LOCUS       NM_001081088           15429 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus low density lipoprotein receptor-related protein 2
            (Lrp2), mRNA.
ACCESSION   NM_001081088 XM_130308
VERSION     NM_001081088.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 15429)
  AUTHORS   Beenken,A., Shen,T., Jin,G., Ghotra,A., Xu,K., Nesanir,K.,
            Sturley,R.E., Vijayakumar,S., Khan,A., Levitman,A., Stauber,J.,
            Chavez,E.Y., Robbins-Juarez,S.Y., Hao,L., Field,T.B.,
            Erdjument-Bromage,H., Neubert,T.A., Shapiro,L., Qiu,A. and
            Barasch,J.
  TITLE     Spns1 is an iron transporter essential for megalin-dependent
            endocytosis
  JOURNAL   Am J Physiol Renal Physiol 327 (5), F775-F787 (2024)
   PUBMED   39265081
REFERENCE   2  (bases 1 to 15429)
  AUTHORS   N'Guetta,P.Y., McLarnon,S.R., Tassou,A., Geron,M., Shirvan,S.,
            Hill,R.Z., Scherrer,G. and O'Brien,L.L.
  TITLE     Comprehensive mapping of sensory and sympathetic innervation of the
            developing kidney
  JOURNAL   Cell Rep 43 (10), 114860 (2024)
   PUBMED   39412983
REFERENCE   3  (bases 1 to 15429)
  AUTHORS   Kurosaki,Y., Matsumoto,T., Uematsu,T., Kawakami,F., Kawashima,R.,
            Tamaki,S., Imai,M., Ichikawa,T., Ishii,N., Kitasato,H., Hanaki,H.
            and Kubo,M.
  TITLE     SARS-CoV-2 infection causes a decline in renal megalin expression
            and affects vitamin D metabolism in the kidney of K18-hACE2 mice
  JOURNAL   Sci Rep 14 (1), 24313 (2024)
   PUBMED   39414885
  REMARK    GeneRIF: SARS-CoV-2 infection causes a decline in renal megalin
            expression and affects vitamin D metabolism in the kidney of
            K18-hACE2 mice.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 15429)
  AUTHORS   Takano-Kawabe,K., Matoba,K., Nakamura,Y. and Moriyama,M.
  TITLE     Low Density Lipoprotein Receptor-related Protein 2 Expression and
            Function in Cultured Astrocytes and Microglia
  JOURNAL   Neurochem Res 49 (1), 199-211 (2024)
   PUBMED   37702891
  REMARK    GeneRIF: Low Density Lipoprotein Receptor-related Protein 2
            Expression and Function in Cultured Astrocytes and Microglia.
REFERENCE   5  (bases 1 to 15429)
  AUTHORS   Goto,S., Yoshida,Y., Hosojima,M., Kuwahara,S., Kabasawa,H.,
            Aoki,H., Iida,T., Sawada,R., Ugamura,D., Yoshizawa,Y., Takemoto,K.,
            Komochi,K., Kobayashi,R., Kaseda,R., Yaoita,E., Nagatoishi,S.,
            Narita,I., Tsumoto,K. and Saito,A.
  TITLE     Megalin is involved in angiotensinogen-induced, angiotensin
            II-mediated ERK1/2 signaling to activate Na + -H + exchanger 3 in
            proximal tubules
  JOURNAL   J Hypertens 41 (11), 1831-1843 (2023)
   PUBMED   37682076
  REMARK    GeneRIF: Megalin is involved in angiotensinogen-induced,
            angiotensin II-mediated ERK1/2 signaling to activate Na + -H +
            exchanger 3 in proximal tubules.
REFERENCE   6  (bases 1 to 15429)
  AUTHORS   Willnow,T.E., Hilpert,J., Armstrong,S.A., Rohlmann,A., Hammer,R.E.,
            Burns,D.K. and Herz,J.
  TITLE     Defective forebrain development in mice lacking gp330/megalin
  JOURNAL   Proc Natl Acad Sci U S A 93 (16), 8460-8464 (1996)
   PUBMED   8710893
REFERENCE   7  (bases 1 to 15429)
  AUTHORS   Jiang,Y., Yu,V.C., Buchholz,F., O'Connell,S., Rhodes,S.J.,
            Candeloro,C., Xia,Y.R., Lusis,A.J. and Rosenfeld,M.G.
  TITLE     A novel family of Cys-Cys, His-Cys zinc finger transcription
            factors expressed in developing nervous system and pituitary gland
  JOURNAL   J Biol Chem 271 (18), 10723-10730 (1996)
   PUBMED   8631881
REFERENCE   8  (bases 1 to 15429)
  AUTHORS   Chowdhary,B.P., Lundgren,S., Johansson,M., Hjalm,G., Akerstrom,G.,
            Gustavsson,I. and Rask,L.
  TITLE     In situ hybridization mapping of a 500-kDa calcium-sensing protein
            gene (LRP2) to human chromosome region 2q31-->q32.1 and porcine
            chromosome region 15q22-->q24
  JOURNAL   Cytogenet Cell Genet 71 (2), 120-123 (1995)
   PUBMED   7656578
REFERENCE   9  (bases 1 to 15429)
  AUTHORS   Gueth-Hallonet,C., Santa-Maria,A., Verroust,P. and Maro,B.
  TITLE     Gp330 is specifically expressed in outer cells during epithelial
            differentiation in the preimplantation mouse embryo
  JOURNAL   Development 120 (11), 3289-3299 (1994)
   PUBMED   7720568
REFERENCE   10 (bases 1 to 15429)
  AUTHORS   Xia,Y.R., Bachinsky,D.R., Smith,J.A., McCluskey,R.T., Warden,C.H.
            and Lusis,A.J.
  TITLE     Mapping of the glycoprotein 330 (Gp330) gene to mouse chromosome 2
  JOURNAL   Genomics 17 (3), 780-781 (1993)
   PUBMED   8244399
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL845489.10.
            
            On Apr 24, 2018 this sequence version replaced NM_001081088.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMN00849374, SAMN00849375
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on single protein-coding
                                         transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-215               AL845489.10        167532-167746       c
            216-323             AL845489.10        134070-134177       c
            324-446             AL845489.10        132547-132669       c
            447-563             AL845489.10        130657-130773       c
            564-674             AL845489.10        119668-119778       c
            675-788             AL845489.10        119232-119345       c
            789-905             AL845489.10        117702-117818       c
            906-1055            AL845489.10        116626-116775       c
            1056-1175           AL845489.10        115170-115289       c
            1176-1304           AL845489.10        109233-109361       c
            1305-1474           AL845489.10        106878-107047       c
            1475-1698           AL845489.10        105638-105861       c
            1699-1905           AL845489.10        104863-105069       c
            1906-2108           AL845489.10        103436-103638       c
            2109-2249           AL845489.10        101631-101771       c
            2250-2453           AL845489.10        100026-100229       c
            2454-2646           AL845489.10        98108-98300         c
            2647-2772           AL845489.10        95854-95979         c
            2773-2903           AL845489.10        94964-95094         c
            2904-3041           AL845489.10        92647-92784         c
            3042-3323           AL845489.10        92060-92341         c
            3324-3569           AL845489.10        90850-91095         c
            3570-3689           AL845489.10        89685-89804         c
            3690-3806           AL845489.10        89482-89598         c
            3807-4184           AL845489.10        88096-88473         c
            4185-4433           AL845489.10        86798-87046         c
            4434-4645           AL845489.10        85104-85315         c
