LOCUS       NM_026278               3420 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus Lrp2 binding protein (Lrp2bp), mRNA.
ACCESSION   NM_026278
VERSION     NM_026278.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3420)
  AUTHORS   Petersen,H.H., Hilpert,J., Militz,D., Zandler,V., Jacobsen,C.,
            Roebroek,A.J. and Willnow,T.E.
  TITLE     Functional interaction of megalin with the megalinbinding protein
            (MegBP), a novel tetratrico peptide repeat-containing adaptor
            molecule
  JOURNAL   J Cell Sci 116 (Pt 3), 453-461 (2003)
   PUBMED   12508107
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC051150.1, AC114558.18 and BB075157.2.
            
            On Sep 14, 2006 this sequence version replaced NM_026278.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC051150.1, SRR11927934.8541966.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1353              BC051150.1         1-1353
            1354-2942           AC114558.18        141007-142595       c
            2943-3420           BB075157.2         180-657
FEATURES             Location/Qualifiers
     source          1..3420
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 25.99 cM"
     gene            1..3420
                     /gene="Lrp2bp"
                     /gene_synonym="1700113N17Rik; 2310006J04Rik;
                     4930479L12Rik; MegBP"
                     /note="Lrp2 binding protein"
                     /db_xref="GeneID:67620"
                     /db_xref="MGI:MGI:1914870"
     exon            1..199
                     /gene="Lrp2bp"
                     /gene_synonym="1700113N17Rik; 2310006J04Rik;
                     4930479L12Rik; MegBP"
                     /inference="alignment:Splign:2.1.0"
     exon            200..320
                     /gene="Lrp2bp"
                     /gene_synonym="1700113N17Rik; 2310006J04Rik;
                     4930479L12Rik; MegBP"
                     /inference="alignment:Splign:2.1.0"
     CDS             221..1261
                     /gene="Lrp2bp"
                     /gene_synonym="1700113N17Rik; 2310006J04Rik;
                     4930479L12Rik; MegBP"
                     /note="megalin-binding protein"
                     /codon_start=1
                     /product="LRP2-binding protein"
                     /protein_id="NP_080554.1"
                     /db_xref="CCDS:CCDS22286.1"
                     /db_xref="GeneID:67620"
                     /db_xref="MGI:MGI:1914870"
                     /translation="MKLSSEKLPKNPFSLSQYAAKQQKFFQWKKEKPDYYLHANLVDT
                     ALQFLKERIRRGDAMAYFLRGQLYFEEGWYEEALAQFEEIQEKDHQAIYQLGVMYYDG
                     LGTIANAEKGVNYMRKILDSSCPQTMHLKFAAAYNLGRAYFEGKGVKRSDEEAERLWL
                     LAADNGNPKASVKAQSILGLFYSMKEPKELEKAFFWHSEACGNGSLESQGALGLMYFY
                     GQGIRQDTDAALHCLREAAERGNVYAQGTLVEYYYKMKFFTKCVSFSKRIADYDEVHD
                     IPMIAHVTDCLPEFIIKGMAMAAFYHGRCLQLGLGIMKDEESAKHYYSKACRLNPTLA
                     DELHSLLIHQRI"
     exon            321..433
                     /gene="Lrp2bp"
                     /gene_synonym="1700113N17Rik; 2310006J04Rik;
                     4930479L12Rik; MegBP"
                     /inference="alignment:Splign:2.1.0"
     exon            434..547
                     /gene="Lrp2bp"
                     /gene_synonym="1700113N17Rik; 2310006J04Rik;
