LOCUS       NM_008512              14907 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus low density lipoprotein receptor-related protein 1
            (Lrp1), mRNA.
ACCESSION   NM_008512
VERSION     NM_008512.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 14907)
  AUTHORS   Chandrashekar,D.V., Roules,G.C., Jagadeesan,N., Panchal,U.R.,
            Oyegbesan,A., Imiruaye,O.E., Zhang,H., Garcia,J., Kaur,K., Win,S.,
            Than,T.A., Kaplowitz,N., Roosan,M.R., Han,D. and Sumbria,R.K.
  TITLE     Hepatic LRP-1 plays an important role in amyloidosis in Alzheimer's
            disease mice: Potential role in chronic heavy alcohol feeding
  JOURNAL   Neurobiol Dis 199, 106570 (2024)
   PUBMED   38885850
  REMARK    GeneRIF: Hepatic LRP-1 plays an important role in amyloidosis in
            Alzheimer's disease mice: Potential role in chronic heavy alcohol
            feeding.
REFERENCE   2  (bases 1 to 14907)
  AUTHORS   Yamamoto,K., Scilabra,S.D., Bonelli,S., Jensen,A., Scavenius,C.,
            Enghild,J.J. and Strickland,D.K.
  TITLE     Novel insights into the multifaceted and tissue-specific roles of
            the endocytic receptor LRP1
  JOURNAL   J Biol Chem 300 (8), 107521 (2024)
   PUBMED   38950861
  REMARK    GeneRIF: Novel insights into the multifaceted and tissue-specific
            roles of the endocytic receptor LRP1.
            Review article
REFERENCE   3  (bases 1 to 14907)
  AUTHORS   Lin,H., Fu,L., Zhou,X., Yu,A., Chen,Y., Liao,W., Shu,G., Zhang,L.,
            Tan,L., Liang,H., Wang,Z., Deng,Q., Wang,J., Jin,M., Chen,Z.,
            Wei,J., Cao,J., Chen,W., Li,X., Li,P., Lu,J. and Luo,J.
  TITLE     LRP1 induces anti-PD-1 resistance by modulating the
            DLL4-NOTCH2-CCL2 axis and redirecting M2-like macrophage
            polarisation in bladder cancer
  JOURNAL   Cancer Lett 593, 216807 (2024)
   PUBMED   38462037
  REMARK    GeneRIF: LRP1 induces anti-PD-1 resistance by modulating the
            DLL4-NOTCH2-CCL2 axis and redirecting M2-like macrophage
            polarisation in bladder cancer.
REFERENCE   4  (bases 1 to 14907)
  AUTHORS   da Cruz Rodrigues,K.C., Kim,S.C., Uner,A.A., Hou,Z.S., Young,J.,
            Campolim,C., Aydogan,A., Chung,B., Choi,A., Yang,W.M., Kim,W.S.,
            Prevot,V., Caldarone,B.J., Lee,H. and Kim,Y.B.
  TITLE     LRP1 in GABAergic neurons is a key link between obesity and memory
            function
  JOURNAL   Mol Metab 84, 101941 (2024)
   PUBMED   38636794
  REMARK    GeneRIF: LRP1 in GABAergic neurons is a key link between obesity
            and memory function.
REFERENCE   5  (bases 1 to 14907)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   6  (bases 1 to 14907)
  AUTHORS   Herz,J., Clouthier,D.E. and Hammer,R.E.
  TITLE     LDL receptor-related protein internalizes and degrades uPA-PAI-1
            complexes and is essential for embryo implantation
  JOURNAL   Cell 71 (3), 411-421 (1992)
   PUBMED   1423604
  REMARK    Erratum:[Cell. 1993 May 7;73(3):428. doi:
            10.1016/0092-8674(93)90130-i.. PMID: 8490961]
REFERENCE   7  (bases 1 to 14907)
  AUTHORS   Hilliker,C., Van Leuven,F. and Van den Berghe,H.
  TITLE     Assignment of the gene coding for the alpha 2-macroglobulin
            receptor to mouse chromosome 15 and to human chromosome 12q13-q14
            by isotopic and nonisotopic in situ hybridization
  JOURNAL   Genomics 13 (2), 472-474 (1992)
   PUBMED   1377168
REFERENCE   8  (bases 1 to 14907)
  AUTHORS   Kristensen,T., Moestrup,S.K., Gliemann,J., Bendtsen,L., Sand,O. and
            Sottrup-Jensen,L.
  TITLE     Evidence that the newly cloned low-density-lipoprotein receptor
            related protein (LRP) is the alpha 2-macroglobulin receptor
  JOURNAL   FEBS Lett 276 (1-2), 151-155 (1990)
   PUBMED   1702392
REFERENCE   9  (bases 1 to 14907)
  AUTHORS   Strickland,D.K., Ashcom,J.D., Williams,S., Burgess,W.H.,
            Migliorini,M. and Argraves,W.S.
  TITLE     Sequence identity between the alpha 2-macroglobulin receptor and
            low density lipoprotein receptor-related protein suggests that this
            molecule is a multifunctional receptor
  JOURNAL   J Biol Chem 265 (29), 17401-17404 (1990)
   PUBMED   1698775
REFERENCE   10 (bases 1 to 14907)
  AUTHORS   Herz,J., Hamann,U., Rogne,S., Myklebost,O., Gausepohl,H. and
            Stanley,K.K.
  TITLE     Surface location and high affinity for calcium of a 500-kd liver
            membrane protein closely related to the LDL-receptor suggest a
            physiological role as lipoprotein receptor
  JOURNAL   EMBO J 7 (13), 4119-4127 (1988)
   PUBMED   3266596
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK078273.1, AF367720.1, AK154429.1, X67469.1, AC167719.2,
            CA888999.1, CF535491.1, BU615020.1 and CB527265.1.
            
            On Feb 6, 2007 this sequence version replaced NM_008512.1.
