LOCUS       NM_053011              14743 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus low density lipoprotein-related protein 1B (Lrp1b),
            mRNA.
ACCESSION   NM_053011 XM_985447
VERSION     NM_053011.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 14743)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 14743)
  AUTHORS   Akkuratova,N., Faure,L., Kameneva,P., Kastriti,M.E. and Adameyko,I.
  TITLE     Developmental heterogeneity of embryonic neuroendocrine chromaffin
            cells and their maturation dynamics
  JOURNAL   Front Endocrinol (Lausanne) 13, 1020000 (2022)
   PUBMED   36237181
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 14743)
  AUTHORS   Kasowitz,S.D., Ma,J., Anderson,S.J., Leu,N.A., Xu,Y., Gregory,B.D.,
            Schultz,R.M. and Wang,P.J.
  TITLE     Nuclear m6A reader YTHDC1 regulates alternative polyadenylation and
            splicing during mouse oocyte development
  JOURNAL   PLoS Genet 14 (5), e1007412 (2018)
   PUBMED   29799838
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 14743)
  AUTHORS   Beer,A.G., Zenzmaier,C., Schreinlechner,M., Haas,J., Dietrich,M.F.,
            Herz,J. and Marschang,P.
  TITLE     Expression of a recombinant full-length LRP1B receptor in human
            non-small cell lung cancer cells confirms the postulated
            growth-suppressing function of this large LDL receptor family
            member
  JOURNAL   Oncotarget 7 (42), 68721-68733 (2016)
   PUBMED   27626682
  REMARK    GeneRIF: Data show that overexpression of full-length mouse Lrp1b
            leads to impaired cellular proliferation, while human LRP1B
            knockdown has the opposite effect.
REFERENCE   5  (bases 1 to 14743)
  AUTHORS   Kur,E., Mecklenburg,N., Cabrera,R.M., Willnow,T.E. and Hammes,A.
  TITLE     LRP2 mediates folate uptake in the developing neural tube
  JOURNAL   J Cell Sci 127 (Pt 10), 2261-2268 (2014)
   PUBMED   24639464
REFERENCE   6  (bases 1 to 14743)
  AUTHORS   Brunskill,E.W., Aronow,B.J., Georgas,K., Rumballe,B.,
            Valerius,M.T., Aronow,J., Kaimal,V., Jegga,A.G., Yu,J.,
            Grimmond,S., McMahon,A.P., Patterson,L.T., Little,M.H. and
            Potter,S.S.
  TITLE     Atlas of gene expression in the developing kidney at microanatomic
            resolution
  JOURNAL   Dev Cell 15 (5), 781-791 (2008)
   PUBMED   19000842
  REMARK    Erratum:[Dev Cell. 2009 Mar;16(3):482. Yu, Jing [added]]
REFERENCE   7  (bases 1 to 14743)
  AUTHORS   Knisely,J.M., Li,Y., Griffith,J.M., Geuze,H.J., Schwartz,A.L. and
            Bu,G.
  TITLE     Slow endocytosis of the LDL receptor-related protein 1B:
            implications for a novel cytoplasmic tail conformation
  JOURNAL   Exp Cell Res 313 (15), 3298-3307 (2007)
   PUBMED   17658514
  REMARK    GeneRIF: both halves of the LRP1B cytoplasmic tail contribute to a
            unique global conformation, which results in less efficient
            recognition by endocytic adaptors and a slow endocytosis rate.
REFERENCE   8  (bases 1 to 14743)
  AUTHORS   Li,Y., Lu,W. and Bu,G.
  TITLE     Striking differences of LDL receptor-related protein 1B expression
            in mouse and human
  JOURNAL   Biochem Biophys Res Commun 333 (3), 868-873 (2005)
   PUBMED   15963947
REFERENCE   9  (bases 1 to 14743)
  AUTHORS   Adams,D.J., Biggs,P.J., Cox,T., Davies,R., van der Weyden,L.,
            Jonkers,J., Smith,J., Plumb,B., Taylor,R., Nishijima,I., Yu,Y.,
            Rogers,J. and Bradley,A.
  TITLE     Mutagenic insertion and chromosome engineering resource (MICER)
  JOURNAL   Nat Genet 36 (8), 867-871 (2004)
   PUBMED   15235602
REFERENCE   10 (bases 1 to 14743)
  AUTHORS   Marschang,P., Brich,J., Weeber,E.J., Sweatt,J.D., Shelton,J.M.,
            Richardson,J.A., Hammer,R.E. and Herz,J.
  TITLE     Normal development and fertility of knockout mice lacking the tumor
            suppressor gene LRP1b suggest functional compensation by LRP1
  JOURNAL   Mol Cell Biol 24 (9), 3782-3793 (2004)
   PUBMED   15082773
  REMARK    GeneRIF: Results show that in contrast to LRP1, LRP1b-deficient
            mice develop normally, most likely due to its restricted expression
            pattern and functional compensation by LRP1 or other receptors.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL928981.7, AL928962.9, AL845293.5, AL928732.7, AL844533.11,
            AL844515.6, AL844553.4, AL805948.9, AL844225.9, BX000439.11,
            BX649304.3 and AL840626.7.
            
            On Jul 25, 2007 this sequence version replaced NM_053011.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments. A downstream AUG is annotated as
            the start codon because, as with the human homolog, extension of
            the 5' boundary of the CDS to an upstream AUG would eradicate the
            signal peptide for this receptor protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF270884.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849379 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: downstream AUG is associated
                                                with N-terminal localization
                                                signal
            RefSeq Select criteria           :: based on conservation,
                                                expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-864               AL928981.7         98889-99752         c
            865-987             AL928962.9         127138-127260       c
            988-1125            AL845293.5         116811-116948       c
            1126-1245           AL928732.7         92401-92520         c
            1246-1374           AL928732.7         74288-74416         c
            1375-1632           AL928732.7         31996-32253         c
            1633-1795           AL844533.11        27495-27657
            1796-2018           AL844515.6         211132-211354       c
            2019-2190           AL844515.6         206372-206543       c
            2191-2334           AL844515.6         201726-201869       c
            2335-2571           AL844515.6         197892-198128       c
            2572-2752           AL844515.6         176362-176542       c
            2753-2972           AL844515.6         170669-170888       c
            2973-3162           AL844515.6         168549-168738       c
            3163-3285           AL844515.6         158027-158149       c
            3286-3426           AL844515.6         148913-149053       c
            3427-3552           AL844515.6         144828-144953       c
            3553-3669           AL844515.6         135244-135360       c
            3670-3750           AL844515.6         108629-108709       c
            3751-3918           AL844515.6         107962-108129       c
            3919-4101           AL844515.6         75561-75743         c