                     4930479L12Rik; MegBP"
                     /inference="alignment:Splign:2.1.0"
     exon            548..690
                     /gene="Lrp2bp"
                     /gene_synonym="1700113N17Rik; 2310006J04Rik;
                     4930479L12Rik; MegBP"
                     /inference="alignment:Splign:2.1.0"
     exon            691..796
                     /gene="Lrp2bp"
                     /gene_synonym="1700113N17Rik; 2310006J04Rik;
                     4930479L12Rik; MegBP"
                     /inference="alignment:Splign:2.1.0"
     exon            797..1020
                     /gene="Lrp2bp"
                     /gene_synonym="1700113N17Rik; 2310006J04Rik;
                     4930479L12Rik; MegBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1195
                     /gene="Lrp2bp"
                     /gene_synonym="1700113N17Rik; 2310006J04Rik;
                     4930479L12Rik; MegBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1196..3420
                     /gene="Lrp2bp"
                     /gene_synonym="1700113N17Rik; 2310006J04Rik;
                     4930479L12Rik; MegBP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1568..1573
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lrp2bp"
                     /gene_synonym="1700113N17Rik; 2310006J04Rik;
                     4930479L12Rik; MegBP"
                     /note="hexamer: ATTAAA"
     polyA_site      1587
                     /gene="Lrp2bp"
                     /gene_synonym="1700113N17Rik; 2310006J04Rik;
                     4930479L12Rik; MegBP"
                     /note="major polyA site"
     regulatory      3372..3377
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lrp2bp"
                     /gene_synonym="1700113N17Rik; 2310006J04Rik;
                     4930479L12Rik; MegBP"
                     /note="hexamer: ATTAAA"
     regulatory      3397..3402
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lrp2bp"
                     /gene_synonym="1700113N17Rik; 2310006J04Rik;
                     4930479L12Rik; MegBP"
                     /note="hexamer: ATTAAA"
     polyA_site      3402
                     /gene="Lrp2bp"
                     /gene_synonym="1700113N17Rik; 2310006J04Rik;
                     4930479L12Rik; MegBP"
     polyA_site      3418
                     /gene="Lrp2bp"
                     /gene_synonym="1700113N17Rik; 2310006J04Rik;
                     4930479L12Rik; MegBP"
ORIGIN      
        1 agcaacaaca gagtttgctg tcttcactac tctcagctta ggccaacctg gactccttca
       61 acccaaatga ggtggcccct acattttata tgaaggctct gatttaccat gcagcagtgg
      121 tccatctggt aacatggcaa tccagtacag actggaagag aagactgagc aacagagcta
      181 aaacacagtg tattcccagg acccacattg tggagacagg atgaagctga gcagcgagaa
      241 gttgcccaaa aaccctttct ctctgtctca gtatgctgcc aaacaacaga aattcttcca
      301 gtggaagaag gaaaagcccg attattacct ccacgctaat ttggtggata cagcattgca
      361 gttcctgaaa gaaagaataa gaagagggga tgctatggca tattttctaa gaggccaact
      421 ctattttgaa gagggctggt atgaagaagc cttggcacag tttgaggaaa tccaggagaa
      481 agaccatcaa gcaatttatc agctaggagt gatgtattat gatgggctgg ggaccattgc
      541 aaatgctgaa aaaggagtga attatatgag gaagatcctc gactcttcat gcccccagac
      601 aatgcacttg aaattcgctg ctgcttacaa cctcgggaga gcttattttg aaggaaaggg
      661 ggtgaagcga tcagatgagg aagcagagag actgtggctg cttgctgccg acaatggaaa
