LOCUS       NM_172784               2671 bp    mRNA    linear   ROD 09-JUN-2024
DEFINITION  Mus musculus low density lipoprotein receptor-related protein 11
            (Lrp11), transcript variant 1, mRNA.
ACCESSION   NM_172784
VERSION     NM_172784.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2671)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2671)
  AUTHORS   Memic,F., Knoflach,V., Morarach,K., Sadler,R., Laranjeira,C.,
            Hjerling-Leffler,J., Sundstrom,E., Pachnis,V. and Marklund,U.
  TITLE     Transcription and Signaling Regulators in Developing Neuronal
            Subtypes of Mouse and Human Enteric Nervous System
  JOURNAL   Gastroenterology 154 (3), 624-636 (2018)
   PUBMED   29031500
REFERENCE   3  (bases 1 to 2671)
  AUTHORS   Xu,J., Cai,R., Lu,L., Duan,C., Tao,X., Chen,D., Liu,Y., Wang,X.,
            Cao,M. and Chen,Y.
  TITLE     Genetic regulatory network analysis reveals that low density
            lipoprotein receptor-related protein 11 is involved in stress
            responses in mice
  JOURNAL   Psychiatry Res 220 (3), 1131-1137 (2014)
   PUBMED   25262641
REFERENCE   4  (bases 1 to 2671)
  AUTHORS   Osipovich,A.B., Long,Q., Manduchi,E., Gangula,R., Hipkens,S.B.,
            Schneider,J., Okubo,T., Stoeckert,C.J. Jr., Takada,S. and
            Magnuson,M.A.
  TITLE     Insm1 promotes endocrine cell differentiation by modulating the
            expression of a network of genes that includes Neurog3 and Ripply3
  JOURNAL   Development 141 (15), 2939-2949 (2014)
   PUBMED   25053427
REFERENCE   5  (bases 1 to 2671)
  AUTHORS   Hald,J., Galbo,T., Rescan,C., Radzikowski,L., Sprinkel,A.E.,
            Heimberg,H., Ahnfelt-Ronne,J., Jensen,J., Scharfmann,R.,
            Gradwohl,G., Kaestner,K.H., Stoeckert,C. Jr., Jensen,J.N. and
            Madsen,O.D.
  TITLE     Pancreatic islet and progenitor cell surface markers with cell
            sorting potential
  JOURNAL   Diabetologia 55 (1), 154-165 (2012)
   PUBMED   21947380
REFERENCE   6  (bases 1 to 2671)
  AUTHORS   Pereira,J.D., Sansom,S.N., Smith,J., Dobenecker,M.W.,
            Tarakhovsky,A. and Livesey,F.J.
  TITLE     Ezh2, the histone methyltransferase of PRC2, regulates the balance
            between self-renewal and differentiation in the cerebral cortex
  JOURNAL   Proc Natl Acad Sci U S A 107 (36), 15957-15962 (2010)
   PUBMED   20798045
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FO907139.2 and AC156391.6.
