LOCUS       NM_172668               8028 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus low density lipoprotein receptor-related protein 4
            (Lrp4), transcript variant 1, mRNA.
ACCESSION   NM_172668
VERSION     NM_172668.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8028)
  AUTHORS   Liu,C., Liu,J. and Chen,H.
  TITLE     Overexpression of miR-7-5p Promoted Fracture Healing Through
            Inhibiting LRP4 and Activating Wnt/beta-Catenin Pathway
  JOURNAL   Int J Low Extrem Wounds 23 (1), 86-91 (2024)
   PUBMED   36883209
  REMARK    GeneRIF: Overexpression of miR-7-5p Promoted Fracture Healing
            Through Inhibiting LRP4 and Activating Wnt/beta-Catenin Pathway.
REFERENCE   2  (bases 1 to 8028)
  AUTHORS   Hendrickx,G., Boudin,E., Mateiu,L., Yorgan,T.A., Steenackers,E.,
            Kneissel,M., Kramer,I., Mortier,G., Schinke,T. and Van Hul,W.
  TITLE     An Additional Lrp4 High Bone Mass Mutation Mitigates the
            Sost-Knockout Phenotype in Mice by Increasing Bone Remodeling
  JOURNAL   Calcif Tissue Int 114 (2), 171-181 (2024)
   PUBMED   38051321
  REMARK    GeneRIF: An Additional Lrp4 High Bone Mass Mutation Mitigates the
            Sost-Knockout Phenotype in Mice by Increasing Bone Remodeling.
REFERENCE   3  (bases 1 to 8028)
  AUTHORS   Eguchi,T., Tezuka,T., Watanabe,Y., Inoue-Yamauchi,A., Sagara,H.,
            Ozawa,M. and Yamanashi,Y.
  TITLE     Calcium-binding protein 7 expressed in muscle negatively regulates
            age-related degeneration of neuromuscular junctions in mice
  JOURNAL   iScience 27 (2), 108997 (2024)
   PUBMED   38327785
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8028)
  AUTHORS   Zhang,X., Sun,Z., Zhang,Y., Pan,L., Jiang,W., Dong,H., Jin,Z.,
            Kang,J., Liu,R. and Ning,B.
  TITLE     Periplocin targets low density lipoprotein receptor-related protein
            4 to attenuate osteoclastogenesis and protect against osteoporosis
  JOURNAL   Biochem Pharmacol 211, 115516 (2023)
   PUBMED   36966936
  REMARK    GeneRIF: Periplocin targets low density lipoprotein
            receptor-related protein 4 to attenuate osteoclastogenesis and
            protect against osteoporosis.
REFERENCE   5  (bases 1 to 8028)
  AUTHORS   Geng,S., Paul,F., Kowalczyk,I., Raimundo,S., Sporbert,A., Mamo,T.M.
            and Hammes,A.
  TITLE     Balancing WNT signalling in early forebrain development: The role
            of LRP4 as a modulator of LRP6 function
  JOURNAL   Front Cell Dev Biol 11, 1173688 (2023)
   PUBMED   37091972
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 8028)
  AUTHORS   Li,Y., Chen,J., Lu,W., McCormick,L.M., Wang,J. and Bu,G.
  TITLE     Mesd binds to mature LDL-receptor-related protein-6 and antagonizes
            ligand binding
  JOURNAL   J Cell Sci 118 (Pt 22), 5305-5314 (2005)
   PUBMED   16263759
REFERENCE   7  (bases 1 to 8028)
  AUTHORS   Johnson,E.B., Hammer,R.E. and Herz,J.
  TITLE     Abnormal development of the apical ectodermal ridge and
            polysyndactyly in Megf7-deficient mice
  JOURNAL   Hum Mol Genet 14 (22), 3523-3538 (2005)
   PUBMED   16207730
  REMARK    GeneRIF: Modulator of cellular signaling pathways involving Wnt
            proteins, bone morphogenetic proteins, fibroblast growth factors
            and sonic hedgehog homolog.
REFERENCE   8  (bases 1 to 8028)
  AUTHORS   Luo,Z.G., Je,H.S., Wang,Q., Yang,F., Dobbins,G.C., Yang,Z.H.,
            Xiong,W.C., Lu,B. and Mei,L.
