LOCUS       NP_766256               1905 aa            linear   ROD 30-APR-2024
DEFINITION  low-density lipoprotein receptor-related protein 4 isoform 1
            precursor [Mus musculus].
ACCESSION   NP_766256
VERSION     NP_766256.3
DBSOURCE    REFSEQ: accession NM_172668.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1905)
  AUTHORS   Liu,C., Liu,J. and Chen,H.
  TITLE     Overexpression of miR-7-5p Promoted Fracture Healing Through
            Inhibiting LRP4 and Activating Wnt/beta-Catenin Pathway
  JOURNAL   Int J Low Extrem Wounds 23 (1), 86-91 (2024)
   PUBMED   36883209
  REMARK    GeneRIF: Overexpression of miR-7-5p Promoted Fracture Healing
            Through Inhibiting LRP4 and Activating Wnt/beta-Catenin Pathway.
REFERENCE   2  (residues 1 to 1905)
  AUTHORS   Hendrickx,G., Boudin,E., Mateiu,L., Yorgan,T.A., Steenackers,E.,
            Kneissel,M., Kramer,I., Mortier,G., Schinke,T. and Van Hul,W.
  TITLE     An Additional Lrp4 High Bone Mass Mutation Mitigates the
            Sost-Knockout Phenotype in Mice by Increasing Bone Remodeling
  JOURNAL   Calcif Tissue Int 114 (2), 171-181 (2024)
   PUBMED   38051321
  REMARK    GeneRIF: An Additional Lrp4 High Bone Mass Mutation Mitigates the
            Sost-Knockout Phenotype in Mice by Increasing Bone Remodeling.
REFERENCE   3  (residues 1 to 1905)
  AUTHORS   Eguchi,T., Tezuka,T., Watanabe,Y., Inoue-Yamauchi,A., Sagara,H.,
            Ozawa,M. and Yamanashi,Y.
  TITLE     Calcium-binding protein 7 expressed in muscle negatively regulates
            age-related degeneration of neuromuscular junctions in mice
  JOURNAL   iScience 27 (2), 108997 (2024)
   PUBMED   38327785
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 1905)
  AUTHORS   Zhang,X., Sun,Z., Zhang,Y., Pan,L., Jiang,W., Dong,H., Jin,Z.,
            Kang,J., Liu,R. and Ning,B.
  TITLE     Periplocin targets low density lipoprotein receptor-related protein
            4 to attenuate osteoclastogenesis and protect against osteoporosis
  JOURNAL   Biochem Pharmacol 211, 115516 (2023)
   PUBMED   36966936
  REMARK    GeneRIF: Periplocin targets low density lipoprotein
            receptor-related protein 4 to attenuate osteoclastogenesis and
            protect against osteoporosis.
REFERENCE   5  (residues 1 to 1905)
  AUTHORS   Geng,S., Paul,F., Kowalczyk,I., Raimundo,S., Sporbert,A., Mamo,T.M.
            and Hammes,A.
  TITLE     Balancing WNT signalling in early forebrain development: The role
            of LRP4 as a modulator of LRP6 function
  JOURNAL   Front Cell Dev Biol 11, 1173688 (2023)
   PUBMED   37091972
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 1905)
  AUTHORS   Li,Y., Chen,J., Lu,W., McCormick,L.M., Wang,J. and Bu,G.
  TITLE     Mesd binds to mature LDL-receptor-related protein-6 and antagonizes
            ligand binding
  JOURNAL   J Cell Sci 118 (Pt 22), 5305-5314 (2005)
   PUBMED   16263759
REFERENCE   7  (residues 1 to 1905)
  AUTHORS   Johnson,E.B., Hammer,R.E. and Herz,J.
  TITLE     Abnormal development of the apical ectodermal ridge and
            polysyndactyly in Megf7-deficient mice
  JOURNAL   Hum Mol Genet 14 (22), 3523-3538 (2005)
   PUBMED   16207730
  REMARK    GeneRIF: Modulator of cellular signaling pathways involving Wnt
            proteins, bone morphogenetic proteins, fibroblast growth factors
            and sonic hedgehog homolog.
REFERENCE   8  (residues 1 to 1905)
  AUTHORS   Luo,Z.G., Je,H.S., Wang,Q., Yang,F., Dobbins,G.C., Yang,Z.H.,
            Xiong,W.C., Lu,B. and Mei,L.
