctcaggtgcg cagacacttg tgaacactga gatcaatgac cccgatggca
     1381 ttgctgtgga ctgggtcgcc cggaacctct actggacaga tacaggcact gacagaattg
     1441 aggtgactcg cctcaacggc acctcccgaa agatcctggt atctgaggac ctggacgaac
     1501 cgcgagccat tgtgttgcac cctgtgatgg gcctcatgta ctggacagac tggggggaga
     1561 accccaaaat cgaatgcgcc aacctagatg ggagagatcg gcatgtcctg gtgaacacct
     1621 cccttgggtg gcccaacgga ctggccctgg acctgcagga gggcaagctg tactgggggg
     1681 atgccaaaac tgataaaatc gaggtgatca acatagatgg gacaaagcgg aagaccctgc
     1741 ttgaggacaa gctcccacat atttttgggt tcacactgct gggggacttc atctactgga
     1801 ccgactggca gagacgcagt attgaaaggg tccacaaggt caaggccagc cgggatgtca
     1861 tcattgatca actccccgac ctgatgggac tcaaagctgt gaatgtggcc aaggttgtcg
     1921 gaaccaaccc atgtgcggat ggaaatggag ggtgcagcca tctgtgcttc ttcaccccac
     1981 gtgccaccaa gtgtggctgc cccattggcc tggagctgtt gagtgacatg aagacctgca
     2041 taatccccga ggccttcctg gtattcacca gcagagccac catccacagg atctccctgg
     2101 agactaacaa caacgatgtg gctatcccac tcacgggtgt caaagaggcc tctgcactgg
     2161 actttgatgt gtccaacaat cacatctact ggactgatgt cagcctcaag acgatcagcc
     2221 gagccttcat gaatgggagc tcagtggagc acgtgattga gtttggcctc gactaccctg
     2281 aaggaatggc tgtggactgg atgggcaaga acctctattg ggcggacaca gggaccaaca
     2341 ggattgaggt ggcccggctg gatgggcagt tccggcaggt gcttgtgtgg agagaccttg
     2401 acaaccccag gtctctggct ctggatccta ctaaaggcta catctactgg actgagtggg
     2461 gtggcaagcc aaggattgtg cgggccttca tggatgggac caattgtatg acactggtag
     2521 acaaggtggg ccgggccaac gacctcacca ttgattatgc cgaccagcga ctgtactgga
     2581 ctgacctgga caccaacatg attgagtctt ccaacatgct gggtcaggag cgcatggtga
     2641 tagctgacga tctgccctac ccgtttggcc tgactcaata tagcgattac atctactgga
     2701 ctgactggaa cctgcatagc attgaacggg cggacaagac cagtgggcgg aaccgcaccc
     2761 tcatccaggg tcacctggac ttcgtcatgg acatcctggt gttccactcc tcccgtcagg
     2821 atggcctcaa cgactgcgtg cacagcaatg gccagtgtgg gcagctgtgc ctcgccatcc
     2881 ccggaggcca ccgctgtggc tgtgcttcac actacacgct ggaccccagc agccgcaact
     2941 gcagcccgcc ctccaccttc ttgctgttca gccagaaatt tgccatcagc cggatgatcc
     3001 ccgatgacca gctcagcccg gaccttgtcc taccccttca tgggctgagg aacgtcaaag
     3061 ccatcaacta tgacccgctg gacaagttca tctactgggt ggacgggcgc cagaacatca
     3121 agagggccaa ggacgacggt acccagccct ccatgctgac ctctcccagc caaagcctga
     3181 gcccagacag acagccacac gacctcagca ttgacatcta cagccggaca ctgttctgga
     3241 cctgtgaggc caccaacact atcaatgtcc accggctgga tggggatgcc atgggagtgg
     3301 tgcttcgagg ggaccgtgac aagccaaggg ccattgctgt caatgctgag cgagggtaca
     3361 tgtactttac caacatgcag gaccatgctg ccaagatcga gcgagcctcc ctggatggca
     3421 cagagcggga ggtcctcttc accacaggcc tcatccgtcc cgtggccctt gtggtggaca
     3481 atgctctggg caagctcttc tgggtggatg ccgacctaaa gcgaatcgaa agctgtgacc
     3541 tctctggggc caaccgcctg accctggaag atgccaacat cgtacagcca gtaggtctga
     3601 cagtgctggg caggcacctc tactggatcg accgccagca gcagatgatc gagcgcgtgg
     3661 agaagaccac tggggacaag cggactaggg ttcagggccg tgtcacccac ctgacaggca
     3721 tccatgccgt ggaggaagtc agcctggagg agttctcagc ccatccttgt gcccgagaca
     3781 atggcggctg ctcccacatc tgtatcgcca agggtgatgg aacaccgcgc tgctcgtgcc
     3841 ctgtccacct ggtgctcctg cagaacctgc tgacttgtgg tgagcctcct acctgctccc
     3901 ctgatcagtt tgcatgtacc actggtgaga tcgactgcat ccccggagcc tggcgctgtg
     3961 acggcttccc tgagtgtgct gaccagagtg atgaagaagg ctgcccagtg tgctccgcct
     4021 ctcagttccc ctgcgctcga ggccagtgtg tggacctgcg gttacgctgc gacggtgagg
     4081 ccgactgcca ggatcgctct gatgaagcta actgcgatgc tgtctgtctg cccaatcagt
     4141 tccggtgcac cagcggccag tgtgtcctca tcaagcaaca gtgtgactcc ttccccgact
     4201 gtgctgatgg gtctgatgag ctcatgtgtg aaatcaacaa gccaccctct gatgacatcc
     4261 cagcccacag cagtgccatt gggcccgtca ttggtatcat cctctccctc ttcgtcatgg
     4321 gcggggtcta ctttgtctgc cagcgtgtga tgtgccagcg ctacacaggg gccagtgggc
     4381 cctttcccca cgagtatgtt ggtggagccc ctcatgtgcc tctcaacttc atagccccag
     4441 gtggctcaca gcacggtccc ttcccaggca tcccgtgcag caagtccgtg atgagctcca
     4501 tgagcctggt gggggggcgc ggcagtgtgc ccctctatga ccggaatcac gtcactgggg
     4561 cctcatccag cagctcgtcc agcacaaagg ccacactata tccgccgatc ctgaacccac
     4621 ccccgtcccc ggccacagac ccctctctct acaacgtgga cgtgttttat tcttcaggca
     4681 tcccggccac cgctagacca tacaggccct acgtcattcg aggtatggca cccccaacaa
     4741 caccgtgcag cacagatgtg tgtgacagtg actacagcac cagtcgctgg aagagcagca
     4801 aatactacct ggacttgaat tcggactcag acccctaccc ccccccgccc accccccaca
     4861 gccagtacct atctgcagag gacagctgcc caccctcacc aggcactgag aggagttact
     4921 gccacctctt cccgccccca ccgtccccct gcacggactc gtcctgacct cggccgtcca
     4981 cccggccctg ctgcctccct gtaaatattt ttaaatatga acaaaggaaa aatatatttt
     5041 atgatttaaa aaataaatat aattgggatt tttaacaagt gagaaatgtg agcggtgaag
     5101 gggtgggcag ggctgggaaa actttgtaca gtggagaaaa tatttataaa cttaattttt
     5161 taaaacatac ct
//