            
            Sequence Note: Although this RefSeq record was created from
            transcript sequence data from multiple strains, its existence in a
            single strain is supported by transcript data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF367720.1, X67469.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2841              AK078273.1         2-2842
            2842-3535           AF367720.1         2813-3506
            3536-7439           AK154429.1         470-4373
            7440-7879           X67469.1           7420-7859
            7880-7881           AC167719.2         176562-176563       c
            7882-8191           X67469.1           7862-8171
            8192-8258           AC167719.2         175128-175194       c
            8259-8384           AF367720.1         8230-8355
            8385-8389           AC167719.2         174137-174141       c
            8390-8942           CA888999.1         1-553
            8943-10012          AF367720.1         8914-9983
            10013-10771         CF535491.1         14-772
            10772-12394         AF367720.1         10743-12365
            12395-12833         X67469.1           12375-12813
            12834-13564         BU615020.1         33-763
            13565-13786         AF367720.1         13536-13757
            13787-14392         X67469.1           13767-14372
            14393-14861         AF367720.1         14364-14832
            14862-14907         CB527265.1         166-211
FEATURES             Location/Qualifiers
     source          1..14907
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 74.52 cM"
     gene            1..14907
                     /gene="Lrp1"
                     /gene_synonym="A2mr; b2b1554Clo; CD91; Lrp"
                     /note="low density lipoprotein receptor-related protein 1"
                     /db_xref="GeneID:16971"
                     /db_xref="MGI:MGI:96828"
     exon            1..531
                     /gene="Lrp1"
                     /gene_synonym="A2mr; b2b1554Clo; CD91; Lrp"
                     /inference="alignment:Splign:2.1.0"
     CDS             462..14099
                     /gene="Lrp1"
                     /gene_synonym="A2mr; b2b1554Clo; CD91; Lrp"
                     /note="prolow-density lipoprotein receptor-related protein
                     1; alpha 2-macroglobulin receptor; LRP-1"
                     /codon_start=1
                     /product="prolow-density lipoprotein receptor-related
                     protein 1 precursor"
                     /protein_id="NP_032538.2"
                     /db_xref="CCDS:CCDS24245.1"
                     /db_xref="GeneID:16971"
                     /db_xref="MGI:MGI:96828"
                     /translation="MLTPPLLLLLPLLSALVSGATMDAPKTCSPKQFACRDQITCISK
                     GWRCDGERDCPDGSDEAPEICPQSKAQRCPPNEHSCLGTELCVPMSRLCNGIQDCMDG
                     SDEGAHCRELRANCSRMGCQHHCVPTPSGPTCYCNSSFQLQADGKTCKDFDECSVYGT
                     CSQLCTNTDGSFTCGCVEGYLLQPDNRSCKAKNEPVDRPPVLLIANSQNILATYLSGA
                     QVSTITPTSTRQTTAMDFSYANETVCWVHVGDSAAQTQLKCARMPGLKGFVDEHTINI
                     SLSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDLELYNPKGIALDPA
                     MGKVFFTDYGQIPKVERCDMDGQNRTKLVDSKIVFPHGITLDLVSRLVYWADAYLDYI
                     EVVDYEGKGRQTIIQGILIEHLYGLTVFENYLYATNSDNANTQQKTSVIRVNRFNSTE
                     YQVVTRVDKGGALHIYHQRRQPRVRSHACENDQYGKPGGCSDICLLANSHKARTCRCR
                     SGFSLGSDGKSCKKPEHELFLVYGKGRPGIIRGMDMGAKVPDEHMIPIENLMNPRALD
                     FHAETGFIYFADTTSYLIGRQKIDGTERETILKDGIHNVEGVAVDWMGDNLYWTDDGP
                     KKTISVARLEKAAQTRKTLIEGKMTHPRAIVVDPLNGWMYWTDWEEDPKDSRRGRLER
                     AWMDGSHRDIFVTSKTVLWPNGLSLDIPAGRLYWVDAFYDRIETILLNGTDRKIVYEG
                     PELNHAFGLCHHGNYLFWTEYRSGSVYRLERGVAGAPPTVTLLRSERPPIFEIRMYDA
                     QQQQVGTNKCRVNNGGCSSLCLATPGSRQCACAEDQVLDTDGVTCLANPSYVPPPQCQ
                     PGEFACANNRCIQERWKCDGDNDCLDNSDEAPALCHQHTCPSDRFKCENNRCIPNRWL
                     CDGDNDCGNSEDESNATCSARTCPPNQFSCASGRCIPISWTCDLDDDCGDRSDESASC
                     AYPTCFPLTQFTCNNGRCININWRCDNDNDCGDNSDEAGCSHSCSSTQFKCNSGRCIP
                     EHWTCDGDNDCGDYSDETHANCTNQATRPPGGCHSDEFQCRLDGLCIPLRWRCDGDTD
                     CMDSSDEKSCEGVTHVCDPNVKFGCKDSARCISKAWVCDGDSDCEDNSDEENCEALAC
                     RPPSHPCANNTSVCLPPDKLCDGKDDCGDGSDEGELCDQCSLNNGGCSHNCSVAPGEG
                     IVCSCPLGMELGSDNHTCQIQSYCAKHLKCSQKCDQNKFSVKCSCYEGWVLEPDGESC
                     RSLDPFKPFIIFSNRHEIRRIDLHKGDYSVLVPGLRNTIALDFHLSQSALYWTDVVED
                     KIYRGKLLDNGALTSFEVVIQYGLATPEGLAVDWIAGNIYWVESNLDQIEVAKLDGTL
                     RTTLLAGDIEHPRAIALDPRDGILFWTDWDASLPRIEAASMSGAGRRTIHRETGSGGW
                     PNGLTVDYLEKRILWIDARSDAIYSARYDGSGHMEVLRGHEFLSHPFAVTLYGGEVYW
                     TDWRTNTLAKANKWTGHNVTVVQRTNTQPFDLQVYHPSRQPMAPNPCEANGGRGPCSH
                     LCLINYNRTVSCACPHLMKLHKDNTTCYEFKKFLLYARQMEIRGVDLDAPYYNYIISF
                     TVPDIDNVTVLDYDAREQRVYWSDVRTQAIKRAFINGTGVETVVSADLPNAHGLAVDW
                     VSRNLFWTSYDTNKKQINVARLDGSFKNAVVQGLEQPHGLVVHPLRGKLYWTDGDNIS
                     MANMDGSNHTLLFSGQKGPVGLAIDFPESKLYWISSGNHTINRCNLDGSELEVIDTMR
                     SQLGKATALAIMGDKLWWADQVSEKMGTCNKADGSGSVVLRNSTTLVMHMKVYDESIQ
                     LEHEGTNPCSVNNGDCSQLCLPTSETTRSCMCTAGYSLRSGQQACEGVGSFLLYSVHE
                     GIRGIPLDPNDKSDALVPVSGTSLAVGIDFHAENDTIYWVDMGLSTISRAKRDQTWRE
                     DVVTNGIGRVEGIAVDWIAGNIYWTDQGFDVIEVARLNGSFRYVVISQGLDKPRAITV
                     HPEKGYLFWTEWGHYPRIERSRLDGTERVVLVNVSISWPNGISVDYQGGKLYWCDARM
                     DKIERIDLETGENREVVLSSNNMDMFSVSVFEDFIYWSDRTHANGSIKRGCKDNATDS
                     VPLRTGIGVQLKDIKVFNRDRQKGTNVCAVANGGCQQLCLYRGGGQRACACAHGMLAE
                     DGASCREYAGYLLYSERTILKSIHLSDERNLNAPVQPFEDPEHMKNVIALAFDYRAGT
                     SPGTPNRIFFSDIHFGNIQQINDDGSGRTTIVENVGSVEGLAYHRGWDTLYWTSYTTS
                     TITRHTVDQTRPGAFERETVITMSGDDHPRAFVLDECQNLMFWTNWNELHPSIMRAAL
                     SGANVLTLIEKDIRTPNGLAIDHRAEKLYFSDATLDKIERCEYDGSHRYVILKSEPVH
                     PFGLAVYGEHIFWTDWVRRAVQRANKYVGSDMKLLRVDIPQQPMGIIAVANDTNSCEL
                     SPCRINNGGCQDLCLLTHQGHVNCSCRGGRILQEDFTCRAVNSSCRAQDEFECANGEC
                     ISFSLTCDGVSHCKDKSDEKPSYCNSRRCKKTFRQCNNGRCVSNMLWCNGVDDCGDGS
                     DEIPCNKTACGVGEFRCRDGSCIGNSSRCNQFVDCEDASDEMNCSTTDCSSYFRLGVK