  TITLE     Implication of geranylgeranyltransferase I in synapse formation
  JOURNAL   Neuron 40 (4), 703-717 (2003)
   PUBMED   14622576
REFERENCE   9  (residues 1 to 1905)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   10 (residues 1 to 1905)
  AUTHORS   Glass,D.J., Bowen,D.C., Stitt,T.N., Radziejewski,C., Bruno,J.,
            Ryan,T.E., Gies,D.R., Shah,S., Mattsson,K., Burden,S.J.,
            DiStefano,P.S., Valenzuela,D.M., DeChiara,T.M. and Yancopoulos,G.D.
  TITLE     Agrin acts via a MuSK receptor complex
  JOURNAL   Cell 85 (4), 513-523 (1996)
   PUBMED   8653787
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY753111.1, BC132240.1, AF247637.1, CN533524.1 and AL691489.21.
            
            On Mar 14, 2009 this sequence version replaced NP_766256.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF247637.1, BC132240.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1905
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 50.63 cM"
     Protein         1..1905
                     /product="low-density lipoprotein receptor-related protein
                     4 isoform 1 precursor"
                     /note="LDLR dan; LRP-4"
                     /calculated_mol_wt=209764
     sig_peptide     1..20
                     /note="/evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8VI56.3)"
                     /calculated_mol_wt=2209
     mat_peptide     21..1905
                     /product="Low-density lipoprotein receptor-related protein
                     4. /id=PRO_0000017326"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VI56.3)"
                     /calculated_mol_wt=209764
     Region          27..66
                     /region_name="LDLa"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; cd00112"
                     /db_xref="CDD:238060"
     Site            order(32,45,56..57)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(49,52,56,62..63)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            59..63
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Region          70..105
                     /region_name="Ldl_recept_a"
                     /note="Low-density lipoprotein receptor domain class A;
                     pfam00057"
                     /db_xref="CDD:395011"
     Site            order(76,84,95..96)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(88,91,95,101..102)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            98..102
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Region          110..142
                     /region_name="LDLa"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; cd00112"
                     /db_xref="CDD:238060"
     Site            order(115,123,134..135)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(127,130,134,140..141)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            137..141
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Region          148..182
                     /region_name="LDLa"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; cd00112"
                     /db_xref="CDD:238060"
     Site            order(153,161,172..173)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(165,168,172,178..179)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            175..179
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Region          231..265
                     /region_name="LDLa"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; cd00112"
                     /db_xref="CDD:238060"
     Site            order(236,244,255..256)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(248,251,255,261..262)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            258..262
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Site            264
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8VI56.3)"
     Region          270..304
                     /region_name="LDLa"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; cd00112"
                     /db_xref="CDD:238060"
     Site            order(275,283,294..295)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(287,290,294,300..301)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            297..301
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Region          311..343
                     /region_name="LDLa"
                     /note="Low-density lipoprotein receptor domain class A;
                     smart00192"
                     /db_xref="CDD:197566"
     Site            order(317,325,336..337)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(329,332,336,342..343)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            339..343
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Region          358..393
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          395..434
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain; smart00179"
                     /db_xref="CDD:214542"
     Site            order(395,398,411)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238011"
     Region          460..502
                     /region_name="LY"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     smart00135"
                     /db_xref="CDD:214531"
