LOCUS       NM_172814               4315 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus low density lipoprotein-related protein 12 (Lrp12),
            transcript variant 1, mRNA.
ACCESSION   NM_172814
VERSION     NM_172814.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4315)
  AUTHORS   Huang,M., Lu,L., Lin,C., Zheng,Y., Pan,X., Wang,S., Chen,S.,
            Zhang,Y., Liu,C., Ge,G., Zeng,Y.A. and Chen,J.
  TITLE     LRP12 is an endogenous transmembrane inactivator of alpha4
            integrins
  JOURNAL   Cell Rep 42 (6), 112667 (2023)
   PUBMED   37330909
  REMARK    GeneRIF: LRP12 is an endogenous transmembrane inactivator of alpha4
            integrins.
REFERENCE   2  (bases 1 to 4315)
  AUTHORS   Grote,A., Robens,B.K., Blumcke,I., Becker,A.J., Schoch,S. and
            Gembe,E.
  TITLE     LRP12 silencing during brain development results in cortical
            dyslamination and seizure sensitization
  JOURNAL   Neurobiol Dis 86, 170-176 (2016)
   PUBMED   26639854
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC101945.33 and AC158567.3.
            
            On Mar 26, 2018 this sequence version replaced NM_172814.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK050512.1, SRR9219382.182075.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-391               AC101945.33        136539-136929
            392-448             AC158567.3         168002-168058       c
            449-584             AC158567.3         148469-148604       c
            585-787             AC158567.3         143583-143785       c
            788-1892            AC158567.3         141258-142362       c
            1893-2025           AC158567.3         139550-139682       c
            2026-4315           AC158567.3         134052-136341       c
FEATURES             Location/Qualifiers
     source          1..4315
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 15.59 cM"
     gene            1..4315
                     /gene="Lrp12"
                     /gene_synonym="C820005L12Rik; LRP-12"
                     /note="low density lipoprotein-related protein 12"
                     /db_xref="GeneID:239393"
                     /db_xref="MGI:MGI:2443132"
     exon            1..391
                     /gene="Lrp12"
                     /gene_synonym="C820005L12Rik; LRP-12"
                     /inference="alignment:Splign:2.1.0"
     CDS             313..2889
                     /gene="Lrp12"
                     /gene_synonym="C820005L12Rik; LRP-12"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; low-density lipoprotein receptor-related
                     protein 12"
                     /codon_start=1
                     /product="low-density lipoprotein receptor-related protein
                     12 isoform 1 precursor"
                     /protein_id="NP_766402.1"
                     /db_xref="CCDS:CCDS27446.1"
                     /db_xref="GeneID:239393"
                     /db_xref="MGI:MGI:2443132"
                     /translation="MARRWSTKESQRRGSAWLLLFLAGVYGNGALAELSENVHISGVS
                     TACGESPEQIRAPSGIITSPGWPSDYPAQVNCSWLIRANPGEIITISFQDFDIQGSRR
                     CTLDWLTIETYKNIESYRACGSTIPPPYISSQDHVWIRFHSDDSVSRKGFRLAYFSGK
                     SEQPDCACDQFRCGNGKCIPEAWKCNSMDECGDSSDEEVCASDAHPPTTTAFQPCAYN
                     QFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDMPTCGQWLKYFYGTFNSPNYP
                     DFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPRKLLRVLTA
                     FDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQVDGFCLPWEIPCGGNWGCYTEQ
                     QRCDGYWHCPNGRDEINCTMCQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNCFF
                     CQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENCPVIVPTRVITAAVIGSLICGLLL
                     VIALGCTCKLYSLRMFERRSFETQLSRVEAELLRREAPPSYGQLIAQGLIPPVEDFPV