            4646-4830           AL845489.10        84195-84379         c
            4831-5059           AL845489.10        83204-83432         c
            5060-5237           AL845489.10        82327-82504         c
            5238-5366           AL845489.10        80909-81037         c
            5367-5533           AL845489.10        78046-78212         c
            5534-5677           AL845489.10        77388-77531         c
            5678-5787           AL845489.10        74069-74178         c
            5788-5965           AL845489.10        73472-73649         c
            5966-6179           AL845489.10        70852-71065         c
            6180-6419           AL845489.10        69540-69779         c
            6420-6608           AL845489.10        67881-68069         c
            6609-7529           AL845489.10        64710-65630         c
            7530-7695           AL845489.10        64414-64579         c
            7696-7854           AL845489.10        63942-64100         c
            7855-8144           AL845489.10        62842-63131         c
            8145-8348           AL845489.10        61733-61936         c
            8349-8591           AL845489.10        60816-61058         c
            8592-8717           AL845489.10        60289-60414         c
            8718-8840           AL845489.10        58727-58849         c
            8841-8972           AL845489.10        57097-57228         c
            8973-9174           AL845489.10        54063-54264         c
            9175-9470           AL845489.10        51090-51385         c
            9471-9987           AL845489.10        48482-48998         c
            9988-10140          AL845489.10        47922-48074         c
            10141-10311         AL845489.10        47306-47476         c
            10312-10535         AL845489.10        46291-46514         c
            10536-10713         AL845489.10        42974-43151         c
            10714-10910         AL845489.10        42058-42254         c
            10911-11156         AL845489.10        41191-41436         c
            11157-11285         AL845489.10        40089-40217         c
            11286-11405         AL845489.10        38540-38659         c
            11406-11522         AL845489.10        37177-37293         c
            11523-11639         AL845489.10        36527-36643         c
            11640-11777         AL845489.10        35509-35646         c
            11778-11900         AL845489.10        32979-33101         c
            11901-12029         AL845489.10        29832-29960         c
            12030-12161         AL845489.10        25397-25528         c
            12162-12293         AL845489.10        24463-24594         c
            12294-12437         AL845489.10        23003-23146         c
            12438-12603         AL845489.10        21489-21654         c
            12604-12732         AL845489.10        20059-20187         c
            12733-12953         AL845489.10        19140-19360         c
            12954-13130         AL845489.10        18285-18461         c
            13131-13250         AL845489.10        16720-16839         c
            13251-13341         AL845489.10        14719-14809         c
            13342-13409         AL845489.10        13900-13967         c
            13410-13527         AL845489.10        13634-13751         c
            13528-13657         AL845489.10        12792-12921         c
            13658-13759         AL845489.10        11980-12081         c
            13760-13888         AL845489.10        10310-10438         c
            13889-13960         AL845489.10        7688-7759           c
            13961-15429         AL845489.10        6052-7520           c
FEATURES             Location/Qualifiers
     source          1..15429
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 40.74 cM"
     gene            1..15429
                     /gene="Lrp2"
                     /gene_synonym="b2b1625.2Clo; D230004K18Rik; Gp330;
                     Megalin"
                     /note="low density lipoprotein receptor-related protein 2"
                     /db_xref="GeneID:14725"
                     /db_xref="MGI:MGI:95794"
     exon            1..215
                     /gene="Lrp2"
                     /gene_synonym="b2b1625.2Clo; D230004K18Rik; Gp330;
                     Megalin"
                     /inference="alignment:Splign:2.1.0"
     CDS             137..14119
                     /gene="Lrp2"
                     /gene_synonym="b2b1625.2Clo; D230004K18Rik; Gp330;
                     Megalin"
                     /note="glycoprotein 330"
                     /codon_start=1
                     /product="low-density lipoprotein receptor-related protein
                     2 precursor"
                     /protein_id="NP_001074557.1"
                     /db_xref="CCDS:CCDS38135.1"
                     /db_xref="GeneID:14725"
                     /db_xref="MGI:MGI:95794"
                     /translation="MERGAAAAAWMLLLAIAACLAPVSGQECGSGNFRCDNGYCIPAS
                     WRCDGTRDCLDDTDEIGCPPRSCGSGFFLCPAEGTCIPSSWVCDQDKDCSDGADEQQN
                     CPGTTCSSQQLTCSNGQCVPIEYRCDHVSDCPDGSDERNCYYPTCDQLTCANGACYNT
                     SQKCDHKVDCRDSSDEANCTTLCSQKEFQCGSGECILRAYVCDHDNDCEDNSDEHNCN
                     YDTCGGHQFTCSNGQCINQNWVCDGDDDCQDSGDEDGCESNQRHHTCYPREWACPGSG
                     RCISMDKVCDGVPDCPEGEDENNATSGRYCGTGLCSILNCEYQCHQTPYGGECFCPPG
                     HIINSNDSRTCIDFDDCQIWGICDQKCESRQGRHQCLCEEGYILERGQHCKSNDSFSA
                     ASIIFSNGRDLLVGDLHGRNFRILAESKNRGIVMGVDFHYQKHRVFWTDPMQAKVFST
                     DINGLNTQEILNVSIDAPENLAVDWINNKLYLVETRVNRIDVVNLEGNQRVTLITENL
                     GHPRGIALDPTVGYLFFSDWGSLSGQPKVERAFMDGSNRKDLVTTKLGWPAGITLDLV
                     SKRVYWVDSRYDYIETVTYDGIQRKTVARGGSLVPHPFGISLFEEHVFFTDWTKMAVM
                     KANKFTDTNPQVYHQSSLTPFGVTVYHALRQPNATNPCGNNNGGCAQICVLSHRTDNG
                     GLGYRCKCEFGFELDADEHHCVAVKNFLLFSSQTAVRGIPFTLSTQEDVMVPVTGSPS
                     FFVGIDFDAQHSTIFYSDLSKNIIYQQKIDGTGKEVITANRLQNVECLSFDWISRNLY
                     WTDGGSKSVTVMKLADKSRRQIISNLNNPRSIVVHPAAGYMFLSDWFRPAKIMRAWSD
                     GSHLMPIVNTSLGWPNGLAIDWSTSRLYWVDAFFDKIEHSNLDGLDRKRLGHVDQMTH
                     PFGLTVFKDNVFLTDWRLGAIIRVRKSDGGDMTVVRRGISSIMHVKAYDADLQTGTNY
                     CSQTTHPNGDCSHFCFPVPNFQRVCGCPYGMKLQRDQMTCEGDPAREPPTQQCGSSSF
                     PCNNGKCVPSIFRCDGVDDCHDNSDEHQCGALNNTCSSSAFTCVHGGQCIPGQWRCDK
                     QNDCLDGSDEQNCPTRSPSSTCPPTSFTCDNHMCIPKEWVCDTDNDCSDGSDEKNCQA
                     SGTCHPTQFRCPDHRCISPLYVCDGDKDCVDGSDEAGCVLNCTSSQFKCADGSSCINS
                     RYRCDGVYDCKDNSDEAGCPTRPPGMCHPDEFQCQGDGTCIPNTWECDGHPDCIQGSD
                     EHNGCVPKTCSPSHFLCDNGNCIYNSWVCDGDNDCRDMSDEKDCPTQPFHCPSSQWQC
                     PGYSICVNLSALCDGVFDCPNGTDESPLCNQDSCLHFNGGCTHRCIQGPFGATCVCPI
