LOCUS       NP_075369                713 aa            linear   ROD 04-JUN-2024
DEFINITION  low-density lipoprotein receptor-related protein 10 precursor [Mus
            musculus].
ACCESSION   NP_075369
VERSION     NP_075369.2
DBSOURCE    REFSEQ: accession NM_022993.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 713)
  AUTHORS   Kimura-Yoshida,C., Mochida,K., Ellwanger,K., Niehrs,C. and
            Matsuo,I.
  TITLE     Fate Specification of Neural Plate Border by Canonical Wnt
            Signaling and Grhl3 is Crucial for Neural Tube Closure
  JOURNAL   EBioMedicine 2 (6), 513-527 (2015)
   PUBMED   26288816
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 713)
  AUTHORS   Lu,C.C., Appler,J.M., Houseman,E.A. and Goodrich,L.V.
  TITLE     Developmental profiling of spiral ganglion neurons reveals insights
            into auditory circuit assembly
  JOURNAL   J Neurosci 31 (30), 10903-10918 (2011)
   PUBMED   21795542
REFERENCE   3  (residues 1 to 713)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   4  (residues 1 to 713)
  AUTHORS   Jeong,Y.H., Ishikawa,K., Someya,Y., Hosoda,A., Yoshimi,T.,
            Yokoyama,C., Kiryu-Seo,S., Kang,M.J., Tchibana,T., Kiyama,H.,
            Fukumura,T., Kim,D.H. and Saeki,S.
  TITLE     Molecular characterization and expression of the low-density
            lipoprotein receptor-related protein-10, a new member of the LDLR
            gene family
  JOURNAL   Biochem Biophys Res Commun 391 (1), 1110-1115 (2010)
   PUBMED   20005200
REFERENCE   5  (residues 1 to 713)
  AUTHORS   Tkatchenko,T.V., Moreno-Rodriguez,R.A., Conway,S.J.,
            Molkentin,J.D., Markwald,R.R. and Tkatchenko,A.V.
  TITLE     Lack of periostin leads to suppression of Notch1 signaling and
            calcific aortic valve disease
  JOURNAL   Physiol Genomics 39 (3), 160-168 (2009)
   PUBMED   19723774
REFERENCE   6  (residues 1 to 713)
  AUTHORS   Brodeur,J., Larkin,H., Boucher,R., Theriault,C., St-Louis,S.C.,
            Gagnon,H. and Lavoie,C.
  TITLE     Calnuc binds to LRP9 and affects its endosomal sorting
  JOURNAL   Traffic 10 (8), 1098-1114 (2009)
   PUBMED   19497050
  REMARK    GeneRIF: Data show that Calnuc is involved in LRP9 endosomal
            sorting to prevent the delivery of LRP9 to lysosomes.
REFERENCE   7  (residues 1 to 713)
  AUTHORS   Boucher,R., Larkin,H., Brodeur,J., Gagnon,H., Theriault,C. and
            Lavoie,C.
  TITLE     Intracellular trafficking of LRP9 is dependent on two acidic
            cluster/dileucine motifs
  JOURNAL   Histochem Cell Biol 130 (2), 315-327 (2008)
   PUBMED   18461348
  REMARK    GeneRIF: These results suggest that LRP9 cycles between the
            trans-Golgi network, endosomes and the plasma membrane through a
            GGA dependent-trafficking mechanism.
REFERENCE   8  (residues 1 to 713)
  AUTHORS   Sugiyama,T., Kumagai,H., Morikawa,Y., Wada,Y., Sugiyama,A.,
            Yasuda,K., Yokoi,N., Tamura,S., Kojima,T., Nosaka,T., Senba,E.,
            Kimura,S., Kadowaki,T., Kodama,T. and Kitamura,T.
  TITLE     A novel low-density lipoprotein receptor-related protein mediating
            cellular uptake of apolipoprotein E-enriched beta-VLDL in vitro
  JOURNAL   Biochemistry 39 (51), 15817-15825 (2000)
   PUBMED   11123907
REFERENCE   9  (residues 1 to 713)
  AUTHORS   Wertz,K. and Herrmann,B.G.
  TITLE     Large-scale screen for genes involved in gonad development
  JOURNAL   Mech Dev 98 (1-2), 51-70 (2000)
   PUBMED   11044607
REFERENCE   10 (residues 1 to 713)
  AUTHORS   Pons,S., Asano,T., Glasheen,E., Miralpeix,M., Zhang,Y.,
            Fisher,T.L., Myers,M.G. Jr., Sun,X.J. and White,M.F.