            4102-4302           AL844515.6         44145-44345         c
            4303-4548           AL844515.6         41418-41663         c
            4549-4746           AL844515.6         12203-12400         c
            4747-4951           AL844515.6         2532-2736           c
            4952-5116           AL844553.4         75803-75967         c
            5117-5361           AL844553.4         75272-75516         c
            5362-5493           AL844553.4         63902-64033         c
            5494-5721           AL844553.4         61844-62071         c
            5722-5896           AL844553.4         48962-49136         c
            5897-5991           AL844553.4         48144-48238         c
            5992-6141           AL844553.4         25747-25896         c
            6142-6282           AL805948.9         176216-176356       c
            6283-6408           AL805948.9         171491-171616       c
            6409-6540           AL805948.9         168548-168679       c
            6541-6675           AL805948.9         106277-106411       c
            6676-6805           AL805948.9         105589-105718       c
            6806-6932           AL805948.9         95646-95772         c
            6933-7084           AL805948.9         95362-95513         c
            7085-7209           AL805948.9         94937-95061         c
            7210-7581           AL805948.9         93432-93803         c
            7582-7771           AL844225.9         122466-122655       c
            7772-7976           AL844225.9         115951-116155       c
            7977-8169           AL844225.9         45728-45920         c
            8170-8295           AL844225.9         45099-45224         c
            8296-8424           AL844225.9         40190-40318         c
            8425-8544           AL844225.9         37034-37153         c
            8545-8658           AL844225.9         21264-21377         c
            8659-8808           AL844225.9         20875-21024         c
            8809-8931           AL844225.9         7120-7242           c
            8932-9051           AL844225.9         4539-4658           c
            9052-9180           BX000439.11        126426-126554       c
            9181-9303           BX000439.11        123751-123873       c
            9304-9444           BX000439.11        120828-120968       c
            9445-9632           BX000439.11        119249-119436       c
            9633-9816           BX000439.11        114507-114690       c
            9817-9902           BX000439.11        113401-113486       c
            9903-10025          BX000439.11        104936-105058       c
            10026-10207         BX000439.11        102688-102869       c
            10208-10407         BX000439.11        95917-96116         c
            10408-10596         BX000439.11        66793-66981         c
            10597-10745         BX000439.11        65872-66020         c
            10746-10839         BX000439.11        54959-55052         c
            10840-10956         BX000439.11        47461-47577         c
            10957-11076         BX000439.11        47177-47296         c
            11077-11196         BX000439.11        45678-45797         c
            11197-11313         BX649304.3         42063-42179         c
            11314-11420         BX649304.3         33925-34031         c
            11421-11550         BX649304.3         21860-21989         c
            11551-11657         BX649304.3         17011-17117         c
            11658-11790         BX649304.3         16545-16677         c
            11791-11913         BX649304.3         6535-6657           c
            11914-12039         AL840626.7         173991-174116       c
            12040-12177         AL840626.7         172888-173025       c
            12178-12312         AL840626.7         171934-172068       c
            12313-12432         AL840626.7         169689-169808       c
            12433-12674         AL840626.7         167527-167768       c
            12675-12898         AL840626.7         149169-149392       c
            12899-13005         AL840626.7         147668-147774       c
            13006-13122         AL840626.7         135250-135366       c
            13123-13296         AL840626.7         133793-133966       c
            13297-13422         AL840626.7         131628-131753       c
            13423-13587         AL840626.7         127541-127705       c
            13588-13749         AL840626.7         117264-117425       c
            13750-13924         AL840626.7         107883-108057       c
            13925-14029         AL840626.7         99784-99888         c
            14030-14106         AL840626.7         81609-81685         c
            14107-14197         AL840626.7         71682-71772         c
            14198-14342         AL840626.7         70431-70575         c
            14343-14441         AL840626.7         68590-68688         c
            14442-14743         AL840626.7         66950-67251         c
FEATURES             Location/Qualifiers
     source          1..14743
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 24.51 cM"
     gene            1..14743
                     /gene="Lrp1b"
                     /gene_synonym="9630004P12Rik; LRP-DIT"
                     /note="low density lipoprotein-related protein 1B"
                     /db_xref="GeneID:94217"
                     /db_xref="MGI:MGI:2151136"
     exon            1..864
                     /gene="Lrp1b"
                     /gene_synonym="9630004P12Rik; LRP-DIT"
                     /inference="alignment:Splign:2.1.0"
     CDS             783..14582
                     /gene="Lrp1b"
                     /gene_synonym="9630004P12Rik; LRP-DIT"
                     /note="low-density lipoprotein receptor-related protein
                     1B; LRP-1B; low-density lipoprotein receptor-related
                     protein-deleted in tumor; low density lipoprotein-related
                     protein 1B (deleted in tumors)"
                     /codon_start=1
                     /product="low-density lipoprotein receptor-related protein
                     1B precursor"
                     /protein_id="NP_443737.2"
                     /db_xref="CCDS:CCDS84520.1"
                     /db_xref="GeneID:94217"
                     /db_xref="MGI:MGI:2151136"
                     /translation="MSQLLLAILTLSGLLPNAEVLIVGANQDQHLCDPGEFLCHDHVT
                     CVSQSWLCDGDPDCPDQSDESLDTCPEEVEIKCPLNHIACHGSSACVHLSKLCNGVVD
                     CPDGFDEGGHCQELLPSCQQLNCQFKCAMVRNATRCYCEDGFEVAEDGRSCKDQDECS
                     IYGICSQTCKNTYGSYACSCVEGYIMQSDNRSCKVKHEPTDKAPMLLISSLETIELFY
                     INGSKMTTLSSANRNEIHTLDFIYSEEMICWIESRESSNQLKCGQITKAGRLTDQRII