                     GYQLANDTKTCEDVNECDIPGFCSQHCVNMRGSFRCACDPEYTLESDGRTCKVTASEN
                     LLLVVASRDKIIMDNITAHTHNIYSLVQDVSFVVALDFDSVTGRVFWSDLLEGKTWSA
                     FQNGTDKRVVHDSGLSLTEMIAVDWIGRNIYWTDYTLETIEVSKIDGSHRTVLISKNV
                     TKPRGLALDPRMGDNVMFWSDWGHHPRIERASMDGTMRTVIVQEKIYWPCGLSIDYPN
                     RLIYFMDAYLDYIEFCDYDGQNRRQVIASDLVLHHPHALTLFEDSVFWTDRGTHQVMQ
                     ANKWHGRNQSVVMYSVPQPLGIIAIHPSRQPSSPNPCASATCSHLCLLSAQEPRHYSC
                     ACPSGWNLSDDSVNCVRGDQPFLISVRENVIFGISLDPEVKSNDAMVPISGIQHGYDV
                     EFDDSEQFIYWVENPGEIHRVKTDGSNRTAFAPLSLLGSSLGLALDWVSRNIYYTTPA
                     SRSIEVLTLRGDTRYGKTLITNDGTPLGVGFPVGIAVDPARGKLYWSDHGTDSGVPAK
                     IASANMDGTSLKILFTGNMEHLEVVTLDIQEQKLYWAVTSRGVIERGNVDGTERMILV
                     HHLAHPWGLVVHGSFLYYSDEQYEVIERVDKSSGSNKVVFRDNIPYLRGLRVYHHRNA
                     ADSSNGCSNNPNACQQICLPVPGGMFSCACASGFKLSPDGRSCSPYNSFIVVSMLPAV
                     RGFSLELSDHSEAMVPVAGQGRNVLHADVDVANGFIYWCDFSSSVRSSNGIRRIKPNG
                     SNFTNIVTYGIGANGIRGVAVDWVAGNLYFTNAFVYETLIEVIRINTTYRRVLLKVSV
                     DMPRHIVVDPKHRYLFWADYGQKPKIERSFLDCTNRTVLVSEGIVTPRGLAVDHDTGY
                     IYWVDDSLDIIARIHRDGGESQVVRYGSRYPTPYGITVFGESIIWVDRNLRKVFQASK
                     QPGNTDPPTVIRDSINLLRDVTIFDEHVQPLSPAELNNNPCLQSNGGCSHFCFALPEL
                     PTPKCGCAFGTLEDDGKNCATSREDFLIYSLNNSLRSLHFDPQDHNLPFQAISVEGMA
                     IALDYDRRNNRIFFTQKLNPIRGQISYVNLYSGASSPTILLSNIGVTDGIAFDWINRR
                     IYYSDFSNQTINSMAEDGSNRAVIARVSKPRAIVLDPCRGYMYWTDWGTNAKIERATL
                     GGNFRVPIVNTSLVWPNGLTLDLETDLLYWADASLQKIERSTLTGSNREVVISTAFHS
                     FGLTVYGQYIYWTDFYTKKIYRANKYDGSDLIAMTTRLPTQPSGISTVVKTQQQQCSN
                     PCDQFNGGCSHICAPGPNGAECQCPHEGSWYLANDNKYCVVDTGARCNQFQFTCLNGR
                     CISQDWKCDNDNDCGDGSDELPTVCAFHTCRSTAFTCANGRCVPYHYRCDFYNDCGDN
                     SDEAGCLFRSCNSTTEFTCSNGRCIPLSYVCNGINNCHDNDTSDEKNCPPITCQPDFA
                     KCQTTNICVPRAFLCDGDNDCGDGSDENPIYCASHTCRSNEFQCVSPHRCIPSYWFCD
                     GEADCVDSSDEPDTCGHSLNSCSANQFHCDNGRCISSSWVCDGDNDCGDMSDEDQRHH
                     CELQNCSSTEFTCINSRPPNRRCIPQHWVCDGDADCADALDELQNCTMRACSTGEFSC
                     ANGRCIRQSFRCDRRNDCGDYSDERGCSYPPCRDDQFTCQNGQCITKLYVCDEDNDCG
                     DGSDEQEHLCHTPEPTCPPHQFRCDNGHCIEMGTVCNHVDDCSDNSDEKGCGINECQD
                     SSISHCDHNCTDTITSFYCSCLPGYKLMSDKRTCVDIDECKETPQLCSQKCENVIGSY
                     ICKCAPGYIREPDGKSCRQNSNIEPYLVFSNRYYIRNLTIDGTSYSLILQGLGNVVAL
                     DFDRVEERLYWIDAEKQIIERMFLNKTNQETIISHRLRRAESLAVDWVSRKLYWLDAI
                     LDCLFVSDLEGRQRKMLAQHCVDANNTFCFENPRGIVLHPQRGYVYWADWGDHAYIAR
                     IGMDGTNKTVIISTKIEWPNAITIDYTNDLLYWADAHLGYIEFSDLEGHHRHTVYDGT
                     LPHPFALTIFEDTVFWTDWNTRTVEKGNKYDGSGRVVLVNTTHKPFDIHVLHPYRQPI
                     MSNPCATNNGGCSHLCLIKAGGRGFTCECPDDFQTVQLRDRTLCMPMCSSTQFLCGNN
                     EKCIPIWWKCDGQKDCSDGSDESDLCPHRFCRLGQFQCRDGNCTSPQALCNARQDCAD
                     GSDEDRVLCEHHRCEANEWQCANKRCIPEYWQCDSVDDCLDNSDEDPSHCASRTCRPG
                     QFKCNNGRCIPQSWKCDVDNDCGDYSDEPIHECMTAAYNCDNHTEFSCKTNYRCIPQW
                     AVCNGFDDCRDNSDEQGCESVPCHPSGDFRCGNHHCIPLRWKCDGIDDCGDNSDEESC
                     VPRECTESEFRCADQQCIPSRWVCDQENDCGDNSDERDCEMKTCHPEHFQCTSGHCVP
                     KALACDGRADCLDASDESACPTRFPNGTYCPAAMFECKNHVCIQSFWICDGENDCVDG
                     SDEEIHLCFNVPCESPQRFRCDNSRCIYGHQLCNGVDDCGDGSDEKEEHCRKPTHKPC
                     TDTEYKCSNGNCVSQHYVCDNVDDCGDLSDETGCNLGENRTCAEKICEQNCTQLSNGG
                     FICSCRPGFKPSTLDKNSCQDINECEEFGICPQSCRNSKGSYECFCVDGFKSMSTHYG
                     ERCAADGSPPLLLLPENVRIRKYNISSEKFSEYLEEEEHIQAIDYDWDPEGIGLSVVY
                     YTVLSQGSQFGAIKRAYLPDFESGSNNPVREVDLGLKYLMQPDGLAVDWVGRHIYWSD
                     AKSQRIEVATLDGRYRKWLITTQLDQPAAIAVNPKLGLMFWTDQGKQPKIESAWMNGE
                     HRSVLASANLGWPNGLSIDYLNGDRIYWSDSKEDVIESIKYDGTDRRLIINDAMKPFS
                     LDIFEDQLYWVAKEKGEVWRQNKFGKGNKEKLLVVNPWLTQVRIFHQLRYNQSVSNPC
                     KQVCSHLCLLRPGGYSCACPQGSDFVTGSTVECDAASELPITMPSPCRCMHGGSCYFD
                     ENDLPKCKCSSGYSGEYCEIGLSRGIPPGTTMALLLTFAMVIIVGALVLVGFFHYRKT
                     GSLLPSLPKLPSLSSLAKPSENGNGVTFRSGADVNMDIGVSPFGPETIIDRSMAMNEQ
                     FVMEVGKQPVIFENPMYAAKDSTSKVGLAVQGPSVSSQVTVPENVENQNYGRSIDPSE
                     IVPEPKPASPGADETQGTKWNIFKRKPKQTTNFENPIYAEMDTEQKEAVAVAPPPSPS
                     LPAKASKRSSTPGYTATEDTFKDTANLVKEDSDV"
     exon            216..323
                     /gene="Lrp2"
                     /gene_synonym="b2b1625.2Clo; D230004K18Rik; Gp330;
                     Megalin"
                     /inference="alignment:Splign:2.1.0"
     exon            324..446
                     /gene="Lrp2"
                     /gene_synonym="b2b1625.2Clo; D230004K18Rik; Gp330;
                     Megalin"
                     /inference="alignment:Splign:2.1.0"
     exon            447..563
                     /gene="Lrp2"
                     /gene_synonym="b2b1625.2Clo; D230004K18Rik; Gp330;
                     Megalin"
                     /inference="alignment:Splign:2.1.0"
     exon            564..674
                     /gene="Lrp2"
                     /gene_synonym="b2b1625.2Clo; D230004K18Rik; Gp330;
                     Megalin"
                     /inference="alignment:Splign:2.1.0"
     exon            675..788
                     /gene="Lrp2"
                     /gene_synonym="b2b1625.2Clo; D230004K18Rik; Gp330;
                     Megalin"
                     /inference="alignment:Splign:2.1.0"
     exon            789..905
                     /gene="Lrp2"
                     /gene_synonym="b2b1625.2Clo; D230004K18Rik; Gp330;
                     Megalin"
                     /inference="alignment:Splign:2.1.0"
     exon            906..1055
                     /gene="Lrp2"
                     /gene_synonym="b2b1625.2Clo; D230004K18Rik; Gp330;
                     Megalin"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1175
                     /gene="Lrp2"
                     /gene_synonym="b2b1625.2Clo; D230004K18Rik; Gp330;
                     Megalin"
                     /inference="alignment:Splign:2.1.0"
     exon            1176..1304
                     /gene="Lrp2"
                     /gene_synonym="b2b1625.2Clo; D230004K18Rik; Gp330;
                     Megalin"
                     /inference="alignment:Splign:2.1.0"
     exon            1305..1474
                     /gene="Lrp2"
                     /gene_synonym="b2b1625.2Clo; D230004K18Rik; Gp330;
                     Megalin"
                     /inference="alignment:Splign:2.1.0"
     exon            1475..1698
                     /gene="Lrp2"
                     /gene_synonym="b2b1625.2Clo; D230004K18Rik; Gp330;
                     Megalin"
                     /inference="alignment:Splign:2.1.0"
     exon            1699..1905
                     /gene="Lrp2"