            
            On Mar 24, 2020 this sequence version replaced NM_172784.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK036676.1, AK050544.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-797               FO907139.2         5958-6754
            798-958             AC156391.6         180126-180286       c
            959-1100            AC156391.6         177542-177683       c
            1101-1226           AC156391.6         173436-173561       c
            1227-1436           AC156391.6         172007-172216       c
            1437-1532           AC156391.6         167751-167846       c
            1533-2671           AC156391.6         151622-152760       c
FEATURES             Location/Qualifiers
     source          1..2671
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 2.23 cM"
     gene            1..2671
                     /gene="Lrp11"
                     /gene_synonym="1700034J19Rik; 6330533B21; 9830160H19Rik"
                     /note="low density lipoprotein receptor-related protein
                     11"
                     /db_xref="GeneID:237253"
                     /db_xref="MGI:MGI:2442989"
     exon            1..797
                     /gene="Lrp11"
                     /gene_synonym="1700034J19Rik; 6330533B21; 9830160H19Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             236..1687
                     /gene="Lrp11"
                     /gene_synonym="1700034J19Rik; 6330533B21; 9830160H19Rik"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; LRP-11"
                     /codon_start=1
                     /product="low-density lipoprotein receptor-related protein
                     11 isoform 1 precursor"
                     /protein_id="NP_766372.1"
                     /db_xref="CCDS:CCDS23686.1"
                     /db_xref="GeneID:237253"
                     /db_xref="MGI:MGI:2442989"
                     /translation="MATRGGGPGPGFRHRALRGLLLLCLWLPGSRPGEPAAPSSGVDR
                     LLQDFRRQLQRARPREELEPELLGGPREDCPGAGGTAVYRAVPDTIIRTQDSIAAGAS
                     FLRAPGSVRGWRQCVTACCSEPSCSVAVVQLPRGPSVPAPMPAPRCYLFNCTARGRSV
                     CKFAPLRGYRTYTLSRAEDAAGIPPRPDEDKPPVSKAGKDVVLHLPTDGVVLDGRESS
                     DDHAIVLYEWTLQQGDPSSVDMKVPQPGTLRLSRLKEGAYIFQLTVTDSVGQRSSDNV
                     SVTVLPRPYSTGGCSSACSRYHFFCDSGCCIDIALACDGVRQCPDGSDEDFCQNLALD
                     RKLVTHTVATSAQPGAMGLNEGEGDPKLEKSQRATTHNQPATVSHPETRIHSTQKAPE
                     SQINPVQPDSNSSGKNQEEGNYDLKSKSGQAGGEHPAPEAGAVLPLALGLAITVLLLL
                     MVTCRLRLVKQKLKKARPITSEESDYLINGMYL"
     exon            798..958
                     /gene="Lrp11"
                     /gene_synonym="1700034J19Rik; 6330533B21; 9830160H19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            959..1100
                     /gene="Lrp11"
                     /gene_synonym="1700034J19Rik; 6330533B21; 9830160H19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1101..1226
                     /gene="Lrp11"
                     /gene_synonym="1700034J19Rik; 6330533B21; 9830160H19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1436
                     /gene="Lrp11"
                     /gene_synonym="1700034J19Rik; 6330533B21; 9830160H19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1437..1532
                     /gene="Lrp11"
                     /gene_synonym="1700034J19Rik; 6330533B21; 9830160H19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1533..2671
                     /gene="Lrp11"
                     /gene_synonym="1700034J19Rik; 6330533B21; 9830160H19Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2653..2658
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lrp11"