                     CSPNQASVLENLRLAVRSQLGFTSIRLPMTGRSSNIWNRIFNFARSRHSGSLALVSGD
                     GDEVVPSQSSSRETERSRPHRSLFSVESDDTDTENERRDTAGASGGVAAPLPQKVPPT
                     TAVEATVGSGGNSSAQSTRGGHADGREVSSVEAPSVSPARHQLTSALSRMTQGLRWVR
                     FTLGRSSSTTQNRSPLRQLDTAVSGREDDDDVEMLIPVSDGASDIDANDCSRPLLDLA
                     SDQVQGFRQPHSAGNPGVRTSNRDGPCERCGIVHTAQIPDTCLEATVKTETSDDEALL
                     LC"
     exon            392..448
                     /gene="Lrp12"
                     /gene_synonym="C820005L12Rik; LRP-12"
                     /inference="alignment:Splign:2.1.0"
     exon            449..584
                     /gene="Lrp12"
                     /gene_synonym="C820005L12Rik; LRP-12"
                     /inference="alignment:Splign:2.1.0"
     exon            585..787
                     /gene="Lrp12"
                     /gene_synonym="C820005L12Rik; LRP-12"
                     /inference="alignment:Splign:2.1.0"
     exon            788..1892
                     /gene="Lrp12"
                     /gene_synonym="C820005L12Rik; LRP-12"
                     /inference="alignment:Splign:2.1.0"
     exon            1893..2025
                     /gene="Lrp12"
                     /gene_synonym="C820005L12Rik; LRP-12"
                     /inference="alignment:Splign:2.1.0"
     exon            2026..4315
                     /gene="Lrp12"
                     /gene_synonym="C820005L12Rik; LRP-12"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4275..4280
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lrp12"
                     /gene_synonym="C820005L12Rik; LRP-12"
                     /note="hexamer: ATTAAA"
     regulatory      4280..4285
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lrp12"
                     /gene_synonym="C820005L12Rik; LRP-12"
                     /note="hexamer: AATAAT"
     polyA_site      4302
                     /gene="Lrp12"
                     /gene_synonym="C820005L12Rik; LRP-12"
                     /note="major polyA site"
     polyA_site      4315
                     /gene="Lrp12"
                     /gene_synonym="C820005L12Rik; LRP-12"
                     /note="major polyA site"
ORIGIN      
        1 gccggctcgc gctcagtctg gcgggtggcg gcgccggctg gttgtgcggc gcgaggccgg
       61 agccccgcag ttgccggccc tgtcgcctgc ggctggcgcg cgcgctgcgc gtccctgccc
      121 ccgggaaggc cggcccgcta ggggctcgcg cgaccgacgc agggccggcg ggagggagcg
      181 cgcgcgggcg gccccgcccc tccccctccg ccgccgcgga gcgcgcaggg agcagccagg
      241 ggctcggcgg cggcggcgtc tggccccagc tcctcctcct ccatctcctc gctccctcca
      301 tctgccgtgg gtatggcccg tcgctggagc acaaaagagt ctcagcggcg ggggtcggcg
      361 tggctcttgc ttttcctcgc tggggtgtac ggaaatggtg ctcttgcaga actttctgaa
      421 aatgtgcata tttcaggagt gtcaactgct tgtggggaga gtccagaaca aattcgagca
      481 ccgagtggaa taatcacgag tccaggctgg ccttcagact atcctgccca agtcaactgc
      541 agctggctca taagggcaaa cccaggggag atcattacta taagttttca ggattttgat
      601 atccaggggt ccagaagatg cactttggac tggctgacaa tagaaacata caagaatatt
      661 gaaagttacc gagcgtgtgg gtccacaatt ccgccaccat atatctcttc ccaagaccac
      721 gtttggatcc ggttccactc agatgacagc gtgtccagga aaggcttcag gctggcgtat
      781 ttttcaggga aatctgagca gccagactgt gcctgtgatc agttccgctg tggaaatgga
      841 aagtgtattc cagaagcctg gaagtgcaac agcatggacg agtgtggaga cagttctgac
      901 gaggaggtct gtgccagcga tgctcacccc ccaaccacga ctgctttcca accctgtgcc
      961 tacaaccagt tccagtgtct gtcccgcttc accaaagttt acacgtgtct ccctgagtcc
     1021 ttaaagtgtg atgggaacat tgactgcctg gacctaggag acgagataga ctgtgacatg
     1081 ccgacatgcg gacaatggtt aaaatacttc tatggcacct tcaattctcc caactacccc
     1141 gacttttatc ctcctggaag taactgcacc tggctgatag acactggtga tcatcggaaa
     1201 gtcatcttac ggttcactga ctttaaactt gatggtaccg ggtatggtga ttatgtcaaa