                     /gene_synonym="b2b1625.2Clo; D230004K18Rik; Gp330;
                     Megalin"
                     /inference="alignment:Splign:2.1.0"
     exon            1906..2108
                     /gene="Lrp2"
                     /gene_synonym="b2b1625.2Clo; D230004K18Rik; Gp330;
                     Megalin"
                     /inference="alignment:Splign:2.1.0"
     exon            2109..2249
                     /gene="Lrp2"
                     /gene_synonym="b2b1625.2Clo; D230004K18Rik; Gp330;
                     Megalin"
                     /inference="alignment:Splign:2.1.0"
     exon            2250..2453
                     /gene="Lrp2"
                     /gene_synonym="b2b1625.2Clo; D230004K18Rik; Gp330;
                     Megalin"
                     /inference="alignment:Splign:2.1.0"
     exon            2454..2646
                     /gene="Lrp2"
                     /gene_synonym="b2b1625.2Clo; D230004K18Rik; Gp330;
                     Megalin"
                     /inference="alignment:Splign:2.1.0"
     exon            2647..2772
                     /gene="Lrp2"
                     /gene_synonym="b2b1625.2Clo; D230004K18Rik; Gp330;
                     Megalin"
                     /inference="alignment:Splign:2.1.0"
     exon            2773..2903
                     /gene="Lrp2"
                     /gene_synonym="b2b1625.2Clo; D230004K18Rik; Gp330;
                     Megalin"
                     /inference="alignment:Splign:2.1.0"
     exon            2904..3041
                     /gene="Lrp2"
                     /gene_synonym="b2b1625.2Clo; D230004K18Rik; Gp330;
                     Megalin"
                     /inference="alignment:Splign:2.1.0"
     exon            3042..3323
                     /gene="Lrp2"
                     /gene_synonym="b2b1625.2Clo; D230004K18Rik; Gp330;
                     Megalin"
                     /inference="alignment:Splign:2.1.0"
     exon            3324..3569
                     /gene="Lrp2"
                     /gene_synonym="b2b1625.2Clo; D230004K18Rik; Gp330;
                     Megalin"
                     /inference="alignment:Splign:2.1.0"
     exon            3570..3689
                     /gene="Lrp2"
                     /gene_synonym="b2b1625.2Clo; D230004K18Rik; Gp330;
                     Megalin"
                     /inference="alignment:Splign:2.1.0"
     exon            3690..3806
                     /gene="Lrp2"
                     /gene_synonym="b2b1625.2Clo; D230004K18Rik; Gp330;
                     Megalin"
                     /inference="alignment:Splign:2.1.0"
     exon            3807..4184
                     /gene="Lrp2"
                     /gene_synonym="b2b1625.2Clo; D230004K18Rik; Gp330;
                     Megalin"
                     /inference="alignment:Splign:2.1.0"
     exon            4185..4433
                     /gene="Lrp2"
                     /gene_synonym="b2b1625.2Clo; D230004K18Rik; Gp330;
                     Megalin"
                     /inference="alignment:Splign:2.1.0"
     exon            4434..4645
                     /gene="Lrp2"
                     /gene_synonym="b2b1625.2Clo; D230004K18Rik; Gp330;
                     Megalin"
                     /inference="alignment:Splign:2.1.0"
     exon            4646..4830
                     /gene="Lrp2"
                     /gene_synonym="b2b1625.2Clo; D230004K18Rik; Gp330;
                     Megalin"
                     /inference="alignment:Splign:2.1.0"
     exon            4831..5059
                     /gene="Lrp2"
                     /gene_synonym="b2b1625.2Clo; D230004K18Rik; Gp330;
                     Megalin"
                     /inference="alignment:Splign:2.1.0"
     exon            5060..5237
                     /gene="Lrp2"
                     /gene_synonym="b2b1625.2Clo; D230004K18Rik; Gp330;
                     Megalin"
                     /inference="alignment:Splign:2.1.0"
     exon            5238..5366
                     /gene="Lrp2"
                     /gene_synonym="b2b1625.2Clo; D230004K18Rik; Gp330;
                     Megalin"
                     /inference="alignment:Splign:2.1.0"
     exon            5367..5533
                     /gene="Lrp2"
                     /gene_synonym="b2b1625.2Clo; D230004K18Rik; Gp330;
                     Megalin"
                     /inference="alignment:Splign:2.1.0"
     exon            5534..5677
                     /gene="Lrp2"
                     /gene_synonym="b2b1625.2Clo; D230004K18Rik; Gp330;
                     Megalin"
                     /inference="alignment:Splign:2.1.0"
     exon            5678..5787
                     /gene="Lrp2"
                     /gene_synonym="b2b1625.2Clo; D230004K18Rik; Gp330;
                     Megalin"
                     /inference="alignment:Splign:2.1.0"
     exon            5788..5965
                     /gene="Lrp2"
                     /gene_synonym="b2b1625.2Clo; D230004K18Rik; Gp330;
                     Megalin"
                     /inference="alignment:Splign:2.1.0"
     exon            5966..6179
                     /gene="Lrp2"
                     /gene_synonym="b2b1625.2Clo; D230004K18Rik; Gp330;
                     Megalin"
                     /inference="alignment:Splign:2.1.0"
     exon            6180..6419
                     /gene="Lrp2"
                     /gene_synonym="b2b1625.2Clo; D230004K18Rik; Gp330;
                     Megalin"
                     /inference="alignment:Splign:2.1.0"
     exon            6420..6608
                     /gene="Lrp2"
                     /gene_synonym="b2b1625.2Clo; D230004K18Rik; Gp330;
                     Megalin"
                     /inference="alignment:Splign:2.1.0"
     exon            6609..7529
                     /gene="Lrp2"
                     /gene_synonym="b2b1625.2Clo; D230004K18Rik; Gp330;
                     Megalin"
                     /inference="alignment:Splign:2.1.0"
     exon            7530..7695
                     /gene="Lrp2"
                     /gene_synonym="b2b1625.2Clo; D230004K18Rik; Gp330;
                     Megalin"
                     /inference="alignment:Splign:2.1.0"
     exon            7696..7854
                     /gene="Lrp2"
                     /gene_synonym="b2b1625.2Clo; D230004K18Rik; Gp330;
                     Megalin"
                     /inference="alignment:Splign:2.1.0"
     exon            7855..8144
                     /gene="Lrp2"
                     /gene_synonym="b2b1625.2Clo; D230004K18Rik; Gp330;
                     Megalin"
                     /inference="alignment:Splign:2.1.0"
     exon            8145..8348
                     /gene="Lrp2"
                     /gene_synonym="b2b1625.2Clo; D230004K18Rik; Gp330;
                     Megalin"
                     /inference="alignment:Splign:2.1.0"
     exon            8349..8591
                     /gene="Lrp2"
                     /gene_synonym="b2b1625.2Clo; D230004K18Rik; Gp330;