                     GVLFQPCERTSLCYAPSWVCDGANDCGDYSDERDCPGVKRPRCPLNYFACPSGRCIPM
                     SWTCDKEDDCENGEDETHCNKFCSEAQFECQNHRCISKQWLCDGSDDCGDGSDEAAHC
                     EGKTCGPSSFSCPGTHVCVPERWLCDGDKDCTDGADESVTAGCLYNSTCDDREFMCQN
                     RLCIPKHFVCDHDRDCADGSDESPECEYPTCGPNEFRCANGRCLSSRQWECDGENDCH
                     DHSDEAPKNPHCTSPEHKCNASSQFLCSSGRCVAEALLCNGQDDCGDGSDERGCHVNE
                     CLSRKLSGCSQDCEDLKIGFKCRCRPGFRLKDDGRTCADLDECSTTFPCSQLCINTHG
                     SYKCLCVEGYAPRGGDPHSCKAVTDEEPFLIFANRYYLRKLNLDGSNYTLLKQGLNNA
                     VALDFDYREQMIYWTDVTTQGSMIRRMHLNGSNVQVLHRTGLSNPDGLAVDWVGGNLY
                     WCDKGRDTIEVSKLNGAYRTVLVSSGLREPRALVVDVQNGYLYWTDWGDHSLIGRIGM
                     DGSGRSIIVDTKITWPNGLTVDYVTERIYWADAREDYIEFASLDGSNRHVVLSQDIPH
                     IFALTLFEDYVYWTDWETKSINRAHKTTGANKTLLISTLHRPMDLHVFHALRQPDVPN
                     HPCKVNNGGCSNLCLLSPGGGHKCACPTNFYLGGDGRTCVSNCTASQFVCKNDKCIPF
                     WWKCDTEDDCGDHSDEPPDCPEFKCRPGQFQCSTGICTNPAFICDGDNDCQDNSDEAN
                     CDIHVCLPSQFKCTNTNRCIPGIFRCNGQDNCGDGEDERDCPEVTCAPNQFQCSITKR
                     CIPRVWVCDRDNDCVDGSDEPANCTQMTCGVDEFRCKDSGRCIPARWKCDGEDDCGDG
                     SDEPKEECDERTCEPYQFRCKNNRCVPGRWQCDYDNDCGDNSDEESCTPRPCSESEFS
                     CANGRCIAGRWKCDGDHDCADGSDEKDCTPRCDMDQFQCKSGHCIPLRWRCDADADCM
                     DGSDEEACGTGVRTCPLDEFQCNNTLCKPLAWKCDGEDDCGDNSDENPEECARFICPP
                     NRPFRCKNDRVCLWIGRQCDGVDNCGDGTDEEDCEPPTAQNPHCKDKKEFLCRNQRCL
                     SSSLRCNMFDDCGDGSDEEDCSIDPKLTSCATNASMCGDEARCVRTEKAAYCACRSGF
                     HTVPGQPGCQDINECLRFGTCSQLCNNTKGGHLCSCARNFMKTHNTCKAEGSEYQVLY
                     IADDNEIRSLFPGHPHSAYEQTFQGDESVRIDAMDVHVKAGRVYWTNWHTGTISYRSL
                     PPAAPPTTSNRHRRQIDRGVTHLNISGLKMPRGIAIDWVAGNVYWTDSGRDVIEVAQM
                     KGENRKTLISGMIDEPHAIVVDPLRGTMYWSDWGNHPKIETAAMDGTLRETLVQDNIQ
                     WPTGLAVDYHNERLYWADAKLSVIGSIRLNGTDPIVAADSKRGLSHPFSIDVFEDYIY
                     GVTYINNRVFKIHKFGHSPLINLTGGLSHASDVVLYHQHKQPEVTNPCDRKKCEWLCL
                     LSPSGPVCTCPNGKRLDNGTCVPVPSPTPPPDAPRPGTCTLQCFNGGSCFLNARRQPK
                     CRCQPRYTGDKCELDQCWEYCHNGGTCAASPSGMPTCRCPTGFTGPKCTAQVCAGYCS
                     NNSTCTVNQGNQPQCRCLPGFLGDRCQYRQCSGFCENFGTCQMAADGSRQCRCTVYFE
                     GPRCEVNKCSRCLQGACVVNKQTGDVTCNCTDGRVAPSCLTCIDHCSNGGSCTMNSKM
                     MPECQCPPHMTGPRCEEQVVSQQQPGHMASILIPLLLLLLLLLVAGVVFWYKRRVRGA
                     KGFQHQRMTNGAMNVEIGNPTYKMYEGGEPDDVGGLLDADFALDPDKPTNFTNPVYAT
                     LYMGGHGSRHSLASTDEKRELLGRGPEDEIGDPLA"
     exon            532..654
                     /gene="Lrp1"
                     /gene_synonym="A2mr; b2b1554Clo; CD91; Lrp"
                     /inference="alignment:Splign:2.1.0"
     exon            655..792
                     /gene="Lrp1"
                     /gene_synonym="A2mr; b2b1554Clo; CD91; Lrp"
                     /inference="alignment:Splign:2.1.0"
     exon            793..912
                     /gene="Lrp1"
                     /gene_synonym="A2mr; b2b1554Clo; CD91; Lrp"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1041
                     /gene="Lrp1"
                     /gene_synonym="A2mr; b2b1554Clo; CD91; Lrp"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1305
                     /gene="Lrp1"
                     /gene_synonym="A2mr; b2b1554Clo; CD91; Lrp"
                     /inference="alignment:Splign:2.1.0"
     exon            1306..1468
                     /gene="Lrp1"
                     /gene_synonym="A2mr; b2b1554Clo; CD91; Lrp"
                     /inference="alignment:Splign:2.1.0"
     exon            1469..1691
                     /gene="Lrp1"
                     /gene_synonym="A2mr; b2b1554Clo; CD91; Lrp"
                     /inference="alignment:Splign:2.1.0"
     exon            1692..1881
                     /gene="Lrp1"
                     /gene_synonym="A2mr; b2b1554Clo; CD91; Lrp"
                     /inference="alignment:Splign:2.1.0"
     exon            1882..2025
                     /gene="Lrp1"
                     /gene_synonym="A2mr; b2b1554Clo; CD91; Lrp"
                     /inference="alignment:Splign:2.1.0"
     exon            2026..2262
                     /gene="Lrp1"
                     /gene_synonym="A2mr; b2b1554Clo; CD91; Lrp"
                     /inference="alignment:Splign:2.1.0"
     exon            2263..2443
                     /gene="Lrp1"
                     /gene_synonym="A2mr; b2b1554Clo; CD91; Lrp"
                     /inference="alignment:Splign:2.1.0"
     exon            2444..2666
                     /gene="Lrp1"
                     /gene_synonym="A2mr; b2b1554Clo; CD91; Lrp"
                     /inference="alignment:Splign:2.1.0"
     exon            2667..2868
                     /gene="Lrp1"
                     /gene_synonym="A2mr; b2b1554Clo; CD91; Lrp"
                     /inference="alignment:Splign:2.1.0"
     exon            2869..2994
                     /gene="Lrp1"
                     /gene_synonym="A2mr; b2b1554Clo; CD91; Lrp"
                     /inference="alignment:Splign:2.1.0"
     exon            2995..3135
                     /gene="Lrp1"
                     /gene_synonym="A2mr; b2b1554Clo; CD91; Lrp"
                     /inference="alignment:Splign:2.1.0"
     exon            3136..3261
                     /gene="Lrp1"
                     /gene_synonym="A2mr; b2b1554Clo; CD91; Lrp"
                     /inference="alignment:Splign:2.1.0"
     exon            3262..3378
                     /gene="Lrp1"
                     /gene_synonym="A2mr; b2b1554Clo; CD91; Lrp"
                     /inference="alignment:Splign:2.1.0"
     exon            3379..3459
                     /gene="Lrp1"
                     /gene_synonym="A2mr; b2b1554Clo; CD91; Lrp"
                     /inference="alignment:Splign:2.1.0"
     exon            3460..3627
                     /gene="Lrp1"
                     /gene_synonym="A2mr; b2b1554Clo; CD91; Lrp"
                     /inference="alignment:Splign:2.1.0"
     exon            3628..3810
                     /gene="Lrp1"
                     /gene_synonym="A2mr; b2b1554Clo; CD91; Lrp"
                     /inference="alignment:Splign:2.1.0"
     exon            3811..4011
                     /gene="Lrp1"