                     NSLQSFQNVEQMAFDWLTRNIYFVDHVSDRIFVCNFNGSVCVTLIESELHNPKAIAAD
                     PIAGKLFFTDYGNVPKIERCDLDGMNRTRIVYSKAEQPSALALDLVNRLVYWVDLYLD
                     YVGVVDYQGKNRHTIVQGRQVKHLYGITVFEDYLYATSSDNFNIIRINRFNGTDIHSI
                     IKMESARGIRTYQKRTQPTVRSHACEVDAYGMPGGCSHICLLSSSYKTRTCRCRTGFN
                     MGSDGRSCKRPKNELFLFYGKGRPGIVRGMDLNTKIADECMIPIENLVNPRALDFHAE
                     ANYIYFADTTSFLIGRQKIDGTERETILKDDLDNVEGIAVDWIGNNLYWTNDGHRKTI
                     NVARLEKASQSRKTLLEGGMSHPRAIVVDPVNGWMYWTDWKEDKIDDSVGRIEKAWMD
                     GVNRQVFVTSKMLWPNGLTLDFHTSTLYWCDAYYDHIEKVFLNGTHRKVVYSGKELNH
                     PFGLSHHGNYVFWTDYMNGSIFQLDLMTNEVTLLRHERAPLFGLQIYDPRKQQGDNMC
                     RINNGGCGTLCLAIPAGRVCACADNQLLDENGTTCTFNPEEIRFHICKPGEFRCKNKH
                     CIQARWKCDGDDDCLDGSDEDSVTCFNHSCPDDQFKCQNNRCIPKRWLCDGANDCGSN
                     EDESNQTCTARTCQADQFSCGNGRCIPTAWLCDREDDCGDQTDEVASCEFPTCEPLTQ
                     FICKSGRCISNKWHCDTDDDCGDRSDEVGCVHSCLDDQFRCSSGRCIPGHWACDGDND
                     CGDFSDETHINCTKEEARSPAGCIGNEFQCRPDGNCIPDLWRCDGEKDCEDGSDEKGC
                     NGTIRLCDHKTKFSCRSTGRCINNAWVCDGDVDCEDQSDEEDCDSFLCGPPKYPCAND
                     TSVCLQPEKLCNGRKDCPDGSDEGDLCDECSLNNGGCSNHCSVVPGRGIVCSCPEGHQ
                     LKKDNRTCEIVDYCASHLRCSQVCEQQKHMVKCSCYEGWALGTDGESCTSVDSFEAFI
                     IFSIRHEIRRIDLHKGDYSLLVPGLRNTIALDFHFNQSLLYWTDVVEDRIYRGKLSES
                     GGVSAIEVVVEHGLATPEGLTVDWIAGNIYWIDSNLDQIEVSKLDGSLRATLIAGAME
                     HPRAIALDPRYGILFWTDWDANFPRIESASMSGAGRKTIYKDMKTGAWPNGLTVDHFE
                     RRIVWTDARSDAIYSAFYDGTNMIEIIRGHEYLSHPFAVSLYGSEVYWTDWRTNTLAK
                     ANKWTGQNVSVIQKTSAQPFDLQIYHPSRQPQAPNPCAANEGRGPCSHLCLINHNRSA
                     ACACPHLMKLSSDKKTCYEMKKFLLYARRSEIRGVDIDNPYVNFITAFTVPDIDDVAV
                     IDFDASEERLYWTDIKTQTITRAFINGTGLETVISRDIQSIRGLAVDWVSRNLYWISS
                     EFDETQINVARLDGSLKTSIIHGIDKPQCLAAHPVRGKLYWTDGNTINMANMDGSNSK
                     ILFQNQKEPVGLSIDYVENKLYWISSGNGTINRCNLDGGNLEVIESMKEELTKATALT
                     IMDKKLWWADQNLAQLGTCNKRDGRNPSILRNKTSGVVHMKVYDKEAQQGSNSCQVNN
                     GGCSQLCLPTSETTRTCMCTVGYYLQKNRMSCQGIESFLMYSVHEGIRGIPLEPRDKV
                     DALMPISGAAFAVGIDFHAENDTIYWTDMGLNKISRAKRDQTWKEDVVTNGLGRVEGI
                     AVDWIAGNIYWTDHGFNLIEVARLNGSFRYVIISQGLDQPRSIAVHPEKGFLFWTEWG
                     QVPCIGKARLDGSEKVMIVSVGITWPNGISIDYEENKLYWCDARSDKIERIDLDTGAN
                     REVLLSGSNVDLFSVAVFGAYIYWSDRAHANGSVRRGHKNDATETVTMRTGLGVNLKE
                     IKIFNRVREKGTNVCAKENGGCQQLCLYRGNSRRTCACAHGYLAGDGVTCLRHEGYLL
                     YSGRTILKSIHLSDETNLNSPVRPYENPNYFKNIIALAFDYNQRREGTNRIFYSDAHF
                     GNIQLIKDNWEDRQVIVENVGSVEGLAYHRAWDTLYWTSSSTSSITRHTVDQTRPGAI
                     DREAVITMSEDDHPHVLALDECQNLMFWTNWNEQHPSIMRATLTGKNAHVVVSTDILT
                     PNGLTIDHRAEKLYFSDGSLGKIERCEYDGSQRHVIVKSGPGTFLSLAVYDSYIFWSD
                     WGRRAILRSNKYTGGETKILRSDIPHQPMGIIAVANDTNSCELSPCALLNGGCHDLCL
                     LTPDGRVNCSCRGDRVLLANNRCVTKNSSCNIYSEFECGNGDCVDYVLTCDGIPHCKD
                     KSDEKLLYCENRSCRSGFKPCYNRRCVPHGKLCDGTNDCGDSSDELDCKVSTCSTVEF
                     RCADGTCIPRSARCNQNMDCSDASDEKGCNNTDCTHFYKLGVKSTGFIRCNSTSLCVL
                     PSWICDGSNDCGDYSDELKCPVQNKHKCEENYFGCPSGRCILNTWVCDGQKDCEDGLD
                     ELHCDSSCSWNQFACSVKKCISKHWICDGEDDCGDSLDESDSICGAVTCAADMFSCQG
                     SHACVPQHWLCDGERDCPDGSDELSSAGCAPNNTCDENAFMCHNKVCIPKQFVCDHDD
                     DCGDGSDEFLQCGYRQCGPEEFRCADGRCLVNTLWQCDGDFDCPDSSDEAPINPRCRS
                     AEHSCNSSFFMCKNGRCIPSDGLCDIRDDCGDGSDETNCHINECLSKKISGCSQDCQD
                     LPVSYKCKCWPGFQLKDDGKTCVDIDECSSGFPCSQQCINTYGTYKCHCAEGYETQPD
                     NPNGCRSLSDEEPFLILADQHEIRKISTDGSNYTLLKQGLNNVIALDFDYREEFIYWI
                     DSSRPNGSRINRMCLNGSDIKVVHNTAVPNALAVDWIGKNLYWSDTEKRIIEVSKLNG
                     LYPTVLVSKRLKFPRDLSLDPRAGNLYWIDCCEYPHIGRVGMDGTNQSVVIETKISRP
                     MALTIDYVNHRLYWADENHIEFSNMDGSHRHKVPNQDIPGVIALTLFEDYIYWTDGKT
                     KSLSRVHKTSGADRLSLINSWHAITDIQVYHSYRQPDVSKHLCTVNNGGCSHLCLLGP
                     GKTHTCACPTNFYLAADNRTCLSNCTASQFRCKTDKCIPFWWKCDTVDDCGDGSDEPD
                     DCPEFKCQPGRFQCGTGLCALPAFICDGENDCGDNSDELNCDTHVCLAGQFKCTKNKK
                     CIPVNLRCNGQDDCGDEEDEKDCPENSCSPDYFQCKTTKHCISKLWVCDEDPDCADAS
                     DEANCDKKTCGPHEFQCKNNNCIPDHWRCDNQNDCSDNSDEDNCKPQTCTLKDFLCSN
                     GDCVSSRFWCDGEFDCADGSDEKNCETSCSKDQFQCSNGQCLSAKWKCDGHEDCKYGE
                     DEKNCEPAFPVCSSSEYMCASGGCLSASLKCNGEPDCVDGSDEMDCVIECKEDQFQCK
                     NKAYCIPIRWLCDGIYDCVDGSDEETCGRGGSICRDDEFLCNNSLCKLHFWVCDGEDD
                     CGDNSDEAPDMCVKFLCPPTRPYRCRNDRICLQLEKICNGINDCGDNSDEEHCSGKLS
                     LKSKPCKKDEFTCSNRNCIPMELQCDSLDDCGDGSDEQGCLKTPIEHTCENNGNPCGD
                     DAYCNQIKTSVFCRCKPGFQRNMKGRECADLNECLLFGICSHHCLNTRGSYKCVCDQN
                     FQEKNNSCIAKGSEDQALYIANDTDILGFVYPFNYSGGHQQISHVEHNSRITGMDVHY
                     QRNVIVWSTQFNPGGIFYKMIDAREKRQANSGLICPEFKRPRDIAVDWVAGNVYWTDH
                     SRMHWFSYYTTHWTSLRYSINVGQLNGPNCTRLLTNMAGEPYAIAVNPKRGMMYWTVI
                     GDHSHIEEAAMDGTLRRVLVQKNLQRPTGLTVDHFGERIYWADFELSIIGSVLYDGSS
                     PVVSVSSKQGLLHPHRIDVFEDYIYGAGPKNGIFRVQKFGHGSVEVLALGVDKTKSIL
                     VSHRYKQLNLPNPCLDLSCDFLCLLNPSGATCICPEGKYMMNGTCHDDSLLDDSCKLT
                     CENGGRCILNEKGDLRCHCWPSYSGGRCEVNHCSNYCQNGGTCIPSTLGRPTCICALG
                     FTGPNCGKAVCEDSCHNGGSCVVTAGNQPYCHCQADYTGDRCQYYVCHHYCVNSESCT
                     IGNDGSVECVCPTRYEGPKCEIDKCVRCHGGHCIINKDNEDIFCNCTNGKIASSCQLC
                     DGYCYNGGTCQLDPETSIPVCVCSTNWSGTQCERPAPKSSKSEHISTRSIAIIVPLVL
                     LVTLVTTLVIGLVVCKRKRRTKTIRRQPIINGGINVEIGNPSYNMYEVDHDHSDGGLL
                     EPSFMIDPVKSRYIGGGSSAFKLPHTAPPIYLNSDLKGPLTSGPTNYSNPVYAKLYMD
                     GQNCRNSLASVDERKELLPKKIEIGIRETVA"
     exon            865..987
                     /gene="Lrp1b"
                     /gene_synonym="9630004P12Rik; LRP-DIT"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1125
                     /gene="Lrp1b"
                     /gene_synonym="9630004P12Rik; LRP-DIT"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1245
                     /gene="Lrp1b"
                     /gene_synonym="9630004P12Rik; LRP-DIT"
                     /inference="alignment:Splign:2.1.0"
     exon            1246..1374
                     /gene="Lrp1b"
                     /gene_synonym="9630004P12Rik; LRP-DIT"
                     /inference="alignment:Splign:2.1.0"
     exon            1375..1632
                     /gene="Lrp1b"
                     /gene_synonym="9630004P12Rik; LRP-DIT"
                     /inference="alignment:Splign:2.1.0"
     exon            1633..1795