                     Megalin"
                     /inference="alignment:Splign:2.1.0"
     exon            8592..8717
                     /gene="Lrp2"
                     /gene_synonym="b2b1625.2Clo; D230004K18Rik; Gp330;
                     Megalin"
                     /inference="alignment:Splign:2.1.0"
     exon            8718..8840
                     /gene="Lrp2"
                     /gene_synonym="b2b1625.2Clo; D230004K18Rik; Gp330;
                     Megalin"
                     /inference="alignment:Splign:2.1.0"
     exon            8841..8972
                     /gene="Lrp2"
                     /gene_synonym="b2b1625.2Clo; D230004K18Rik; Gp330;
                     Megalin"
                     /inference="alignment:Splign:2.1.0"
     exon            8973..9174
                     /gene="Lrp2"
                     /gene_synonym="b2b1625.2Clo; D230004K18Rik; Gp330;
                     Megalin"
                     /inference="alignment:Splign:2.1.0"
     exon            9175..9470
                     /gene="Lrp2"
                     /gene_synonym="b2b1625.2Clo; D230004K18Rik; Gp330;
                     Megalin"
                     /inference="alignment:Splign:2.1.0"
     exon            9471..9987
                     /gene="Lrp2"
                     /gene_synonym="b2b1625.2Clo; D230004K18Rik; Gp330;
                     Megalin"
                     /inference="alignment:Splign:2.1.0"
     exon            9988..10140
                     /gene="Lrp2"
                     /gene_synonym="b2b1625.2Clo; D230004K18Rik; Gp330;
                     Megalin"
                     /inference="alignment:Splign:2.1.0"
     exon            10141..10311
                     /gene="Lrp2"
                     /gene_synonym="b2b1625.2Clo; D230004K18Rik; Gp330;
                     Megalin"
                     /inference="alignment:Splign:2.1.0"
     exon            10312..10535
                     /gene="Lrp2"
                     /gene_synonym="b2b1625.2Clo; D230004K18Rik; Gp330;
                     Megalin"
                     /inference="alignment:Splign:2.1.0"
     exon            10536..10713
                     /gene="Lrp2"
                     /gene_synonym="b2b1625.2Clo; D230004K18Rik; Gp330;
                     Megalin"
                     /inference="alignment:Splign:2.1.0"
     exon            10714..10910
                     /gene="Lrp2"
                     /gene_synonym="b2b1625.2Clo; D230004K18Rik; Gp330;
                     Megalin"
                     /inference="alignment:Splign:2.1.0"
     exon            10911..11156
                     /gene="Lrp2"
                     /gene_synonym="b2b1625.2Clo; D230004K18Rik; Gp330;
                     Megalin"
                     /inference="alignment:Splign:2.1.0"
     exon            11157..11285
                     /gene="Lrp2"
                     /gene_synonym="b2b1625.2Clo; D230004K18Rik; Gp330;
                     Megalin"
                     /inference="alignment:Splign:2.1.0"
     exon            11286..11405
                     /gene="Lrp2"
                     /gene_synonym="b2b1625.2Clo; D230004K18Rik; Gp330;
                     Megalin"
                     /inference="alignment:Splign:2.1.0"
     exon            11406..11522
                     /gene="Lrp2"
                     /gene_synonym="b2b1625.2Clo; D230004K18Rik; Gp330;
                     Megalin"
                     /inference="alignment:Splign:2.1.0"
     exon            11523..11639
                     /gene="Lrp2"
                     /gene_synonym="b2b1625.2Clo; D230004K18Rik; Gp330;
                     Megalin"
                     /inference="alignment:Splign:2.1.0"
     exon            11640..11777
                     /gene="Lrp2"
                     /gene_synonym="b2b1625.2Clo; D230004K18Rik; Gp330;
                     Megalin"
                     /inference="alignment:Splign:2.1.0"
     exon            11778..11900
                     /gene="Lrp2"
                     /gene_synonym="b2b1625.2Clo; D230004K18Rik; Gp330;
                     Megalin"
                     /inference="alignment:Splign:2.1.0"
     exon            11901..12029
                     /gene="Lrp2"
                     /gene_synonym="b2b1625.2Clo; D230004K18Rik; Gp330;
                     Megalin"
                     /inference="alignment:Splign:2.1.0"
     exon            12030..12161
                     /gene="Lrp2"
                     /gene_synonym="b2b1625.2Clo; D230004K18Rik; Gp330;
                     Megalin"
                     /inference="alignment:Splign:2.1.0"
     exon            12162..12293
                     /gene="Lrp2"
                     /gene_synonym="b2b1625.2Clo; D230004K18Rik; Gp330;
                     Megalin"
                     /inference="alignment:Splign:2.1.0"
     exon            12294..12437
                     /gene="Lrp2"
                     /gene_synonym="b2b1625.2Clo; D230004K18Rik; Gp330;
                     Megalin"
                     /inference="alignment:Splign:2.1.0"
     exon            12438..12603
                     /gene="Lrp2"
                     /gene_synonym="b2b1625.2Clo; D230004K18Rik; Gp330;
                     Megalin"
                     /inference="alignment:Splign:2.1.0"
     exon            12604..12732
                     /gene="Lrp2"
                     /gene_synonym="b2b1625.2Clo; D230004K18Rik; Gp330;
                     Megalin"
                     /inference="alignment:Splign:2.1.0"
     exon            12733..12953
                     /gene="Lrp2"
                     /gene_synonym="b2b1625.2Clo; D230004K18Rik; Gp330;
                     Megalin"
                     /inference="alignment:Splign:2.1.0"
     exon            12954..13130
                     /gene="Lrp2"
                     /gene_synonym="b2b1625.2Clo; D230004K18Rik; Gp330;
                     Megalin"
                     /inference="alignment:Splign:2.1.0"
     exon            13131..13250
                     /gene="Lrp2"
                     /gene_synonym="b2b1625.2Clo; D230004K18Rik; Gp330;
                     Megalin"
                     /inference="alignment:Splign:2.1.0"
     exon            13251..13341
                     /gene="Lrp2"
                     /gene_synonym="b2b1625.2Clo; D230004K18Rik; Gp330;
                     Megalin"
                     /inference="alignment:Splign:2.1.0"
     exon            13342..13409
                     /gene="Lrp2"
                     /gene_synonym="b2b1625.2Clo; D230004K18Rik; Gp330;
                     Megalin"
                     /inference="alignment:Splign:2.1.0"
     exon            13410..13527
                     /gene="Lrp2"
                     /gene_synonym="b2b1625.2Clo; D230004K18Rik; Gp330;
                     Megalin"
                     /inference="alignment:Splign:2.1.0"
     exon            13528..13657
                     /gene="Lrp2"
                     /gene_synonym="b2b1625.2Clo; D230004K18Rik; Gp330;