     Region          480..522
                     /region_name="LDL-receptor class B 1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VI56.3)"
     Site            498
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8VI56.3)"
     Region          505..545
                     /region_name="LY"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     smart00135"
                     /db_xref="CDD:214531"
     Region          523..565
                     /region_name="LDL-receptor class B 2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VI56.3)"
     Region          566..609
                     /region_name="LDL-receptor class B 3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VI56.3)"
     Region          566..607
                     /region_name="Ldl_recept_b"
                     /note="Low-density lipoprotein receptor repeat class B;
                     pfam00058"
                     /db_xref="CDD:459654"
     Region          590..632
                     /region_name="LY"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     smart00135"
                     /db_xref="CDD:214531"
     Region          610..652
                     /region_name="LDL-receptor class B 4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VI56.3)"
     Region          633..673
                     /region_name="LY"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     smart00135"
                     /db_xref="CDD:214531"
     Region          653..693
                     /region_name="LDL-receptor class B 5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VI56.3)"
     Region          702..>729
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Site            719
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8VI56.3)"
     Region          749..982
                     /region_name="YncE"
                     /note="DNA-binding beta-propeller fold protein YncE
                     [General function prediction only]; COG3391"
                     /db_xref="CDD:442618"
     Region          785..827
                     /region_name="LDL-receptor class B 6"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VI56.3)"
     Region          808..850
                     /region_name="LY"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     smart00135"
                     /db_xref="CDD:214531"
     Region          828..870
                     /region_name="LDL-receptor class B 7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VI56.3)"
     Region          871..914
                     /region_name="LDL-receptor class B 8"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VI56.3)"
     Region          871..912
                     /region_name="Ldl_recept_b"
                     /note="Low-density lipoprotein receptor repeat class B;
                     pfam00058"
                     /db_xref="CDD:459654"
     Region          895..937
                     /region_name="LY"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     smart00135"
                     /db_xref="CDD:214531"
     Site            901
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8VI56.3)"
     Region          915..956
                     /region_name="LDL-receptor class B 9"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VI56.3)"
     Region          957..998
                     /region_name="LDL-receptor class B 10"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VI56.3)"
     Region          1006..1043
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Site            1077
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8VI56.3)"
     Region          <1085..1277
                     /region_name="NHL"
                     /note="NHL repeat unit of beta-propeller proteins;
                     cl18310"
                     /db_xref="CDD:302697"
     Region          1085..1123
                     /region_name="NHL repeat"
                     /note="NHL repeat [structural motif]"
                     /db_xref="CDD:271320"
     Region          1093..1135
                     /region_name="LDL-receptor class B 11"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VI56.3)"
     Region          1128..1161
                     /region_name="NHL repeat"
                     /note="NHL repeat [structural motif]"
                     /db_xref="CDD:271320"
     Region          1136..1178
                     /region_name="LDL-receptor class B 12"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VI56.3)"
     Region          1166..1203
                     /region_name="NHL repeat"
                     /note="NHL repeat [structural motif]"
                     /db_xref="CDD:271320"
     Region          1179..1222
                     /region_name="LDL-receptor class B 13"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VI56.3)"
     Region          1179..1219
                     /region_name="Ldl_recept_b"
                     /note="Low-density lipoprotein receptor repeat class B;
                     pfam00058"
                     /db_xref="CDD:459654"
     Region          1212..1244
                     /region_name="NHL repeat"
                     /note="NHL repeat [structural motif]"
                     /db_xref="CDD:271320"