                     /gene="Lrp1b"
                     /gene_synonym="9630004P12Rik; LRP-DIT"
                     /inference="alignment:Splign:2.1.0"
     exon            1796..2018
                     /gene="Lrp1b"
                     /gene_synonym="9630004P12Rik; LRP-DIT"
                     /inference="alignment:Splign:2.1.0"
     exon            2019..2190
                     /gene="Lrp1b"
                     /gene_synonym="9630004P12Rik; LRP-DIT"
                     /inference="alignment:Splign:2.1.0"
     exon            2191..2334
                     /gene="Lrp1b"
                     /gene_synonym="9630004P12Rik; LRP-DIT"
                     /inference="alignment:Splign:2.1.0"
     exon            2335..2571
                     /gene="Lrp1b"
                     /gene_synonym="9630004P12Rik; LRP-DIT"
                     /inference="alignment:Splign:2.1.0"
     exon            2572..2752
                     /gene="Lrp1b"
                     /gene_synonym="9630004P12Rik; LRP-DIT"
                     /inference="alignment:Splign:2.1.0"
     exon            2753..2972
                     /gene="Lrp1b"
                     /gene_synonym="9630004P12Rik; LRP-DIT"
                     /inference="alignment:Splign:2.1.0"
     exon            2973..3162
                     /gene="Lrp1b"
                     /gene_synonym="9630004P12Rik; LRP-DIT"
                     /inference="alignment:Splign:2.1.0"
     exon            3163..3285
                     /gene="Lrp1b"
                     /gene_synonym="9630004P12Rik; LRP-DIT"
                     /inference="alignment:Splign:2.1.0"
     exon            3286..3426
                     /gene="Lrp1b"
                     /gene_synonym="9630004P12Rik; LRP-DIT"
                     /inference="alignment:Splign:2.1.0"
     exon            3427..3552
                     /gene="Lrp1b"
                     /gene_synonym="9630004P12Rik; LRP-DIT"
                     /inference="alignment:Splign:2.1.0"
     exon            3553..3669
                     /gene="Lrp1b"
                     /gene_synonym="9630004P12Rik; LRP-DIT"
                     /inference="alignment:Splign:2.1.0"
     exon            3670..3750
                     /gene="Lrp1b"
                     /gene_synonym="9630004P12Rik; LRP-DIT"
                     /inference="alignment:Splign:2.1.0"
     exon            3751..3918
                     /gene="Lrp1b"
                     /gene_synonym="9630004P12Rik; LRP-DIT"
                     /inference="alignment:Splign:2.1.0"
     exon            3919..4101
                     /gene="Lrp1b"
                     /gene_synonym="9630004P12Rik; LRP-DIT"
                     /inference="alignment:Splign:2.1.0"
     exon            4102..4302
                     /gene="Lrp1b"
                     /gene_synonym="9630004P12Rik; LRP-DIT"
                     /inference="alignment:Splign:2.1.0"
     exon            4303..4548
                     /gene="Lrp1b"
                     /gene_synonym="9630004P12Rik; LRP-DIT"
                     /inference="alignment:Splign:2.1.0"
     exon            4549..4746
                     /gene="Lrp1b"
                     /gene_synonym="9630004P12Rik; LRP-DIT"
                     /inference="alignment:Splign:2.1.0"
     exon            4747..4951
                     /gene="Lrp1b"
                     /gene_synonym="9630004P12Rik; LRP-DIT"
                     /inference="alignment:Splign:2.1.0"
     exon            4952..5116
                     /gene="Lrp1b"
                     /gene_synonym="9630004P12Rik; LRP-DIT"
                     /inference="alignment:Splign:2.1.0"
     exon            5117..5361
                     /gene="Lrp1b"
                     /gene_synonym="9630004P12Rik; LRP-DIT"
                     /inference="alignment:Splign:2.1.0"
     exon            5362..5493
                     /gene="Lrp1b"
                     /gene_synonym="9630004P12Rik; LRP-DIT"
                     /inference="alignment:Splign:2.1.0"
     exon            5494..5721
                     /gene="Lrp1b"
                     /gene_synonym="9630004P12Rik; LRP-DIT"
                     /inference="alignment:Splign:2.1.0"
     exon            5722..5896
                     /gene="Lrp1b"
                     /gene_synonym="9630004P12Rik; LRP-DIT"
                     /inference="alignment:Splign:2.1.0"
     exon            5897..5991
                     /gene="Lrp1b"
                     /gene_synonym="9630004P12Rik; LRP-DIT"
                     /inference="alignment:Splign:2.1.0"
     exon            5992..6141
                     /gene="Lrp1b"
                     /gene_synonym="9630004P12Rik; LRP-DIT"
                     /inference="alignment:Splign:2.1.0"
     exon            6142..6282
                     /gene="Lrp1b"
                     /gene_synonym="9630004P12Rik; LRP-DIT"
                     /inference="alignment:Splign:2.1.0"
     exon            6283..6408
                     /gene="Lrp1b"
                     /gene_synonym="9630004P12Rik; LRP-DIT"
                     /inference="alignment:Splign:2.1.0"
     exon            6409..6540
                     /gene="Lrp1b"
                     /gene_synonym="9630004P12Rik; LRP-DIT"
                     /inference="alignment:Splign:2.1.0"
     exon            6541..6675
                     /gene="Lrp1b"
                     /gene_synonym="9630004P12Rik; LRP-DIT"
                     /inference="alignment:Splign:2.1.0"
     exon            6676..6805
                     /gene="Lrp1b"
                     /gene_synonym="9630004P12Rik; LRP-DIT"
                     /inference="alignment:Splign:2.1.0"
     exon            6806..6932
                     /gene="Lrp1b"
                     /gene_synonym="9630004P12Rik; LRP-DIT"
                     /inference="alignment:Splign:2.1.0"
     exon            6933..7084
                     /gene="Lrp1b"
                     /gene_synonym="9630004P12Rik; LRP-DIT"
                     /inference="alignment:Splign:2.1.0"
     exon            7085..7209
                     /gene="Lrp1b"
                     /gene_synonym="9630004P12Rik; LRP-DIT"
                     /inference="alignment:Splign:2.1.0"
     exon            7210..7581
                     /gene="Lrp1b"
                     /gene_synonym="9630004P12Rik; LRP-DIT"
                     /inference="alignment:Splign:2.1.0"
     exon            7582..7771
                     /gene="Lrp1b"
                     /gene_synonym="9630004P12Rik; LRP-DIT"
                     /inference="alignment:Splign:2.1.0"
     exon            7772..7976
                     /gene="Lrp1b"
                     /gene_synonym="9630004P12Rik; LRP-DIT"
                     /inference="alignment:Splign:2.1.0"
     exon            7977..8169
                     /gene="Lrp1b"