  TITLE     Implication of geranylgeranyltransferase I in synapse formation
  JOURNAL   Neuron 40 (4), 703-717 (2003)
   PUBMED   14622576
REFERENCE   9  (bases 1 to 8028)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   10 (bases 1 to 8028)
  AUTHORS   Glass,D.J., Bowen,D.C., Stitt,T.N., Radziejewski,C., Bruno,J.,
            Ryan,T.E., Gies,D.R., Shah,S., Mattsson,K., Burden,S.J.,
            DiStefano,P.S., Valenzuela,D.M., DeChiara,T.M. and Yancopoulos,G.D.
  TITLE     Agrin acts via a MuSK receptor complex
  JOURNAL   Cell 85 (4), 513-523 (1996)
   PUBMED   8653787
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY753111.1, BC132240.1, AF247637.1, CN533524.1 and AL691489.21.
            
            On Mar 14, 2009 this sequence version replaced NM_172668.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF247637.1, BC132240.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-77                BY753111.1         1-77
            78-2887             BC132240.1         1-2810
            2888-3898           AF247637.1         2718-3728
            3899-4378           BC132240.1         3822-4301
            4379-5419           AF247637.1         4209-5249
            5420-5676           CN533524.1         496-752
            5677-8028           AL691489.21        51595-53946
FEATURES             Location/Qualifiers
     source          1..8028
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 50.63 cM"
     gene            1..8028
                     /gene="Lrp4"
                     /gene_synonym="6430526J12Rik; D230026E03; mdig; Megf7"
                     /note="low density lipoprotein receptor-related protein 4"
                     /db_xref="GeneID:228357"
                     /db_xref="MGI:MGI:2442252"
     exon            1..222
                     /gene="Lrp4"
                     /gene_synonym="6430526J12Rik; D230026E03; mdig; Megf7"
                     /inference="alignment:Splign:2.1.0"
     CDS             171..5888
                     /gene="Lrp4"
                     /gene_synonym="6430526J12Rik; D230026E03; mdig; Megf7"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; LDLR dan; LRP-4"
                     /codon_start=1
                     /product="low-density lipoprotein receptor-related protein
                     4 isoform 1 precursor"
                     /protein_id="NP_766256.3"
                     /db_xref="CCDS:CCDS16432.1"
                     /db_xref="GeneID:228357"
                     /db_xref="MGI:MGI:2442252"
                     /translation="MRRWWGALLLGALLCAHGIASSLECACGRSHFTCAVSALGECTC
                     IPAQWQCDGDNDCGDHSDEDGCTLPTCSPLDFHCDNGKCIRRSWVCDGDNDCEDDSDE
                     QDCPPRECEEDEFPCQNGYCIRSLWHCDGDNDCGDNSDEQCDMRKCSDKEFRCSDGSC
                     IAEHWYCDGDTDCKDGSDEESCPSAVPSPPCNLEEFQCAYGRCILDIYHCDGDDDCGD
                     WSDESDCSSHQPCRSGEFMCDSGLCINSGWRCDGDADCDDQSDERNCTTSMCTAEQFR
                     CRSGRCVRLSWRCDGEDDCADNSDEENCENTGSPQCASDQFLCWNGRCIGQRKLCNGI
                     NDCGDSSDESPQQNCRPRTGEENCNVNNGGCAQKCQMVRGAVQCTCHTGYRLTEDGRT
                     CQDVNECAEEGYCSQGCTNTEGAFQCWCEAGYELRPDRRSCKALGPEPVLLFANRIDI
                     RQVLPHRSEYTLLLNNLENAIALDFHHRRELVFWSDVTLDRILRANLNGSNVEEVVST
                     GLESPGGLAVDWVHDKLYWTDSGTSRIEVANLDGAHRKVLLWQSLEKPRAIALHPMEG