                     /gene_synonym="A2mr; b2b1554Clo; CD91; Lrp"
                     /inference="alignment:Splign:2.1.0"
     exon            4012..4257
                     /gene="Lrp1"
                     /gene_synonym="A2mr; b2b1554Clo; CD91; Lrp"
                     /inference="alignment:Splign:2.1.0"
     exon            4258..4455
                     /gene="Lrp1"
                     /gene_synonym="A2mr; b2b1554Clo; CD91; Lrp"
                     /inference="alignment:Splign:2.1.0"
     exon            4456..4660
                     /gene="Lrp1"
                     /gene_synonym="A2mr; b2b1554Clo; CD91; Lrp"
                     /inference="alignment:Splign:2.1.0"
     exon            4661..4825
                     /gene="Lrp1"
                     /gene_synonym="A2mr; b2b1554Clo; CD91; Lrp"
                     /inference="alignment:Splign:2.1.0"
     exon            4826..5070
                     /gene="Lrp1"
                     /gene_synonym="A2mr; b2b1554Clo; CD91; Lrp"
                     /inference="alignment:Splign:2.1.0"
     exon            5071..5202
                     /gene="Lrp1"
                     /gene_synonym="A2mr; b2b1554Clo; CD91; Lrp"
                     /inference="alignment:Splign:2.1.0"
     exon            5203..5430
                     /gene="Lrp1"
                     /gene_synonym="A2mr; b2b1554Clo; CD91; Lrp"
                     /inference="alignment:Splign:2.1.0"
     exon            5431..5605
                     /gene="Lrp1"
                     /gene_synonym="A2mr; b2b1554Clo; CD91; Lrp"
                     /inference="alignment:Splign:2.1.0"
     exon            5606..5700
                     /gene="Lrp1"
                     /gene_synonym="A2mr; b2b1554Clo; CD91; Lrp"
                     /inference="alignment:Splign:2.1.0"
     exon            5701..5850
                     /gene="Lrp1"
                     /gene_synonym="A2mr; b2b1554Clo; CD91; Lrp"
                     /inference="alignment:Splign:2.1.0"
     exon            5851..5991
                     /gene="Lrp1"
                     /gene_synonym="A2mr; b2b1554Clo; CD91; Lrp"
                     /inference="alignment:Splign:2.1.0"
     exon            5992..6126
                     /gene="Lrp1"
                     /gene_synonym="A2mr; b2b1554Clo; CD91; Lrp"
                     /inference="alignment:Splign:2.1.0"
     exon            6127..6258
                     /gene="Lrp1"
                     /gene_synonym="A2mr; b2b1554Clo; CD91; Lrp"
                     /inference="alignment:Splign:2.1.0"
     exon            6259..6393
                     /gene="Lrp1"
                     /gene_synonym="A2mr; b2b1554Clo; CD91; Lrp"
                     /inference="alignment:Splign:2.1.0"
     exon            6394..6523
                     /gene="Lrp1"
                     /gene_synonym="A2mr; b2b1554Clo; CD91; Lrp"
                     /inference="alignment:Splign:2.1.0"
     exon            6524..6650
                     /gene="Lrp1"
                     /gene_synonym="A2mr; b2b1554Clo; CD91; Lrp"
                     /inference="alignment:Splign:2.1.0"
     exon            6651..6802
                     /gene="Lrp1"
                     /gene_synonym="A2mr; b2b1554Clo; CD91; Lrp"
                     /inference="alignment:Splign:2.1.0"
     exon            6803..6927
                     /gene="Lrp1"
                     /gene_synonym="A2mr; b2b1554Clo; CD91; Lrp"
                     /inference="alignment:Splign:2.1.0"
     exon            6928..7305
                     /gene="Lrp1"
                     /gene_synonym="A2mr; b2b1554Clo; CD91; Lrp"
                     /inference="alignment:Splign:2.1.0"
     exon            7306..7495
                     /gene="Lrp1"
                     /gene_synonym="A2mr; b2b1554Clo; CD91; Lrp"
                     /inference="alignment:Splign:2.1.0"
     exon            7496..7700
                     /gene="Lrp1"
                     /gene_synonym="A2mr; b2b1554Clo; CD91; Lrp"
                     /inference="alignment:Splign:2.1.0"
     exon            7701..7893
                     /gene="Lrp1"
                     /gene_synonym="A2mr; b2b1554Clo; CD91; Lrp"
                     /inference="alignment:Splign:2.1.0"
     exon            7894..8019
                     /gene="Lrp1"
                     /gene_synonym="A2mr; b2b1554Clo; CD91; Lrp"
                     /inference="alignment:Splign:2.1.0"
     exon            8020..8148
                     /gene="Lrp1"
                     /gene_synonym="A2mr; b2b1554Clo; CD91; Lrp"
                     /inference="alignment:Splign:2.1.0"
     exon            8149..8268
                     /gene="Lrp1"
                     /gene_synonym="A2mr; b2b1554Clo; CD91; Lrp"
                     /inference="alignment:Splign:2.1.0"
     exon            8269..8382
                     /gene="Lrp1"
                     /gene_synonym="A2mr; b2b1554Clo; CD91; Lrp"
                     /inference="alignment:Splign:2.1.0"
     exon            8383..8532
                     /gene="Lrp1"
                     /gene_synonym="A2mr; b2b1554Clo; CD91; Lrp"
                     /inference="alignment:Splign:2.1.0"
     exon            8533..8655
                     /gene="Lrp1"
                     /gene_synonym="A2mr; b2b1554Clo; CD91; Lrp"
                     /inference="alignment:Splign:2.1.0"
     exon            8656..8772
                     /gene="Lrp1"
                     /gene_synonym="A2mr; b2b1554Clo; CD91; Lrp"
                     /inference="alignment:Splign:2.1.0"
     exon            8773..8901
                     /gene="Lrp1"
                     /gene_synonym="A2mr; b2b1554Clo; CD91; Lrp"
                     /inference="alignment:Splign:2.1.0"
     exon            8902..9024
                     /gene="Lrp1"
                     /gene_synonym="A2mr; b2b1554Clo; CD91; Lrp"
                     /inference="alignment:Splign:2.1.0"
     exon            9025..9165
                     /gene="Lrp1"
                     /gene_synonym="A2mr; b2b1554Clo; CD91; Lrp"
                     /inference="alignment:Splign:2.1.0"
     exon            9166..9356
                     /gene="Lrp1"
                     /gene_synonym="A2mr; b2b1554Clo; CD91; Lrp"
                     /inference="alignment:Splign:2.1.0"
     exon            9357..9540
                     /gene="Lrp1"