                     /gene_synonym="9630004P12Rik; LRP-DIT"
                     /inference="alignment:Splign:2.1.0"
     exon            8170..8295
                     /gene="Lrp1b"
                     /gene_synonym="9630004P12Rik; LRP-DIT"
                     /inference="alignment:Splign:2.1.0"
     exon            8296..8424
                     /gene="Lrp1b"
                     /gene_synonym="9630004P12Rik; LRP-DIT"
                     /inference="alignment:Splign:2.1.0"
     exon            8425..8544
                     /gene="Lrp1b"
                     /gene_synonym="9630004P12Rik; LRP-DIT"
                     /inference="alignment:Splign:2.1.0"
     exon            8545..8658
                     /gene="Lrp1b"
                     /gene_synonym="9630004P12Rik; LRP-DIT"
                     /inference="alignment:Splign:2.1.0"
     exon            8659..8808
                     /gene="Lrp1b"
                     /gene_synonym="9630004P12Rik; LRP-DIT"
                     /inference="alignment:Splign:2.1.0"
     exon            8809..8931
                     /gene="Lrp1b"
                     /gene_synonym="9630004P12Rik; LRP-DIT"
                     /inference="alignment:Splign:2.1.0"
     exon            8932..9051
                     /gene="Lrp1b"
                     /gene_synonym="9630004P12Rik; LRP-DIT"
                     /inference="alignment:Splign:2.1.0"
     exon            9052..9180
                     /gene="Lrp1b"
                     /gene_synonym="9630004P12Rik; LRP-DIT"
                     /inference="alignment:Splign:2.1.0"
     exon            9181..9303
                     /gene="Lrp1b"
                     /gene_synonym="9630004P12Rik; LRP-DIT"
                     /inference="alignment:Splign:2.1.0"
     exon            9304..9444
                     /gene="Lrp1b"
                     /gene_synonym="9630004P12Rik; LRP-DIT"
                     /inference="alignment:Splign:2.1.0"
     exon            9445..9632
                     /gene="Lrp1b"
                     /gene_synonym="9630004P12Rik; LRP-DIT"
                     /inference="alignment:Splign:2.1.0"
     exon            9633..9816
                     /gene="Lrp1b"
                     /gene_synonym="9630004P12Rik; LRP-DIT"
                     /inference="alignment:Splign:2.1.0"
     exon            9817..9902
                     /gene="Lrp1b"
                     /gene_synonym="9630004P12Rik; LRP-DIT"
                     /inference="alignment:Splign:2.1.0"
     exon            9903..10025
                     /gene="Lrp1b"
                     /gene_synonym="9630004P12Rik; LRP-DIT"
                     /inference="alignment:Splign:2.1.0"
     exon            10026..10207
                     /gene="Lrp1b"
                     /gene_synonym="9630004P12Rik; LRP-DIT"
                     /inference="alignment:Splign:2.1.0"
     exon            10208..10407
                     /gene="Lrp1b"
                     /gene_synonym="9630004P12Rik; LRP-DIT"
                     /inference="alignment:Splign:2.1.0"
     exon            10408..10596
                     /gene="Lrp1b"
                     /gene_synonym="9630004P12Rik; LRP-DIT"
                     /inference="alignment:Splign:2.1.0"
     exon            10597..10745
                     /gene="Lrp1b"
                     /gene_synonym="9630004P12Rik; LRP-DIT"
                     /inference="alignment:Splign:2.1.0"
     exon            10746..10839
                     /gene="Lrp1b"
                     /gene_synonym="9630004P12Rik; LRP-DIT"
                     /inference="alignment:Splign:2.1.0"
     exon            10840..10956
                     /gene="Lrp1b"
                     /gene_synonym="9630004P12Rik; LRP-DIT"
                     /inference="alignment:Splign:2.1.0"
     exon            10957..11076
                     /gene="Lrp1b"
                     /gene_synonym="9630004P12Rik; LRP-DIT"
                     /inference="alignment:Splign:2.1.0"
     exon            11077..11196
                     /gene="Lrp1b"
                     /gene_synonym="9630004P12Rik; LRP-DIT"
                     /inference="alignment:Splign:2.1.0"
     exon            11197..11313
                     /gene="Lrp1b"
                     /gene_synonym="9630004P12Rik; LRP-DIT"
                     /inference="alignment:Splign:2.1.0"
     exon            11314..11420
                     /gene="Lrp1b"
                     /gene_synonym="9630004P12Rik; LRP-DIT"
                     /inference="alignment:Splign:2.1.0"
     exon            11421..11550
                     /gene="Lrp1b"
                     /gene_synonym="9630004P12Rik; LRP-DIT"
                     /inference="alignment:Splign:2.1.0"
     exon            11551..11657
                     /gene="Lrp1b"
                     /gene_synonym="9630004P12Rik; LRP-DIT"
                     /inference="alignment:Splign:2.1.0"
     exon            11658..11790
                     /gene="Lrp1b"
                     /gene_synonym="9630004P12Rik; LRP-DIT"
                     /inference="alignment:Splign:2.1.0"
     exon            11791..11913
                     /gene="Lrp1b"
                     /gene_synonym="9630004P12Rik; LRP-DIT"
                     /inference="alignment:Splign:2.1.0"
     exon            11914..12039
                     /gene="Lrp1b"
                     /gene_synonym="9630004P12Rik; LRP-DIT"
                     /inference="alignment:Splign:2.1.0"
     exon            12040..12177
                     /gene="Lrp1b"
                     /gene_synonym="9630004P12Rik; LRP-DIT"
                     /inference="alignment:Splign:2.1.0"
     exon            12178..12312
                     /gene="Lrp1b"
                     /gene_synonym="9630004P12Rik; LRP-DIT"
                     /inference="alignment:Splign:2.1.0"
     exon            12313..12432
                     /gene="Lrp1b"
                     /gene_synonym="9630004P12Rik; LRP-DIT"
                     /inference="alignment:Splign:2.1.0"
     exon            12433..12674
                     /gene="Lrp1b"
                     /gene_synonym="9630004P12Rik; LRP-DIT"
                     /inference="alignment:Splign:2.1.0"
     exon            12675..12898
                     /gene="Lrp1b"
                     /gene_synonym="9630004P12Rik; LRP-DIT"
                     /inference="alignment:Splign:2.1.0"
     exon            12899..13005
                     /gene="Lrp1b"
                     /gene_synonym="9630004P12Rik; LRP-DIT"
                     /inference="alignment:Splign:2.1.0"
     exon            13006..13122
                     /gene="Lrp1b"
                     /gene_synonym="9630004P12Rik; LRP-DIT"
                     /inference="alignment:Splign:2.1.0"
     exon            13123..13296
                     /gene="Lrp1b"
                     /gene_synonym="9630004P12Rik; LRP-DIT"
