LOCUS       NM_001024707            4007 bp    mRNA    linear   ROD 04-AUG-2023
DEFINITION  Mus musculus low density lipoprotein receptor-related protein 3
            (Lrp3), transcript variant 1, mRNA.
ACCESSION   NM_001024707
VERSION     NM_001024707.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4007)
  AUTHORS   Cao C, Shi Y, Zhang X, Li Q, Zhang J, Zhao F, Meng Q, Dai W, Liu Z,
            Yan W, Duan X, Zhang J, Fu X, Cheng J, Hu X and Ao Y.
  TITLE     Cholesterol-induced LRP3 downregulation promotes cartilage
            degeneration in osteoarthritis by targeting Syndecan-4
  JOURNAL   Nat Commun 13 (1), 7139 (2022)
   PUBMED   36414669
  REMARK    GeneRIF: Cholesterol-induced LRP3 downregulation promotes cartilage
            degeneration in osteoarthritis by targeting Syndecan-4.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4007)
  AUTHORS   Spoelgen R, Adams KW, Koker M, Thomas AV, Andersen OM, Hallett PJ,
            Bercury KK, Joyner DF, Deng M, Stoothoff WH, Strickland DK, Willnow
            TE and Hyman BT.
  TITLE     Interaction of the apolipoprotein E receptors low density
            lipoprotein receptor-related protein and sorLA/LR11
  JOURNAL   Neuroscience 158 (4), 1460-1468 (2009)
   PUBMED   19047013
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ106421.1, AK149314.1 and BC094349.1.
            
            On Mar 15, 2014 this sequence version replaced NM_001024707.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK149314.1, SRR7345562.248769.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-476               CJ106421.1         4-479
            477-3927            AK149314.1         2-3452
            3928-4007           BC094349.1         2022-2101
FEATURES             Location/Qualifiers
     source          1..4007
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 21.15 cM"
     gene            1..4007
                     /gene="Lrp3"
                     /note="low density lipoprotein receptor-related protein 3"
                     /db_xref="GeneID:435965"
                     /db_xref="MGI:MGI:3584516"
     exon            1..490
                     /gene="Lrp3"
                     /inference="alignment:Splign:2.1.0"
     CDS             418..2790
                     /gene="Lrp3"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /codon_start=1
                     /product="low-density lipoprotein receptor-related protein
                     3 isoform 1 precursor"
                     /protein_id="NP_001019878.1"
                     /db_xref="CCDS:CCDS52202.1"
                     /db_xref="GeneID:435965"
                     /db_xref="MGI:MGI:3584516"
                     /translation="MEKRAAAGPEGAPGARAPLAVVCLVNLFLTGRLSSAVPALGKAG
                     ATWGFGFQAATEPTGTQAACSGKLEQHTERRGVIYSPAWPLNYPPGTNCSWYIQGDRG
                     DMITISFRNFDVEESHQCSLDWLLLGPAAPPRQEAFRLCGSAIPPAFISARDHVWIFF
                     HSDASSSGQAQGFRLSYIRGKLGQTSCQTDEFRCDNGKCLPGPWQCNMVDECGDGSDE
                     GNCSAPASEPPGSLCPGGTFPCSGARSTRCLPVERRCDGTQDCGDGSDEAGCPDLACG
                     RRLGSFYGSFASPDLFGAARGPSDLHCTWLVDTQDPRRVLLQLELRLGYDDYVQVYEG
                     LGERGDRLLQTLSYRSNHRPVSLEAAQGRLTVAYHARARSAGHGFNATYQVKGYCLPW