                     /gene_synonym="A2mr; b2b1554Clo; CD91; Lrp"
                     /inference="alignment:Splign:2.1.0"
     exon            9541..9626
                     /gene="Lrp1"
                     /gene_synonym="A2mr; b2b1554Clo; CD91; Lrp"
                     /inference="alignment:Splign:2.1.0"
     exon            9627..9746
                     /gene="Lrp1"
                     /gene_synonym="A2mr; b2b1554Clo; CD91; Lrp"
                     /inference="alignment:Splign:2.1.0"
     exon            9747..9934
                     /gene="Lrp1"
                     /gene_synonym="A2mr; b2b1554Clo; CD91; Lrp"
                     /inference="alignment:Splign:2.1.0"
     exon            9935..10140
                     /gene="Lrp1"
                     /gene_synonym="A2mr; b2b1554Clo; CD91; Lrp"
                     /inference="alignment:Splign:2.1.0"
     exon            10141..10329
                     /gene="Lrp1"
                     /gene_synonym="A2mr; b2b1554Clo; CD91; Lrp"
                     /inference="alignment:Splign:2.1.0"
     exon            10330..10478
                     /gene="Lrp1"
                     /gene_synonym="A2mr; b2b1554Clo; CD91; Lrp"
                     /inference="alignment:Splign:2.1.0"
     exon            10479..10572
                     /gene="Lrp1"
                     /gene_synonym="A2mr; b2b1554Clo; CD91; Lrp"
                     /inference="alignment:Splign:2.1.0"
     exon            10573..10689
                     /gene="Lrp1"
                     /gene_synonym="A2mr; b2b1554Clo; CD91; Lrp"
                     /inference="alignment:Splign:2.1.0"
     exon            10690..10809
                     /gene="Lrp1"
                     /gene_synonym="A2mr; b2b1554Clo; CD91; Lrp"
                     /inference="alignment:Splign:2.1.0"
     exon            10810..10932
                     /gene="Lrp1"
                     /gene_synonym="A2mr; b2b1554Clo; CD91; Lrp"
                     /inference="alignment:Splign:2.1.0"
     exon            10933..11058
                     /gene="Lrp1"
                     /gene_synonym="A2mr; b2b1554Clo; CD91; Lrp"
                     /inference="alignment:Splign:2.1.0"
     exon            11059..11175
                     /gene="Lrp1"
                     /gene_synonym="A2mr; b2b1554Clo; CD91; Lrp"
                     /inference="alignment:Splign:2.1.0"
     exon            11176..11282
                     /gene="Lrp1"
                     /gene_synonym="A2mr; b2b1554Clo; CD91; Lrp"
                     /inference="alignment:Splign:2.1.0"
     exon            11283..11415
                     /gene="Lrp1"
                     /gene_synonym="A2mr; b2b1554Clo; CD91; Lrp"
                     /inference="alignment:Splign:2.1.0"
     exon            11416..11535
                     /gene="Lrp1"
                     /gene_synonym="A2mr; b2b1554Clo; CD91; Lrp"
                     /inference="alignment:Splign:2.1.0"
     exon            11536..11658
                     /gene="Lrp1"
                     /gene_synonym="A2mr; b2b1554Clo; CD91; Lrp"
                     /inference="alignment:Splign:2.1.0"
     exon            11659..11799
                     /gene="Lrp1"
                     /gene_synonym="A2mr; b2b1554Clo; CD91; Lrp"
                     /inference="alignment:Splign:2.1.0"
     exon            11800..11934
                     /gene="Lrp1"
                     /gene_synonym="A2mr; b2b1554Clo; CD91; Lrp"
                     /inference="alignment:Splign:2.1.0"
     exon            11935..12054
                     /gene="Lrp1"
                     /gene_synonym="A2mr; b2b1554Clo; CD91; Lrp"
                     /inference="alignment:Splign:2.1.0"
     exon            12055..12323
                     /gene="Lrp1"
                     /gene_synonym="A2mr; b2b1554Clo; CD91; Lrp"
                     /inference="alignment:Splign:2.1.0"
     exon            12324..12502
                     /gene="Lrp1"
                     /gene_synonym="A2mr; b2b1554Clo; CD91; Lrp"
                     /inference="alignment:Splign:2.1.0"
     exon            12503..12609
                     /gene="Lrp1"
                     /gene_synonym="A2mr; b2b1554Clo; CD91; Lrp"
                     /inference="alignment:Splign:2.1.0"
     exon            12610..12726
                     /gene="Lrp1"
                     /gene_synonym="A2mr; b2b1554Clo; CD91; Lrp"
                     /inference="alignment:Splign:2.1.0"
     exon            12727..12903
                     /gene="Lrp1"
                     /gene_synonym="A2mr; b2b1554Clo; CD91; Lrp"
                     /inference="alignment:Splign:2.1.0"
     exon            12904..13044
                     /gene="Lrp1"
                     /gene_synonym="A2mr; b2b1554Clo; CD91; Lrp"
                     /inference="alignment:Splign:2.1.0"
     exon            13045..13218
                     /gene="Lrp1"
                     /gene_synonym="A2mr; b2b1554Clo; CD91; Lrp"
                     /inference="alignment:Splign:2.1.0"
     exon            13219..13380
                     /gene="Lrp1"
                     /gene_synonym="A2mr; b2b1554Clo; CD91; Lrp"
                     /inference="alignment:Splign:2.1.0"
     exon            13381..13555
                     /gene="Lrp1"
                     /gene_synonym="A2mr; b2b1554Clo; CD91; Lrp"
                     /inference="alignment:Splign:2.1.0"
     exon            13556..13657
                     /gene="Lrp1"
                     /gene_synonym="A2mr; b2b1554Clo; CD91; Lrp"
                     /inference="alignment:Splign:2.1.0"
     exon            13658..13722
                     /gene="Lrp1"
                     /gene_synonym="A2mr; b2b1554Clo; CD91; Lrp"
                     /inference="alignment:Splign:2.1.0"
     exon            13723..13813
                     /gene="Lrp1"
                     /gene_synonym="A2mr; b2b1554Clo; CD91; Lrp"
                     /inference="alignment:Splign:2.1.0"
     exon            13814..13958
                     /gene="Lrp1"
                     /gene_synonym="A2mr; b2b1554Clo; CD91; Lrp"
                     /inference="alignment:Splign:2.1.0"
     exon            13959..14892
                     /gene="Lrp1"
                     /gene_synonym="A2mr; b2b1554Clo; CD91; Lrp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      14872..14877