                     /inference="alignment:Splign:2.1.0"
     exon            13297..13422
                     /gene="Lrp1b"
                     /gene_synonym="9630004P12Rik; LRP-DIT"
                     /inference="alignment:Splign:2.1.0"
     exon            13423..13587
                     /gene="Lrp1b"
                     /gene_synonym="9630004P12Rik; LRP-DIT"
                     /inference="alignment:Splign:2.1.0"
     exon            13588..13749
                     /gene="Lrp1b"
                     /gene_synonym="9630004P12Rik; LRP-DIT"
                     /inference="alignment:Splign:2.1.0"
     exon            13750..13924
                     /gene="Lrp1b"
                     /gene_synonym="9630004P12Rik; LRP-DIT"
                     /inference="alignment:Splign:2.1.0"
     exon            13925..14029
                     /gene="Lrp1b"
                     /gene_synonym="9630004P12Rik; LRP-DIT"
                     /inference="alignment:Splign:2.1.0"
     exon            14030..14106
                     /gene="Lrp1b"
                     /gene_synonym="9630004P12Rik; LRP-DIT"
                     /inference="alignment:Splign:2.1.0"
     exon            14107..14197
                     /gene="Lrp1b"
                     /gene_synonym="9630004P12Rik; LRP-DIT"
                     /inference="alignment:Splign:2.1.0"
     exon            14198..14342
                     /gene="Lrp1b"
                     /gene_synonym="9630004P12Rik; LRP-DIT"
                     /inference="alignment:Splign:2.1.0"
     exon            14343..14441
                     /gene="Lrp1b"
                     /gene_synonym="9630004P12Rik; LRP-DIT"
                     /inference="alignment:Splign:2.1.0"
     exon            14442..14743
                     /gene="Lrp1b"
                     /gene_synonym="9630004P12Rik; LRP-DIT"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgctgagtc actaattttg catctctatc cccaagtgcc actcagcata aaagttacta
       61 gtgcagttgg gaaagctctg tgagctgtca agtggaggaa accatttccc taagagagaa
      121 aaccatcctg gcttgccttg gcttcccaga aaggaagctt ccttacagcc aaggcatcaa
      181 atccgctttg cttgagaagc cctttgctcc tcccaaaagt agggacttct cagctggctg
      241 ttgatgcttt ctggcacctt gctggcttgg cccactgcag ttccccttct ctaaggaccc
      301 agatccctac agaaccagcg cggagttact ttctttccct tcaaggaggc agaaagagca
      361 gtgatttgca gcgatcttat ttacggctgt ttccctatca tgttaactgc cgcttactag
      421 tagtagatct gatttctgtg ggcaacagag gagagtgcgg aggactcggt gattaatagt
      481 gaattcccat cggcgggcat ctctctgccc ctcttgcgtg atgtaagatc agacgtaccc
      541 tgcatcgaaa agtccagaca cacagagcct ggctggcgct cgcacgctct ccgcaggcgc
      601 gctttcgctc accttccaca tcctgctcct ggcagagcaa ggcggactgg ctggacccac
      661 cgaccaggga tttccagtga catttgtaaa tgacgcggct ccgttccagg ctgccagccg
      721 ccgcggcccg gccgagggtg ccgccgaaca gtctgcagca caggctcacc gggaagatca
      781 tcatgtccca gttgctcctt gccatcctta ctctctcggg attattgcct aacgctgagg
      841 tgctgattgt gggagccaac caagatcagc atttgtgtga ccctggcgaa tttctttgcc
      901 acgaccatgt gacttgtgtc tcccagagtt ggctgtgcga tggagaccct gactgccctg
      961 accagtcaga tgagtcttta gatacctgtc ccgaggaggt ggagatcaag tgccccttga
     1021 atcacattgc ttgccatggc tctagcgcat gtgtccattt gtcaaaactg tgcaacggag
     1081 tggtcgattg cccagatggc tttgatgaag gagggcattg ccaggaatta ttacccagtt
     1141 gtcagcagtt gaattgccag tttaaatgtg caatggtcag aaatgctaca agatgttatt
     1201 gcgaggatgg atttgaagta gcagaagatg gaagaagctg taaagatcaa gatgaatgca
     1261 gcatttatgg tatttgcagc cagacctgca agaacacata tgggtcctat gcttgcagct
     1321 gcgtggaagg ctatataatg cagtcagaca acagatcttg caaggtcaaa catgaaccca
     1381 cagataaggc accaatgtta ttaatttcaa gtcttgaaac aattgagctc ttctacatca
     1441 atggaagtaa aatgacaact ctaagctcag ccaacagaaa tgaaatccat acgctagatt
     1501 ttatttatag tgaagaaatg atttgctgga ttgaatcaag agagtcttct aatcaactca
     1561 aatgtggcca gataacaaaa gcaggaagat tgacagatca aaggataatt aacagtcttc
     1621 aatccttcca aaatgtggaa caaatggcat ttgactggct taccagaaat atctacttcg
     1681 tggaccatgt cagtgaccgg atctttgttt gtaatttcaa tggctctgtg tgtgtcactc
     1741 tgattgaatc ggagcttcac aatcctaagg ccatagcagc agatcccatc gcaggaaaac
     1801 ttttctttac tgactatggg aatgttccca aaatagagag atgtgacttg gatgggatga
     1861 acagaacaag gatagtttat tcaaaggcag agcagccatc ggccctagct ttggacctcg
     1921 tcaacagatt ggtttattgg gtagatctct acttggacta cgtgggagta gtagactacc
     1981 aaggcaaaaa caggcataca attgttcaag gcagacaggt taaacatctc tatggcataa
     2041 ctgtatttga agattattta tatgcaacca gttctgataa cttcaatatc atacgaataa
     2101 acagatttaa tggcactgat attcactcaa taattaaaat ggagagtgct cgaggaatcc
     2161 gaacctatca gaagagaaca cagccaacag tgagaagcca tgcctgcgaa gtggatgcat
     2221 atggaatgcc agggggatgt tcacacatct gtctgctcag cagcagttat aagacacgga
     2281 cctgtcgctg caggactggc ttcaatatgg ggagcgatgg caggtcatgc aaaaggccaa
     2341 agaatgaatt gttcctcttt tatgggaaag gacgcccagg aattgttaga ggaatggact
     2401 tgaataccaa aatagctgat gaatgcatga ttcccataga aaatctggta aaccctcgtg
     2461 ctttagattt tcacgcggaa gctaattata tctactttgc tgacacgacc agtttcttaa
     2521 ttggccggca gaagatagat ggcacagaga gagaaaccat cctgaaagat gatctggata
     2581 atgtagaagg tattgcagtg gactggattg gaaataacct ttattggacc aatgatggtc
     2641 acagaaaaac catcaatgtg gccaggctgg aaaaggcttc tcagagccgg aaaactctgc
     2701 tggaaggagg aatgtctcat ccaagagcaa ttgtggtaga tccagtcaac ggttggatgt
     2761 actggacaga ctggaaggaa gataaaatag atgacagcgt gggaaggatt gagaaagctt
     2821 ggatggatgg tgtcaatcga caggtttttg tgacttcaaa gatgctgtgg ccaaatggct
     2881 taacactgga ctttcacacc agcacattat attggtgtga tgcttactat gatcatattg
     2941 agaaagtatt tttgaatgga acccacagaa aggttgtata cagtggtaaa gagctgaacc
     3001 atccttttgg actgtcacat catgggaatt atgtgttctg gacagattac atgaatggtt
     3061 caatttttca actagatttg atgaccaatg aggtgacgtt gctgaggcat gaaagagcac
     3121 ccctgtttgg gcttcagatt tatgatccac gaaaacaaca aggtgacaat atgtgccgca
     3181 ttaacaatgg gggctgtggc accctctgcc tggccattcc agcaggccga gtgtgtgctt
     3241 gtgctgataa tcaacttttg gatgaaaatg gaactacttg cacgtttaat cctgaagaaa
     3301 taaggtttca tatctgtaaa cctggagaat ttcgctgcaa gaacaaacac tgtatccaag
     3361 cacgatggaa atgtgacggc gacgatgact gcctagacgg gagtgatgag gactctgtca
     3421 catgcttcaa tcacagctgt ccggatgatc aatttaagtg ccagaataat cgttgtatcc
     3481 ccaagagatg gctttgtgat ggagcaaatg attgtgggag caatgaagat gagtctaacc
     3541 aaacctgtac agccaggacc tgccaggctg accaattttc ttgtggaaat gggcgctgca
     3601 ttcccacagc atggctatgt gaccgagagg atgactgtgg tgaccagaca gatgaagtgg
     3661 catcctgtga atttccaacc tgtgagcctc tgactcagtt catatgcaag agtgggagat
     3721 gcatcagcaa caaatggcac tgcgacactg atgatgactg tggagacagg agtgatgagg
     3781 tgggctgtgt tcactcctgc cttgatgacc agttcagatg ttcaagtggc cggtgtatcc
     3841 cagggcactg ggcctgtgat ggtgacaatg actgcggaga cttcagtgat gaaacacata