                     EQPCGSSEGDDDSTGEQGCFSEPQRCDGWWHCASGRDEQGCPACPPDQYPCEGGSGLC
                     YAPADRCNNQKSCPDGADEKNCFSCQPGTFHCGTNLCIFETWRCDGQEDCQDGSDEHG
                     CLAAVPRKVITAALIGSLVCGLLLVIALGCAFKLYSLRTQEYRAFETQMTRLEAEFVR
                     REAPPSYGQLIAQGLIPPVEDFPVYSASQASVLQNLRTAMRRQMRRHASRRGPSRRRL
                     GRLWNRLFHRPRAPRGQIPLLTAARTSQTVLGDGLLQAAPGPVPEPPAPNTDTGSPRE
                     AGDGPPSGSGHAPEVGPSVPPPPLNLRDPEYRPEDKERKACVEPLEDSPAPVDTPPEP
                     CLAQDPHPQTPTASGTQDPHSAEPLGVCRSPPPPCSPILEASDDEALLVC"
     exon            491..538
                     /gene="Lrp3"
                     /inference="alignment:Splign:2.1.0"
     exon            539..601
                     /gene="Lrp3"
                     /inference="alignment:Splign:2.1.0"
     exon            602..740
                     /gene="Lrp3"
                     /inference="alignment:Splign:2.1.0"
     exon            741..955
                     /gene="Lrp3"
                     /inference="alignment:Splign:2.1.0"
     exon            956..2069
                     /gene="Lrp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2070..2202
                     /gene="Lrp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2203..3994
                     /gene="Lrp3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggcctccc ggctccgggc ttaggcgagg ggccggccgg gaggacggac ggaccgagcg
       61 acgcaccctc gtaggcaccg tgcggcgcag cgcgggcggc ccggggaccg acgggcaggg
      121 cgcgccgggg catgggcgcg ccggaggtct cggtgcgcag gccgggctgg gcgcgccggc
      181 cggggctccg ggacagcggc gggcgagggt cttccctggc gaccgccgct gagcccccgc
      241 ggggcccgtg acgccgcggc cgatgtggcc ccgcgcgttg cgggcctgca ccgccgccgc
      301 acaaagacgc cgccgcagcc gccgcccgca cccgggccgc agccgccgcg ccagccctag
      361 ccccaggcgg agccccggcc gcagggcagc aggcgtccgc gcgcggcccg ccccggcatg
      421 gagaagcgcg cggccgcggg gccggagggg gcgccgggcg ccagggcgcc gctcgcagtc
      481 gtctgcctgg tgaacctctt tctcactggg aggctcagca gtgcagttcc cgccttaggc
      541 aaagcaggag ctacgtgggg tttcgggttt caggctgcca ctgagcccac tgggactcaa
      601 gccgcctgca gtgggaagtt ggaacagcac actgaacgtc gaggggttat ctacagccca
      661 gcctggcccc tcaactaccc tccaggcacc aactgcagct ggtacattca aggagaccgt
      721 ggtgacatga tcactatcag tttccgaaac ttcgatgtag aggagtctca ccagtgttcc
      781 ctcgactggc tcctgttggg cccagcagct cctcctcgcc aggaggcctt ccgcctctgc
      841 ggctcagcca tcccacccgc cttcatctct gcccgtgacc acgtctggat cttcttccac
      901 tcagacgcct ccagctctgg ccaggcccag ggcttccgcc tctcctatat ccgagggaag
      961 ctgggccaga catcctgcca gacagatgag ttccgctgtg acaacggtaa atgcctgcct
     1021 ggtccttggc agtgcaacat ggtggatgag tgtggagacg gctcggatga gggtaactgc
     1081 tcagcacctg cctcagagcc accaggcagc ctgtgccccg ggggcacctt cccctgcagc
     1141 ggagcccgct ccacacgctg cctgcctgtg gagcggcgct gcgacggcac tcaggactgc
     1201 ggtgacggct ctgatgaggc tggctgcccc gacctagcat gtggccggcg gctgggcagc
     1261 ttttacggtt ccttcgcctc cccagacttg tttggcgccg cccgtgggcc ttcggacctt
     1321 cactgcacgt ggctggtgga cacgcaggac ccgaggcgcg tgctgctgca gctggagcta
     1381 cgactgggtt atgatgacta tgtccaggtg tatgaaggcc tgggcgagcg tggggaccgt
     1441 ctgctgcaaa cgctttccta ccgcagcaac caccggcccg tgagcctgga agcagctcag