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lrp1"
                     /gene_synonym="A2mr; b2b1554Clo; CD91; Lrp"
                     /note="hexamer: AAGAAA"
     polyA_site      14892
                     /gene="Lrp1"
                     /gene_synonym="A2mr; b2b1554Clo; CD91; Lrp"
                     /note="major polyA site"
ORIGIN      
        1 agtcagggga gcagcggtgc gagctccagg ccagtgcact gaggaggcgg aaacggggga
       61 gcccctagtg ctccatcagg cccctaccaa ggcaccccca tcgggtccac gccccccacc
      121 ccccaccccg cctcctccca attgtgcatt tttgcagcca gaggcggctc cgagatgggg
      181 ctgtgagctt cgccctggga gggggagagg agcgaggagt aaagcagggg tgaagggttc
      241 gaatttgggg gcagggggcg cacccgcgtc agcaggccct tcccaggggg ctcggaactg
      301 taccatttca cctatgcccc tggttcgctt tgcttaagga aaggataaga atagaagagt
      361 cggggagagg aagataaagg gggacccccc aattgggggg ggcgaggaca agaagtaaca
      421 ggaccagagg gtgggggctg ctgtttgcat cggcccacac catgctgacc ccgccgttgc
      481 tgctgctgct gccgctgctt tcagctctgg tctccggggc cactatggat gcccctaaaa
      541 cttgcagccc taagcagttt gcctgcagag accaaatcac ctgtatctca aagggctggc
      601 ggtgtgacgg tgaaagagat tgccccgacg gctctgatga agcccctgag atctgtccac
      661 agagtaaagc ccagagatgc ccgccaaatg agcacagttg tctggggact gagctatgtg
      721 tccccatgtc tcgtctctgc aacgggatcc aggactgcat ggatggctca gacgagggtg
      781 ctcactgccg agagctccga gccaactgtt ctcgaatggg ttgtcaacac cattgtgtac
      841 ctacacccag tgggcccacg tgctactgta acagcagctt ccagctgcag gcagatggca
      901 agacgtgcaa agattttgac gagtgttccg tgtatggcac ctgcagccag ctttgcacca
      961 acacagatgg ctccttcaca tgtggctgtg ttgaaggcta cctgctgcaa ccggacaacc
     1021 gctcctgcaa ggccaagaat gagccagtag atcggccgcc agtgctactg attgccaact
     1081 ctcagaacat cctagctacg tacctgagtg gggcccaagt gtctaccatc acacccacca
     1141 gcacccgaca aaccacggcc atggacttca gttatgccaa tgagaccgta tgctgggtgc
     1201 acgttgggga cagtgctgcc cagacacagc tcaagtgtgc ccggatgcct ggcctgaagg
     1261 gctttgtgga tgagcatacc atcaacatct ccctcagcct gcaccacgtg gagcagatgg
     1321 caatcgactg gctgacggga aacttctact ttgtcgacga cattgacgac aggatctttg
     1381 tctgtaaccg aaacggggac acctgtgtca ctctgctgga cctggaactc tacaacccca
     1441 aaggcatcgc cttggacccc gccatgggga aggtgttctt cactgactac gggcagatcc
     1501 caaaggtgga gcgctgtgac atggatggac agaaccgcac caagctggtg gatagcaaga
     1561 tcgtgtttcc acacggcatc accctggacc tggtcagccg cctcgtctac tgggcggacg
     1621 cctacctaga ctacatcgag gtggtagact acgaagggaa gggtcggcag accatcatcc
     1681 aaggcatcct gatcgagcac ctgtacggcc tgaccgtgtt tgagaactat ctctacgcca
     1741 ccaactcgga caatgccaac acgcagcaga agacgagcgt gatccgagtg aaccggttca
     1801 acagtactga gtaccaggtc gtcacccgtg tggacaaggg tggtgccctg catatctacc
     1861 accagcgacg ccagccccga gtgcggagtc acgcctgtga gaatgaccag tacgggaagc
     1921 caggtggctg ctccgacatc tgcctcctgg ccaacagtca caaggcaagg acctgcaggt
     1981 gcaggtctgg cttcagcctg ggaagtgatg ggaagtcttg taagaaacct gaacatgagc
     2041 tgttcctcgt gtatggcaag ggccgaccag gcatcattag aggcatggac atgggggcca
     2101 aggtcccaga tgagcacatg atccccatcg agaaccttat gaatccacgc gctctggact
     2161 tccacgccga gaccggcttc atctactttg ctgacaccac cagctacctc attggccgcc
     2221 agaaaattga tggcacggag agagagacta tcctgaagga tggcatccac aatgtggagg
     2281 gcgtagccgt ggactggatg ggagacaatc tttactggac tgatgatggc cccaagaaga
     2341 ccattagtgt ggccaggctg gagaaagccg ctcagacccg gaagactcta attgagggca
     2401 agatgacaca ccccagggcc attgtagtgg atccactcaa tgggtggatg tactggacag
     2461 actgggagga ggaccccaag gacagtcggc gagggcggct cgagagggct tggatggacg
     2521 gctcacaccg agatatcttt gtcacctcca agacagtgct ttggcccaat gggctaagcc
     2581 tggatatccc agccggacgc ctctactggg tggatgcctt ctatgaccga attgagacca
     2641 tactgctcaa tggcacagac cggaagattg tatatgaggg tcctgaactg aatcatgcct
     2701 tcggcctgtg tcaccatggc aactacctct tttggaccga gtaccggagc ggcagcgtct
     2761 accgcttgga acggggcgtg gcaggcgcac cgcccactgt gacccttctg cgcagcgaga
     2821 gaccgcctat ctttgagatc cgaatgtacg acgcgcagca gcagcaagtg ggtaccaaca
     2881 aatgccgggt aaataacgga ggctgcagca gcctgtgcct cgccaccccc gggagccgcc
     2941 agtgtgcctg tgccgaggac caggtgttgg acacagatgg tgtcacctgc ttggcgaacc
     3001 catcctacgt gcccccaccc cagtgccagc cgggcgagtt tgcctgtgcc aacaaccgct
     3061 gcatccagga gcgctggaag tgtgacggag acaacgactg tctggacaac agcgatgagg
     3121 ccccagcact gtgccatcaa cacacctgtc cctcggaccg attcaagtgt gagaacaacc
     3181 ggtgtatccc caaccgctgg ctctgtgatg gggataatga ttgtggcaac agcgaggacg
     3241 aatccaatgc cacgtgctca gcccgcacct gtccacccaa ccagttctcc tgtgccagtg
     3301 gccgatgcat tcctatctca tggacctgtg atctggatga tgactgtggg gaccggtccg
     3361 atgagtcagc ctcatgcgcc taccccacct gcttccccct gactcaattt acctgcaaca
     3421 atggcagatg tattaacatc aactggcggt gtgacaacga caatgactgt ggggacaaca
     3481 gcgacgaagc cggctgcagt cactcctgct ccagtaccca gttcaagtgc aacagtggca
     3541 gatgcatccc cgagcactgg acgtgtgatg gggacaatga ttgtggggac tacagcgacg
     3601 agacacacgc caactgtacc aaccaggcta caagacctcc tggtggctgc cactcggatg
     3661 agttccagtg ccgcctagat ggcctgtgca tccccctgag gtggcgctgc gacggggaca
     3721 ccgactgcat ggattccagc gatgagaaga gctgtgaggg cgtgacccat gtttgtgacc
     3781 cgaatgtcaa gtttggctgc aaggactccg cccggtgcat cagcaaggcg tgggtgtgtg
     3841 atggcgacag cgactgtgaa gataactccg acgaggagaa ctgtgaggcc ctggcctgca
     3901 ggccaccctc ccatccctgc gccaacaaca cctctgtctg cctgcctcct gacaagctgt
     3961 gcgacggcaa ggatgactgt ggagacggct cggatgaggg cgagctctgt gaccagtgtt
     4021 ctctgaataa tggtggctgt agtcacaact gctcagtggc ccctggtgaa ggcatcgtgt
     4081 gctcttgccc tctgggcatg gagctgggct ctgacaacca cacctgccag atccagagct
     4141 actgtgccaa gcacctcaaa tgcagccaga agtgtgacca gaacaagttc agtgtgaagt
     4201 gctcctgcta cgagggctgg gtcttggagc ctgacgggga aagctgccgc agtctggatc
     4261 ccttcaaacc gttcatcatc ttctccaacc gccacgagat caggcgcatt gaccttcaca
     4321 agggggacta cagcgtccta gtgcctggcc tgcgcaacac tattgccctg gacttccacc
     4381 tcagccagag tgccctctac tggaccgacg tggtagagga caagatctac cgtgggaaac
     4441 tcctggacaa cggagccctg accagctttg aggtggtgat tcagtatggc ttggccacac
     4501 cagagggcct ggctgtagat tggattgcag gcaacatcta ctgggtggag agcaacctgg
     4561 accagatcga agtggccaag ctggacggaa ccctccgaac cactctgctg gcgggtgaca
     4621 ttgagcaccc gagggccatc gctctggacc ctcgggatgg gattctgttt tggacagact
     4681 gggatgccag cctgccacga atcgaggctg cgtccatgag tggggctggc cgccgaacca
     4741 tccaccggga gacaggctct gggggctggc ccaacgggct caccgtggat tacctggaga