                     TIYWTDWGNTPRIEASSMDGSGRRIIADTHLFWPNGLTIDYAGRRMYWVDAKHHVIER
                     ANLDGSHRKAVISQGLPHPFAITVFEDSLYWTDWHTKSINSANKFTGKNQEIIRNKLH
                     FPMDIHTLHPQRQPAGKNRCGDNNGGCTHLCLPSGQNYTCACPTGFRKINSHACAQSL
                     DKFLLFARRMDIRRISFDTEDLSDDVIPLADVRSAVALDWDSRDDHVYWTDVSTDTIS
                     RAKWDGTGQEVVVDTSLESPAGLAIDWVTNKLYWTDAGTDRIEVANTDGSMRTVLIWE
                     NLDRPRDIVVEPMGGYMYWTDWGASPKIERAGMDASSRQVIISSNLTWPNGLAIDYGS
                     QRLYWADAGMKTIEFAGLDGSKRKVLIGSQLPHPFGLTLYGQRIYWTDWQTKSIQSAD
                     RLTGLDRETLQENLENLMDIHVFHRQRPPVTTLCAVENGGCSHLCLRSPNPSGFSCTC
                     PTGINLLRDGKTCSPGMNSFLIFARRIDVRMVSLDIPYFADVVVPINMTMKNTIAIGV
                     DPLEGKVYWSDSTLHRISRASLDGSQHEDIITTGLQTTDGLAVDAIGRKVYWTDTGTN
                     RIEVGNLDGSMRKVLVWQNLDSPRAIVLYHEMGFMYWTDWGENAKLERSGMDGSDRTV
                     LINNNLGWPNGLTVDKTSSQLLWADAHTERIEVADLNGANRHTLVSPVQHPYGLTLLD
                     SYIYWTDWQTRSIHRADKSTGSNVILVRSNLPGLMDIQAVDRAQPLGFNKCGSRNGGC
                     SHLCLPRPSGFSCACPTGIQLKGDRKTCDPSPETYLLFSSRGSIRRISLDTDDHTDVH
                     VPVPGLNNVISLDYDSVHGKVYYTDVFLDVIRRADLNGSNMETVIGHGLKTTDGLAVD
                     WVARNLYWTDTGRNTIEASRLDGSCRKVLINNSLDEPRAIAVFPRKGYLFWTDWGHIA
                     KIERANLDGSERKVLINTDLGWPNGLTLDYDTRRIYWVDAHLDRIESADLNGKLRQVL
                     VSHVSHPFALTQQDRWIYWTDWQTKSIQRVDKYSGRNKETVLANVEGLMDIIVVSPQR
                     QTGTNACGVNNGGCTHLCFARASDFVCACPDEPDGHPCSLVPGLVPPAPRATSMNEKS
                     PVLPNTLPTTLHSSTTKTRTSLEGAGGRCSERDAQLGLCAHSNEAVPAAPGEGLHVSY
                     AIGGLLSILLILLVIAALMLYRHRKSKFTDPGMGNLTYSNPSYRTSTQEVKLEAAPKP
                     AVYNQLCYKKEGGPDHSYTKEKIKIVEGIRLLAGDDAEWGDLKQLRSSRGGLLRDHVC
                     MKTDTVSIQASSGSLDDTETEQLLQEEQSECSSVHTAATPERRGSLPDTGWKHERKLS
                     SESQV"
     exon            223..369
                     /gene="Lrp4"
                     /gene_synonym="6430526J12Rik; D230026E03; mdig; Megf7"
                     /inference="alignment:Splign:2.1.0"
     exon            370..486
                     /gene="Lrp4"
                     /gene_synonym="6430526J12Rik; D230026E03; mdig; Megf7"
                     /inference="alignment:Splign:2.1.0"
     exon            487..600
                     /gene="Lrp4"
                     /gene_synonym="6430526J12Rik; D230026E03; mdig; Megf7"
                     /inference="alignment:Splign:2.1.0"
     exon            601..717
                     /gene="Lrp4"
                     /gene_synonym="6430526J12Rik; D230026E03; mdig; Megf7"
                     /inference="alignment:Splign:2.1.0"
     exon            718..846
                     /gene="Lrp4"
                     /gene_synonym="6430526J12Rik; D230026E03; mdig; Megf7"
                     /inference="alignment:Splign:2.1.0"
     exon            847..966
                     /gene="Lrp4"
                     /gene_synonym="6430526J12Rik; D230026E03; mdig; Megf7"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1092
                     /gene="Lrp4"
                     /gene_synonym="6430526J12Rik; D230026E03; mdig; Megf7"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1218
                     /gene="Lrp4"