      721 cccaaaagct agtgtgaagg cgcaaagtat tctaggattg ttttattcaa tgaaagagcc
      781 caaagagttg gaaaaggcat ttttctggca ttcggaagct tgtggcaacg gaagtctgga
      841 gtcccagggt gcacttggtc tcatgtactt ttacggacag ggaatccgcc aagacactga
      901 tgccgccctg cactgcttac gggaagcagc tgagcgaggg aatgtctatg cccaggggac
      961 tcttgtggaa tactactaca agatgaagtt ttttaccaag tgtgtttcgt tttccaaaag
     1021 gatagcagac tatgatgaag tccacgacat ccccatgata gcccacgtca cggactgtct
     1081 cccagagttt atcatcaaag gcatggccat ggcggctttc taccacgggc gctgtctcca
     1141 gctgggctta ggcatcatga aagacgaaga atctgccaag cactactact ctaaagcttg
     1201 ccgtctgaac cctacattgg cagatgaact tcactcctta ctcattcacc agagaattta
     1261 gaccacagtg cattctgtca aagaacttaa actacaaagc atttcaacaa agaccatcaa
     1321 ttctaatttg aaacaatgtg tgtatgttta cagcagctac atctgtatcc ctgttacatt
     1381 atccagggta tttcacagaa attttagttt tgttcttata tttttattct gtaattttta
     1441 caaactaaaa tttagacacc aatcaaattg ctgggaagag tattccgaga gcaacctctt
     1501 agcctgtaga gtggcctggg ctgaactggg tttgaaaaca tgccaagagc aaatacctct
     1561 ctgccttatt aaatgcagtg tctgtaacta cctagtacag attgagtttt gtcatttcca
     1621 aagtacatgt gctgccaact taaaaacgta attggaaagc ttaattctta tgttttctct
     1681 agcatttgtt taattttatg aatttttcta atttaaaata tatttagtca tctaaaatgt
     1741 ttcagaaaat taaatgaagg ccaagggaaa tttaacgata agactttcaa atcctttttg
     1801 cagaaagtgt atgatgtttc tataacttat ttaaagattc ttatagataa ttggctaatt
     1861 tgtaaatttt aaaaaagggg tttaaggaat tatttagtat catgtccctc caaatgtgcc
     1921 ctcaaagatc ttaatttaat gaacaaaacc attaagactc ctagatgaag aattatagta
     1981 atatgctttt gtttgagttc attttttaca tttttaaaca aatcctagaa acatttctat
     2041 acgagataaa atatgggaaa acctcataag aagtattaac ctaagaattg catctgattg
     2101 ttttgtcatc tagcctaaga aagcttactt agaaaaagat ttcttcataa acaatgtgta
     2161 ggttagaaca catagaaatg gatttcctca tgacatcctc atatgtgtgt tcccatactc
     2221 tggtctcatc ttctccctca ccaccctccc ttgagccaca cccccacaga cagcccctcc
     2281 cctccatcac caccctccct ccctcagatc ccaccaccac cagtagcccc tccctcactg
     2341 cccaccttcc cttgagccac acgcccaccg tgatgcctaa gacatcactg cccctttcct
     2401 ttcttcagct aatttcgcct tctattcttc cccacttccc ttgagattcc ctcctcttat
     2461 gatcctctat tctcatgagc tataaacaca cacagataaa tacaaacact gctctacata
     2521 tacacacatt ttcaaatctt ggttccatgt cagggaaaac aggggtttgc ccttcaagtc
     2581 ttatttaaca tgatgccttc cagtcccatc cattttcctg aaagcatgct gtttttcatt
     2641 atggatgcat cagagtccac tgccttggtt tcgaattttc tttctccact catctgtaaa
     2701 tggaagctgg ttgcacttcc tagctgtgaa gagtgcagag ataaatatgg atgcttatct
     2761 ctgtggtgtg ttgtccagaa gaatccttta ggcacacacc caggagtgat atagctaggc
     2821 aaagtgtagt tatttttgcc catctacttg gttggataaa tctgggtttt actgtctaat
     2881 ttttgtagtt atttgtatag catagatatt aaagttatta ttagttaatg aagaattttt
     2941 cctattttgt agattttctc ttcactctga tactctcgcc ttcactttga agaaacttct
     3001 aaatacttat gaaattaatt agcagacatt tttccttatg tttgtgacat aatatctaag
     3061 tattgtataa aaattaaatt agcaggctag gtggcacttg ggaggcagag gcaggtggtt
     3121 atcgtttgag tttgaggtta gccaggggta taatgagact gtctcagaaa aaaagaaaga
     3181 acatgtaatt agcaacagcc tatcttactg tcaatgaaat ctgccaaaaa aaggtgacag
     3241 tgaaaacagt acaaggtatg ttttaattgt gtagtgccat gtttgtgaaa tgtattaaaa
     3301 acaataggtt ttaaggttat cttaattccc ccttttgtca gcatattagc tggtatgacc
     3361 ttaatttata aattaaatgt cattttcctt tgaaaaatta aattttattt tgtgtgtatg
//