                     Megalin"
                     /inference="alignment:Splign:2.1.0"
     exon            13658..13759
                     /gene="Lrp2"
                     /gene_synonym="b2b1625.2Clo; D230004K18Rik; Gp330;
                     Megalin"
                     /inference="alignment:Splign:2.1.0"
     exon            13760..13888
                     /gene="Lrp2"
                     /gene_synonym="b2b1625.2Clo; D230004K18Rik; Gp330;
                     Megalin"
                     /inference="alignment:Splign:2.1.0"
     exon            13889..13960
                     /gene="Lrp2"
                     /gene_synonym="b2b1625.2Clo; D230004K18Rik; Gp330;
                     Megalin"
                     /inference="alignment:Splign:2.1.0"
     exon            13961..15429
                     /gene="Lrp2"
                     /gene_synonym="b2b1625.2Clo; D230004K18Rik; Gp330;
                     Megalin"
                     /inference="alignment:Splign:2.1.0"
     regulatory      15406..15411
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lrp2"
                     /gene_synonym="b2b1625.2Clo; D230004K18Rik; Gp330;
                     Megalin"
                     /note="hexamer: AATAAA"
     polyA_site      15427
                     /gene="Lrp2"
                     /gene_synonym="b2b1625.2Clo; D230004K18Rik; Gp330;
                     Megalin"
                     /note="major polyA site"
ORIGIN      
        1 ggctttctgc ctctaggagc cagcgactgc tgctgagcaa gactcctgtt ccggagcgga
       61 gtaacctgcc tgtgcccgct gcgacgcgcg cccacctccc ggggaaggaa cggcgaggcc
      121 cggggccgtc tccgcgatgg agcgcggggc cgcggcggcg gcatggatgc tgctgctggc
      181 gatcgctgcc tgcctggcgc cagtcagtgg ccaagaatgt ggcagtggga attttcgctg
      241 tgacaacgga tactgtatcc ctgcatcctg gaggtgtgat gggaccagag actgtttgga
      301 tgacactgat gaaattggct gtcctcccag gtcctgcggt tcaggctttt tcctgtgtcc
      361 tgccgaaggc acctgcatcc ctagctcctg ggtgtgtgac caggataagg attgttccga
      421 tggtgcagat gaacagcaaa attgccctgg gaccacgtgc tcaagccagc agctgacgtg
      481 ctccaatggt cagtgtgttc ccatcgagta caggtgtgac catgtcagtg actgccccga
      541 tggctctgac gagagaaact gctattatcc aacatgtgat caacttactt gtgccaacgg
      601 agcctgctat aacacgagtc agaagtgtga ccacaaagtt gactgcaggg actcctctga
      661 cgaagctaac tgcactacgc tgtgttcgca aaaagaattc caatgtggca gtggagagtg
      721 catccttcgt gcctatgtct gtgaccatga caatgactgt gaagataaca gcgatgagca
      781 caattgcaac tatgacacct gcggaggcca ccagttcact tgctccaatg gccagtgcat
      841 taaccagaac tgggtttgtg atggggacga tgattgccag gattctggtg atgaggatgg
      901 ctgtgaaagt aaccaacgtc atcatacatg ttacccaaga gaatgggcgt gtcctgggtc
      961 tggacgatgc atctcaatgg ataaagtttg tgatggagtt cccgactgtc cagaaggaga
     1021 ggatgagaac aatgccacaa gtggacgata ctgtggtacg ggtctctgct ctatcttaaa
     1081 ctgtgagtac caatgccatc agacgccata tggaggagaa tgcttctgcc cgccaggtca
     1141 tattatcaac agcaatgaca gccgtacttg cattgatttc gatgactgcc agatatgggg
     1201 aatttgtgac cagaagtgtg agagccgaca gggccgtcac cagtgcctct gtgaagaagg
     1261 ttatatcctg gagcgcgggc agcattgcaa atccaacgac tccttcagtg cggcctccat
     1321 tatcttctct aatggtcggg atttgctagt tggagatctt catggaagaa acttccggat
     1381 tctagcagag tctaagaacc gtggaatagt tatgggagtg gattttcact atcagaagca
     1441 cagagttttt tggacagacc ccatgcaggc gaaggttttt tccactgaca ttaatggctt
     1501 aaatacccaa gaaattctta atgtttctat tgatgctcca gagaatctgg ctgtggattg
     1561 gattaataat aaactttatc tggtagagac aagagtcaac cgcattgatg tggtcaactt
     1621 ggagggaaat cagcgtgtta ctctcataac tgaaaacttg gggcatccta gaggaattgc
     1681 ccttgatcca actgtgggct atttgttttt ctcagattgg ggaagcctct ctgggcaacc
     1741 caaggtggag agagccttca tggatggtag caatcggaaa gacctggtaa cgaccaaatt
     1801 ggggtggcct gctgggatca ctctggatct tgtatccaag cgagtttact gggtggactc
     1861 tcgttatgac tacattgaaa ctgtaacata tgatggaatt caaaggaaga cggtagcgcg
     1921 tggaggctcc ctcgtccctc atccgtttgg aataagctta tttgaggagc acgtgttctt
     1981 tactgattgg acaaagatgg cggtgatgaa ggcaaacaag ttcacagaca ccaaccctca
     2041 agtgtaccac cagtcttccc tgacgccttt cggagtgaca gtttaccatg ccctcaggca
     2101 gcccaatgcc accaatccgt gcggaaacaa caatgggggc tgtgcgcaga tctgtgttct
     2161 tagtcacagg acggataatg gcggcctggg ctaccggtgc aagtgtgaat ttggctttga
     2221 actggatgca gatgagcacc actgtgttgc cgttaagaac ttcctgctct tctcatcaca
     2281 aacggctgtg cgtgggatcc cattcaccct ctccacccag gaagatgtca tggttcctgt
     2341 tacagggagt ccttccttct ttgttggaat tgactttgat gctcaacaca gtaccatctt
     2401 ctactcagat ttgtcgaaaa acataattta tcaacaaaaa attgatggca caggaaaaga
     2461 agtcatcaca gcaaacaggt tgcaaaatgt tgagtgtctg tcctttgact ggatctcaag
     2521 gaatctctac tggacagatg gagggtcgaa gagtgtcact gtcatgaagc tggctgataa
     2581 gtcccgacga cagataatca gcaacttaaa caaccctcga tccattgtgg tgcatcccgc
     2641 tgctgggtat atgttcctga gtgattggtt ccgtcctgca aagattatga gagcatggag
     2701 cgatggatct cacctaatgc ccatagtcaa cactagtctg gggtggccca atggcttggc
     2761 catcgattgg agtacttccc ggttgtactg ggtggatgcc ttttttgata agattgagca
     2821 cagcaacctt gatggtttag acaggaaaag actgggccat gttgaccaga tgacacatcc
     2881 gtttggactc accgttttta aagataacgt gttcttaaca gactggagac tgggtgcgat
     2941 tattcgggtc aggaagtctg atggtggtga tatgaccgtt gttcgacgtg gcatcagcag
     3001 cataatgcac gtgaaagcgt acgatgctga cctccagacc ggaactaact actgcagtca
     3061 gaccacccat cccaacggcg actgcagcca tttctgcttc ccagttccaa acttccagcg
     3121 ggtgtgtggc tgcccctatg gaatgaagct tcagagggac caaatgactt gtgagggaga
     3181 cccagcccga gagcccccca cacagcagtg tggctcctct tcctttccct gcaacaatgg
     3241 caagtgtgtg cccagtatct tccgctgtga tggagtggat gattgccatg acaacagtga
     3301 tgagcatcag tgtggggcac ttaataacac ctgctcatct tcggctttta cttgtgtcca
     3361 cggtggacag tgcatccctg gccagtggcg ctgtgacaaa cagaatgact gtctagatgg
     3421 cagtgatgag caaaactgcc ccactcgttc accgtcgtct acttgcccgc ccacctcctt
     3481 cacctgcgac aatcacatgt gtatccccaa agagtgggtc tgtgacacag acaatgattg
     3541 ttcggatgga tcagatgaaa agaactgtca agcttcgggg acctgccacc ctacccagtt
     3601 tcgctgccct gaccaccggt gtatcagccc actgtatgtc tgtgatgggg acaaggactg
     3661 tgttgatggc tcggatgagg caggctgtgt gttaaactgc acaagctctc agttcaagtg
     3721 tgctgacggg agttcttgca ttaatagcag gtaccgctgt gatggggtgt acgattgcaa
     3781 ggacaactct gatgaggcgg gctgtccgac caggcctcct ggtatgtgcc acccagatga
     3841 gtttcagtgc cagggagatg gtacctgcat ccctaacacc tgggagtgtg atgggcaccc
     3901 ggactgtatc cagggctcgg atgaacacaa cggctgtgtt cctaagacct gctccccgtc
     3961 tcatttcctc tgtgacaatg gaaactgcat ctacaactcg tgggtctgtg atggggacaa
     4021 tgattgcagg gacatgagtg atgagaagga ctgtcctacc cagccttttc actgtcctag
     4081 ctcacagtgg cagtgcccag gctacagcat ctgtgtcaat ctgagcgccc tgtgtgacgg
     4141 cgtctttgac tgtcccaatg ggaccgatga gtccccgctt tgcaatcaag acagctgctt
     4201 acattttaat ggtggctgta ctcaccggtg catacaaggg ccctttggag ccacctgcgt
     4261 gtgtccaata ggataccaac ttgccaatga taccaagacc tgtgaagatg taaatgagtg
     4321 tgatattcca ggcttttgca gccagcactg tgtcaacatg agagggtcct tccggtgcgc