                     /gene_synonym="1700034J19Rik; 6330533B21; 9830160H19Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      2671
                     /gene="Lrp11"
                     /gene_synonym="1700034J19Rik; 6330533B21; 9830160H19Rik"
                     /note="major polyA site"
ORIGIN      
        1 agccgctgtc cgcacgccgg tgctgatcca cgtagaggcc gctcgtcgtc ccggtgcgct
       61 tccgcggccg gagcgaagat agaagcaccg aaagctcgca gcctggtagc agggccaggg
      121 cggcgccgag tccggccgag tccggcccgc gatgcctctc gaagccggca cactcgccgc
      181 ctccgtgaag cagccaggcc ccggggccgc cgagctctga ggccgcgctc gtgccatggc
      241 cacaagggga ggaggaccgg gccccggctt ccggcaccgc gcgctccgcg ggctgctgct
      301 gctctgcctc tggctgcccg gcagccggcc cggggagccc gccgctccgt cgtccggagt
      361 ggataggctg cttcaggact ttcgccggca gctacagcgg gcacggcctc gcgaggagct
      421 agagccggag ctactgggcg gcccgcggga ggattgcccg ggtgcgggcg gtacggcggt
      481 ctaccgggcg gtgcccgata ccatcatccg cacccaggat tccatcgcgg cgggagccag
      541 cttcctgcgc gcacccggga gcgtgcgggg ttggcggcag tgcgtgacgg cctgctgctc
      601 cgagccgagc tgctcggtgg cagtggtgca gctgccccgg gggcccagcg tgcccgcacc
      661 tatgcccgca ccccgctgct acctgttcaa ctgcacggcg cgcggccgca gcgtctgcaa
      721 gttcgcgcca ctccgcgggt accgcactta caccctcagt cgcgccgagg acgccgctgg
      781 gatccctccc cggccagatg aggacaagcc tcccgttagc aaggctggga aggatgtggt
      841 tttacatctg cccacagacg gggtagttct agatggtcga gaaagctcgg acgaccacgc
      901 cattgtcctt tatgagtgga cgctgcagca gggtgaccca tcgtcagtgg acatgaaggt
      961 gcctcagcca ggaaccctga ggctgtcccg cctgaaggaa ggagcttaca tcttccagct
     1021 gactgtgact gactccgtgg gtcagagaag ctccgataac gtctctgtca ctgtgcttcc
     1081 caggccctac tccacgggag gatgctccag tgcttgctcg cgctaccatt tcttctgtga
     1141 cagtggctgc tgtattgaca tagcgttggc ttgtgatggc gtgaggcagt gtcccgacgg
     1201 gtctgatgaa gacttctgtc aaaacttggc tcttgaccgc aagttggtga cacacacagt
     1261 ggctacttct gcccagccag gagccatggg attaaatgaa ggtgaaggag accccaagtt
     1321 ggaaaaatcc cagagagcca ctacccacaa ccaacccgct actgtatccc acccagagac
     1381 gaggatccac tccacccaga aggcgccaga gagtcagatc aatcctgtcc agccagacag
     1441 caattcctca ggaaagaacc aagaagaagg aaattatgat ctcaagtcca agagtggcca
     1501 agcaggaggg gagcacccgg ccccggaagc aggtgcggtg ctacctctgg cattaggtct
     1561 ggccatcact gttttgttgc ttctcatggt gacatgccga ctccgactgg tgaagcagaa
     1621 actcaagaaa gcccggccca ttacatctga ggaatcggac tacctcatca atgggatgta
     1681 tctgtaacaa cgctatttaa gcagctcggg gcaaggatgg ctatcactca caatctgttc
     1741 tttgggttct atcattaaga tgttttgttt taaactgtgc tagaagacag tgcaaacaca
     1801 agccttgact tatcatgaaa taatttccct gggatgtaca atgtcttcaa aggtagagag
     1861 gaattcataa gactgaagct tgtttgctga gacagaaagt cagcatgtga caaggtgaca
     1921 gatggaagtc ctgcctttta tttgtgaggt gccaactgct ggcccctatc agctttctta
     1981 tcttctggct ctcttctctc cactgagttc tcatgagcta cactttcttt tcctctgcta
     2041 aatacctctg aaaaaggatc ttaagtgaat ttaccctcag tgagatgtta ccaatggcag
     2101 gtctgtctgg atgttataag catgctgatt agatcagtga tgtcccacag gggaggaata
     2161 taggttctcc acccagcccc accctatgct tctgaccagg ccaaggtggt agctgccaca
     2221 cctggctgac cttagaagaa tcccttttgg ctaggggcaa ctgtaggtgg ttatgaaatg
     2281 agaacaagct ggcagcagag gagagggacc tggcaggcaa aagcaaatag aaccccagcc
     2341 gtgggattcg taaggacaat ctactcaatg ctgcttcatg gaatggagcg gtgtggctgc
     2401 tttacatgtg cactggtttt caacatgagc ctttctgatg aaaaaacgtg cgaattatca
     2461 atccaaaagg tgatgtctgg gtgtttgtaa acatgttgcc atgtccaggt atcacaggct
     2521 tttcaatgga atgggtcctg atgcttccct tcgtgtgtct tgcagggctg gaggtgggac
     2581 ccaggagcct ggttgggcta gataagtgct ctaccactga tctacacccc agccctcact
     2641 gttctttatg ttattaaaat gttataatgt a
//