                     /gene_synonym="6430526J12Rik; D230026E03; mdig; Megf7"
                     /inference="alignment:Splign:2.1.0"
     exon            1219..1353
                     /gene="Lrp4"
                     /gene_synonym="6430526J12Rik; D230026E03; mdig; Megf7"
                     /inference="alignment:Splign:2.1.0"
     exon            1354..1479
                     /gene="Lrp4"
                     /gene_synonym="6430526J12Rik; D230026E03; mdig; Megf7"
                     /inference="alignment:Splign:2.1.0"
     exon            1480..1710
                     /gene="Lrp4"
                     /gene_synonym="6430526J12Rik; D230026E03; mdig; Megf7"
                     /inference="alignment:Splign:2.1.0"
     exon            1711..1867
                     /gene="Lrp4"
                     /gene_synonym="6430526J12Rik; D230026E03; mdig; Megf7"
                     /inference="alignment:Splign:2.1.0"
     exon            1868..2085
                     /gene="Lrp4"
                     /gene_synonym="6430526J12Rik; D230026E03; mdig; Megf7"
                     /inference="alignment:Splign:2.1.0"
     exon            2086..2262
                     /gene="Lrp4"
                     /gene_synonym="6430526J12Rik; D230026E03; mdig; Megf7"
                     /inference="alignment:Splign:2.1.0"
     exon            2263..2385
                     /gene="Lrp4"
                     /gene_synonym="6430526J12Rik; D230026E03; mdig; Megf7"
                     /inference="alignment:Splign:2.1.0"
     exon            2386..2594
                     /gene="Lrp4"
                     /gene_synonym="6430526J12Rik; D230026E03; mdig; Megf7"
                     /inference="alignment:Splign:2.1.0"
     exon            2595..2676
                     /gene="Lrp4"
                     /gene_synonym="6430526J12Rik; D230026E03; mdig; Megf7"
                     /inference="alignment:Splign:2.1.0"
     exon            2677..2782
                     /gene="Lrp4"
                     /gene_synonym="6430526J12Rik; D230026E03; mdig; Megf7"
                     /inference="alignment:Splign:2.1.0"
     exon            2783..2984
                     /gene="Lrp4"
                     /gene_synonym="6430526J12Rik; D230026E03; mdig; Megf7"
                     /inference="alignment:Splign:2.1.0"
     exon            2985..3174
                     /gene="Lrp4"
                     /gene_synonym="6430526J12Rik; D230026E03; mdig; Megf7"
                     /inference="alignment:Splign:2.1.0"
     exon            3175..3306
                     /gene="Lrp4"
                     /gene_synonym="6430526J12Rik; D230026E03; mdig; Megf7"
                     /inference="alignment:Splign:2.1.0"
     exon            3307..3447
                     /gene="Lrp4"
                     /gene_synonym="6430526J12Rik; D230026E03; mdig; Megf7"
                     /inference="alignment:Splign:2.1.0"
     exon            3448..3534
                     /gene="Lrp4"
                     /gene_synonym="6430526J12Rik; D230026E03; mdig; Megf7"
                     /inference="alignment:Splign:2.1.0"
     exon            3535..3706
                     /gene="Lrp4"
                     /gene_synonym="6430526J12Rik; D230026E03; mdig; Megf7"
                     /inference="alignment:Splign:2.1.0"