     3901 tcaattgtac aaaagaggaa gctcgttctc ctgctggttg catcgggaat gaatttcagt
     3961 gccgtcctga tggaaactgc atccctgatc tgtggcgctg tgatggagag aaagactgtg
     4021 aggatggcag tgatgagaag ggctgcaatg gtaccattcg actgtgtgac cacaaaacca
     4081 agttttcctg caggagtaca gggagatgca tcaacaatgc ctgggtatgt gatggagatg
     4141 ttgactgtga agatcagtct gatgaagaag actgtgacag tttcttgtgt ggaccaccca
     4201 agtacccttg tgctaatgac acctctgtgt gcctgcagcc agagaaactc tgcaatggga
     4261 ggaaggactg tccagatggg tcagatgaag gcgacctttg tgatgagtgt tctctgaaca
     4321 atggagggtg tagcaaccac tgttctgttg ttcctggaag aggaattgtc tgttcctgcc
     4381 cagaaggaca tcagctcaag aaagacaata gaacatgtga aatcgtggac tactgtgcct
     4441 cccacctgag gtgcagccaa gtgtgtgagc agcaaaaaca tatggtcaag tgctcctgct
     4501 atgaaggctg ggcgttgggg actgatgggg aaagctgcac cagtgtggat tcttttgagg
     4561 cattcatcat cttttctata cgccatgaaa ttcgaaggat tgatctgcat aaaggagact
     4621 acagcctact tgttcctgga ctgagaaata ccatagcact tgattttcac ttcaatcaaa
     4681 gtttacttta ctggacagat gttgtggaag acagaatata caggggcaag ctgtcagaga
     4741 gtggaggtgt cagtgccata gaagtggttg tggaacatgg cttggcaacc ccagaaggcc
     4801 tgacggttga ctggatagct ggcaacattt attggataga tagcaatctg gaccaaattg
     4861 aagtgtctaa acttgatggt tccctgaggg ctacactaat agcaggagcc atggagcatc
     4921 ccagggccat agcactggat ccaagatatg gaattctttt ctggacagac tgggatgcca
     4981 atttccctcg cattgaatct gcttcaatga gtggtgccgg aagaaaaacc atctataaag
     5041 acatgaaaac tggggcatgg cctaatggac tgaccgtgga ccactttgaa agaagaatag
     5101 tttggacgga tgccaggtca gatgctattt attcagcttt ctatgatgga acaaacatga
     5161 tagaaattat ccgaggacac gagtacctgt cacatccctt tgctgtgtct ttgtatggga
     5221 gtgaggtgta ctggactgat tggaggacca acacactggc taaagccaac aagtggacag
     5281 ggcagaatgt cagtgtgatc cagaagacga gtgcacaacc attcgacctt cagatttacc
     5341 atcccagtag acagccacaa gctcccaacc cttgtgcagc caatgaaggt agaggcccct
     5401 gctctcacct gtgcctcatc aatcataata ggagtgcagc ttgtgcctgc ccccacctaa
     5461 tgaagctttc ctctgacaag aaaacctgct atgaaatgaa aaaatttctt ctttatgcaa
     5521 gacgttctga gatccgaggg gtggacattg acaatcccta tgtgaacttc atcacagcct
     5581 tcactgtccc agatattgac gatgttgctg taatagactt cgatgcctct gaagagcgtt
     5641 tgtactggac agacatcaaa acacaaacca ttacacgggc tttcattaac gggacgggac
     5701 tagagacagt tatttcaaga gatattcaga gtatcagagg gttagcagtg gactgggttt
     5761 cacgtaattt atactggatt agctcagaat tcgatgaaac acaaattaat gtggcaagat
     5821 tagatggctc tttgaaaacc tcaattattc acggaatcga taaaccgcag tgtctggcag
     5881 cccacccagt cagagggaaa ctgtactgga cagatggaaa tacaataaac atggcaaata
     5941 tggatggaag taacagcaag attctctttc agaaccaaaa ggaaccagtt ggtctatcga
     6001 tagactatgt ggagaataag ctttattgga tcagttctgg aaatggaacc ataaaccgat
     6061 gcaacctaga tggtggtaat ttagaagtaa tagagtcaat gaaggaagaa ttaacaaaag
     6121 ctacagcctt aaccatcatg gataagaaac tctggtgggc agatcaaaac ttagctcaac
     6181 tgggaacttg taacaaaaga gatggaagaa atcccagcat tctgcgaaat aagacttccg
     6241 gagttgttca catgaaagtg tatgacaaag aagcacaaca aggcagcaat tcttgccaag
     6301 taaacaatgg tgggtgttct cagctttgct taccaacatc ggaaacaacc aggacttgca
     6361 tgtgtacagt gggatattat ctccagaaga accgcatgtc atgccaaggt atagaatctt
     6421 ttcttatgta ctctgttcat gaaggaatcc gggggatccc tcttgagcca cgtgacaagg
     6481 tggatgccct gatgccaata tcaggagctg cttttgctgt ggggatagac ttccatgcag
     6541 aaaatgacac catctattgg acagacatgg gccttaataa aatcagcaga gctaaaagag
     6601 accagacttg gaaagaagac gttgttacca atggcttggg cagagtggaa ggaatagctg
     6661 ttgactggat tgctggcaac atatattgga cagatcatgg tttcaattta attgaggttg
     6721 caagactcaa tggctctttt cgttatgtaa ttatttccca aggactggat caaccaagat
     6781 ctatagccgt gcacccagaa aaaggcttct tgttctggac tgaatgggga caagtgcctt
     6841 gtattgggaa agctcgctta gatggttctg agaaggtcat gattgtaagc gtgggaataa
     6901 catggcccaa tggcatctcc attgactatg aggaaaataa attatactgg tgtgatgctc
     6961 gctcagacaa gatagagaga attgaccttg acactggtgc gaatcgtgaa gtgttgctgt
     7021 ctgggagcaa cgtggatctg ttttcagttg cagtctttgg ggcttacatc tactggtctg
     7081 acagagcaca cgccaatgga tcagtcagaa gaggccacaa gaatgatgcc acagagacag
     7141 taaccatgag aacaggactt ggagttaacc taaaggagat caaaattttt aaccgagtaa
     7201 gagagaaagg gaccaatgtc tgtgccaaag aaaatggtgg ctgtcagcaa ctatgtcttt
     7261 atcgaggaaa ttcccgaaga acctgtgcct gtgcccatgg atatttggct ggggatggag
     7321 ttacttgtct aaggcatgaa ggttatttgc tatattcagg aagaacaata ttaaaaagca
     7381 tacatctttc tgatgaaacc aatttaaatt ccccagtacg gccctacgag aacccaaatt
     7441 atttcaagaa tattatagcc ctggcttttg actataatca aagaagagaa ggtaccaatc
     7501 ggatctttta cagtgatgca cactttggaa atatacagct tattaaagat aactgggaag
     7561 acagacaagt aattgtggaa aatgtgggct ctgttgaggg cctcgcctat cacagagcct
     7621 gggatactct gtactggacc agctccagca cgtcgtccat caccaggcac acagtagacc
     7681 agactcggcc cggagcgatt gacagggaag cagtcatcac catgtcagag gatgatcacc
     7741 ctcatgtgct agctttagat gaatgccaaa atttaatgtt ttggacaaat tggaatgaac
     7801 agcatcccag catcatgaga gccaccttga ctgggaaaaa cgcacatgtg gtggtcagca
     7861 cagacattct tactccaaat ggactcacca ttgaccaccg tgctgaaaag ctgtatttct
     7921 cagatggcag cttaggaaaa attgaaagat gtgaatacga tggatcacaa cgacatgtga
     7981 ttgtcaagtc tggaccagga acttttctta gtctggcagt ttatgacagt tatatcttct
     8041 ggtcagactg gggacgaaga gctattttgc gttccaacaa gtacacagga ggagaaacca
     8101 aaattcttcg ttctgatatt ccacatcaac caatgggaat catagctgtt gctaatgaca
     8161 ccaatagctg cgaactctct ccgtgtgcat tattaaatgg aggttgtcat gacctctgcc
     8221 ttttaacacc agatggaaga gtgaattgtt cctgtagagg ggatcgagta ttgctagcta
     8281 acaacagatg tgtgactaaa aactcttctt gtaatatcta ttctgagttt gagtgtggaa
     8341 atggggattg tgtagactat gtcctcacct gtgatggtat ccctcactgt aaggacaaat
     8401 ccgatgaaaa gttactctac tgtgaaaacc gaagttgccg aagtgggttt aaaccgtgct
     8461 acaatcgtcg ctgtgttcct catggcaaac tgtgcgatgg tacaaatgat tgtggggaca
     8521 gctctgatga gttggattgt aaagtgtcta cctgctccac agttgagttc cgctgtgcag
     8581 atgggacttg cattccaaga tcagcacggt gcaaccaaaa catggactgt tcagatgctt
     8641 cagatgaaaa gggttgcaat aatacagatt gcacacattt ctacaaactt ggagtgaaat
     8701 ccacaggatt cattaggtgt aactctacct cactgtgtgt tctaccaagc tggatatgtg
     8761 atggatctaa tgactgtgga gactattctg atgaattaaa gtgcccagtt caaaacaaac
     8821 acaaatgtga agagaattat tttggttgtc ctagtggaag atgcattttg aatacctggg
     8881 tatgtgatgg tcagaaggac tgcgaggacg ggctggatga gctacactgt gattcttctt
     8941 gctcttggaa tcaatttgct tgttctgtaa aaaaatgtat ttctaaacac tggatctgtg
     9001 atggagagga tgactgtgga gacagcttag atgaaagtga cagcatttgt ggtgcagtca
     9061 cttgtgctgc tgacatgttc agctgccagg gctcccatgc ctgtgtgccc caacactggc
     9121 tgtgtgatgg tgagagagac tgtcccgacg ggagtgatga gctatccagt gcaggctgtg
     9181 cacccaacaa tacatgtgac gaaaatgctt tcatgtgcca taataaggtg tgcattccca
     9241 agcagtttgt ctgtgaccat gacgatgact gtggagatgg gtcagatgaa ttcctacagt
