LOCUS       NM_022993               3013 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus low-density lipoprotein receptor-related protein 10
            (Lrp10), mRNA.
ACCESSION   NM_022993
VERSION     NM_022993.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3013)
  AUTHORS   Kimura-Yoshida,C., Mochida,K., Ellwanger,K., Niehrs,C. and
            Matsuo,I.
  TITLE     Fate Specification of Neural Plate Border by Canonical Wnt
            Signaling and Grhl3 is Crucial for Neural Tube Closure
  JOURNAL   EBioMedicine 2 (6), 513-527 (2015)
   PUBMED   26288816
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3013)
  AUTHORS   Lu,C.C., Appler,J.M., Houseman,E.A. and Goodrich,L.V.
  TITLE     Developmental profiling of spiral ganglion neurons reveals insights
            into auditory circuit assembly
  JOURNAL   J Neurosci 31 (30), 10903-10918 (2011)
   PUBMED   21795542
REFERENCE   3  (bases 1 to 3013)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   4  (bases 1 to 3013)
  AUTHORS   Jeong,Y.H., Ishikawa,K., Someya,Y., Hosoda,A., Yoshimi,T.,
            Yokoyama,C., Kiryu-Seo,S., Kang,M.J., Tchibana,T., Kiyama,H.,
            Fukumura,T., Kim,D.H. and Saeki,S.
  TITLE     Molecular characterization and expression of the low-density
            lipoprotein receptor-related protein-10, a new member of the LDLR
            gene family
  JOURNAL   Biochem Biophys Res Commun 391 (1), 1110-1115 (2010)
   PUBMED   20005200
REFERENCE   5  (bases 1 to 3013)
  AUTHORS   Tkatchenko,T.V., Moreno-Rodriguez,R.A., Conway,S.J.,
            Molkentin,J.D., Markwald,R.R. and Tkatchenko,A.V.
  TITLE     Lack of periostin leads to suppression of Notch1 signaling and
            calcific aortic valve disease
  JOURNAL   Physiol Genomics 39 (3), 160-168 (2009)
   PUBMED   19723774
REFERENCE   6  (bases 1 to 3013)
  AUTHORS   Brodeur,J., Larkin,H., Boucher,R., Theriault,C., St-Louis,S.C.,
            Gagnon,H. and Lavoie,C.
  TITLE     Calnuc binds to LRP9 and affects its endosomal sorting
  JOURNAL   Traffic 10 (8), 1098-1114 (2009)
   PUBMED   19497050
  REMARK    GeneRIF: Data show that Calnuc is involved in LRP9 endosomal
            sorting to prevent the delivery of LRP9 to lysosomes.
REFERENCE   7  (bases 1 to 3013)
  AUTHORS   Boucher,R., Larkin,H., Brodeur,J., Gagnon,H., Theriault,C. and
            Lavoie,C.
  TITLE     Intracellular trafficking of LRP9 is dependent on two acidic
            cluster/dileucine motifs
  JOURNAL   Histochem Cell Biol 130 (2), 315-327 (2008)
   PUBMED   18461348
  REMARK    GeneRIF: These results suggest that LRP9 cycles between the
            trans-Golgi network, endosomes and the plasma membrane through a
            GGA dependent-trafficking mechanism.
REFERENCE   8  (bases 1 to 3013)
  AUTHORS   Sugiyama,T., Kumagai,H., Morikawa,Y., Wada,Y., Sugiyama,A.,
            Yasuda,K., Yokoi,N., Tamura,S., Kojima,T., Nosaka,T., Senba,E.,
            Kimura,S., Kadowaki,T., Kodama,T. and Kitamura,T.
  TITLE     A novel low-density lipoprotein receptor-related protein mediating
            cellular uptake of apolipoprotein E-enriched beta-VLDL in vitro
  JOURNAL   Biochemistry 39 (51), 15817-15825 (2000)
   PUBMED   11123907
REFERENCE   9  (bases 1 to 3013)
  AUTHORS   Wertz,K. and Herrmann,B.G.
  TITLE     Large-scale screen for genes involved in gonad development
  JOURNAL   Mech Dev 98 (1-2), 51-70 (2000)
   PUBMED   11044607
REFERENCE   10 (bases 1 to 3013)
  AUTHORS   Pons,S., Asano,T., Glasheen,E., Miralpeix,M., Zhang,Y.,
            Fisher,T.L., Myers,M.G. Jr., Sun,X.J. and White,M.F.
  TITLE     The structure and function of p55PIK reveal a new regulatory
            subunit for phosphatidylinositol 3-kinase
  JOURNAL   Mol Cell Biol 15 (8), 4453-4465 (1995)
   PUBMED   7542745
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CAAA01001439.1 and BC052378.1.