     Region          1223..1263
                     /region_name="LDL-receptor class B 14"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VI56.3)"
     Region          1253..1277
                     /region_name="NHL repeat"
                     /note="NHL repeat [structural motif]"
                     /db_xref="CDD:271320"
     Region          1264..1306
                     /region_name="LDL-receptor class B 15"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VI56.3)"
     Region          1313..1348
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          1359..1583
                     /region_name="Vgb"
                     /note="Streptogramin lyase [Defense mechanisms]; COG4257"
                     /db_xref="CDD:443399"
     Region          1397..1439
                     /region_name="LDL-receptor class B 16"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VI56.3)"
     Site            1415
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8VI56.3)"
     Region          1440..1482
                     /region_name="LDL-receptor class B 17"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VI56.3)"
     Site            1467
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8VI56.3)"
     Region          1483..1526
                     /region_name="LDL-receptor class B 18"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VI56.3)"
     Region          1483..1524
                     /region_name="Ldl_recept_b"
                     /note="Low-density lipoprotein receptor repeat class B;
                     pfam00058"
                     /db_xref="CDD:459654"
     Region          1507..1547
                     /region_name="LY"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     smart00135"
                     /db_xref="CDD:214531"
     Region          1527..1568
                     /region_name="LDL-receptor class B 19"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VI56.3)"
     Region          1569..1610
                     /region_name="LDL-receptor class B 20"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VI56.3)"
     Region          1617..1648
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          1661..1696
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VI56.3)"
     Site            1726..1746
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VI56.3)"
     Region          1852..1905
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VI56.3)"
     CDS             1..1905
                     /gene="Lrp4"
                     /gene_synonym="6430526J12Rik; D230026E03; mdig; Megf7"
                     /coded_by="NM_172668.3:171..5888"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /db_xref="CCDS:CCDS16432.1"
                     /db_xref="GeneID:228357"
                     /db_xref="MGI:MGI:2442252"
ORIGIN      
        1 mrrwwgalll gallcahgia sslecacgrs hftcavsalg ectcipaqwq cdgdndcgdh
       61 sdedgctlpt cspldfhcdn gkcirrswvc dgdndcedds deqdcpprec eedefpcqng
      121 ycirslwhcd gdndcgdnsd eqcdmrkcsd kefrcsdgsc iaehwycdgd tdckdgsdee
      181 scpsavpspp cnleefqcay grcildiyhc dgdddcgdws desdcsshqp crsgefmcds
      241 glcinsgwrc dgdadcddqs derncttsmc taeqfrcrsg rcvrlswrcd geddcadnsd
      301 eencentgsp qcasdqflcw ngrcigqrkl cngindcgds sdespqqncr prtgeencnv
      361 nnggcaqkcq mvrgavqctc htgyrltedg rtcqdvneca eegycsqgct ntegafqcwc
      421 eagyelrpdr rsckalgpep vllfanridi rqvlphrsey tlllnnlena ialdfhhrre
      481 lvfwsdvtld rilranlngs nveevvstgl espgglavdw vhdklywtds gtsrievanl
      541 dgahrkvllw qslekpraia lhpmegtiyw tdwgntprie assmdgsgrr iiadthlfwp
      601 ngltidyagr rmywvdakhh vieranldgs hrkavisqgl phpfaitvfe dslywtdwht
      661 ksinsankft gknqeiirnk lhfpmdihtl hpqrqpagkn rcgdnnggct hlclpsgqny
      721 tcacptgfrk inshacaqsl dkfllfarrm dirrisfdte dlsddvipla dvrsavaldw
      781 dsrddhvywt dvstdtisra kwdgtgqevv vdtslespag laidwvtnkl ywtdagtdri
      841 evantdgsmr tvliwenldr prdivvepmg gymywtdwga spkieragmd assrqviiss
      901 nltwpnglai dygsqrlywa dagmktiefa gldgskrkvl igsqlphpfg ltlygqriyw
      961 tdwqtksiqs adrltgldre tlqenlenlm dihvfhrqrp pvttlcaven ggcshlclrs
     1021 pnpsgfsctc ptginllrdg ktcspgmnsf lifarridvr mvsldipyfa dvvvpinmtm
     1081 kntiaigvdp legkvywsds tlhrisrasl dgsqhediit tglqttdgla vdaigrkvyw
     1141 tdtgtnriev gnldgsmrkv lvwqnldspr aivlyhemgf mywtdwgena klersgmdgs
     1201 drtvlinnnl gwpngltvdk tssqllwada hterievadl nganrhtlvs pvqhpygltl
     1261 ldsyiywtdw qtrsihradk stgsnvilvr snlpglmdiq avdraqplgf nkcgsrnggc
     1321 shlclprpsg fscacptgiq lkgdrktcdp spetyllfss rgsirrisld tddhtdvhvp
     1381 vpglnnvisl dydsvhgkvy ytdvfldvir radlngsnme tvighglktt dglavdwvar
     1441 nlywtdtgrn tieasrldgs crkvlinnsl depraiavfp rkgylfwtdw ghiakieran
     1501 ldgserkvli ntdlgwpngl tldydtrriy wvdahldrie sadlngklrq vlvshvshpf
     1561 altqqdrwiy wtdwqtksiq rvdkysgrnk etvlanvegl mdiivvspqr qtgtnacgvn
     1621 nggcthlcfa rasdfvcacp depdghpcsl vpglvppapr atsmnekspv lpntlpttlh
     1681 ssttktrtsl egaggrcser daqlglcahs neavpaapge glhvsyaigg llsillillv
     1741 iaalmlyrhr kskftdpgmg nltysnpsyr tstqevklea apkpavynql cykkeggpdh
     1801 sytkekikiv egirllagdd aewgdlkqlr ssrggllrdh vcmktdtvsi qassgslddt
     1861 eteqllqeeq secssvhtaa tperrgslpd tgwkherkls sesqv
//