     9301 gtggataccg gcagtgtggt ccagaagagt tccgctgtgc tgatgggcgc tgcctcgtga
     9361 atactctgtg gcagtgtgat ggtgactttg actgtcctga cagttccgat gaggctccaa
     9421 tcaacccaag gtgcaggagt gcagaacatt catgcaacag ttcatttttt atgtgcaaaa
     9481 atggcaggtg cattcccagt gatggtcttt gtgacattag ggatgactgc ggtgatggct
     9541 cagatgagac aaactgccac ataaatgaat gtctgagtaa gaaaatcagc ggatgttctc
     9601 aagactgtca ggatttgcca gtcagttaca agtgtaaatg ctggcctgga ttccaactga
     9661 aggatgatgg taaaacatgt gtagacattg atgaatgttc ctcaggtttc ccctgtagtc
     9721 agcaatgcat caatacatat ggaacctaca agtgccactg tgcagaaggc tatgaaacac
     9781 aacctgataa cccaaatgga tgcaggtcac tctcagatga agaacccttc ttaattctcg
     9841 ccgaccaaca cgaaattaga aaaattagca cagatggctc caactacaca cttctaaagc
     9901 agggattaaa caatgttatt gctctagact tcgattatag agaagaattc atatattgga
     9961 ttgattctag cagacccaat ggaagtcgca taaacagaat gtgtctaaat ggaagtgaca
    10021 tcaaggtagt gcataacact gctgtcccca atgcacttgc tgttgattgg attggcaaaa
    10081 acctttattg gtctgacaca gagaaaagga taattgaagt atccaaactc aatggcttat
    10141 accctactgt acttgttagc aaaaggctga agtttcccag ggacctgtct ttagatccac
    10201 gagccgggaa tttgtactgg attgattgct gtgagtatcc tcacattggc cgtgtcggaa
    10261 tggatggaac aaatcagagt gttgtcatag aaaccaagat ttctagacct atggcactaa
    10321 caatagatta tgtcaaccat agactctatt gggctgatga aaatcacatt gaatttagca
    10381 acatggatgg atctcataga cacaaagtcc ctaatcaaga tattccaggg gtgattgcac
    10441 tcactttgtt tgaagactac atctactgga ctgatgggaa aaccaagtca ctcagccgtg
    10501 tccataaaac ctcgggagca gacagacttt cactgattaa ctcatggcat gccatcacag
    10561 atatccaggt gtatcattct tatagacaac ccgatgtctc caaacatctt tgcacagtaa
    10621 ataatggagg atgcagccat ttgtgccttt taggccctgg gaagacccac acctgtgcat
    10681 gtcctaccaa cttctacctt gcagctgata atagaacttg cttatccaac tgcacagcca
    10741 gtcagtttcg atgcaaaact gataaatgca tccctttctg gtggaaatgt gacactgtgg
    10801 atgactgtgg tgatggatct gatgagcctg acgactgtcc tgaatttaag tgtcagccag
    10861 gccgatttca gtgtggaaca gggctctgtg cactccctgc cttcatctgt gacggggaga
    10921 atgactgcgg tgacaactcg gatgaactta actgtgacac acatgtctgc ctggcaggtc
    10981 agttcaagtg taccaagaac aagaaatgta tcccagtaaa cctcagatgt aatggacaag
    11041 atgattgtgg cgatgaggaa gatgagaagg actgtcctga aaacagctgc tctcctgact
    11101 atttccagtg taagactaca aagcattgca tctccaagct gtgggtttgt gatgaggacc
    11161 cggactgtgc tgatgcctct gatgaggcca actgtgataa aaagacttgt ggacctcatg
    11221 agttccagtg taagaacaac aactgtattc cagatcactg gcgatgtgat aaccagaatg
    11281 actgcagtga taattctgac gaagacaact gtaagccaca gacctgtaca ctgaaagact
    11341 ttctctgcag caacggagac tgtgtatcat caaggttctg gtgtgatgga gagtttgact
    11401 gtgctgatgg ctctgatgag aaaaattgtg aaacaagttg ttccaaagat cagtttcagt
    11461 gttctaatgg ccaatgcctg tcagcgaagt ggaagtgcga tggacatgag gactgtaaat
    11521 acggagaaga tgagaaaaac tgtgagccag cctttcctgt ctgctcatca agtgaatata
    11581 tgtgtgccag tggaggatgt ctgtcagcat ctttgaaatg taatggagaa cctgactgtg
    11641 ttgatggttc agatgagatg gactgtgtga tagaatgtaa ggaagatcag tttcaatgca
    11701 aaaataaagc atactgtata ccaatccgat ggctgtgcga tggaatttat gattgtgtgg
    11761 atggcagtga tgaagagaca tgtggcagag gaggaagtat atgcagagat gatgagttcc
    11821 tgtgcaataa ctccctttgc aagctccatt tctgggtctg tgatggagaa gatgactgtg
    11881 gcgacaactc tgatgaagcc cctgacatgt gtgtcaaatt tctgtgccca cccacgaggc
    11941 cttacagatg cagaaatgat agaatctgcc tgcaacttga gaagatatgc aacgggatta
    12001 atgactgtgg ggacaactct gatgaagaac actgcagtgg taaactgtca ttgaaatcca
    12061 agccttgtaa gaaggatgag tttacttgta gcaacagaaa ctgcatcccc atggagctgc
    12121 aatgtgatag ccttgatgac tgtggtgatg gctctgatga acaaggctgc ctgaagactc
    12181 ccattgaaca cacctgtgag aacaatggga atccatgtgg agatgatgca tattgtaatc
    12241 aaatcaaaac atctgttttc tgtcgctgta agccaggatt tcagagaaac atgaaaggca
    12301 gagagtgtgc agatctcaat gaatgcctgc tgtttggaat atgctctcac cactgtctaa
    12361 acacacgagg atcatataaa tgtgtctgtg accagaactt tcaagaaaaa aacaacagct
    12421 gtatagcaaa aggctctgaa gatcaagctc tctacatagc taatgacact gacatcctgg
    12481 gttttgtata tccattcaac tacagtggcg gtcatcagca gatttctcat gttgaacata
    12541 attcaagaat aacagggatg gatgtacatt atcaaagaaa tgtgattgtc tggagtactc
    12601 agtttaatcc aggcgggatt ttctacaaaa tgatcgatgc cagagaaaag agacaagcga
    12661 atagtggctt gatttgtcct gaatttaaaa gacctcgaga cattgccgtt gactgggttg
    12721 caggaaatgt ttactggaca gatcattcca gaatgcactg gttcagctac tatactactc
    12781 actggaccag cctgaggtac tccatcaatg taggacagct caatggtccc aactgcacca
    12841 gactcttaac aaatatggct ggggagccct atgctattgc tgtaaatcct aaaagaggga
    12901 tgatgtactg gaccgtaatt ggggatcact cccatataga ggaggcagca atggatggca
    12961 ctctgaggag ggttttagta caaaaaaact tacagagacc cacaggtctg actgttgatc
    13021 attttggtga acgcatctac tgggcagact ttgagctctc catcattggc agtgtcctgt
    13081 atgatggttc cagtccagtg gtctctgtca gcagcaaaca aggtttgttg catcctcaca
    13141 gaattgatgt ctttgaagat tatatatatg gagcaggacc taaaaatggt atattcagag
    13201 ttcaaaaatt tggtcatggc tcagtagagg tcctagcttt aggcgttgac aaaacaaaga
    13261 gcattttggt atcacatcgc tataaacaac taaatttacc caatccttgc ttggatttgt
    13321 catgtgactt tctctgctta ctgaatcctt ctggagccac atgtatctgc ccagagggaa
    13381 aatatatgat gaatgggacc tgccatgatg acagtctgtt agatgattct tgcaaactga
    13441 cttgtgaaaa tggaggaaga tgcattttaa atgagaaggg tgatctgaga tgtcactgct
    13501 ggcccagtta ttcaggagga aggtgtgaag tcaatcattg tagcaattac tgtcagaatg
    13561 gagggacctg cataccatcc actctaggaa gacccacctg tatctgtgcc ctgggcttta
    13621 ctgggcccaa ctgcggcaag gcagtctgcg aagactcttg tcacaatggt ggaagctgtg
    13681 ttgtcactgc tgggaaccag ccttactgcc attgccaggc agactacact ggagacagat
    13741 gccagtacta tgtgtgccac cactattgtg tgaattcaga atcatgtacc attgggaatg
    13801 atggaagtgt tgaatgtgtc tgcccaacac gctatgaagg accaaaatgt gagattgaca
    13861 aatgtgtacg gtgccatggg ggtcactgta ttataaataa agacaatgaa gatatatttt
    13921 gcaactgtac taatgggaag attgcctcta gctgtcagtt atgtgatggc tactgttaca
    13981 atggtggcac atgccagctg gaccctgaga ctagtatacc tgtgtgtgtg tgctccacta
    14041 attggtcagg gacacagtgt gagaggccag ccccaaagag cagcaaatct gagcatatca
    14101 gcacaaggag cattgctatc atcgtgccac ttgtcctttt ggtgaccttg gtaaccactc
    14161 tagtgattgg tttagtggtt tgtaagagaa aaagaagaac aaagacaatt agaaggcagc
    14221 ctatcatcaa tggaggaata aatgtagaaa tcggcaatcc atcatacaat atgtatgaag
    14281 tggaccacga ccacagtgat gggggtcttt tagaaccaag tttcatgata gatccagtaa
    14341 agtccaggta cataggggga gggtccagtg ctttcaagct cccacataca gcaccgccca
    14401 tctacctaaa ctctgatttg aaaggaccac taacttctgg gccaacaaat tactccaacc
    14461 cagtatatgc aaaattatat atggatggac agaactgtcg aaactcctta gcaagtgtgg
    14521 atgaacggaa agaacttctt ccaaagaaaa ttgaaattgg catcagagaa acagtagcat
    14581 aatgaaggac acttttctat gctgtataaa tgtataaaat ataaggatta cttttatatg
    14641 ttccaacagt attatactta ttttagcatc aacatcatct ctttatcttt ttcctcgtta
    14701 attgttttct gagtttgggg ggttttattt tttgctaatg aat
//