     exon            3707..3869
                     /gene="Lrp4"
                     /gene_synonym="6430526J12Rik; D230026E03; mdig; Megf7"
                     /inference="alignment:Splign:2.1.0"
     exon            3870..4095
                     /gene="Lrp4"
                     /gene_synonym="6430526J12Rik; D230026E03; mdig; Megf7"
                     /inference="alignment:Splign:2.1.0"
     exon            4096..4399
                     /gene="Lrp4"
                     /gene_synonym="6430526J12Rik; D230026E03; mdig; Megf7"
                     /inference="alignment:Splign:2.1.0"
     exon            4400..4618
                     /gene="Lrp4"
                     /gene_synonym="6430526J12Rik; D230026E03; mdig; Megf7"
                     /inference="alignment:Splign:2.1.0"
     exon            4619..4753
                     /gene="Lrp4"
                     /gene_synonym="6430526J12Rik; D230026E03; mdig; Megf7"
                     /inference="alignment:Splign:2.1.0"
     exon            4754..4862
                     /gene="Lrp4"
                     /gene_synonym="6430526J12Rik; D230026E03; mdig; Megf7"
                     /inference="alignment:Splign:2.1.0"
     exon            4863..5007
                     /gene="Lrp4"
                     /gene_synonym="6430526J12Rik; D230026E03; mdig; Megf7"
                     /inference="alignment:Splign:2.1.0"
     exon            5008..5121
                     /gene="Lrp4"
                     /gene_synonym="6430526J12Rik; D230026E03; mdig; Megf7"
                     /inference="alignment:Splign:2.1.0"
     exon            5122..5257
                     /gene="Lrp4"
                     /gene_synonym="6430526J12Rik; D230026E03; mdig; Megf7"
                     /inference="alignment:Splign:2.1.0"
     exon            5258..5325
                     /gene="Lrp4"
                     /gene_synonym="6430526J12Rik; D230026E03; mdig; Megf7"
                     /inference="alignment:Splign:2.1.0"
     exon            5326..5413
                     /gene="Lrp4"
                     /gene_synonym="6430526J12Rik; D230026E03; mdig; Megf7"
                     /inference="alignment:Splign:2.1.0"
     exon            5414..5555
                     /gene="Lrp4"
                     /gene_synonym="6430526J12Rik; D230026E03; mdig; Megf7"
                     /inference="alignment:Splign:2.1.0"
     exon            5556..8028
                     /gene="Lrp4"
                     /gene_synonym="6430526J12Rik; D230026E03; mdig; Megf7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8006..8011
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lrp4"
                     /gene_synonym="6430526J12Rik; D230026E03; mdig; Megf7"
                     /note="hexamer: TATAAA"
     polyA_site      8028
                     /gene="Lrp4"
                     /gene_synonym="6430526J12Rik; D230026E03; mdig; Megf7"
                     /note="major polyA site"
ORIGIN      
        1 aggaggcagc agcagcccgg agggcgactt gcagggcgcg ccggccgagc tggacccggg
       61 acgcttttca acccggggga accctccgct gattctctcc gccccggcgt cccttgggag
      121 cccgcgggac ccccgggccg gcagggaacg ccggcggcgg ccgcagcacc atgaggcggt
      181 ggtggggcgc gctgctgctt ggcgccctgc tctgcgcaca cggaatagcc agcagtctgg