            
            On Feb 2, 2005 this sequence version replaced NM_022993.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK144035.1, BC052378.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                CAAA01001439.1     24246-24274         c
            30-3001             BC052378.1         6-2977
            3002-3013           CAAA01001439.1     18127-18138         c
FEATURES             Location/Qualifiers
     source          1..3013
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 27.8 cM"
     gene            1..3013
                     /gene="Lrp10"
                     /gene_synonym="Lrp9"
                     /note="low-density lipoprotein receptor-related protein
                     10"
                     /db_xref="GeneID:65107"
                     /db_xref="MGI:MGI:1929480"
     exon            1..465
                     /gene="Lrp10"
                     /gene_synonym="Lrp9"
                     /inference="alignment:Splign:2.1.0"
     CDS             429..2570
                     /gene="Lrp10"
                     /gene_synonym="Lrp9"
                     /note="LRP-10"
                     /codon_start=1
                     /product="low-density lipoprotein receptor-related protein
                     10 precursor"
                     /protein_id="NP_075369.2"
                     /db_xref="CCDS:CCDS27089.1"
                     /db_xref="GeneID:65107"
                     /db_xref="MGI:MGI:1929480"
                     /translation="MLSALPLLFLLLGGALARPDRITFPRSACEAPPAVLSEVQGTLQ
                     RPLGRDSRSSPANCTWVILGSKDQTVTVRFQKLHLACGSEHLILHSPLQPPISLCEAP
                     SGPLQLPGGNVTITYSYAGARAPMGQGFLLTYSQDWLLCLQEEFQCLNHRCIPAAQRC
                     DGIDACGDGSDEAGCSSDPFPNLNPAPAPTLACNLTLEDFYGVFSSPGYSHLASVSHP
                     QSCLWLLDPHDGRRLAVRFTALDLSYGDAVHVYDGAGPPETPRLLRSLTHFSNGKAVT
                     VETLSGQAVVSYHTVAWSSGRGFNATYHVRGYCLPWDRPCGLGSGLGASENLGERCYS
                     EAQRCDGSWDCADGTDEEGCPGCPPGHFPCGAAGTPGATACYLPADRCNYQTFCADGA
                     DERRCRHCQPGNFRCRDEKCVYETWVCDGQPDCTDGSDEWDCSYALPRKVITAAVIGS
                     LVCGLLLVIALGCTCKLYAIRTQEYSIFAPLSRMEAEIVQQQAPPSYGQLIAQGAIPP
                     VEDFPTENPNDNSVLGNLRSLLQILRQDMTPGGTSGGRRRQRGRSIRRLVRRLRRWGL
                     LPRTNTPARAPETRSQVTPSVPSEALDDSTGQACEGGAVGGQDGEQAPPLPIKTPIPT
                     PSTLPALATVSEPPGPLPSVPVESSLLSGVVQVLRGRLLPSLWSPGPTWTQTGTHTTV
                     LSPEDEDDVLLLPLAEPEVWVVEAEDEPLLA"
     exon            466..510
                     /gene="Lrp10"
                     /gene_synonym="Lrp9"
                     /inference="alignment:Splign:2.1.0"
     exon            511..646
                     /gene="Lrp10"
                     /gene_synonym="Lrp9"
                     /inference="alignment:Splign:2.1.0"
     exon            647..837
                     /gene="Lrp10"
                     /gene_synonym="Lrp9"
                     /inference="alignment:Splign:2.1.0"
     exon            838..1855
                     /gene="Lrp10"
                     /gene_synonym="Lrp9"
                     /inference="alignment:Splign:2.1.0"
     exon            1856..1985
                     /gene="Lrp10"
                     /gene_synonym="Lrp9"
                     /inference="alignment:Splign:2.1.0"
     exon            1986..3013
                     /gene="Lrp10"
                     /gene_synonym="Lrp9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2980..2985
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lrp10"
                     /gene_synonym="Lrp9"
                     /note="hexamer: AATAAA"
     regulatory      2991..2996
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lrp10"
                     /gene_synonym="Lrp9"
                     /note="hexamer: CATAAA"
     polyA_site      3001
                     /gene="Lrp10"
                     /gene_synonym="Lrp9"
                     /note="major polyA site"