     1501 ggccgcctca ctgtggccta ccatgctcgt gctcgcagtg ctggtcacgg cttcaacgcc
     1561 acataccagg tgaagggcta ctgcctcccg tgggagcaac catgtgggag cagcgaggga
     1621 gatgacgaca gcacagggga acaggggtgc ttctcagagc cacaacgctg tgatggctgg
     1681 tggcattgtg caagcggccg agatgagcag ggctgtccag cgtgccctcc ggaccagtat
     1741 ccctgtgagg gtggtagtgg cctgtgctat gcacctgccg atcgttgcaa caaccagaaa
     1801 agctgccccg atggcgccga tgagaagaac tgcttttcct gccagccggg caccttccac
     1861 tgtggtacga acctgtgcat ctttgagacg tggcgctgtg acggtcagga ggactgccaa
     1921 gatggcagcg atgagcatgg ctgcctggct gccgtgcccc gcaaggtcat caccgccgcc
     1981 ctcattggca gcctagtatg cggactgctg cttgttattg ccctaggctg tgccttcaaa
     2041 ctctactccc tgcgcacgca ggagtacagg gcctttgaga cccaaatgac acgcttagag
     2101 gcagagtttg tgcggcgcga agccccccca tcctacggtc agctcatcgc acagggcctc
     2161 atcccaccgg ttgaggattt tcctgtctac agtgcatccc aggcttcagt gctacagaac
     2221 cttcgcacag ccatgcgacg acagatgcgt cggcatgcct cccgcagggg gccatctcgt
     2281 cgaagactgg gccgcctctg gaacaggctc ttccaccggc cacgggcacc tcgaggccag
     2341 atcccactgc tgaccgccgc tcgtacctca cagaccgtgc tgggtgatgg gctcctccag
     2401 gcagcaccgg ggcctgtccc agagccccca gcacccaata cagacacagg cagccctagg
     2461 gaggctggag atgggcctcc tagtggctct ggccatgcac cagaagtggg gccttcagtg
     2521 ccacccccac ccttaaatct gcgagaccca gagtacaggc cagaggacaa ggagagaaag
     2581 gcctgtgtgg aacctctgga agacagccca gcccctgtgg acacgcctcc agagccctgc
     2641 ttggcacaag acccccaccc tcagactccc actgccagtg gcacccaaga cccccactca
     2701 gcagagccac tgggggtctg caggagccct ccaccaccct gctccccaat attggaggct
     2761 agtgatgatg aggcccttct ggtctgctga cccattggac acgccggtga ctgccacagc
     2821 cccgctttgg aaccagggaa tacacagtca tttctaccct gcctctgcat tctttcttac
     2881 agaggcccac ccagcagccc ctgtgagggg cctgggctct cagtcagtca gctgcctctg
     2941 caaccctatt gctctgaaga gctgcgttgc tggcaggggc ttcgggggtt ggcctgggga
     3001 agagggtgga gtgacgagac cacctctgag atcagcatga gcatagccct tggagtctcc
     3061 cagcaaattg ctctgccaca cggatctggg gattcatttc cagaaaggca ggagagccag
     3121 aaccaggctt tctggaatgt tccctgtggc ttcccagttc attcacctgc agtggcacca
     3181 gctgctcatc cccagaactg tgtcaggagc tgtagtcgag gcctgaaaag gccatgggag
     3241 gggttgcacc tcattcatgg tgagtgcttc catgcagggt ccctggggaa gatggcccag
     3301 tggcttctgc cccagccttg tgcctgtggc agcagcatgg gcctggctag gctgcattag
     3361 tccccaagca ttatggtaag gctaaaagta tatgagatag gatgaccgca agagaggcca
     3421 gtctatgcct tctcaggaga cagaagtcaa ggcaccagct gacaatggaa acaaccatcc
     3481 tgtcctgcct cagagactca gtttccccac ctgaagccag ggctgtgcta tcagaagttg
     3541 tagcattcac tctggtgatt ttgggggagg acagtagtcc cacttaggga tttctgggtt
     3601 ctcttggatc gctgagtcgt agatggagcc tcactgtctc ctctgggcag cctccagttc
     3661 aaccagcaaa acccactagg gctgaaaacc ttttccatgg caccttccca gctagcagcc
     3721 catataccgc gctgaggcat gtttccacgg actccccttg cacacagcaa caaccagccc
     3781 tgtttattta caggcatttc tggagaagct agcagggcat tgctaaggca ggaagcccga
     3841 ccccagtggc cagtccctta caataggcct ctaagggttg ggtctctctt tctctctctc
     3901 tctctctctc tctctctctt tttttgcaga aaaaaaattt ttgaaaacaa aacaaaacac
     3961 aacccccttc tcaataaaca acatgtaaac agaaaaaaaa aaaaaaa
//