     4381 ttgtgaccca gaatatacat tggaaagtga tgggcggact tgcaaagtca cagcatctga
     4441 aaatctgctg ttagttgtag ccagtcgtga caaaatcatt atggacaata tcactgccca
     4501 cacgcacaac atctattctt tggtccagga tgtttctttt gtggttgctc tggattttga
     4561 ttcagtcact ggtcgtgtct tttggagtga cttattggag ggtaaaacct ggagtgcctt
     4621 tcaaaacgga accgacaaga gagtggtcca tgacagtggt ctctctttga cagaaatgat
     4681 tgcagtagac tggataggtc gcaacattta ctggacagac tatactcttg aaacaatcga
     4741 agtctctaaa attgatggaa gtcacaggac agtactgatc agcaaaaatg tcacaaaacc
     4801 taggggactc gcattagatc ctagaatggg tgacaatgta atgttttggt ctgactgggg
     4861 tcatcaccct cgcattgagc gggccagcat ggatggcacc atgcgcacag tcattgtcca
     4921 ggaaaagata tactggccct gtggcttaag tattgactac cccaatcgcc tcatctactt
     4981 catggatgcc tatcttgatt acattgaatt ctgtgattat gatggacaga accgaaggca
     5041 ggtcattgct agcgatttgg ttctccacca tccgcacgct cttactctgt ttgaagactc
     5101 tgtgttctgg actgaccgcg gcactcacca ggtcatgcag gccaacaagt ggcacgggag
     5161 gaaccaatct gttgtaatgt acagcgttcc ccaaccgctc ggaataattg ccatccatcc
     5221 ctccaggcaa ccatcttccc cgaatccatg tgcctctgcc acttgcagcc atctttgcct
     5281 gctttctgca caggagccta gacattactc ttgtgcttgt ccctcagggt ggaacctttc
     5341 tgatgattct gtcaactgtg tgagaggcga tcaacctttc ttgatatccg taagagaaaa
     5401 tgtaattttt ggaatttccc ttgatcctga ggtgaagagc aacgatgcca tggtccccat
     5461 atcggggata cagcatggtt atgatgttga atttgatgac tcagagcagt tcatctattg
     5521 ggttgagaat ccaggtgaaa ttcacagagt gaagaccgat ggcagcaaca ggacagcgtt
     5581 tgctcctctg tctctgctgg ggtcttcttt gggcctggcc ttagactggg tatcaagaaa
     5641 catttattat accactcctg caagtcggtc cattgaggtg ttgacactcc ggggagatac
     5701 gaggtatggg aaaaccctga ttaccaatga tggcaccccg cttggtgttg gtttcccggt
     5761 tggcatagct gttgatcctg cacgtgggaa actgtattgg tcagaccacg ggacggacag
     5821 tggggttcct gccaagattg caagtgctaa catggatgga acatctttaa aaattctctt
     5881 cactgggaac atggaacatc tggaggttgt caccctggac atccaggagc aaaagctcta
     5941 ctgggcggtc accagcagag gcgtgattga aagaggaaat gtggacggta cagagaggat
     6001 gatcctggtg caccacctgg cccacccgtg gggtcttgtg gtccacggct ccttccttta
     6061 ttattccgat gaacagtatg aggtcattga aagagttgac aagtcctctg ggagtaacaa
     6121 agtcgtcttc agagataaca tcccatacct gaggggtctc cgggtttacc accatcgcaa
     6181 tgctgctgac tcttccaatg gctgtagcaa caacccaaat gcttgccagc agatctgcct
     6241 gcccgtacca ggcggaatgt tctcctgcgc ctgtgccagt gggttcaagc tcagccccga
     6301 tggtcgctcc tgttctccat ataactcttt catagtcgtt tccatgctgc ctgcagttag
     6361 aggctttagc ttggagttgt ctgatcactc agaggccatg gtgccagtgg ctggccaagg
     6421 acgaaatgtt ctgcatgcgg acgtggatgt tgccaatggc tttatttact ggtgtgattt
     6481 tagcagctct gtgagatcct ctaacggaat tcgtagaatc aaacccaacg ggtctaattt
     6541 taccaacatt gttacctacg gcatcggggc gaatggaatc cggggtgtgg cagtggattg
     6601 ggtagcagga aatctttatt tcaccaatgc ctttgtgtat gagacactga tagaagtgat
     6661 acggatcaat accacatacc gccgtgtcct cctcaaagtc tcagtggata tgcccaggca
     6721 tatcgttgtt gaccccaagc acagatatct cttctgggcc gactacgggc agaagccgaa
     6781 gattgaacgc tcttttcttg actgtaccaa tagaactgta cttgtttctg aaggcattgt
     6841 cacccctcgg ggcctggcag tggaccatga cactggctat atttattggg ttgatgattc
     6901 cttagatata attgccagga tccatcgtga cggaggagaa tcccaagtgg ttcgttatgg
     6961 cagtcgttac ccaactcctt atggcatcac cgtctttgga gagtcgatca tttgggtgga
     7021 tagaaatttg agaaaagtct tccaagccag caagcaacct gggaatacag acccaccaac
     7081 agtgataaga gatagtatca acttgctacg ggatgtgacc atctttgatg agcatgtcca
     7141 gcccctctca ccggcagagc ttaacaataa cccttgtttg caaagcaatg gtgggtgttc
     7201 ccacttttgc tttgccttac ctgagttgcc tacccccaaa tgtggatgtg cttttgggac
     7261 tctggaagat gatggcaaga actgtgctac ttcccgagaa gatttcctca tctattcctt
     7321 aaataattcc ttgagaagtt tacactttga ccctcaagac cataacctgc ctttccaagc
     7381 gataagtgtg gaaggaatgg ccatcgcact ggactatgac cgcagaaata atagaatctt
     7441 cttcacacaa aagttaaacc ctatccgtgg ccagatttcc tatgtcaacc tgtactcagg
     7501 ggccagctct ccaactatcc tgctctcaaa tataggggtt actgatggca ttgcctttga
     7561 ctggataaat agaagaattt attacagtga cttttcaaat cagacaataa attccatggc
     7621 tgaagatgga tctaatcgcg ctgtgatcgc ccgtgtttcc aaaccaagag ctattgtatt
     7681 agatccttgc cgagggtaca tgtattggac tgactggggt accaatgcca aaattgaaag
     7741 agccacactg ggagggaact tccgggtccc cattgtgaac accagcctgg tttggcccaa
     7801 tggactcact ctggacctgg agaccgacct tctctactgg gcggatgcta gcctgcagaa
     7861 aatagagcgc agtactctca cgggctccaa ccgagaagtt gtcatcagca ctgccttcca
     7921 ttcctttggc ttaactgtct acggccagta catttactgg acagactttt acaccaaaaa
     7981 aatctaccgt gctaacaagt acgatgggtc agacctgatt gcaatgacca ctcgtttgcc
     8041 cacccagcct agtggcatct ccacagttgt caagacccag cagcagcagt gtagcaatcc
     8101 ttgtgaccag ttcaatggag gatgcagcca tatctgtgct ccaggtccaa acggagctga
     8161 gtgccagtgt ccacacgaag gcagctggta tctggccaac gataacaagt actgtgtggt
     8221 ggacacaggt gcccgctgta atcagttcca gttcacctgc cttaatgggc gttgtatctc
     8281 tcaggattgg aaatgtgaca atgacaacga ctgtggtgat ggcagtgatg agctgcccac
     8341 agtctgtgcc tttcacacgt gccgatcaac agccttcact tgtgccaatg ggcgatgtgt
     8401 gccataccat tatcgctgtg atttctacaa tgactgcggg gacaacagcg atgaggcagg
     8461 atgcctattc aggagctgca acagcaccac agagttcact tgcagcaacg ggaggtgtat
     8521 acctcttagt tatgtctgca atggcataaa caactgccat gacaatgaca cctcagatga
     8581 gaaaaactgc cctcccatca cttgccagcc ggacttcgca aaatgccaga ctacaaacat
     8641 ttgtgttccc cgagctttct tgtgtgatgg agacaatgac tgtggagatg ggagcgacga
     8701 gaaccccatt tactgcgcct cacacacatg ccgcagcaat gagttccagt gcgtctcccc
     8761 ccaccggtgt atcccaagct attggttctg tgatggggaa gccgactgtg tggatagctc
     8821 ggatgagcct gacacttgtg ggcattctct aaacagctgc tcagccaatc agttccactg
     8881 tgataacggc aggtgcatct caagtagctg ggtctgtgat ggtgataatg actgcggaga
     8941 catgagtgac gaggaccagc gacatcactg tgagcttcag aactgttcca gtactgagtt
     9001 tacctgtata aacagcagac ctccaaacag gaggtgcatt ccacaacact gggtctgtga
     9061 cggcgacgca gactgcgcgg atgccctcga cgagctgcag aactgcacca tgagagcgtg
     9121 ctctacggga gagttcagct gtgcaaatgg acggtgtatc aggcagtcat tcaggtgtga
     9181 taggcgcaac gactgtgggg actacagtga tgagaggggc tgctcgtacc caccctgccg
     9241 agatgatcaa tttacttgtc agaacgggca atgtatcact aagctctatg tctgtgatga
     9301 ggacaatgac tgtggagatg ggtcggatga acaggagcac ctatgtcaca ccccagaacc
     9361 cacgtgcccc cctcatcagt tccggtgtga caacgggcac tgcatcgaga tggggactgt
     9421 ctgtaaccat gtggatgact gctcagacaa cagtgatgag aaaggctgtg gcattaatga
     9481 gtgccaggat tcttcaatca gtcattgtga ccacaactgt acagatacca taaccagttt
     9541 ctactgttcc tgtcttcctg ggtacaaact catgtctgac aaacgtactt gcgtggatat
     9601 tgacgagtgc aaggagacac cccagctctg tagccagaag tgtgagaatg tcataggctc
     9661 ctacatttgt aagtgtgccc ctggctacat ccgtgagcca gatgggaaga gctgccggca
     9721 gaatagcaac attgagccct acctcgtctt cagcaaccgt tattatataa gaaacttaac
     9781 tatagatggc acgtcatact ctctgatttt gcaaggattg ggcaatgttg tggccctgga
     9841 ctttgataga gtagaggaga ggctgtattg gatcgatgca gagaaacaaa ttatcgagag