     polyA_site      3013
                     /gene="Lrp10"
                     /gene_synonym="Lrp9"
ORIGIN      
        1 ggggccaagc tggccgcgcc cctcgtcgcc ggctgctggg cttcggccgg ggtccgctgg
       61 ggcaccgcga gctgtgcaaa gccgccgtcc cctaagggcc gcggggaccg agccgcacgc
      121 cggctcgggg acgggcagtc cacaaagttt ggtccgcgga ggacgcagcg tcgagcccgg
      181 caggtgcggc cgggcctggc cggggcgctc gcggccttcc gggcgagcac cgccgggcac
      241 tggtaaggag cgatcaactc tgaagttagc aagaggcgtc acgcctgttc ctctccgccg
      301 tgcgtccagc cctggcaccc cgagcctggg tcgcaccggg gctatgcagc ccccacccgg
      361 cgaggagctt cctgccaggt agacaagagg cgccccggga ccctgccggc acccctgttc
      421 aacccaggat gctatcggcc ctccctcttc ttttcctcct cctcggaggt gctctggccc
      481 gcccagaccg gatcactttc ccacgttctg cttgtgaggc gcccccagct gtgctctcag
      541 aagtacaagg cactttacag aggcctctag gccgggacag ccgaagctcc cctgccaact
      601 gcacctgggt tatcctgggc agcaaggatc agacagtaac tgtcaggttc cagaagctgc
      661 atctggcctg tggctcagag catttaatcc tgcactcccc tctacagcca ccaatctccc
      721 tgtgtgaggc cccttctggc cctttgcagc taccaggggg caatgtcacc attacataca
      781 gctatgctgg ggccagagca cccatgggcc agggcttctt gctgacttac agtcaagatt
      841 ggctactgtg cctgcaagaa gaattccagt gcctgaacca ccgctgcatt ccagctgctc
      901 agcgctgtga tgggattgat gcctgcgggg atggctcaga cgaggcaggc tgcagctcag
      961 atccattccc taacctgaac ccagcccccg caccaactct ggcctgcaat ctcaccttgg
     1021 aggactttta tggggtcttt tcttcccctg gatattcaca cctggcctca gtctcccacc
     1081 cccagtcctg cctgtggctg ctggaccccc atgatggccg gaggctggca gtgcgcttca
     1141 cagccctgga cttgagttac ggagatgcag tgcatgtgta tgatggtgct ggaccccccg
     1201 agacccctcg actgctacgt agcctcaccc acttcagcaa tggcaaggct gtcactgtgg
     1261 agaccctgtc tggtcaggct gttgtgtcct accacacagt tgcttggagc agtggccggg
     1321 gctttaatgc tacctaccat gtccggggct actgtttacc ttgggacaga ccctgtggct
     1381 tgggctctgg cctgggggct agtgagaacc taggtgagcg ttgctatagc gaggcacagc
     1441 gctgtgatgg ctcatgggac tgtgccgatg gcacagatga ggagggttgc cctggctgcc
     1501 caccagggca cttcccctgt ggagctgcag gcacccctgg tgccacagcc tgctacctgc
     1561 ctgctgaccg ctgcaactac cagacgttct gcgccgatgg agcggatgag aggcgctgcc
     1621 ggcattgcca gcccggcaac ttccggtgcc gggatgagaa gtgtgtgtat gagacatggg
     1681 tgtgtgatgg gcagccagac tgtactgacg gcagtgatga gtgggactgc tcctacgccc
     1741 tgccccgaaa agtcatcaca gcagcagtca ttggcagcct ggtgtgtggc ctgttgctgg
     1801 tcatcgctct cggctgcacc tgcaaactct atgccatccg cacccaggaa tacagcatct
     1861 ttgccccgct ctcccggatg gaggctgaga ttgtgcagca acaggcaccc ccttcctatg
     1921 ggcagctcat tgcccagggt gccatcccgc ctgtggaaga cttccccaca gagaacccta
     1981 acgataactc tgtgctggga aacctacgtt ctctgcttca gatcttacgc caggatatga
     2041 ctccaggtgg tacttcaggg ggccgccgtc gccagcgtgg acgctccatc cgccgtctgg
     2101 ttcgccgtct ccgtcgttgg ggcctgcttc ctcgaactaa taccccagct cgggcccctg
     2161 agaccagatc ccaggtcaca ccctctgttc cctctgaggc cctggatgac agcacaggcc
     2221 aagcctgtga gggtggggca gtaggggggc aagatgggga gcaggctcct ccactgccca
     2281 tcaagacccc catcccaacc ccaagcacac ttcctgccct tgctactgtc tctgagcccc
     2341 cagggccact accctcagtg cctgtagaat catcactgtt gtctggagtt gtccaggtcc
     2401 tacgaggccg cctcctaccc agcctgtggt ccccaggccc cacttggacc caaactggaa
     2461 ctcacacaac agtcctgtcc ccagaggatg aggacgatgt attgttattg ccactggctg
     2521 agccagaagt ctgggtggtg gaggcagagg atgaaccatt gcttgcctga gggactctag
     2581 gcacaatggt atgatccttg gaagtggttc agcttcccca ctgatctatg tagcacagaa
     2641 agttagtgtc tctccagcag ggagagcatt cactgtacac accttctggt atgacaagag
     2701 acttcaccac caccctctgc ccagcctgct atccaggtgg ctgtgttaca aaaggtccca
     2761 caagggtcac aggcttggac actccgttct ttccagctcc ccacccaaaa gtggccttaa
     2821 ctactagact ggttggctgg agacctagcc accaagggga ggatttggcc agggtgatgg
     2881 ttttgccagc ctccatccct gtggtgcctg gcccacttag aggacacaag tgcttttgcc
     2941 ctgtagctgc atcattgtcc aggaaatcaa gatgacaaaa ataaaggaat cataaacttc
     3001 agcccttggt aaa
//