     4801 agcgcatcct ctggattgat gctaggtcag atgccatcta ttcagcccgg tatgacggct
     4861 ccggccacat ggaggtgctt cggggacacg agttcctgtc acacccattt gccgtgacac
     4921 tgtacggtgg ggaggtgtac tggaccgact ggcgaacaaa tacactggct aaggccaaca
     4981 agtggactgg ccacaacgtc accgtggtac agaggaccaa cacccagccc ttcgacctgc
     5041 aggtgtatca cccttcccgg cagcccatgg ctccaaaccc atgtgaggcc aatggcggcc
     5101 ggggcccctg ttcccatctg tgcctcatca actacaaccg gaccgtctcc tgcgcctgtc
     5161 cccacctcat gaagctgcac aaggacaaca ccacctgcta tgagtttaag aagttcctgc
     5221 tgtacgcacg tcagatggag atccggggcg tggacctgga tgccccgtac tacaattata
     5281 tcatctcctt cacggtgcct gatatcgaca atgtcacggt gctggactat gatgcccgag
     5341 agcagcgagt ttactggtct gatgtgcgga ctcaagccat caaaagggca tttatcaacg
     5401 gcactggcgt ggagaccgtt gtctctgcag acttgcccaa cgcccacggg ctggctgtgg
     5461 actgggtctc ccgaaatctg ttttggacaa gttacgacac caacaagaag cagattaacg
     5521 tggcccggct ggacggctcc ttcaagaatg cggtggtgca gggcctggag cagccccacg
     5581 gcctggtcgt ccacccgctt cgtggcaagc tctactggac tgatggggac aacatcagca
     5641 tggccaacat ggatgggagc aaccacactc tgctcttcag tggccagaag ggccctgtgg
     5701 ggttggccat tgacttccct gagagcaaac tctactggat cagctctggg aaccacacaa
     5761 tcaaccgttg caatctggat gggagcgagc tggaggtcat cgacaccatg cggagccagc
     5821 tgggcaaggc cactgccctg gccatcatgg gggacaagct gtggtgggca gatcaggtgt
     5881 cagagaagat gggcacgtgc aacaaagccg atggctctgg gtccgtggtg ctgcggaaca
     5941 gtaccacgtt ggttatgcac atgaaggtgt atgacgagag catccagcta gagcatgagg
     6001 gcaccaaccc ctgcagtgtc aacaacggag actgttccca gctctgcctg ccaacatcag
     6061 agacgactcg ctcctgtatg tgtacagccg gttacagcct ccggagcgga cagcaggcct
     6121 gtgagggtgt gggctctttt ctcctgtact ctgtacatga gggaattcgg gggattccac
     6181 tagatcccaa tgacaagtcg gatgccctgg tcccagtgtc cggaacttca ctggctgtcg
     6241 gaatcgactt ccatgccgaa aatgacacta tttattgggt ggatatgggc ctaagcacca
     6301 tcagcagggc caagcgtgac cagacatggc gagaggatgt ggtgaccaac ggtattggcc
     6361 gtgtggaggg catcgcggtg gactggatcg caggcaacat atactggacg gaccagggct
     6421 tcgatgtcat cgaggttgcc cggctcaatg gctcttttcg ttatgtggtc atttcccagg
     6481 gtctggacaa gcctcgggcc atcactgtcc acccagagaa ggggtacttg ttctggaccg
     6541 agtggggtca ttacccacgt attgagcggt ctcgccttga tggcacagag agagtggtgt
     6601 tggttaatgt cagcatcagc tggcccaatg gcatctcagt agactatcag ggcggcaagc
     6661 tctactggtg tgatgctcgg atggacaaga tcgagcgcat cgacctggaa acgggcgaga
     6721 accgggaggt ggtcctgtcc agcaataaca tggatatgtt ctccgtgtcc gtgtttgagg
     6781 acttcatcta ctggagtgac agaactcacg ccaatggctc catcaagcgc ggctgcaaag
     6841 acaatgctac agactccgtg cctctgagga caggcattgg tgttcagctt aaagacatca
     6901 aggtcttcaa cagggacagg cagaagggta ccaatgtgtg cgcggtagcc aacggcgggt
     6961 gccagcagct ctgcttgtat cggggtggcg gacagcgagc ctgtgcctgt gcccacggga
     7021 tgctggcaga agacggggcc tcatgccgag agtacgctgg ctacctgctc tactcagagc
     7081 ggaccatcct caagagcatc cacctgtcgg atgagcgtaa cctcaacgca ccggtgcagc
     7141 cctttgaaga ccccgagcac atgaaaaatg tcatcgccct ggcctttgac taccgagcag
     7201 gcacctcccc ggggacccct aaccgcatct tcttcagtga catccacttt gggaacatcc
     7261 agcagatcaa tgacgatggc tcgggcagga ccaccatcgt ggaaaatgtg ggctctgtgg
     7321 aaggcctggc ctatcaccgt ggctgggaca cactgtactg gacaagctac accacatcca
     7381 ccatcacccg ccacaccgtg gaccagactc gcccaggggc cttcgagagg gagacagtca
     7441 tcaccatgtc cggagacgac cacccgagag cctttgtgct ggatgagtgc cagaacctga
     7501 tgttctggac caattggaac gagctccatc caagcatcat gcgggcagcc ctatccggag
     7561 ccaacgtcct gaccctcatt gagaaggaca tccgcacgcc caatgggttg gccatcgacc
     7621 accgggcgga gaagctgtac ttctcggatg ccaccttgga caagatcgag cgctgcgagt
     7681 acgacggctc ccaccgctat gtgatcctaa agtcggagcc cgtccacccc tttgggttgg
     7741 cggtgtacgg agagcacatt ttctggactg actgggtgcg gcgggctgtg cagcgagcca
     7801 acaagtatgt gggcagcgac atgaagctgc ttcgggtgga cattccccag caacccatgg
     7861 gcatcatcgc cgtggccaac gacaccaaca gctgtgaact ctccccctgc cgtatcaaca
     7921 atggaggctg ccaggatctg tgtctgctca cccaccaagg ccacgtcaac tgttcctgtc
     7981 gagggggccg gatcctccag gaggacttca cctgccgggc tgtgaactcc tcttgtcggg
     8041 cacaagatga gtttgagtgt gccaatgggg aatgtatcag cttcagcctc acctgtgatg
     8101 gcgtctccca ctgcaaggac aagtccgatg agaagccctc ctactgcaac tcacgccgct
     8161 gcaagaagac tttccgccag tgtaacaatg gtcgctgtgt atccaacatg ctgtggtgca
     8221 atggggtgga tgactgtggg gatggctctg atgagattcc ttgcaacaag actgcctgtg
     8281 gtgtgggtga gttccgctgc cgggatgggt cctgcatcgg gaactccagt cgctgcaacc
     8341 agtttgtgga ttgtgaggat gcctcggatg agatgaattg cagtaccaca gactgcagca
     8401 gctatttccg cctgggcgtg aaaggtgtcc tcttccagcc gtgcgagcgg acatccctgt
     8461 gctacgcacc tagctgggtg tgtgatggcg ccaacgactg tggagactac agcgatgaac
     8521 gtgactgtcc aggtgtgaag cgccctaggt gcccgctcaa ttactttgcc tgccccagcg
     8581 ggcgctgtat ccccatgagc tggacgtgtg acaaggagga tgactgtgag aacggcgagg
     8641 acgagaccca ctgcaacaag ttctgctcag aggcacagtt cgagtgccag aaccaccggt
     8701 gtatctccaa gcagtggctg tgtgacggta gcgatgattg cggggatggc tccgatgagg
     8761 cagctcactg tgaaggcaag acatgtggcc cctcctcctt ctcctgtccc ggcacccacg
     8821 tgtgtgtccc tgagcgctgg ctctgtgatg gcgacaagga ctgtaccgat ggcgcggatg
     8881 agagtgtcac tgctggctgc ctgtacaaca gcacctgtga tgaccgtgag ttcatgtgcc
     8941 agaaccgctt gtgtattccc aagcatttcg tgtgcgacca tgaccgtgac tgtgctgatg
     9001 gctctgatga atcccctgag tgtgagtacc caacctgcgg ccccaatgaa ttccgctgtg
     9061 ccaatgggcg ttgtctgagc tcccgtcagt gggaatgtga tggggagaat gactgtcacg
     9121 accacagcga tgaggctccc aagaacccac actgcaccag cccagagcac aaatgcaatg
     9181 cctcatcaca gttcctgtgc agcagcgggc gctgcgtggc tgaggcgttg ctctgcaacg
     9241 gccaggacga ctgtggggac ggttcagacg aacgcgggtg ccatgtcaac gagtgtctca
     9301 gccgcaagct cagtggctgc agtcaggact gcgaggacct caagataggc tttaagtgcc
     9361 gctgtcgccc gggcttccgg ctaaaggacg atggcaggac ctgtgccgac ctggatgagt
     9421 gcagcaccac cttcccctgc agccagctct gcatcaacac ccacggaagt tacaagtgtc
     9481 tgtgtgtgga gggctatgca ccccgtggcg gtgaccccca cagctgcaaa gctgtgaccg
     9541 atgaggagcc atttctcatc tttgccaacc ggtactacct gcggaagctc aacctggacg
     9601 gctccaacta cacactgctt aagcagggcc tgaacaatgc ggtcgccttg gactttgact
     9661 accgagagca gatgatctac tggacggacg tgaccaccca gggcagcatg attcgcagga
     9721 tgcacctcaa cggcagcaac gtgcaggttc tgcaccggac gggccttagt aacccagatg
     9781 ggctggctgt ggactgggtg ggtggcaacc tgtactggtg tgacaagggc agagatacca