     1261 atatatgacg gactggagga gaatcctcgc aagctcttgc gggtgctaac tgctttcgat
     1321 tctcacgctc ctctgacggt cgtttcttcc tccggacaga taagagtaca tttctgtgct
     1381 gataaagtga atgctgcaag agggttcaac gctacttacc aagtcgatgg cttctgtttg
     1441 ccatgggaaa taccctgtgg gggcaactgg gggtgctaca cagagcagca gcgctgtgac
     1501 gggtactggc attgcccaaa cggaagggat gaaatcaatt gtaccatgtg ccaaaaggaa
     1561 gaatttccat gttctcgaaa tggtgtctgc taccctcgtt ctgatcgctg caactaccaa
     1621 aaccattgtc cgaacggctc tgatgaaaaa aactgcttct tttgccagcc agggaatttc
     1681 cactgtaaga acaaccgctg tgtgtttgaa agctgggtgt gtgattccca ggatgactgc
     1741 ggtgacggca gtgacgagga gaactgccca gtcattgtgc ctaccagagt cataacagca
     1801 gcagtcatcg ggagcctcat ctgtggcctg ctgctcgtca ttgcattggg gtgcacttgc
     1861 aagctttatt ctctgagaat gtttgaacgg agatcatttg agacccagtt gtcacgcgtg
     1921 gaagcagaac ttctccgaag agaggctcct ccctcatatg gacagttgat cgctcaggga
     1981 ctaatcccac ccgtagaaga ttttcctgtc tgttcaccta atcaggcttc cgttttagaa
     2041 aacctgaggc tagctgtccg atctcagctg ggatttactt caatcaggct tcctatgaca
     2101 ggcagatcta gcaacatttg gaatcgtatt tttaattttg caagatcccg tcattcaggg
     2161 tcattggctt tggtctcggg agatggagat gaggttgtcc ctagccagag cagcagcaga
     2221 gaaactgaga ggagtcgccc tcacagaagc ttattctccg tggagtccga tgacactgac
     2281 acagaaaatg agagaaggga tacggcggga gcatcgggtg gggttgcagc accgttgccc
     2341 cagaaggtcc ctcccacgac cgccgtggag gccacagtgg gatcaggtgg gaattcctct
     2401 gctcagagca ccagaggtgg ccatgcagat ggaagggaag tgtcaagtgt ggaagccccg
     2461 agtgtgagcc cagcacgtca ccagctcaca agtgctttaa gtcggatgac tcagggcctg
     2521 cgctgggtcc gctttacact aggtcgatcg agctccacta cccagaaccg gagtcctttg
     2581 agacagctgg acaccgcagt gagtggacga gaagacgacg atgacgtcga aatgctaatt
     2641 ccagtttcag acggagcttc ggacattgat gccaatgact gctccagacc tcttcttgac
     2701 cttgcctcag accaagtaca agggtttaga cagccacaca gtgcaggaaa ccctggagtg
     2761 agaacaagta accgggacgg cccctgcgag cgctgtggca ttgtgcacac agcccagata
     2821 ccagacactt gcttagaagc cacagtgaag acggaaacga gtgatgacga ggctttgctg
     2881 ctgtgttagg acagaatcgc cagactgtat gcaagctgga gcaatatcca ctcactgttt
     2941 tgtaacttta caattaaact agttttagtt taaaatgaaa agatgcaggg tgatttctta
     3001 ttatatgtta gcctgcatgg ttaaatttaa caatgtgtaa ctctaggagc tagagtttgc
     3061 tgttttagca gctaaaaatg cattatgtat tcgtagtctt cagtcatgtt cttccgtttg
     3121 cttatacctg gttttgtttt gtttttttaa atcctggtac ttaagtttaa tagtagaaat
     3181 atggctgctt tattcatgta actgccattt tatctatctt atgttaaaag gttggtttgt
     3241 acaaaacggt accttctttc cattgactct tggatgctct ttgccatcat gtaacttatt
     3301 atactagatg ctgaggttgt taatgtacaa aaaaggagac agctccttag agtcacctct
     3361 ttgtttgcat aacactgtct gctagtagat ttcatcatat ggacctgtcg caggcaaaga
     3421 atctgctctc tcattcaaca cacagtgatg taaaagttcc gtggcgttcg agaaaattgc
     3481 tgtcgggaaa caaaactctt ttatagattt tctaatgctg actttactac tctggtgtgg
     3541 ttcagaccaa atggtgaaat cccaacacgt ttctgttttc atctcaattt agggacagaa
     3601 gtaagcggat gaagattctc tactatgcat tacattttga actttataaa ataggtacag
     3661 aaattgtacc cgctcagctc cacggggtaa tgtctttccc tgacacggag gtttgcctga
     3721 gttggaccct agggatttgc actacagtcc tgtcaaggtc tcagatgagt ttagcgcaca
     3781 ggcactgtca cagcaggtac tgtcattgct accacagtga cgttatattt ccatagcttt
     3841 ggggctgggg gaccattttt attacaactt gaaattgctt tgctggtttc atatttattt
     3901 gttgtattta aaaactgcat tattgtgaga gtgatttttt tccaggatat tttattcttg
     3961 ggggaggggg tcagtgctat aatcttgaag aaaagcaaat taaagtgttc agattgcccc
     4021 ccctctttaa gtagagggaa ttacaagccc catttatttt tctttaattg ttaattcttg
     4081 tttatttatt ccttagctgt ctgttttagc agcttaatga ttgggtatga aatgtgtttg
     4141 tgtgtgatta tcgctattta ttacaccttc agtactttgc tgaatgtcat tttaaagcat
     4201 gtttgaggtc ttgtgtatct gtcctgttat gctgtcagga agacctgacg aaaatgtttt
     4261 aatatgtatc aaaaattaaa ataatttttt ttattgcctt gaggtacttt ttaaa
//