      241 agtgtgcatg tggtcggagc cacttcacat gtgcggtgag cgcgcttggc gaatgtacct
      301 gtatccccgc ccagtggcag tgtgatggag acaatgactg tggagaccac agcgatgagg
      361 atggctgtac gctgcctacc tgctcccctc tggacttcca ctgtgacaac ggcaagtgca
      421 tccgacgctc ctgggtgtgt gacggggaca atgactgtga agatgactct gatgagcagg
      481 actgtccccc ccgggagtgt gaggaggacg aattcccctg ccagaacggc tactgcattc
      541 ggagtctgtg gcactgtgat ggggacaacg actgtggtga caacagtgac gagcaatgcg
      601 acatgcgcaa gtgctcagac aaggaattcc gctgcagcga cggcagctgc attgctgagc
      661 attggtactg cgatggtgac acagactgca aagatggctc tgatgaggaa agctgccctt
      721 cagcagtacc ctctcctcct tgcaacctgg aagagttcca gtgcgcctat ggccgctgca
      781 tcctcgacat ctaccactgt gacggagatg acgactgtgg agactggtca gacgagtctg
      841 actgctcctc ccaccagccc tgccgctctg gggaattcat gtgtgacagt ggcctgtgca
      901 tcaactcggg ctggcgctgt gatggtgatg cagactgtga tgaccagtct gatgaacgca
      961 actgcaccac ctccatgtgc acagccgaac agtttcgctg tcggtcaggc cgttgcgtcc
     1021 gtctgtcctg gcgctgtgat ggggaggatg actgtgcgga caacagcgat gaagaaaact
     1081 gtgagaacac aggaagcccc cagtgcgcct ctgaccagtt cctgtgttgg aacgggcgct
     1141 gtattgggca gaggaagctg tgcaacggga tcaacgactg cggtgacagc agtgacgaaa
     1201 gtccacagca gaactgtcgg ccccggacgg gtgaggagaa ctgcaatgtt aacaacggtg
     1261 gctgtgccca gaagtgtcag atggtgcgag gggcagtgca gtgtacctgc cacacaggct
     1321 accggctcac agaggatggg agaacgtgcc aggatgtaaa cgaatgtgct gaggaggggt
     1381 actgcagcca gggctgcaca aacactgaag gggctttcca gtgctggtgt gaagcagggt
     1441 atgagctacg gcccgatcgg cgcagctgca aagctctggg gccagaacct gtgctactgt
     1501 ttgccaatcg tatcgacatc cggcaggtgc tcccgcaccg ctccgagtac acgctgctac
     1561 tgaacaacct ggagaacgcc attgccctcg actttcatca ccggcgggag ctggtcttct
     1621 ggtcggatgt caccctggac cgcatcctcc gtgccaacct taatggcagc aatgtagagg
     1681 aggtggtgtc tactgggcta gagagcccag ggggcctagc ggtggattgg gtccatgaca
     1741 agctctactg gaccgactct gggacgtcga ggattgaggt ggctaatctg gatggggccc
     1801 accggaaggt gctgctatgg cagagcctag agaagcccag agccattgcc ctacacccca
     1861 tggagggaac catttattgg acagactggg gcaacacccc ccgcattgag gcctccagca
     1921 tggacggctc tgggcgtcgc atcattgctg acactcatct tttctggccc aacggcctca
     1981 ccatcgacta cgctggtcgc cgcatgtact gggtggatgc taagcaccac gtcatcgaga
     2041 gggccaatct agatgggagt caccgcaagg ctgtcattag ccagggcctc ccacatccct
     2101 ttgccatcac agtgtttgaa gacagcttgt attggacaga ctggcacacc aagagcatca
     2161 atagtgccaa caagtttacg gggaagaacc aggaaatcat tcgcaacaag ctccactttc
     2221 ctatggacat tcataccttg cacccccagc gccagcccgc agggaaaaac cgctgtgggg
     2281 acaacaatgg aggttgcact cacctgtgtc tacccagtgg ccagaactac acctgtgcct
     2341 gccccaccgg cttccgcaag atcaacagcc acgcctgtgc ccagagtctt gacaagttcc
     2401 tgctttttgc ccgaaggatg gacatccgtc ggatcagctt cgacacagag gacctgtccg
     2461 acgatgtcat cccactggct gacgtgcgca gtgctgtggc ccttgactgg gactcccggg
     2521 atgaccacgt gtattggaca gatgtcagca ctgataccat cagcagggcc aagtgggatg
     2581 gaacaggaca ggaggtggta gtggatacca gtttggagag ccctgctggc ctggcaattg
     2641 attgggtcac caacaagctc tactggacag atgcaggcac ggacaggatc gaagtggcca
     2701 acacagatgg cagcatgagg acagtgctca tctgggagaa ccttgaccgt cctcgggaca
     2761 tagtggtaga gcccatgggc gggtacatgt attggactga ctggggtgca agtcccaaga