  TITLE     The structure and function of p55PIK reveal a new regulatory
            subunit for phosphatidylinositol 3-kinase
  JOURNAL   Mol Cell Biol 15 (8), 4453-4465 (1995)
   PUBMED   7542745
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CAAA01001439.1 and BC052378.1.
            
            On Jun 19, 2003 this sequence version replaced NP_075369.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK144035.1, BC052378.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..713
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 27.8 cM"
     Protein         1..713
                     /product="low-density lipoprotein receptor-related protein
                     10 precursor"
                     /note="LRP-10"
                     /calculated_mol_wt=74767
     sig_peptide     1..17
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=1713
     mat_peptide     18..713
                     /product="low-density lipoprotein receptor-related protein
                     10"
                     /calculated_mol_wt=74767
     Region          35..135
                     /region_name="CUB"
                     /note="CUB domain; extracellular domain; present in
                     proteins mostly known to be involved in development; not
                     found in prokaryotes, plants and yeast; cd00041"
                     /db_xref="CDD:238001"
     Site            order(40,42,44,71,76,105,131,133,135)
                     /site_type="other"
                     /note="heterodimerization interface [polypeptide binding]"
                     /db_xref="CDD:238001"
     Site            57
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q7TQH7.2)"
     Site            112
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q7TQH7.2)"
     Region          141..175
                     /region_name="LDLa"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; cd00112"
                     /db_xref="CDD:238060"
     Site            order(146,154,165..166)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(158,161,165,171..172)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            168..172
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Region          193..303
                     /region_name="CUB"
                     /note="CUB domain; extracellular domain; present in
                     proteins mostly known to be involved in development; not
                     found in prokaryotes, plants and yeast; cd00041"
                     /db_xref="CDD:238001"
     Site            194
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q7TQH7.2)"
     Site            order(201,203,205,234,239,276,300,302)
                     /site_type="other"
                     /note="heterodimerization interface [polypeptide binding]"
                     /db_xref="CDD:238001"
     Site            300
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q7TQH7.2)"
     Region          <331..354
                     /region_name="LDLa"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; cd00112"
                     /db_xref="CDD:238060"
     Site            order(337,340,344,350..351)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            347..351
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Region          400..434
                     /region_name="LDLa"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; cd00112"
                     /db_xref="CDD:238060"
     Site            order(405,413,424..425)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(417,420,424,430..431)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            427..431
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Site            442..462
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TQH7.2)"
     Region          566..636
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TQH7.2)"
     Site            596
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q7Z4F1; propagated from
                     UniProtKB/Swiss-Prot (Q7TQH7.2)"
     CDS             1..713
                     /gene="Lrp10"
                     /gene_synonym="Lrp9"
                     /coded_by="NM_022993.3:429..2570"
                     /db_xref="CCDS:CCDS27089.1"
                     /db_xref="GeneID:65107"
                     /db_xref="MGI:MGI:1929480"
ORIGIN      
        1 mlsalpllfl llggalarpd ritfprsace appavlsevq gtlqrplgrd srsspanctw
       61 vilgskdqtv tvrfqklhla cgsehlilhs plqppislce apsgplqlpg gnvtitysya
      121 garapmgqgf lltysqdwll clqeefqcln hrcipaaqrc dgidacgdgs deagcssdpf
      181 pnlnpapapt lacnltledf ygvfsspgys hlasvshpqs clwlldphdg rrlavrftal
      241 dlsygdavhv ydgagppetp rllrslthfs ngkavtvetl sgqavvsyht vawssgrgfn
      301 atyhvrgycl pwdrpcglgs glgasenlge rcyseaqrcd gswdcadgtd eegcpgcppg
      361 hfpcgaagtp gatacylpad rcnyqtfcad gaderrcrhc qpgnfrcrde kcvyetwvcd
      421 gqpdctdgsd ewdcsyalpr kvitaavigs lvcglllvia lgctcklyai rtqeysifap
      481 lsrmeaeivq qqappsygql iaqgaippve dfptenpndn svlgnlrsll qilrqdmtpg
      541 gtsggrrrqr grsirrlvrr lrrwgllprt ntparapetr sqvtpsvpse alddstgqac
      601 eggavggqdg eqapplpikt piptpstlpa latvseppgp lpsvpvessl lsgvvqvlrg
      661 rllpslwspg ptwtqtgtht tvlspededd vlllplaepe vwvveaedep lla
//