     9841 ttgaggtgtc caagcttaac ggggcctatc ggacagtgct ggtcagctct ggcctccggg
     9901 agcccagagc tctggtagtg gatgtacaga atgggtacct gtactggaca gactggggtg
     9961 accactcact gatcggccgg attggcatgg atggatctgg ccgcagcatc atcgtggaca
    10021 ctaagatcac atggcccaat ggcctgaccg tggactacgt cacggaacgc atctactggg
    10081 ctgacgcccg tgaggactac atcgagttcg ccagcctgga tggctccaac cgtcacgttg
    10141 tgctgagcca agacatccca cacatctttg cgctgaccct atttgaagac tacgtctact
    10201 ggacagactg ggaaacgaag tccatcaacc gggcccacaa gaccacgggt gccaacaaaa
    10261 cactcctcat cagcaccctg caccggccca tggacttaca tgtattccac gccctgcgcc
    10321 agccagatgt gcccaatcac ccctgcaaag tcaacaatgg tggctgcagc aacctgtgcc
    10381 tgctgtcccc tgggggtggt cataaatgcg cctgccccac caacttctat ctgggtggcg
    10441 atggccgtac ctgtgtgtcc aactgcacag caagccagtt tgtgtgcaaa aatgacaagt
    10501 gcatcccctt ctggtggaag tgtgacacgg aggacgactg tggggatcac tcagacgagc
    10561 ctccagactg tcccgagttc aagtgccgcc caggccagtt ccagtgctcc accggcatct
    10621 gcaccaaccc tgccttcatc tgtgatgggg acaatgactg ccaagacaat agtgatgagg
    10681 ccaattgcga cattcacgtc tgcttgccca gccaattcaa gtgcaccaac accaaccgct
    10741 gcattcctgg catcttccgt tgcaatgggc aggacaactg cggggacggc gaggatgagc
    10801 gggattgccc tgaggtgacc tgcgccccca accagttcca gtgctccatc accaagcgct
    10861 gcatccctcg cgtctgggtc tgtgacaggg ataatgactg tgtggacggc agtgatgagc
    10921 ctgccaactg tacccaaatg acctgtggag tggatgagtt ccgctgcaag gattctggcc
    10981 gctgcatccc cgcgcgctgg aagtgtgacg gagaagatga ctgtggggat ggttcagatg
    11041 agcccaagga agagtgtgat gagcgcacct gtgagccata ccagttccgc tgcaaaaaca
    11101 accgctgtgt cccaggccgt tggcaatgtg actacgacaa cgactgcgga gataactcgg
    11161 acgaggagag ctgcacacct cggccctgct ctgagagtga gttttcctgt gccaatggcc
    11221 gctgcatcgc tgggcgctgg aagtgtgatg gggaccatga ctgtgccgac ggctcagacg
    11281 agaaagactg caccccccgc tgtgatatgg accagttcca gtgcaagagt ggccactgca
    11341 tccccctgcg ctggcgctgt gacgcggatg ctgactgtat ggacggcagt gacgaggaag
    11401 cctgtggcac tggggtgagg acctgcccat tggatgagtt tcaatgtaac aacaccttgt
    11461 gcaagccgct ggcctggaag tgtgatggag aggacgactg tggggacaac tcagatgaga
    11521 accccgagga atgcgcccgg ttcatctgcc ctcccaaccg gcctttccgc tgcaagaatg
    11581 accgagtctg cctgtggatt gggcgccagt gtgatggcgt ggacaactgt ggagatggga
    11641 ctgacgagga ggactgtgag ccccccacgg cccagaaccc ccactgcaaa gacaagaagg
    11701 agttcctgtg ccgaaaccag cgctgtctat catcctccct gcgctgtaac atgttcgatg
    11761 actgcggcga tggctccgat gaagaagatt gcagcatcga ccccaagctg accagctgtg
    11821 ccaccaatgc cagcatgtgt ggggacgaag ctcgttgtgt gcgcactgag aaagctgcct
    11881 actgtgcctg ccgctcgggc ttccatactg tgccgggcca gcccggatgc caggacatca
    11941 acgagtgcct gcgctttggt acctgctctc agctctgcaa caacaccaag ggaggccacc
    12001 tctgcagctg tgcccgcaac ttcatgaaga cacacaacac ctgcaaagct gaaggctccg
    12061 agtaccaggt gctatacatc gcggatgaca acgagatccg cagcttgttc ccgggccacc
    12121 cccactcagc ctacgagcag acattccagg gcgatgagag tgtccgcata gatgccatgg
    12181 atgtccatgt caaggccggc cgtgtctact ggactaactg gcacacgggc acaatctcct
    12241 acaggagcct gccccctgcc gcccctccta ccacttccaa ccgccaccgg aggcagatcg
    12301 accggggtgt cacccacctc aatatttcag ggctgaagat gccgaggggt atcgctatcg
    12361 actgggtggc cgggaatgtg tactggaccg attccggccg agacgtgatt gaggtggcgc
    12421 aaatgaaggg cgagaaccgc aagacgctca tctcgggcat gattgatgag ccccatgcca
    12481 tcgtggtgga ccctctgagg ggcaccatgt actggtcaga ctgggggaac caccccaaga
    12541 ttgaaacagc agcgatggat ggcacccttc gggagactct cgtgcaagac aacattcagt
    12601 ggcctacagg gctggctgtg gactatcaca atgaacggct ctactgggca gatgccaagc
    12661 tttcggtcat cggcagcatc cggctcaacg gcactgaccc cattgtggct gctgacagca
    12721 aacgaggcct aagtcacccc ttcagcatcg atgtgtttga agactacatc tacggagtca
    12781 cttacatcaa taatcgtgtc ttcaagatcc acaagtttgg acacagcccc ttgatcaacc
    12841 taactggggg cctgagccat gcctctgatg tagtccttta ccatcaacac aagcagcctg
    12901 aagtgaccaa cccctgtgac cgcaagaaat gtgaatggct gtgtctgctg agccccagcg
    12961 ggcctgtctg cacctgtccc aatggaaaga ggctggataa tggcacctgt gtgcctgtgc
    13021 cctctccaac accccctcca gatgccccta ggcctggaac ctgcactctg cagtgcttca
    13081 atggtggtag ttgtttcctc aatgctcgga ggcagcccaa gtgccgttgc cagccccgtt
    13141 acacaggcga taagtgtgag ctggatcagt gctgggaata ctgtcacaac ggaggcacct
    13201 gtgcggcttc cccatctggc atgcccacgt gccgctgtcc cactggcttc acgggcccca
    13261 aatgcaccgc acaggtgtgt gcaggctact gctctaacaa cagcacctgc accgtcaacc
    13321 agggcaacca gccccagtgc cgatgtctac ctggcttcct gggcgaccgt tgccagtacc
    13381 ggcagtgctc tggcttctgt gagaactttg gcacctgtca gatggctgct gatggctccc
    13441 gacaatgtcg ctgcaccgtc tactttgagg gaccaaggtg tgaggtgaac aagtgtagtc
    13501 gctgtctcca aggcgcctgt gtggtcaata agcagaccgg agatgtcaca tgcaactgca
    13561 ctgatggccg ggtagccccc agttgtctga cctgcatcga tcactgtagc aatggtggct
    13621 cctgcaccat gaacagcaag atgatgcctg agtgccagtg cccgccccat atgacaggac
    13681 cccggtgcga ggagcaggtt gttagtcagc aacagcctgg gcatatggcc tccatcctga
    13741 tccctctgct gctgcttctc ctgctgcttc tggtggctgg cgtggtgttc tggtataagc
    13801 ggcgagtccg aggggctaag ggcttccagc accagcggat gaccaatggg gccatgaatg
    13861 tggaaattgg aaaccctacc tacaagatgt atgaaggtgg agagcccgat gatgtcgggg
    13921 gcctactgga tgctgatttt gcccttgacc ctgacaagcc taccaacttc accaacccag
    13981 tgtatgccac gctctacatg gggggccacg gcagccgcca ttccctggcc agcacggacg
    14041 agaagcgaga actgctgggc cggggacctg aagacgagat aggagatccc ttggcatagg
    14101 gccctgcccc gacggatgtc cccagaaagc cccctgccac atgagtcttt caatgaaccc
    14161 cctccccagc cggcccttct ccggccctgc cgggtgtaca aatgtaaaaa tgaaggaatt
    14221 actttttata tgtgagcgag caagcgagca agcacagtat tatctctttg catttccttc
    14281 ctgcctgctc ctcagtatcc cccccatgct gccttgaggg ggcggggagg gctttgtggc
    14341 tcaaaggtat gaaggagtcc acatgttccc taccgagcat acccctggaa gctggcggca
    14401 cggcctcccc accacgcctg tgcaagacac tcaacggggc tccgtgtccc agctttcctt
    14461 tccttggctc tctggggtta gttcagggga ggtggagtcc tctgctgacc ctgtctggaa
    14521 gatttggctc tagctgagga aggagtcttt tagttgaggg aagtcacccc aaaccccagc
    14581 tcccactttc aggggcacct ctcagatggc catgctcagt atcccttcca gacaggccct
    14641 cccctctcta gcgccccctc tgtggctcct agggctgaac acattctttg gtaactgtcc
    14701 cccaagcctc ccatccccct gagggccagg aagagtcggg gcacaccaag gaagggcaag
    14761 cgggcagccc cattttgggg acgtgaacgt tttaataatt tttgctgaat tcctttacaa
    14821 ctaaataaca cagatattgt tataaataaa attgtaaaaa aggaaaaaaa aaagaaaaga
    14881 aaagaaaaga aaaaaaaaaa aaaaaaa
//