     2821 ttgaacgggc tggcatggac gcctccagcc gacaagtcat catctcttcg aacctgacct
     2881 ggcctaatgg attggctatt gactacggct ctcagcggct gtactgggcg gatgccggca
     2941 tgaagactat tgaatttgct gggctggatg gcagcaagag gaaggtacta attggaagcc
     3001 agctccccca cccttttggg ctgactctat atggacagcg catctattgg actgactggc
     3061 agaccaagag tatacaaagt gctgaccggc tgactgggct agaccgggag actctgcagg
     3121 agaacctgga gaacctcatg gacattcatg tcttccaccg ccagaggcct ccagtgacga
     3181 cgctgtgtgc cgtggagaat ggcggctgca gccatttgtg tctcaggtcc ccaaatccga
     3241 gcggcttcag ctgcacctgc cccacaggta tcaacctgct acgagatggc aagacatgct
     3301 caccaggcat gaacagtttc ctcatcttcg ccaggaggat tgatgttcgc atggtctcct
     3361 tggatatccc ttattttgct gatgtggtgg tacccatcaa catgaccatg aagaacacca
     3421 tcgccattgg agtggatccg ctggaaggaa aagtgtactg gtctgacagc acgctgcaca
     3481 ggatcagccg tgccagcctg gatggctcac agcatgagga catcatcact acaggtctgc
     3541 agaccacaga cgggcttgca gtggatgcca tcggccggaa agtgtactgg acagacacag
     3601 gaacgaatcg gattgaagtt ggcaacctgg atgggtctat gcggaaagtg ttggtgtggc
     3661 agaaccttga cagtccccgg gccattgtat tataccatga aatggggttc atgtactgga
     3721 cagactgggg ggagaacgcc aaattagagc gttccggaat ggatggctca gaccgtactg
     3781 tgctcatcaa caacaaccta gggtggccca atggactgac tgtggacaag accagttccc
     3841 aactgctgtg ggctgatgcc catactgaga gaattgaggt ggcagacctg aatggcgcta
     3901 atcggcatac actggtgtca ccagtccagc acccatatgg cctcactctg cttgactcct
     3961 atatctactg gactgactgg cagacccgca gcatccaccg ggccgacaag agtactggca
     4021 gcaatgtcat ccttgtgagg tccaacctgc caggcctcat ggacatccaa gctgttgacc
     4081 gggcacagcc actgggtttt aataaatgtg gctcaagaaa tggcggctgt tcccacctct
     4141 gtttacctcg gccttctggt ttctcctgtg cctgtcccac tggcattcag ctgaagggag
     4201 acaggaagac ctgtgacccc tctccagaaa cctacctgct cttctctagc cgaggctcta
     4261 ttcgccgtat ctcactggac accgatgacc acacagacgt gcacgttcct gttcctgggc
     4321 tcaacaatgt catctcccta gactatgaca gtgtgcatgg aaaggtctat tacacagatg
     4381 tgttcctgga tgttatcagg cgagcagacc tgaatggcag caacatggag actgttattg
     4441 gacacgggct taagaccact gacgggctgg cagtggactg ggttgccaga aacctgtact
     4501 ggacagatac cggccgaaat accatcgaag catctcggct agatggatcc tgtcgcaaag
     4561 tgctaatcaa caacagtcta gacgagcccc gggccattgc tgttttcccc agaaaggggt
     4621 acctcttctg gacagactgg ggccacattg ccaagattga acgggcaaac ctggatggct
     4681 ctgagaggaa ggtcctcatc aacacagacc taggctggcc caacggcctc accttggact
     4741 atgatacccg caggatctac tgggtagatg cacatctgga tcggatcgag agtgctgacc
     4801 tcaatgggaa gctgaggcag gtcttggtca gccatgtgtc ccaccccttt gccctcacac
     4861 agcaggacag gtggatctac tggacggact ggcagaccaa atcgatccaa cgtgtcgaca
     4921 agtactcggg ccgcaacaag gagacagtac tggccaacgt ggagggactt atggatatta
     4981 ttgtggtgtc ccctcagcgg cagacaggga ccaatgcctg cggtgtgaat aatggtggct
     5041 gtactcacct ctgctttgcc cgagcctctg actttgtgtg cgcgtgtcct gatgagcctg
     5101 acggtcatcc ctgctccctt gtacctggcc tcgtacctcc tgctcccaga gctaccagca
     5161 tgaatgagaa gagcccagtg ctacccaaca cgctgcccac caccttacat tcttctacca
     5221 ccaagacccg cacctctctg gagggggcag gaggaagatg ctctgaaagg gatgcccagc
     5281 tgggcctctg tgcacattcc aatgaagccg tccctgctgc tccaggtgaa ggactgcacg
     5341 tcagctatgc catcggtgga ctcctcagta tcctgctgat tttgttggtg atcgcggctt
     5401 tgatgctata cagacacaga aaatccaagt tcacggatcc tggaatggga aacctgacct