     9901 gatgtttttg aataagacaa accaggagac catcataagc cacaggttaa gacgtgctga
     9961 aagtctggct gtagactggg tcagcagaaa actctattgg ttggatgcca tcctagattg
    10021 cctgtttgtc tctgaccttg aaggtcgaca acgcaaaatg ctagcccagc actgtgtgga
    10081 tgcaaacaat accttctgtt ttgaaaatcc caggggaatt gtccttcatc ctcaaagagg
    10141 gtatgtctac tgggcagatt ggggtgatca tgcatacatt gcaagaattg gcatggatgg
    10201 aaccaataag actgtgatta tctctaccaa gatcgaatgg cccaatgcca tcaccattga
    10261 ctacaccaat gatctcttgt actgggcaga tgctcacctg ggttacatcg agttctctga
    10321 tttggagggt caccatcgac acacagtgta tgacggaaca ctgccccacc cctttgctct
    10381 caccattttt gaagacactg ttttttggac agattggaat acacggacag ttgaaaaggg
    10441 aaacaaatat gatggatcag ggcgagtcgt gctggtgaac acaacccaca aaccctttga
    10501 catccacgtg ttacatccat accggcagcc gattatgagc aatccctgtg ctaccaacaa
    10561 cggtggctgt tctcacctgt gcctcatcaa agcaggaggg agaggattca cctgcgagtg
    10621 tcccgatgac ttccagaccg ttcagcttcg agacaggaca ctctgtatgc ccatgtgctc
    10681 cagcacgcag ttcctgtgtg gcaacaatga aaagtgtatc cctatctggt ggaaatgtga
    10741 tggacagaaa gactgctctg atggttctga tgaatcagac ctgtgtccac accgcttctg
    10801 ccgtctggga cagttccagt gccgagatgg caactgcacg agcccccagg ctttgtgcaa
    10861 tgctcgccag gattgtgccg atggctctga tgaagaccgt gttctctgtg aacatcaccg
    10921 gtgtgaagcc aatgagtggc agtgtgccaa caagcgttgc atccctgagt actggcagtg
    10981 tgactccgtg gacgactgcc tggataattc agatgaagac ccttcgcact gtgccagccg
    11041 gacctgcagg cccggccagt tcaagtgtaa caatggacgc tgcatcccgc agagctggaa
    11101 gtgtgacgta gacaatgact gtggagacta ttccgacgag cccatccatg aatgcatgac
    11161 tgctgcttac aactgtgaca accacacaga attcagctgc aaaactaatt accgctgcat
    11221 cccgcagtgg gcagtgtgca atggttttga cgactgcagg gacaacagtg acgagcaagg
    11281 ctgtgaatcg gtgccgtgtc acccttctgg ggatttccgg tgtggaaatc accactgcat
    11341 ccctctccgc tggaaatgtg acggcattga tgactgtgga gacaactcag atgaggaaag
    11401 ttgtgttcct cgggagtgca cagagagcga gtttcgatgt gctgatcagc aatgcatccc
    11461 ctctcgatgg gtctgtgacc aagaaaatga ctgtggagac aactcggatg aacgggactg
    11521 tgagatgaag acgtgccatc ctgaacattt tcagtgtacg agtggacact gtgtgcccaa
    11581 ggcgttggca tgcgatggga gagcagactg tctggatgct tctgatgagt ccgcttgccc
    11641 gactcgcttt cccaatggta cctactgccc agctgccatg ttcgaatgta aaaaccacgt
    11701 gtgcatccag tcattttgga tatgtgatgg ggaaaatgac tgtgtcgacg gttctgatga
    11761 ggagattcac ctgtgcttca atgttccatg tgagtcacca cagcgtttcc ggtgtgataa
    11821 cagtcgctgt atttatggcc accagctgtg caatggtgtg gatgactgtg gagatggaag
    11881 cgatgagaaa gaagaacact gtagaaaacc aacacacaaa ccttgcacag acaccgaata
    11941 caagtgcagc aatgggaact gcgtctcgca gcactatgtg tgtgataatg tggacgactg
    12001 tggagacctt tctgatgaaa ctggttgcaa tctaggagaa aatagaacat gtgctgaaaa
    12061 aatatgtgaa cagaactgca cccagttaag caatggagga tttatctgct cctgtcgacc
    12121 tgggttcaaa cctagtactt tggacaaaaa ttcatgtcaa gacatcaatg aatgtgagga
    12181 gtttggcatt tgcccccaaa gctgccgaaa cagcaaagga agttatgaat gtttctgtgt
    12241 cgatggcttc aagtctatga gtacccacta tggagaacgg tgtgcagctg atggaagccc
    12301 tcctctcttg ctcctgcctg agaacgtccg catccggaag tacaatatct cctctgagaa
    12361 gttctcagag tatctggaag aagaggaaca tatccaagcc attgactacg actgggaccc
    12421 cgagggcata ggcctcagtg ttgtatacta cactgtgctg tcacagggct ctcaattcgg
    12481 tgcaatcaaa cgtgcctacc ttcccgactt tgaatctggt agcaacaatc ccgtccgtga
    12541 agttgacctg ggcctgaaat atttaatgca gccagatgga ttagccgtgg actgggttgg
    12601 aaggcatatt tactggtcag atgctaagag tcaacggatt gaggtagcta cccttgacgg
    12661 aaggtaccgg aagtggctga tcaccaccca actggatcaa ccagccgcca ttgctgtgaa
    12721 tcctaagcta gggctcatgt tctggactga ccagggaaag cagcctaaaa ttgagtctgc
    12781 ctggatgaat ggggagcacc gcagtgttct ggcttctgcg aaccttggct ggccaaatgg
    12841 tctttccata gattacctga atggtgatcg aatctattgg agtgactcca aagaagatgt
    12901 tattgaaagc ataaaatacg atgggactga caggagactc atcataaacg atgcaatgaa
    12961 gcccttcagt ctggacatct ttgaagacca gctctactgg gtagctaagg aaaagggaga
    13021 agtgtggaga caaaataaat ttgggaaagg gaacaaagag aaattgctgg tggtgaaccc
    13081 ctggctcact caagtccgca tcttccatca actgagatac aaccagtcag tgtccaaccc
    13141 ttgcaagcag gtctgtagcc acctctgcct gctgagacca ggaggctaca gctgtgcctg
    13201 tccccaaggc tccgacttcg taactggcag caccgttgag tgtgatgcag ccagtgaact
    13261 ccccatcacc atgccttccc catgcaggtg catgcacgga ggaagttgct attttgatga
    13321 gaatgacctc cccaaatgca agtgttctag cggctacagt ggagagtact gtgagattgg
    13381 gctctcgaga ggcatccctc cagggacgac aatggctctt ctgttgacat tcgcgatggt
    13441 catcattgtt ggggctctgg tactcgttgg attctttcac tacaggaaaa ctggctccct
    13501 tttaccctct ctgcccaagc tgccaagctt aagcagcctt gccaaaccct ctgaaaatgg
    13561 aaacggggtg actttcagat caggggctga tgtgaacatg gacatcggtg tgtctccttt
    13621 tggccctgag acaattattg acagatccat ggcaatgaat gaacaattcg tcatggaggt
    13681 aggcaagcag cctgtgatat ttgaaaaccc aatgtatgca gccaaagaca gtacttccaa
    13741 agtgggcctg gcagtgcagg gaccgtcagt aagctcacag gtgactgtac cagaaaatgt
    13801 ggaaaaccag aactatggaa ggtccataga tccttctgag atagttccag agccaaagcc
    13861 agcctcccct ggagctgatg aaactcaggg cacaaaatgg aatatcttca aacgaaaacc
    13921 caagcagaca acgaacttcg aaaatccaat ctatgcagag atggacactg agcaaaagga
    13981 agctgtggct gtggctcccc ctccatctcc ttctcttcct gctaaagctt caaaaagaag
    14041 ttcgactcca ggctacactg ccacagaaga cacctttaaa gacaccgcaa accttgtgaa
    14101 ggaagactct gatgtatagc cttgccaact ctctagggaa catttagaca ctcacttttg
    14161 cacatatatt ttttacagac aaatgaaaaa gaagttaaca ttcaatactt tataaaaaaa
    14221 tatatttttc tctgtttgcc tataattgaa ggtgtgtcgt gtgtcttttt tactgatgcc
    14281 atttcctatt tttacaatta tcatgaggta ctgtgtatat cttgcactga tgttgtcagg
    14341 aggtgatgct gtgaatatat tgtacttgtg taaatttcag aaggattata acatctctgc
    14401 ctctgctaat gagagtgcct gctgagtggg gtcgctgagc tgaagaataa atgatctggt
    14461 gaggaaagga gttggcttag ggctttgggt ctctctagag aagagatagt actcatgttt
    14521 cctttgaaac aatctaggaa gaaagccctt taagcttcat ttgtgggtcc gtttttacat
    14581 gtcagcactt aatcaataat caatattcaa cattacgtgt caacctgatt agtaagtgta
    14641 ccaatagggg ccagtgttgg cttcatacac tgtagacgct tctgaccaca cagaaggtac
    14701 acaaagtgat tcagttggac ccttccacgt gcctctgtct tctaacccca gctgtgaccc
    14761 taattgccaa gtcaacatct gtatctgcca tgtcacgtcc cacactgagt ttctgtttca
    14821 ttgaatgagc tcttgcttga cagaccttaa atcaaccctt gcctggcatc tcaggtgtca
    14881 cctcccttag tgactggaat tctggagctg actgactaaa accaaaccta cttcataaag
    14941 tagggtgcca aacagatacc agttaatcga aacctcagct gggtgtttgg ctctgggtgc
    15001 aaactgttat tgtattgact atttatttcc tcagttgacg acgaaaagaa agggaaaaca
    15061 ttcttactga gcctttttca cgtctttgcc taaagctgta cgtttgtgtc aggatgtact
    15121 gtatgtcccg gctcttctga gcagttgctg aattctctat cacaggaacc atggcacgag
    15181 cgtacatttt ctatagcaag tagcattccc ggtttctctg tgctaatatt gcacgtgtgt
    15241 taacgaatga atggaagggt gggagagtgg atgaatgaaa tatactactg attattttat
    15301 tctcaagtcc tcgaaatatt ttgttgctca tattttgagt accgattgta attactttga
    15361 ttagaaaaga aaaagctact ggaaatgatg ctgctggaaa tttctaataa atgtgtattt
    15421 tatcagatg
//