     5461 atagcaaccc ctcctaccga acttccactc aggaagtgaa acttgaagca gctcccaagc
     5521 cagccgtgta taatcagctg tgctataaga aagagggtgg acctgaccac agctacacca
     5581 aggagaagat caagattgta gagggaatcc gcctcctggc tggggatgac gctgaatggg
     5641 gtgacctcaa gcaactgcgc agctccaggg ggggccttct acgggatcac gtatgcatga
     5701 agacagacac agtgtccatc caggccagct ctggctccct agatgacacg gagacagagc
     5761 agctgcttca ggaagagcag tctgagtgta gcagtgttca cactgcagcc actccggaga
     5821 gacggggctc tctgccagac acaggctgga aacacgaacg caagctctcc tcagaaagcc
     5881 aggtctaagt gctgcccaca ttctcttccc tgcctgcctg ttcattctcc tctgtggact
     5941 tctgatcctt gtgctcacat aacaacgcgg gccctttccc atgcacgcat cttcctcctc
     6001 ccaccccaaa gtgctcccga gcccccatag aacctgttac tcatctgagt ccaaaactac
     6061 ctggggacaa gaagtgaggg cacatctcaa gaatttagac ctggatttta ccatgaactt
     6121 cacctcttgc actctatcct gggccccctg aagctgggct cagtgtgatt ccttgtcagc
     6181 acagagctcc gtctcccttt gccctggcat cctatgtgcc tgccccacag caccgatgca
     6241 attcatgata taagactctg gtcttcccca tcacagctgg catgatggcc tccctgtgaa
     6301 ctggcctacc aggggctggg actggaggtc acaggttaaa aggtaatgga cagaggttga
     6361 gagaaggaag aagcagccca gctggtctgg gtgcttggga aacctccagc ctcaagtgtt
     6421 ggtaattatg aaaaaccttg gggggcgggg attcgagccc tggaatcatg tccattgctg
     6481 gcagtggaca ttctcctcat ccagaagtca ctgctttgtc agttgtgata caggtgaagt
     6541 gtgggaatgg cttaggctct tcttcctcct gctggaatgt ctggggccat ttctaccttg
     6601 gataactgga tagctcctgc catggcaact cactaatagg aattccctcc tggtgctgtg
     6661 atgggccgta cttttcttaa gcctttagct atgctgtgag cttgagtgaa cattgggtgg
     6721 gccttggaga gcagacttgt agaacgttta agaagctctg caaagaaagc atagcatcct
     6781 acccgagctt cacctattct actcttctct cttccattct gtgggattct aagggaaaca
     6841 attctgtcac agcctttcaa agactggctc aacattttcc taaatggtca gaaagagcaa
     6901 ctagagagac acaagacacc caggggctca ggaggagaat tgtgaggttg aacctcttga
     6961 gttcattctc aagtgctcag ggatccaagt tcatggacac agcctgtggc tctcgggtgg
     7021 taaaggtcat gtgccaactc ttctcagccc ctgtccacac taaagtgcca gcattagctt
     7081 catgctcctt taggccaagg gcttctctca ggggagctga gatttttttt tttttttttt
     7141 tttttttttt tttgtgctgc cctagaatct catcccagtt tttctacttc tgagagaggg
     7201 gagtctagcc ttgctttctc taaccggtcc tgtgtcacct caatcgctaa tgtccaatga
     7261 tgaggagggt cagtgaagat gtaaagtggt aagcaaggag tggagaggtg gtgagaacca
     7321 gtccagagca agttcaggca cttctccata gaaaccgaag cacaggagag attggcaggt
     7381 gctgagaatg gaggagagga cttttagggg aagtttcctg acataaaaca tctttcatgg
     7441 tttattgcta ttcagagatc agcagccagg catcgcatga acaaacaaga tcaaatcttt
     7501 tctggtcagt tattacgagt aagagacaga tgtcaaacca ttagtcttgt tgtcattagc
     7561 taggcccaga tatatgtctg cacacagagc cagagcaggc caatggcctt ttccagtaaa
     7621 ccaattgaga aaagtacagt gccacttcta agaggaaaga tggacatttc acacagaatg
     7681 aggcagcact tgagccttta aatccatagt tggggaggag gggggggggg ggaaacagaa
     7741 gcgtggtgtc ctcctgagtg gaaaggggca aggatctttt tgcacttggg ctgttcagaa
     7801 tgtagaaagg acgaatttga ggaaatatct atttgagcac tgatttactc tgtaaaaagg
     7861 gcaaaaatct ctctgtccta aactaatgga agcgattttc ccatgctcat gtgtaatgat
     7921 tttaacatta ctcactggag agattggact ttctggagtt atttaaccac tatgttcagt
     7981 attttagggc tttatgataa tttaatataa atttagcttt cttaatta
//
